Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-08T07:21:11.924Z Has data issue: false hasContentIssue false

8 - Seizure disorders

Published online by Cambridge University Press:  13 August 2009

Scott J. Hunter
Affiliation:
University of Chicago
Jacobus Donders
Affiliation:
Mary Free Bed Rehabilitation Hospital, Grand Rapids
Get access

Summary

A diagnosis of epilepsy is made when a person experiences two or more unprovoked seizures, i.e. seizures without an immediate precipitating event such as fever, a blow to the head, active brain infection, or metabolic disturbance. Epileptic seizures result from abnormal electrical discharges which may be confined to a part of the brain or involve the entire cortex. The diagnostic classification system initially developed by the Commission on Classification and Terminology of the International League Against Epilepsy (1989) reflects both the manner in which the seizure begins (partial versus generalized) and the effects of the abnormal discharge (see Table 8.1).

Approximately 1% of children in the United States are diagnosed with epilepsy by age 20 (Epilepsy Foundation of America, 2002). The risk of developing seizures peaks during the first two years of life but declines over the childhood years (Camfield & Camfield, 1997). Epilepsy may develop as the result of or in association with a wide variety of medical conditions, as indicated in Table 8.2.

Typically, the diagnosis of epilepsy is based on behavior during the seizure and the characteristics of the electroencephalogram (EEG). For some children, the EEG will be abnormal only during the seizure event. An accurate description of the seizure by observers, and in some cases by the child experiencing the event, becomes essential in making the diagnosis. Medical and family history may facilitate identification of etiology.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aldenkamp, A. P. & Arends, J. (2004). Effects of epileptiform EEG discharges on cognitive function: Is the concept of “transient cognitive impairment” still valid?Epilepsy and Behavior, 5(Suppl 1), 25–34.CrossRefGoogle ScholarPubMed
Aldenkamp, A. P., Beitler, J., Arends, J., Linden, I. & Diepman, L. (2005). Acute effects of subclinical epileptiform EEG discharges on cognitive activation. Functional Neurology, 20, 23–28.Google ScholarPubMed
Aldenkamp, A. P., Overweg-Plandsoen, W. C. & Arends, J. (1999). An open, nonrandomized clinical comparative study evaluating the effect of epilepsy on learning. Journal of Child Neurology, 14, 795–800.CrossRefGoogle ScholarPubMed
Aldenkamp, A., Bronswijk, K., Braken, M.et al. (2000). A clinical comparative study evaluating the effect of epilepsy versus ADHD on timed cognitive tasks in children. Child Neuropsychology, 6, 209–17.CrossRefGoogle ScholarPubMed
Austin, J. K., Dunn, D. W., Johnson, C. S. & Perkins, S. M. (2004). Behavioral issues involving children and adolescents with epilepsy and the impact of their families: Recent research data. Epilepsy and Behavior, 5 (Suppl. 2), S33–S41.CrossRefGoogle ScholarPubMed
Austin, J. K., Harezlak, J., Dunn, D. W.et al. (2001). Behavior problems in children before first recognized seizures. Pediatrics, 107, 115–22.CrossRefGoogle ScholarPubMed
Austin, J. K., McNelis, A. M., Shore, C. P., Dunn, D. W. & Musick, B. (2002 a). A feasibility study of a family seizure management program: “Be seizure smart.”Journal of Neuroscience Nursing, 34, 30–37.CrossRefGoogle Scholar
Austin, J. K., Shafer, P. O. & Deering, J. B. (2002 b). Epilepsy familiarity, knowledge, and perceptions of stigma: Report from a survey of adolescents in the general population. Epilepsy and Behavior, 3, 368–75.CrossRefGoogle ScholarPubMed
Bailet, L. L. & Turk, W. R. (2000). The impact of childhood epilepsy on neurocognitive and behavioral performance: A prospective longitudinal study. Epilepsia, 41, 426–31.CrossRefGoogle ScholarPubMed
Bauman, R. J., Wilson, J. F. & Wiese, H. J. (1995). Kentuckians' attitudes toward children with epilepsy. Epilepsia, 36, 1003–8.CrossRefGoogle Scholar
