Bacterial Protein Toxins: Role in the Interference with Cell Growth Regulation

doi:10.1017/CBO9780511546280

Bacterial Protein Toxins

Role in the Interference with Cell Growth Regulation

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Edited by Alistair J. Lax, King's College London

Publisher:: Cambridge University Press
Online publication date:: September 2009
Print publication year:: 2005
Online ISBN:: 9780511546280
DOI:: https://doi.org/10.1017/CBO9780511546280

Subjects:: Life Sciences, Pathology and Laboratory Science, Microbiology and Immunology, Molecular Biology, Biochemistry, and Structural Biology
Series:: Advances in Molecular and Cellular Microbiology (7)

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Bacterial toxins that act inside cells interact very specifically with key components of the cell and some even manipulate the cell in subtle ways for their own purposes. These potent toxins, described in this 2005 book, will be of interest to both microbiologists and cell biologists. Some of these toxins are conventional multidomain toxins that are self-programmed to enter cells. Others are delivered by type III mechanisms, often as a package of potent molecules. The molecular targets for all these toxins mediate signal transduction and the cell cycle to regulate the crucial processes of cell growth, cell division and differentiation. Thus these potent toxins are not only responsible for disease, but also provide a powerful set of tools with which to interrogate the biology of the cell. In addition such toxins may act directly to promote carcinogenesis and hence their study is also of interest in a wider context.

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Bacterial Protein Toxins

Role in the Interference with Cell Growth Regulation

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Frontmatter
pp i-vi

Contents
pp vii-viii

List of Contributors
pp ix-xii

Preface
pp xiii-xiv

1 - Toxins and the interaction between bacterium and host
pp 1-6

2 - The mitogenic Pasteurella multocida toxin and cellular signalling
pp 7-32

3 - Rho-activating toxins and growth regulation
pp 33-52

4 - Cytolethal distending toxins: A paradigm for bacterial cyclostatins
pp 53-80

5 - Bartonella signaling and endothelial cell proliferation
pp 81-116

6 - Type III–delivered toxins that target signalling pathways
pp 117-146

7 - Bacterial toxins and bone remodelling
pp 147-168

8 - Helicobacter pylori mechanisms for inducing epithelial cell proliferation
pp 169-198

9 - Bacteria and cancer
pp 199-226

10 - What is there still to learn about bacterial toxins?
pp 227-230

Index
pp 231-239

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Bacterial Protein Toxins

Role in the Interference with Cell Growth Regulation

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