Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-25T19:15:00.729Z Has data issue: false hasContentIssue false

Chapter 10 - Comorbidities and Postoperative Neurocognitive Disorder

from Section 2 - Pathophysiology of the Perioperative Neurocognitive Disorders

Published online by Cambridge University Press:  11 April 2019

By
Mervyn Maze  and
Xiaomei Feng
Edited by
Roderic G. Eckenhoff  and
Niccolò Terrando
Roderic G. Eckenhoff
Affiliation:
University of Pennsylvania
Niccolò Terrando
Affiliation:
Duke University, North Carolina
Get access
Type
Chapter
Information
The Perioperative Neurocognitive Disorders , pp. 115 - 122
Publisher: Cambridge University Press
Print publication year: 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ancelin, ML, et al. (2001) Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology in the elderly. British Journal of Psychiatry 178:360–366.Google Scholar
Hudetz, JA, Patterson, KM, Amole, O, Riley, AV, & Pagel, PS (2011) Postoperative cognitive dysfunction after noncardiac surgery: effects of metabolic syndrome. Journal of Anesthesia 25(3):337–344.Google Scholar
Hudetz, JA, Patterson, KM, Iqbal, Z, Gandhi, SD, & Pagel, PS (2011) Metabolic syndrome exacerbates short-term postoperative cognitive dysfunction in patients undergoing cardiac surgery: results of a pilot study. Journal of Cardiothoracic and Vascular Anesthesia 25(2):282–287.Google Scholar
Moller, JT, et al. (1998) Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. The Lancet 351(9106):857–861.Google Scholar
Weiser, TG, et al. (2008) An estimation of the global volume of surgery: a modelling strategy based on available data. The Lancet 372(9633):139–144.Google Scholar
Krenk, L, Rasmussen, LS, & Kehlet, H (2010) New insights into the pathophysiology of postoperative cognitive dysfunction. Acta Anaesthesiologica Scandinavica 54(8):951–956.Google Scholar
Ansaloni, L, et al. (2010) Risk factors and incidence of postoperative delirium in elderly patients after elective and emergency surgery. British Journal of Surgery 97(2):273–280.Google Scholar
Abildstrom, H, et al. (2000) Cognitive dysfunction 1–2 years after non-cardiac surgery in the elderly. ISPOCD group. International Study of Post-Operative Cognitive Dysfunction. Acta Anaesthesiologica Scandinavica 44(10):1246–1251.Google Scholar
Roach, GW, et al. (1996) Adverse cerebral outcomes after coronary bypass surgery. Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation Investigators. New England Journal of Medicine 335(25):1857–1863.Google Scholar
Stockton, P, Cohen-Mansfield, J, & Billig, N (2000) Mental status change in older surgical patients: cognition, depression, and other comorbidity. American Journal of Geriatric Psychiatry 8(1):40–46.Google Scholar
Rasmussen, LS (2006) Postoperative cognitive dysfunction: incidence and prevention: best practice and research. Clinical Anaesthesiology 20(2):315–330.Google Scholar
Barrientos, RM, Hein, AM, Frank, MG, Watkins, LR, & Maier, SF (2012) Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. Journal of Neuroscience 32(42):14641–14648.Google Scholar
Cibelli, M, et al. (2010) Role of interleukin-1beta in postoperative cognitive dysfunction. Annals of Neurology 68(3):360–368.Google Scholar
Tang, JX, et al. (2011) Human Alzheimer and inflammation biomarkers after anesthesia and surgery. Anesthesiology 115(4):727–732.Google Scholar
Wan, Y, et al. (2007) Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology 106(3):436–443.Google Scholar
Yirmiya, R & Goshen, I (2011) Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain, Behavior, and Immunity 25(2):181–213.Google Scholar
Fidalgo, AR, et al. (2011) Peripheral orthopaedic surgery down-regulates hippocampal brain-derived neurotrophic factor and impairs remote memory in mouse. Neuroscience 190:194–199.Google Scholar
Hovens, IB, et al. (2014) Postoperative cognitive dysfunction: involvement of neuroinflammation and neuronal functioning. Brain, Behavior, and Immunity 38:202–210.Google Scholar
Peng, L, Xu, L, & Ouyang, W (2013) Role of peripheral inflammatory markers in postoperative cognitive dysfunction (POCD): a meta-analysis. PLoS One 8(11):e79624.Google Scholar
Ramlawi, B, et al. (2006) C-Reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery. Surgery 140(2):221–226.Google Scholar
Terrando, N, et al. (2010) Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proceedings of the National Academy of Sciences of the United States of America 107(47):20518–20522.Google Scholar
Dilger, RN & Johnson, RW (2008) Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. Journal of Leukocyte Biology 84(4):932–939.Google Scholar
Luz Correa, B, et al. (2014) The inverted CD4:CD8 ratio is associated with cytomegalovirus, poor cognitive and functional states in older adults. Neuroimmunomodulation 21(4):206–212.Google Scholar
Martorana, A, et al. (2012) Immunosenescence, inflammation and Alzheimer’s disease. Longevity and Healthspan 1:8.Google Scholar
Shaw, AC, Joshi, S, Greenwood, H, Panda, A, & Lord, JM (2010) Aging of the innate immune system. Current Opinion in Immunology 22(4):507–513.Google Scholar
Lucin, KM & Wyss-Coray, T (2009) Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 64(1):110–122.Google Scholar
Tracey, KJ (2009) Reflex control of immunity. Nature Reviews Immunology 9(6):418–428.Google Scholar
Serhan, CN (2011) The resolution of inflammation: the devil in the flask and in the details. FASEB Journal 25(5):1441–1448.Google Scholar
Serhan, CN, Chiang, N, & Van Dyke, TE (2008) Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nature Reviews Immunology 8(5):349–361.Google Scholar
Spite, M & Serhan, CN (2010) Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. Circulation Research 107(10):1170–1184.Google Scholar
