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17 - Memories and Memory: A Physicist's Approach to the Brain

from Part Two - Thought and Consciousness

Published online by Cambridge University Press:  05 November 2014

Leon N. Cooper
Affiliation:
Brown University, Rhode Island
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Summary

It is remarkable how little we need to know about ourselves in order to survive and reproduce. Humans are probably the only animals that have made conjectures about what goes on inside the body. And even then, it has taken a long time to arrive at a clue.

This essay is based on an article originally published in the International Journal of Physics, A, 15(26), in 2000.

It was less than four hundred years ago that Harvey taught us that the heart was a pump. The great Aristotle had conjectured that the heart was the seat of intellect, reserving for the brain the function of a cooling system, which (in addition to some other functions of more than minor interest) it is. In dealing with questions about our own nature we have to survive ideology – endless discussions about organic versus inorganic, vital versus non-vital, living versus non-living. These hotly disputed questions quietly fade away when the cool light of patient investigation and hard thought finally provide illumination. Today we are engaged in the quest of understanding our brain. When we have finally worked out the details, this remarkable organ, for all of its lofty pretensions – seat of intellect, home of the soul – will very likely join other remarkable pieces of biological machinery. Remarkable, certainly, but not mysterious or possessed of any supernatural qualities.

How then do we go about trying to understand a system as complex as the brain? Obviously we cannot just make observations.

Type
Chapter
Information
Science and Human Experience
Values, Culture, and the Mind
, pp. 132 - 147
Publisher: Cambridge University Press
Print publication year: 2014

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References

Bienenstock, E. L., Cooper, L. N., and Munro, P. W. (1982). Theory for the Development of Neuron Selectivity: Orientation Specificity and Binocular Interaction in Visual Cortex, Journal of Neuroscience, 2(32), 32–48,CrossRefGoogle ScholarPubMed
Intrator, N. and Cooper, L. N (1992). Objective Function Formulation of the BCM Theory of Visual Cortical Plasticity: Statistical Connections, Stability Conditions, Neural Networks, 5(1), 3–17.CrossRefGoogle Scholar
Blais, B. S., Shouval, H. Z., and Cooper, L. N (1999). The Role of Presynaptic Activity in Monocular Deprivation: Comparison of Homosynaptic and Heterosynaptic Mechanisms, Proceedings of the National Academy of Sciences USA, 96(3), 1083–1087.CrossRefGoogle ScholarPubMed
Rittenhouse, C. D., Shouval, H. Z., Paradiso, M. A., and Bear, M. F. (1999). Monocular Deprivation Induces Homosynaptic Long-term Depression in Visual Cortex, Nature, 397, 347–350.CrossRefGoogle ScholarPubMed
Dudek, S. M. and Bear, M. F. (1992). Homosynaptic Long-term Depression in Area CA1 of Hippocampus and Effects of N-methyl-D-aspartate Receptor Blockade, Proceedings of the National Academy of Sciences USA, 89(10), 4363–4367.CrossRefGoogle ScholarPubMed
Kirkwood, A., Rioult, M. G., and Bear, M. F. (1996). Experience-dependent Modification of Synaptic Plasticity in Visual Cortex, Nature, 381, 526–528.CrossRefGoogle ScholarPubMed
Chen, W. R. et al. (1996). Long-term Modifications of Synaptic Efficacy in the Human Inferior and Middle Temporal Cortex, Proceedings of the National Academy of Sciences USA, 93(15), 8011–8015.CrossRefGoogle ScholarPubMed
Mayford, M., Wang, J., Kandel, E., and O'Dell, T. (1995). CaMKII Regulates the Frequency-Response Function of Hippocampal Synapses for the Production of both LTD and LTP, Cell, 81(1), 891–904.CrossRefGoogle ScholarPubMed
Tang, Y. P., Shimizu, E., Dube, G. R., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., and Tsien, J. Z. (1999). Genetic Enhancement of Learning and Memory in Mice, Nature, 401, 63–69.CrossRefGoogle ScholarPubMed
Quinlan, E. M., Olstein, D. H., and Bear, M. F. (1999). Bidirectional, Experience-dependent Regulation of NMDA Receptor Subunit Composition in Rat Visual Cortex during Postnatal Development, Proceedings of the National Academy of Sciences USA, 96(22), 12876–12880.CrossRefGoogle ScholarPubMed

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