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8 - The protozoan parasites

from Section 1 - Agents

Published online by Cambridge University Press:  12 January 2010

By
David A. Leiby  and
Silvano Wendel
Edited by
John A. J. Barbara ,
Fiona A. M. Regan  and
Marcela Contreras
David A. Leiby
Affiliation:
Chief of Parasitology, American Red Cross, Holland Laboratory, Rockville, MD, USA
Silvano Wendel
Affiliation:
Medical Director, Blood Bank, Hospital Sírio Libanês, São Paulo, Brazil
John A. J. Barbara
Affiliation:
University of the West of England, Bristol
Fiona A. M. Regan
Affiliation:
HNSBT and Hammersmith Hospitals NHS Trust, London
Marcela Contreras
Affiliation:
University of the West of England, Bristol
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Summary

Transmission of infectious agents by blood transfusion has been an ongoing concern of transfusion medicine for decades. For years, the focus of concern has appropriately been on a variety of viral agents (e.g. HIV, hepatitis viruses, West Nile virus) that are known to pose blood safety risks. However, in recent years, infections resulting from protozoan parasites have received more prominent attention largely due to two factors. First, the success in controlling transfusion-transmitted viral agents has resulted in those infections caused by parasitic agents being more visible. Second, changing donor demographics and the norm of worldwide travel have introduced many parasitic agents, which were once thought to be exotic, to non-endemic developed countries. With the increased interest in preventing the transmission of protozoan parasites, new interventions, not based on viral models, are required. In this chapter we have attempted to explore these and other transfusion issues surrounding those protozoan parasites that pose blood safety risks (see Table 8.1).

Plasmodium spp. – malaria

Malaria is a life-threatening parasitic disease transmitted by mosquitoes (Warrell et al., 2002). Human malaria is transmitted by four different species: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malariae, which require two different hosts to complete their life cycle – an Anopheles mosquito (sexual stage) and humans (asexual stage).

When infected female mosquitoes bite humans (see Figure 8.1), they release small asexual sporozoites through their salivary gland into the bloodstream. These are amotile, spindle shaped, 10–15 μm long organisms.

Type
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Information
Transfusion Microbiology , pp. 117 - 140
Publisher: Cambridge University Press
Print publication year: 2008

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