Chawla, A, Nguyen, KD, & Goh, YP (2011) Macrophage-mediated inflammation in metabolic disease. Nature Reviews Immunology 11(11):738–749.Google Scholar
Odegaard, JI, et al. (2008) Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metabolism 7(6):496–507.Google Scholar
Abeywardena, MY & Patten, GS (2011) Role of omega3 long-chain polyunsaturated fatty acids in reducing cardio-metabolic risk factors. Endocrine, Metabolic and Immune Disorders Drug Targets 11(3):232–246.Google Scholar
Masson, CJ & Mensink, RP (2011) Exchanging saturated fatty acids for (n-6) polyunsaturated fatty acids in a mixed meal may decrease postprandial lipemia and markers of inflammation and endothelial activity in overweight men. Journal of Nutrition 141(5):816–821.Google Scholar
Bernik, TR, et al. (2002) Pharmacological stimulation of the cholinergic antiinflammatory pathway. Journal of Experimental Medicine 195(6):781–788.Google Scholar
Wang, H, et al. (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421(6921):384–388.Google Scholar
Borovikova, LV, et al. (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405(6785):458–462.Google Scholar
van Maanen, MA, Stoof, SP, Larosa, GJ, Vervoordeldonk, MJ, & Tak, PP (2010) Role of the cholinergic nervous system in rheumatoid arthritis: aggravation of arthritis in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice. Annals of the Rheumatic Diseases 69(9):1717–1723.Google Scholar
Ghia, JE, Blennerhassett, P, El-Sharkawy, RT, & Collins, SM (2007) The protective effect of the vagus nerve in a murine model of chronic relapsing colitis. Gastrointestinal and Liver Physiology 293(4):711–718.Google Scholar
O’Mahony, C, van der Kleij, H, Bienenstock, J, Shanahan, F, & O’Mahony, L (2009) Loss of vagal anti-inflammatory effect: in vivo visualization and adoptive transfer. American Journal of Physiology 297(4):1118–1126.Google Scholar
Rosas-Ballina, M, et al. (2011) Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science 334(6052):98–101.Google Scholar
de Jonge, WJ, et al. (2005) Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nature Immunology 6(8):844–851.Google Scholar
Fujisaka, S, et al. (2009) Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 58(11):2574–2582.Google Scholar
Godbout, JP & Johnson, RW (2009) Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Immunology and Allergy Clinics of North America 29(2):321–337.Google Scholar
Hovens, IB, et al. (2015) Prior infection exacerbates postoperative cognitive dysfunction in aged rats. American Journal of Physiology 309(2):148–159.Google Scholar
Hudetz, JA, et al. (2011) Postoperative delirium and short-term cognitive dysfunction occur more frequently in patients undergoing valve surgery with or without coronary artery bypass graft surgery compared with coronary artery bypass graft surgery alone: results of a pilot study. Journal of Cardiothoracic and Vascular Anesthesia 25(5):811–816.Google Scholar
Eckel, RH, Alberti, KG, Grundy, SM, & Zimmet, PZ (2010) The metabolic syndrome. The Lancet 375(9710):181–183.Google Scholar
Kajimoto, K, et al. (2009) Metabolic syndrome is an independent risk factor for stroke and acute renal failure after coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery 137(3):658–663.Google Scholar
Feng, X, et al. (2013) Surgery results in exaggerated and persistent cognitive decline in a rat model of the metabolic syndrome. Anesthesiology 118(5):1098–1105.Google Scholar
Su, X, et al. (2012) Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Molecular Medicine 18:1481–1490.Google Scholar
Terrando, N, et al. (2011) Resolving postoperative neuroinflammation and cognitive decline. Annals of Neurology 70(6):986–995.Google Scholar
Buechler, C, Wanninger, J, & Neumeier, M (2010) Adiponectin receptor binding proteins – recent advances in elucidating adiponectin signalling pathways. FEBS Letters 584(20):4280–4286.Google Scholar
Choudhary, S, et al. (2011) NF-kappaB-inducing kinase (NIK) mediates skeletal muscle insulin resistance: blockade by adiponectin. Endocrinology 152(10):3622–3627.Google Scholar
Puntener, U, Booth, SG, Perry, VH, & Teeling, JL (2012) Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia. Journal of Neuroinflammation 9:146.Google Scholar
Bilbo, SD (2010) Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline. Neurobiology of Learning and Memory 94(1):57–64.Google Scholar
Cortese, GP, Barrientos, RM, Maier, SF, & Patterson, SL (2011) Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes. Journal of Neuroscience 31(11):4274–4279.Google Scholar
Barrientos, RM, et al. (2006) Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiology of Aging 27(5):723–732.Google Scholar
O’Connor, JC, et al. (2009) Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. Journal of Neuroscience 29(13):4200–4209.Google Scholar
Rector, JL, et al. (2014) Consistent associations between measures of psychological stress and CMV antibody levels in a large occupational sample. Brain, Behavior, and Immunity 38:133–141.Google Scholar
Strandberg, TE, Pitkala, KH, Linnavuori, KH, & Tilvis, RS (2003) Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases. Stroke 34(9):2126–2131.Google Scholar
Wichmann, MA, et al. (2014) Long-term systemic inflammation and cognitive impairment in a population-based cohort. Journal of the American Geriatrics Society 62(9):1683–1691.Google Scholar
Hovens, IB, et al. (2015) Postoperative cognitive dysfunction and microglial activation in associated brain regions in old rats. Neurobiology of Learning and Memory 118:74–79.Google Scholar
Fidalgo, AR, et al. (2011) Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Neuroscience Letters 498(1):63–66.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×