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Chapter 13 - Acute Treatment of Intracerebral Haemorrhage

from Part IV - Acute Treatment of Haemorrhagic Stroke

Published online by Cambridge University Press:  15 December 2020

By
Tom Moullaali ,
Rustam Al-Shahi Salman  and
Craig Anderson
Edited by
Jeffrey L. Saver  and
Graeme J. Hankey
Jeffrey L. Saver
Affiliation:
David Geffen School of Medicine, University of Ca
Graeme J. Hankey
Affiliation:
University of Western Australia, Perth
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Summary

Acute non-traumatic intracerebral haemorrhage (ICH) has a poor prognosis and is the least treatable form of acute stroke.Although less common than acute ischaemic stroke, ICH causes greater premature loss of productive life years on a global scale due to its predilection to affect people at younger ages with devastating consequences.Prognosis from ICH is related to location, initial volume and speed of expansion of the haematoma, and associated intraventricular haemorrhage. Care in a specialised stroke or neurointensive care unit improves outcome. Surgical haematoma evacuation should be pursued as for patients with cerebellar haemorrhage with neurologic deterioration, hydrocephalus, orsd brainstem compression. Haematoma evacuation may be considered, as a life-saving measure, in patients with coma or large haematoma with mass effect.Minimally-invasive surgery in stable patients is of uncertain benefit and is being evaluated in RCTs.Clinicians should not routinely use haemostatic therapies where there is no evidence of coagulopathy or anticoagulant use.When coagulopathy is present, early corrective measures should be taken. Early moderate intensity BP lowering to a systolic BP target of 140 mmHg is reasonable.Medical therapies to reduce mass effect and intracranial pressure should not be used routinely, but hyperventilation and hypertonic saline or colloidal osmotic agents are reasonable in patients with imminent herniation as a bridge to definitive neurosurgical intervention. Corticosteroids should be avoided.Novel neuroprotective approaches hold promise.

Keywords

Intracerebral hemorrhageintraventricular hemorrhageprognosishydrocephalusherniationhematoma evacuationblood pressure loweringcoagulopathyhyperventilationhypertonic saline.managementtreatmen
Type
Chapter
Information
Stroke Prevention and Treatment
An Evidence-based Approach
 , pp. 239 - 259
Publisher: Cambridge University Press
Print publication year: 2020

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References

Al-Shahi Salman, R, Frantzias, J, Lee, RJ, Lyden, PD, Battey, TWK, Ayres, AM, at al. (2018) Absolute risk and predictors of the growth of acute spontaneous intracerebral hemorrhage: a systematic review and meta-analysis of individual patient data. Lancet Neurol, 17, 885–94.Google Scholar
Al-Shahi Salman, R, Labovitz, DL, Stapf, C. (2009). Spontaneous intracerebral hemorrhage. BMJ, 339, b2586.Google Scholar
Al-Shahi Salman, R, Law, ZK, Bath, PM, Steiner, T, Sprigg, N. (2018). Hemostatic therapies for acute spontaneous intracerebral hemorrhage. Cochrane Database Syst Rev, 4. CD005951. doi:10.1002/14651858.CD005951.pub4.Google Scholar
Anderson, C, Heeley, E, Huang, Y, Wang, J, Stapf, C, Delcourt, C, et al. (2013). Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med, 368(25), 2355–65.CrossRefGoogle ScholarPubMed
Anderson, CS, Huang, Y, Wang, JG, Arima, H, Neal, B, Peng, B, et al. (2008). Intensive blood pressure reduction in acute cerebral hemorrhage trial (INTERACT): a randomised pilot trial. Lancet Neurol, 7(5), 391–9.Google Scholar
Anderson, CS, Arima, H, Lavados, P, Billot, L, Hackett, ML, Olavarria, VV, et al. (2017a). Cluster-randomized, crossover trial of head positioning in acute stroke. New Engl J Med, 376(25), 2437–47.Google Scholar
