Book contents
- Uncommon Causes of Stroke
- Uncommon Causes of Stroke
- Copyright page
- Contents
- List of Contributors
- Preface
- PART I: INFECTIOUS AND INFLAMMATORY CONDITIONS
- PART II: HEREDITARY AND GENETIC CONDITIONS AND MALFORMATIONS
- PART III: VASCULAR CONDITIONS OF THE EYES, EARS, AND BRAIN
- PART IV: DISORDERS INVOLVING ABNORMAL COAGULATION
- PART V: SYSTEMIC DISORDERS THAT ALSO INVOLVE THE CEREBROVASCULAR SYSTEM
- 43 MICROSCOPIC POLYANGIITIS AND POLYARTERITIS NODOSA
- 44 CHURG-STRAUSS SYNDROME
- 45 SYSTEMIC LUPUS ERYTHEMATOSUS
- 46 RHEUMATOID ARTHRITIS AND CEREBROVASCULAR DISEASE
- 47 HYPERVISCOSITY AND STROKE
- 48 CALCIUM, HYPERCALCEMIA, MAGNESIUM, AND BRAIN ISCHEMIA
- 49 STROKE AND SUBSTANCE ABUSE
- 50 CANCER AND PARANEOPLASTIC STROKES
- 51 KOHLMEIER-DEGOS’ DISEASE (MALIGNANT ATROPHIC PAPULOSIS)
- 52 STROKE IN PATIENTS WHO HAVE INFLAMMATORY BOWEL DISEASE
- 53 SWEET’S SYNDROME (ACUTE FEBRILE NEUTROPHILIC DERMATOSIS)
- 54 NEPHROTIC SYNDROME AND OTHER RENAL DISEASES AND STROKE
- 55 EPIDERMAL NEVUS SYNDROME
- 56 SNEDDON’S SYNDROME
- 57 MITOCHONDRIAL AND METABOLIC CAUSES OF STROKE
- 58 BONE DISORDERS AND CEREBROVASCULAR DISEASES
- 59 SCLERODERMA
- PART VI: NONINFLAMMATORY DISORDERS OF THE ARTERIAL WALL
- PART VII: VENOUS OCCLUSIVE CONDITIONS
- PART VIII: VASOSPASTIC CONDITIONS AND OTHER MISCELLANEOUS VASCULOPATHIES
- PART IX: OTHER MISCELLANEOUS CONDITIONS
- Index
43 - MICROSCOPIC POLYANGIITIS AND POLYARTERITIS NODOSA
from PART V: - SYSTEMIC DISORDERS THAT ALSO INVOLVE THE CEREBROVASCULAR SYSTEM
Published online by Cambridge University Press: 06 January 2010
Book contents
- Uncommon Causes of Stroke
- Uncommon Causes of Stroke
- Copyright page
- Contents
- List of Contributors
- Preface
- PART I: INFECTIOUS AND INFLAMMATORY CONDITIONS
- PART II: HEREDITARY AND GENETIC CONDITIONS AND MALFORMATIONS
- PART III: VASCULAR CONDITIONS OF THE EYES, EARS, AND BRAIN
- PART IV: DISORDERS INVOLVING ABNORMAL COAGULATION
- PART V: SYSTEMIC DISORDERS THAT ALSO INVOLVE THE CEREBROVASCULAR SYSTEM
- 43 MICROSCOPIC POLYANGIITIS AND POLYARTERITIS NODOSA
- 44 CHURG-STRAUSS SYNDROME
- 45 SYSTEMIC LUPUS ERYTHEMATOSUS
- 46 RHEUMATOID ARTHRITIS AND CEREBROVASCULAR DISEASE
- 47 HYPERVISCOSITY AND STROKE
- 48 CALCIUM, HYPERCALCEMIA, MAGNESIUM, AND BRAIN ISCHEMIA
- 49 STROKE AND SUBSTANCE ABUSE
- 50 CANCER AND PARANEOPLASTIC STROKES
- 51 KOHLMEIER-DEGOS’ DISEASE (MALIGNANT ATROPHIC PAPULOSIS)
- 52 STROKE IN PATIENTS WHO HAVE INFLAMMATORY BOWEL DISEASE
- 53 SWEET’S SYNDROME (ACUTE FEBRILE NEUTROPHILIC DERMATOSIS)
- 54 NEPHROTIC SYNDROME AND OTHER RENAL DISEASES AND STROKE
- 55 EPIDERMAL NEVUS SYNDROME
- 56 SNEDDON’S SYNDROME
- 57 MITOCHONDRIAL AND METABOLIC CAUSES OF STROKE
- 58 BONE DISORDERS AND CEREBROVASCULAR DISEASES
- 59 SCLERODERMA
- PART VI: NONINFLAMMATORY DISORDERS OF THE ARTERIAL WALL
- PART VII: VENOUS OCCLUSIVE CONDITIONS
- PART VIII: VASOSPASTIC CONDITIONS AND OTHER MISCELLANEOUS VASCULOPATHIES
- PART IX: OTHER MISCELLANEOUS CONDITIONS
- Index
Summary
This chapter explores the complex relationship of stroke with polyarteritis nodosa (PAN) and microscopic polyangiitis (MPA). MPA is a systemic necrotizing vasculitis that clinically and histologically involves capillaries, venules, or arterioles without granulomata, and is associated with necrotizing crescentic glomerulonephritis and hemorrhagic pulmonary capillaritis, which are the main causes of mortality and morbidity. Hemorrhagic strokes occur more frequently than ischemic infarction in MPA. Immunohistochemical studies from muscle and nerve biopsies showed that macrophages and T cells, mostly CD8+, are involved in the pathogenesis of PAN. Neurological symptoms and signs are a major and common feature of PAN, occurring in nearly three-quarters of patients. A close relationship between the use of corticosteroids and stroke exists in PAN. From a therapeutic point of view, antiplatelet drugs, which inhibit platelet thromboxane production, might reduce the risk of corticosteroid-induced, antiplatelet drugs in PAN. The use of aspirin and corticosteroids prospectively prevents stroke recurrence.
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- Uncommon Causes of Stroke , pp. 311 - 330Publisher: Cambridge University PressPrint publication year: 2008