Book contents
- Practical Emergency Resuscitation and Critical Care
- Practical Emergency Resuscitation and Critical Care
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 General Critical Care
- Section 2 Infectious Disease Emergencies
- Section 3 Neurological Emergencies
- Section 4 Cardiovascular Emergencies
- Section 5 Respiratory Emergencies
- Section 6 Gastrointestinal Emergencies
- Section 7 Renal Emergencies
- Section 8 Hematology–Oncology Emergencies
- 37 Reversal of Anticoagulation
- 38 Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndrome and Disseminated Intravascular Coagulation
- 39 Sickle Cell Emergencies
- Section 9 Endocrine Emergencies
- Section 10 Environmental Emergencies
- Section 11 Trauma
- Section 12 End of Life
- Index
- References
39 - Sickle Cell Emergencies
from Section 8 - Hematology–Oncology Emergencies
Published online by Cambridge University Press: 02 November 2023
By
Book contents
- Practical Emergency Resuscitation and Critical Care
- Practical Emergency Resuscitation and Critical Care
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 General Critical Care
- Section 2 Infectious Disease Emergencies
- Section 3 Neurological Emergencies
- Section 4 Cardiovascular Emergencies
- Section 5 Respiratory Emergencies
- Section 6 Gastrointestinal Emergencies
- Section 7 Renal Emergencies
- Section 8 Hematology–Oncology Emergencies
- 37 Reversal of Anticoagulation
- 38 Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndrome and Disseminated Intravascular Coagulation
- 39 Sickle Cell Emergencies
- Section 9 Endocrine Emergencies
- Section 10 Environmental Emergencies
- Section 11 Trauma
- Section 12 End of Life
- Index
- References
Summary
Sickle cell disease (SCD) is caused by an autosomal recessive mutation in the β-globin chain of hemoglobin A (HbA), causing the mutated hemoglobin S (HbS). In a vaso-occlusive crisis (VOC), sickled red blood cells (RBCs) increase the viscosity of blood and cause microvascular occlusion, contributing to hypoxia, acidosis and further sickling. The clinical manifestations of SCD are diverse and are related to chronic hemolysis with periodic episodes of vascular occlusion that can affect nearly every organ system.
- Type
- Chapter
- Information
- Practical Emergency Resuscitation and Critical Care , pp. 397 - 410Publisher: Cambridge University PressPrint publication year: 2023
References
Simon, E, Long, B, Koyfman, A. Emergency medicine management of sickle cell disease complications: an evidence-based update. J Emerg Med 2016;51:370–381.CrossRefGoogle ScholarPubMed
Ware, RE, de Montalembert, M, Tshilolo, L, et al. Sickle cell disease. Lancet 2017;390:311–323.CrossRefGoogle ScholarPubMed