Anderson, CS, Selim, MH, Molina, CA, Qureshi, AI. (2017b). Intensive blood pressure lowering in intracerebral hemorrhage. Stroke, 48, 2034–7.Google Scholar
Arima, H, Heeley, E, Delcourt, C, Hirakawa, Y, Wang, X, Woodward, M, et al. (2015). Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2. Neurology, 84(5), 464–71.CrossRefGoogle ScholarPubMed
Arima, H, Huang, Y, Wang, JG, Heeley, E, Delcourt, C, Parsons, M, et al. (2012). Earlier blood pressure-lowering and greater attenuation of hematoma growth in acute intracerebral hemorrhage: INTERACT pilot phase. Stroke, 43(8), 2236–8.CrossRefGoogle ScholarPubMed
Asdaghi, N, Manawadu, D, Butcher, K. (2007) Therapeutic management of acute intracerebral hemorrhage. Expert Opin Pharmacother, 8, 3097–116Google Scholar
AVERT Trial Collaboration Group. (2015). Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial. Lancet, 386(9988), 46–55.Google Scholar
Baharoglu, MI, Cordonnier, C, Al-Shahi Salman, R, de Gans, K, Koopman, MM, Brand, A, et al. (2016). Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral hemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial. Lancet, 387(10038), 2605–13.Google Scholar
Bereczki, D, Liu, M, Do Prado, GF, Fekete, I. (2008) Mannitol for acute stroke. Stroke, 39(2), 512–13.Google Scholar
Boulis, NM, Bobek, MP, Schmaier, A, Hoff, JT. (1999). Use of factor IX complex in warfarin-related intracranial hemorrhage. Neurosurgery, 45(5), 1113–19.Google Scholar
Boulouis, G, Morott, A, Goldstein, JN, Charidimou, A. (2017). Intensive blood pressure lowering in patients with acute intracerebral hemorrhage: clinical outcomes and hemorrhage expansion. Systematic review and meta-analysis of randomised trials. J Neurol Neurosurg Psychiatry, 88(4), 339–45.Google Scholar
Brott, T, Broderick, J, Kothari, R, Barsan, W, Tomsick, T, Sauerbeck, L, Spilker, J, et al. (1997). Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke, 28(1), 1–5.Google Scholar
Buletko, AB, Thacker, T, Cho, SM, Mathew, J, Thompson, NR, Organek, N, et al. (2018). Cerebral ischemia and deterioration with lower blood pressure target in intracerebral hemorrhage. Neurology, 91, e1058-e1066.Google Scholar
Butcher, KS, Jeerakathil, T, Hill, M, Demchuk, AM, Dowlatshahi, D, Coutts, SB, et al. (2013). The intracerebral hemorrhage acutely decreasing arterial pressure trial. Stroke, 44(3), 620–6.CrossRefGoogle ScholarPubMed
Connolly, SJ, Milling, TJ Jr, Eikelboom, JW, Gibson CM, Curnutte JT, Gold A, et al. (2016). Andexanet alfa for acute major bleeding associated with factor Xa inhibitors. New Engl J Med, 375, 1131–41.Google Scholar
Davis, SM, Broderick, J, Hennerici, M, Brun, NC, Diringer, MN, Mayer, SA, et al. (2006). Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology, 66(8), 1175–81.Google Scholar
Demchuk, AM, Dowlatshahi, D, Rodriguez-Luna, D, Molina, CA, Glas, YS, Dzialowski, I, et al. (2012). Prediction of hematoma growth and outcome in patients with intracerebral hemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study. Lancet Neurol, 11(4), 307–14.Google Scholar
England, TJ, Sprigg, N, Alasheev, AM, Belkin, AA, Kumar, A, Prasad, K, et al. (2016). Granulocyte-colony stimulating factor (G-CSF) for stroke: An individual patient data meta-analysis. Sci Rep, 6, 36567.Google Scholar
Feigin, VL, Anderson, N, Rinkel, GJE, Algra, A, van Gijn, J, Bennett, D. (2005). Corticosteroids for aneurysmal subarachnoid hemorrhage and primary intracerebral hemorrhage. Cochrane Database Syst Rev, 3. CD004583. doi:10.1002/14651858.CD004583.pub2.Google Scholar
Feigin, VL, Krishnamurthi, RV, Parmar, P, Norrving, B, Mensah, GA, Bennett, DA, et al. (2015). Update on the global burden of ischemic and hemorrhagic stroke in 1990–2013: the GBD 2013 study. Neuroepidemiology, 45(3), 161–176.Google Scholar
