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37 - Comparison of REM sleep-deprivation methods: role of stress and validity of use

from Section V - Functional significance

Published online by Cambridge University Press:  07 September 2011

By
Deborah Suchecki  and
Sergio Tufik
Edited by
Birendra N. Mallick ,
S. R. Pandi-Perumal ,
Robert W. McCarley  and
Adrian R. Morrison
Deborah Suchecki
Affiliation:
Universidade Federal de São Paulo, Brazil
Sergio Tufik
Affiliation:
Universidade Federal de São Paulo, Brazil
Birendra N. Mallick
Affiliation:
Jawaharlal Nehru University
S. R. Pandi-Perumal
Affiliation:
Somnogen Canada Inc, Toronto
Robert W. McCarley
Affiliation:
Harvard University, Massachusetts
Adrian R. Morrison
Affiliation:
University of Pennsylvania
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Summary

Summary

Sleep-deprivation protocols are useful to examine the consequences of inadequate or insufficient sleep on health. By employing different paradigms of sleep deprivation or sleep restriction in humans and animals, numerous laboratories have come to the conclusion that insufficient sleep is stressful. Particularly, activation of stress response systems – the locus coeruleus/ adrenal medulla and the hypothalamic–pituitary–adrenal (HPA) axis – appears to be a caveat of instrumental methods to induce REM-sleep deprivation. However, not all effects of REM-sleep deprivation are mediated by increased secretion of glucocorticoids (the final outcome of HPA axis activation) nor are these effects common to other protracted stressors. Therefore, the present chapter presents an overview of the very peculiar form of stress represented by inadequate or insufficient sleep, by means of REM-sleep deprivation.

Type
Chapter
Information
Rapid Eye Movement Sleep
Regulation and Function
 , pp. 368 - 382
Publisher: Cambridge University Press
Print publication year: 2011

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