from Part I - General Principles
Published online by Cambridge University Press: 19 October 2021
The relationship between food products and pharmacodynamically active agents traces at least to antiquity, even if Hippocrates never actually did say “let food be thy medicine and medicine be thy food” (Cardenas, 2013). In modern times the relationship between dietary supplements and medicine has come to pose a rather peculiar dichotomy between what might be called “legitimate” or “mainstream” medicine and nonstandard or “alternative” medicine. Interventions in the latter category suffer from issues of credibility due to an often less rigorous RCT database, at times poorly established rationales and/or mechanisms of action, and lack of regulatory agency product oversight for quality assurance purposes. Many patients obtain information about herbal products or dietary supplements simply from internet searches with little awareness of the scientific rigor or credibility behind advertising claims or consumer postings and testimonials, or cognizance of potential pharmacokinetic interactions.
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