Feigin, VL, Lawes, CM, Bennett, DA, Barker-Collo, SL, Parag, V. (2009). Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol, 8(4), 355–69.Google Scholar
Fiorella, D, Arthur, AS, Mocco, JD. (2016). O-027 The INVEST trial: a randomized, controlled trial to investigate the safety and efficacy of image-guided minimally invasive endoscopic surgery with Apollo vs best medical management for supratentorial intracerebral hemorrhage. J NeuroInterv Surg, 8, A18Google Scholar
Fischer, U, Cooney, MT, Bull, LM, Silver, LE, Chalmers, J, Anderson, CS, et al. (2014). Acute post-stroke blood pressure relative to premorbid levels in intracerebral hemorrhage versus major ischemic stroke: A population-based study. Lancet Neurol, 13(4), 374–84.Google Scholar
Frontera, JA, Lewin, JJ Rabinstein, 3rd AA, Aisiku, IP, Alexandrov, AW, Cook, AM, et al. (2016). Guideline for reversal of antithrombotics in intracranial hemorrhage. Neurocrit Care, 24(1), 6–46.Google Scholar
Gao, L, Zhao, H, Liu, Q, Song, J, Xu, C, Liu, P, et al. (2012). Improvement of hematoma absorption and neurological function in patients with acute intracerebral hemorrhage treated with Xueshuantong. J Neurolog Sci, 323(1–2), 236–40.CrossRefGoogle ScholarPubMed
Gong, S, Lin, C, Zhang, D, Kong, X, Chen, J, Wang, C, et al. (2017). Effects of intensive blood pressure reduction on acute intracerebral hemorrhage: a systematic review and meta-analysis. Sci Rep, 7(1), 10694.Google Scholar
Gu, Y, Hua, Y, Keep, RF, Morgenstern, LB, Xi, G. (2009). Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets. Stroke, 40(6), 2241–3.Google Scholar
Haley, EC, Thompson, JLP, Levin, B, Davis, S, Lees, KR, Pittman, JG, et al. (2005). Gavestinel does not improve outcome after acute intracerebral hemorrhage: An analysis from the GAIN International and GAIN Americas studies. Stroke, 36(5), 1006–10.CrossRefGoogle Scholar
Hanley, DF, Lane, K, McBee, N, Ziai, W, Tuhrim, S, Lees, KR, et al. (2017). Thrombolytic removal of intraventricular hemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial. Lancet, 389(10069), 603–11.CrossRefGoogle ScholarPubMed
Hanley, DF, Thompson, RE, Rosenblum, M, Yenokyan, G, Lane, K, McBee, N, et al. (2019). Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded end-point phase 3 trial. Lancet, 393(10175), 1021–32.Google Scholar
Hemphill, JC, Greenberg, SM, Anderson, CS, Becker, K, Bendok, BR, Cushman, M, et al. (2015). Guidelines for the management of spontaneous intracerebral hemorrhage. Stroke, 46(7), 2032–60.CrossRefGoogle ScholarPubMed
Herrick, DB, Ullman, N, Nekoovaght-Tak, S, Hanley, DF, Awad, I, LeDroux, S, et al. (2014). Determinants of external ventricular drain placement and associated outcomes in patients with spontaneous intraventricular hemorrhage. Neurocrit Care, 21(3), 426–34.Google Scholar
Iranmanesh, F, Vakilian, A. (2008). Efficiency of citicoline in increasing muscular strength of patients with nontraumatic cerebral hemorrhage: a double-blind randomized clinical trial. J Stroke Cerebrovasc Dis, 17(3), 153–5.Google Scholar
Jeffrey, S. (2017). No benefit of hemostatic therapy in patients with “spot sign” ICH. Medscape Neurology (news article). https://www.medscape.com/viewarticle/877707#vp_2 (accessed Dec 2018).Google Scholar
Khan, NR, Tsivgoulis, G, Lee, SL, Jones, GM, Green, CS, Katsanos, AH, et al. (2014). Fibrinolysis for intraventricular hemorrhage: an updated meta-analysis and systematic review of the literature. Stroke, 45(9), 2662–9.Google Scholar
Khan, U, Porteous, L, Hassan, A, Markus, HS. (2007). Risk factor profile of cerebral small vessel disease and its subtypes. J Neurol Neurosurg Psychiatry, 78(7), 702–6.Google Scholar
Koch, S, Romano, JG, Forteza, AM, Otero, CM, Rabinstein, AA. (2008) Rapid blood pressure reduction in acute intracerebral hemorrhage: feasibility and safety. Neurocrit Care, 8(3), 316–21.Google Scholar
