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Chapter 3 - Investigation of Male Infertility

Published online by Cambridge University Press:  03 June 2019

By
Arie Parnham  and
Asif Muneer
Edited by
Jane A. Stewart
Jane A. Stewart
Affiliation:
Newcastle Hospitals NHS Foundation Trust
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Summary

Male factor infertility is a contributory factor for approximately 50% of couples that present seeking investigation and treatment for infertility, either in isolation (25%) or in combination with a female factor (25%) [1]. Therefore an accurate and complete investigation of the male partner is essential in assessing all couples with infertility. A significant number of male factors are either reversible or amenable to treatment provided that an accurate assessment and diagnosis is made.

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Subfertility, Reproductive Endocrinology and Assisted Reproduction , pp. 10 - 23
Publisher: Cambridge University Press
Print publication year: 2019

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References

Tielemans, E., et al., Sources of bias in studies among infertility clients. Am J Epidemiol, 2002. 156(1): 86–92.CrossRefGoogle ScholarPubMed
Jarow, J., Sigman, M., Kolettis, P.N., Lipshultz, L.R., McClure, R.D., Nangia, A.K., Naughton, C.K., Prins, G.S., Sandlow, J.I., Schlegel, P.N.MD. The optimal evaluation of the infertile male: Best practice statement. 2011 [cited 2018 29/11/2018] Available from: www.auanet.org/guidelines/male-infertility-optimal-evaluation.Google Scholar
World Health Organization, WHO Laboratory Manual for the Examination and Processing of Human Semen. 5th edn. 2010, Geneva: World Health Organization. xiv, 271 p.Google Scholar
Jungwirth, a., Diemer, T., Dohle, G.R., Giwercman, A., Kopa, Z., Krausz, C., Tournaye, H., European Association of Urology guidelines on male infertility. 2017 [cited 2018 29/11/2018] Available at: http://uroweb.org/wp-content/uploads/17-Male-Infertility_2017_web.pdf.Google Scholar
Cooper, T.G., et al., World Health Organization reference values for human semen characteristics. Hum Reprod Update, 2010. 16(3): 231–45.Google ScholarPubMed
Tüttelmann, F., Nieschlag, E., Classification of Andrological Disorders, in Andrology, Nieschlag, E., Hermann, B.M., Nieschlag, S., eds. 2010, Berlin: Springer-Verlag Berlin Heidelberg. p. 90.Google Scholar
Fertility problems: assessment and treatment [CG156]. 2013 [cited 2016 13/01/2016]; Available from: www.nice.org.uk/guidance/cg156/chapter/recommendations - investigation-of-fertility-problems-and-management-strategies.Google Scholar
Agarwal, A., et al., Effect of vaginal lubricants on sperm motility and chromatin integrity: a prospective comparative study. Fertil Steril, 2008. 89(2): 375–9.Google Scholar
Lee, P.A., et al., Paternity after bilateral cryptorchidism. A controlled study. Arch Pediatr Adolesc Med, 1997. 151(3): 260–3.CrossRefGoogle ScholarPubMed
Miller, K.D., Coughlin, M.T., Lee, P.A., Fertility after unilateral cryptorchidism. Paternity, time to conception, pretreatment testicular location and size, hormone and sperm parameters. Horm Res, 2001. 55(5): 249–53.Google Scholar
Inci, K., Gunay, L.M., Exogenous Medication or Substance-Induced Factors, in Male Infertility. Contemporary Clinical Approaches, Andrology, ART & Antioxidants, Parrekattil, S.J., Agarwal, A., eds. 2012, New York: Springer-Verlag. p. 297–306.Google Scholar
WHO, WHO Manual for the Standardized Investigation, Diagnosis abd Management of the Infertile Male. 2000, Cambridge: Cambridge University Press.Google Scholar
Stewart, T.M., et al., Associations between andrological measures, hormones and semen quality in fertile Australian men: inverse relationship between obesity and sperm output. Hum Reprod, 2009. 24(7): 1561–8.CrossRefGoogle ScholarPubMed
Slama, R., et al., Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities. Hum Reprod, 2002. 17(2): 503–15.CrossRefGoogle ScholarPubMed
Swan, S.H., et al., Geographic differences in semen quality of fertile U.S. males. Environ Health Perspect, 2003. 111(4): 414–20.Google Scholar
Jensen, T.K., et al., Regional differences in waiting time to pregnancy among fertile couples from four European cities. Hum Reprod, 2001. 16(12): 2697–704.Google Scholar
Haugen, T.B., Egeland, T., Magnus, O. Semen parameters in Norwegian fertile men. J Androl, 2006. 27(1): 66–71.CrossRefGoogle ScholarPubMed
Spira, A., Epidemiology of human reproduction. Hum Reprod, 1986. 1(2): 111–15.CrossRefGoogle ScholarPubMed
Eberhard Nieschlag, E., Behre, H.M., Nieschlag, S., Andrology. 3rd edn. 2010, Berlin: Springer-Verlag Berlin Heidelberg.CrossRefGoogle Scholar
Clementini, E., et al., Prevalence of chromosomal abnormalities in 2078 infertile couples referred for assisted reproductive techniques. Hum Reprod, 2005. 20(2): 437–42.Google Scholar
Vincent, M.C., et al., Cytogenetic investigations of infertile men with low sperm counts: a 25-year experience. J Androl, 2002. 23(1): 18–22; discussion 44–5.CrossRefGoogle ScholarPubMed
Chillon, M., et al., Mutations in the cystic fibrosis gene in patients with congenital absence of the vas deferens. N Engl J Med, 1995. 332(22): 1475–80.CrossRefGoogle ScholarPubMed
De Braekeleer, M., Ferec, C., Mutations in the cystic fibrosis gene in men with congenital bilateral absence of the vas deferens. Mol Hum Reprod, 1996. 2(9): 669–77.CrossRefGoogle ScholarPubMed
Tiepolo, L., Zuffardi, O., Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum Genet, 1976. 34(2): 119–24.CrossRefGoogle ScholarPubMed
Vogt, P.H., et al., Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. Hum Mol Genet, 1996. 5(7): 933–43.Google Scholar
Krausz, C., Degl’Innocenti, S., Y chromosome and male infertility: update, 2006. Front Biosci, 2006. 11: 3049–61.CrossRefGoogle ScholarPubMed
Krausz, C., McElreavey, K., Y chromosome and male infertility. Front Biosci, 1999. 4: E1–8.CrossRefGoogle ScholarPubMed
Hopps, C.V., et al., Detection of sperm in men with Y chromosome microdeletions of the AZFa, AZFb and AZFc regions. Hum Reprod, 2003. 18(8): 1660–5.CrossRefGoogle ScholarPubMed

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