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Chapter 13 - Effects of Antiepileptic Drugs on Cognition

Published online by Cambridge University Press:  10 August 2021

By
Kimford Meador  and
Zahra Sadat-Hossieny
Edited by
Marco Mula
Marco Mula
Affiliation:
St George's Hospital Medical School, University of London
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Summary

Patients with traumatic brain injury frequently develop epilepsy, cognitive dysfunction and behavioral imbalance. Understanding the interplay between antiseizure medications, mood and cognition is essential to any provider who cares for patients with TBI and seizures. Antiseizure medications can be classified into those that have low, moderate and high cognitive side effect profiles, and they can also be classified into medications that cause positive, intermediate and negative effects on mood. For example, Lamotrigine is a medication that both has low cognitive side effects and has positive effects on mood. But there is no drug without side effects, and each antiseizure medication has its own unique side effect profile. Choosing the antiseizure medication that will lead to the best outcomes for each individual patient requires evaluating the unique characteristics of each medication. Only with an understanding of the cognitive and behavioral effects of each medication is it possible to create a successful treatment regimen for each individual. This chapter will examine many antiseizure medications and their unique side effect profiles, with a focus on the cognitive and behavioral implications of each medication.

Keywords

AEDsantiepileptic medicationsantiseizure medicationsseizuremooddepressioncognition
Type
Chapter
Information
Post-traumatic Epilepsy , pp. 169 - 178
Publisher: Cambridge University Press
Print publication year: 2021

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