Koenig, MA, Bryan, M, Lewin, JL 3rd, Mirski, MA, Geocadin, RG, Stevens, RD. (2008). Reversal of transtentorial herniation with hypertonic saline. Neurology, 70, 1023–9.Google Scholar
Kohler, E, Prentice, DA, Bates, TR, Hankey, GJ, Claxton, A, van Heerden, J, et al. (2013). Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis. Stroke, 44(9), 2493–9.Google Scholar
Krishnan, K, Scutt, P, Woodhouse, L, Adami, A, Becker, JL, Berge, E, et al. (2016). Glyceryl trinitrate for acute intracerebral hemorrhage: results from the Efficacy of Nitric Oxide in Stroke (ENOS) trial, a subgroup analysis. Stroke, 47, 44–52.Google Scholar
Langhorne, P, Fearon, P, Ronning, OM, Kaste, M, Palomaki, H, Vemmos, K, et al. (2013). Stroke unit care benefits patients with intracerebral hemorrhage: Systematic review and meta-analysis. Stroke, 44(11), 3044–9.Google Scholar
Lattanzi, S, Cagnetti, C, Provinciali, L, Silvestrini, M. (2017). How should we lower blood pressure after cerebral hemorrhage? A systematic review and meta-analysis. Cerebrovasc Dis, 43(5–6), 207–13.Google Scholar
Lee, SH, Park, HK, Ryu, WS, Lee, JS, Bae, HJ, Han, MK, et al. (2013). Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: a multicenter randomized controlled trial. Eur J Neurol, 20(8), 1161–9.Google Scholar
Lewis, SR, Pritchard, MW, Evans, DJ, Butler, AR, Alderson, P, Smith, AF, et al. (2018). Colloids versus crystalloids for fluid resuscitation in critically ill people. Cochrane Database Syst Rev, 8. CD000567.Google Scholar
Lodder, J, van Raa, L, Hilton, A, Hardy, E, Kessels, A; EGASIS Study Group. (2006). Diazepam to improve acute stroke outcome: results of the early GABA-Ergic activation study in stroke trial. a randomized double-blind placebo-controlled trial. Cerebrovasc Dis, 21(1–2), 120–7.Google Scholar
Lovasik, BP, McCracken, DJ, McCracken, CE, McDougal, ME, Frerich, JM, Samuels, OB, et al. (2016). The effect of external ventricular drain use in intracerebral hemorrhage. World Neurosurg, 94, 309–18.Google Scholar
Lovelock, C, Molyneux, A, Rothwell, P. (2007). Change in incidence and etiology of intracerebral hemorrhage in Oxfordshire, UK, between 1981 and 2006: a population-based study. Lancet Neurol, 6(6), 487–93.Google Scholar
Lyden, PD, Shuaib, A, Lees, KR, Davalos, A, Davis, SM, Diener, HC, et al. (2007). Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT trial. Stroke, 38(8), 2262–9.CrossRefGoogle ScholarPubMed
Lyden, PD, Shuaib, A, Ng, K, Atkinson, R. (2000) The clomethiazole acute stroke study in hemorrhagic stroke (CLASS-H): final results. J Stroke Cerebrovasc Dis, 9(6), 268–75.Google Scholar
Manning, LS, Robinson, TG. (2015). New insights into blood pressure control for intracerebral hemorrhage. Front Neurol Neurosci, 37, 35–50.Google Scholar
Mendelow, AD, Gregson, BA, Rowan, EN, Murray, GD, Gholkar, A, Mitchell, PM; STICH II Investigators. (2013). Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral hematomas (STICH II): a randomised trial. Lancet, 382(9890), 397–408.Google Scholar
Menon, RS, Burgess, RE, Wing, JJ, Gibbons, MC, Shara, NM, Fernandez, S, et al. (2012). Predictors of highly prevalent brain ischemia in intracerebral hemorrhage. Ann Neurol, 71, 199–205.Google Scholar
Moussa, WMM, Khedr, W. (2017). Decompressive craniectomy and expansive duraplasty with evacuation of hypertensive intracerebral hematoma, a randomized controlled trial. Neurosurg Rev, 40(1), 115–27.Google Scholar
Nakamura, T, Keep, RF, Hua, Y, Schallert, T, Hoff, JT, Xi, G. (2004). Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J Neurosurg, 100(4), 672–8.Google Scholar
O’Donnell, MJ, Xavier, D, Liu, L, Zhang, H, Chin, SL, Rao-Melacini, P, et al. (2010). Risk factors for ischemic and intracerebral hemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet, 376(9735), 112–23.Google Scholar
Ong, CJ, Keyrouz, SG, Diringer, MN. (2015). The role of osmotic therapy in hemispheric stroke. Neurocrit Care, 23, 285–91.Google Scholar
Parry-Jones, AR, Paley, L, Bray, BD, Hoffman, AM, James, M, Cloud, GC, et al. (2016). Care-limiting decisions in acute stroke and association with survival: Analyses of UK national quality register data. Int J Stroke, 11(3), 321–31.Google Scholar
Pollack, CV Jr, Reilly, PA, van Ryn, J, Eikelboom, JW, Glund, S, Bernstein, RA, et al. (2017). Idarucizumab for dabigatran reversal – full cohort analysis. N Engl J Med, 377, 431–41.Google Scholar
Poon, MT, Bell, SM, Al-Shahi Salman, R. (2015). Epidemiology of intracerebral hemorrhage. Front Neurol Neurosci, 37, 1–12.Google Scholar
Poon, MTC, Fonville, AF, Al-Shahi Salman, R. (2014). Long-term prognosis after intracerebral hemorrhage: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry, 85(6), 660–7.CrossRefGoogle ScholarPubMed
Prasad, K, Mendelow, AD, Gregson, B. (2008). Surgery for primary supratentorial intracerebral haemorrhage. Cochrane Database Syst Rev, 4. CD000200.CrossRefGoogle ScholarPubMed
Qureshi, AI, Ezzeddine, MA, Nasar, A, Suri, MF, Kirmani, JF, Husseing, HM, et al. (2007). Prevalence of elevated blood pressure in 563,704 adult patients with stroke presenting to the ED in the United States. Am J Emerg Med, 25, 32–8.Google Scholar
Qureshi, AI, Palesch, YY, Barsan, WG, Hanley, DF, Hsu, CY, Martin, RL, et al. (2016). Intensive blood-pressure lowering in patients with acute cerebral hemorrhage. N Engl J Med, 375(11), 1033–43.CrossRefGoogle ScholarPubMed
Rapsomaniki, E, Timmis, A, George, J, Pujades-Rodriguez, M, Shah, AD, Denaxas, S, et al. (2014). Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. Lancet, 383(9932), 1899–1911.Google Scholar
Righetti, E, Celani, MG, Cantisani, TA, Sterzi, R, Boysen, G, Ricci, S. (2002). Glycerol for acute stroke: a Cochrane systematic review. J Neurol, 249(4), 445–51.Google Scholar
Samarasekera, N, Fonville, A, Lerpiniere, C, Farrall, AJ, Wardlaw, JM, White, PM, et al. (2015). Influence of intracerebral hemorrhage location on incidence, characteristics, and outcome: population-based study. Stroke, 46(2), 361–8.Google Scholar
Saver, JL, Starkman, S, Eckstein, M, Stratton, SJ, Pratt, FD, Hamilton, S, et al. (2015). Prehospital use of magnesium sulfate as neuroprotection in acute stroke. N Engl J Med, 372(6), 528–36.Google Scholar
Selim, M. (2009). Deferoxamine mesylate: A new hope for intracerebral hemorrhage: from bench to clinical trials. Stroke, 40(3 Suppl), S90–1.Google Scholar
Selim, M. (2013). iDEF: Intracerebral Hemorrhage Deferoxamine Trial. https://www.nihstrokenet.org/docs/default-source/default-document-library/idef_060314.pdf?sfvrsn=2 (accessed Dec 2018).Google Scholar
Selim, M, Foster, LD, Moy, CS, Xi, G, Hill, MD, Morgenstern, LB, et al. (2019). Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial. Lancet Neurol, 18, 428–38.CrossRefGoogle ScholarPubMed
Sharafadinzadeh, N, Baghebanian, SM, Pipelzadeh, M, Moravej Ale Ali, A, Ghanavati, P. (2008). Effects of dexamethasone in primary intracerebral hemorrhage in the South West of Iran. Pakistan J Med Sci, 24(4), 502–505.Google Scholar
Shawkat, H, Westwood, M-M, Mortimer, A. (2012). Mannitol: a review of its clinical uses. Continuing Educ Anaesth Crit Care Pain, 12(2), 82–5.Google Scholar
Shi, L, Xu, S, Zheng, J, Xu, J, Zhang, J. (2017). Blood pressure management for acute intracerebral hemorrhage: a meta-analysis. Sci Rep, 7(1), 14345.Google Scholar
Shkirkova, K, Saver, JL, Starkman, S, Wong, G, Weng, J, Hamilton, S, et al. (2018). Frequency, predictors, and outcomes of prehospital and early postarrival neurological deterioration in acute stroke: exploratory analysis of the FAST-MAG randomized clinical trial. JAMA Neurol, 75, 1364–74.Google Scholar
Specogna, AV, Turin, TC, Patten, SB, Hill, MD. (2014). Factors associated with early deterioration after spontaneous intracerebral hemorrhage: a systematic review and meta-analysis. PLoS ONE, 9(5), e96743.CrossRefGoogle ScholarPubMed
Staykov, D, Kuramatsu, JB, Bardutzky, J, Volbers, B, Gerner, ST, Kloska, SP, et al. (2017). Efficacy and safety of combined intraventricular fibrinolysis with lumbar drainage for prevention of permanent shunt dependency after intracerebral hemorrhage with severe ventricular involvement: A randomized trial and individual patient data meta-analysis. Ann Neurol, 81(1), 93–103.Google Scholar
Steiner, T, Al-Shahi Salman, R, Beer, R. Christensen, H, Cordonnier, C, Csiba, L, et al. (2014). European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage. Int J Stroke, 9(7), 840–55.Google Scholar
Steiner, T, Poli, S, Griebe, M, Husing, J, Haida, J, Freiberger, A, et al. (2016) Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial hemorrhage related to vitamin K antagonists (INCH): A randomised trial. Lancet Neurol, 15(6), 566–73.Google Scholar
van Asch, CJ, Luitse, MJ, Rinkel, GJ, van der Tweel, I, Algra, A, Klijn, CJ. (2010). Incidence, case fatality, and functional outcome of intracerebral hemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol, 9(2), 167–76.Google Scholar
van Asch, CJJ, Velthuis, BK, Rinkel, GJE, Algra, A, de Kort, GA, Witkamp, TD, et al. (2015). Diagnostic yield and accuracy of CT angiography, MR angiography, and digital subtraction angiography for detection of macrovascular causes of intracerebral hemorrhage: Prospective, multicentre cohort study. BMJ, 351.Google Scholar
Vespa, P, Hanley, D, Betz, J, Hoffer, A, Engh, J, Carter, R, et al. (2016). ICES (Intraoperative Stereotactic Computed Tomography-Guided Endoscopic Surgery) for brain hemorrhage: a multicenter randomized controlled trial. Stroke, 47(11), 2749–55.Google Scholar
Wijdicks, EFM, Sheth, KN, Carter, BS, Greer, DM, Kasner, SE, Kimberly, WT, et al.; American Heart Association Stroke Council. (2014). Recommendations for the management of cerebral and cerebellar infarction with swelling. Stroke, 45, 1222–38.Google Scholar
Willmot, M, Leonardi-Bee, J, Bath, PMW. (2004). High blood pressure in acute stroke and subsequent outcome a systematic review. Hypertension, 43 (1), 18–24.Google Scholar
Witsch, J, Neugebauer, H, Zweckberger, K, Jüttler, E. (2013). Primary cerebellar hemorrhage: complications, treatment and outcome. Clin Neurol Neurosurg, 115(7), 863–869.Google Scholar
Xi, G, Keep, RF, Hoff, JT. (2006). Mechanisms of brain injury after intracerebral hemorrhage. Lancet Neurol, 5(1), 53–63.Google Scholar
Yaghi, S, Boehme, AK, Dibu, J, Leon Guerrero, CR, Ali, S, Martin-Schild, S, et al. (2015). Treatment and outcome of thrombolysis-related hemorrhage: a multicenter retrospective study. JAMA Neurol, 72, 1451–7.Google Scholar
Yang, J, Arima, H, Wu, G, Heeley, E, Delcourt, C, Zhou, J, et al. (2015). Prognostic significance of perihematomal edema in acute intracerebral hemorrhage: pooled analysis from the intensive blood pressure reduction in acute cerebral hemorrhage trial studies. Stroke, 46(4), 1009–13.Google Scholar
Yao, Z, Ma, L, You, C, He, M. (2017). Decompressive craniectomy for spontaneous intracerebral hemorrhage: a systematic review and meta-analysis. World Neurosurg, 110, 121–8.Google Scholar
Yu, Y, Zhao, W, Zhu, C, Kong, Z, Xu, Y, Liu, G, et al. (2015). The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage. PLoS ONE, 10(4), e0122371.Google Scholar
Yu, Z, Ma, L, Zheng, J, You, C. (2017). Prognostic role of perihematomal edema in intracerebral hemorrhage: a systematic review. Turk Neurosurg, doi:10.5137/1019-5149.JTN.19659-16.0. Epub ahead of print.Google Scholar

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