Berg, A. T., Lin, J., Ebrahimi, N.et al. (2004). Modeling remission and relapse in pediatric epilepsy: Application of a Markov process. Epilepsy Research, 60, 31–40.CrossRefGoogle ScholarPubMed
Berg, A. T., Shinnar, S., Levy, S. R.et al. (2001). Two-year remission and subsequent relapse in children with newly diagnosed epilepsy. Epilepsia, 42, 1553–62.CrossRefGoogle ScholarPubMed
Bernstein, J. H., Prather, P. A. & Rey-Casserly, C. (1995). Neuropsychological assessment in preoperative and postoperative evaluation. Neurosurgery Clinics of North America, 6, 443–54.Google ScholarPubMed
Besag, F. M. (2004). Behavioral aspects of pediatric epilepsy syndromes. Epilepsy and Behavior, 59 (Suppl 1), 3–13.CrossRefGoogle Scholar
Binnie, C. D. (1993). Significance and management of transitory cognitive impairment due to subclinical EEG discharges in children. Brain and Development, 15, 23–30.CrossRefGoogle ScholarPubMed
Buelow, J. M. & McNelis, A. (2002). Should every child with epilepsy undergo a neuropsychological evaluation?Epilepsy and Behavior, 3, 210–13.CrossRefGoogle ScholarPubMed
Camfield, P. R. & Camfield, C. S. (1997). Management and treatment of febrile seizures. Current Problems in Pediatrics, 27, 6–14.CrossRefGoogle ScholarPubMed
Camfield, P. R. & Camfield, C. S. (2002). Epileptic syndromes in childhood: Clinical features, outcomes, and treatment. Epilepsia, 43 (Suppl. 3), 27–32.CrossRefGoogle Scholar
Carlton-Ford, S., Miller, R., Nealeigh, N. & Sanchez, N. (1997). The effects of perceived stigma and psychological over-control on he behavioral problems of children with epilepsy. Seizure, 6, 383–91.CrossRefGoogle Scholar
Chapieski, L., Brewer, V., Evankovich, K.et al. (2005). Adaptive functioning in children with seizures: Impact of maternal anxiety about epilepsy. Epilepsy and Behavior, 7, 246–52.CrossRefGoogle ScholarPubMed
Commission on Classification and Terminology of the Internal League Against Epilepsy. (1989). Proposal for revised classification of epilepsy and epileptic syndromes, Epilepsia, 30, 389–99.
Czochanska, J., Langner-Tyszka, B., Losiowski, Z. & Schmidt-Sidor, B. (1994). Children who develop epilepsy in the first year of life: a prospective study. Developmental Medicine and Child Neurology, 36, 345–50.Google ScholarPubMed
Drysdale, K., Shores, A. & Levick, W. (2004). Use of the Everyday Memory Questionnaire with children. Child Neuropsychology, 10, 67–88.CrossRefGoogle ScholarPubMed
Duchowny, M. (2001). Surgical evaluation. In Pellock, J. M., Dodson, W. E. & Bourgeois, B. F. D., eds. Pediatric epilepsy: Diagnosis and therapy. New York: Demos Medical Publishing, pp. 575–87.Google Scholar
Dunn, D. W., Austin, J. K., Harezlak, J. & Ambrosius, W. T. (2003). ADHD and epilepsy in childhood. Developmental Medicine and Child Neurology, 45, 50–4.CrossRefGoogle ScholarPubMed
Epilepsy Foundation of America, . (2005). You are not alone: parenting your teen with epilepsy. Landover, MD: Epilepsy Foundation of America.Google Scholar
Epilepsy Foundation of America. (2002). Answer place: epilepsy and seizure statistics. Retreived from www.epilepsyfoundation.org. October 19, 2005.
Everett, L. L., VanRooyan, I. F., Warner, M. H. et al. (2006). Use of dexmedetomidine in awake craniotomy in adolescents: Report of two cases. Pediatric Anesthesia, 16, 338–42.CrossRef
Farwell, J. R., Dodrill, C. B. & Batzel, L. W. (1985). Neuropsychological abilities of children with epilepsy. Epilepsia, 26, 395–400.CrossRefGoogle ScholarPubMed
Feldman, H., Crumrine, P., Handen, B. L., Alvin, R. & Teodori, J. (1989). Methylphenidate in children with seizures and attention-deficit disorder. American Journal of Diseases in Childhood, 143, 1081–6.Google ScholarPubMed
Freeman, J. M., Freeman, J. & Kelly, M. (2000). The Ketogenic diet: A treatment for epilepsy, 3rd edn. New York: Demos Medical Publishing.Google Scholar
Glauser, T. A. (2004). Effects of antiepileptic medications on psychiatric and behavioral comorbidities in children and adolescents with epilepsy. Epilepsy and Behavior, 5 (Suppl. 3), 25–32.CrossRefGoogle ScholarPubMed
Goldstein, J., Plioplys, S., Zelko, F.et al. (2004). Multidisciplinary approach to childhood epilepsy: exploring the scientific rationale and practical aspects of implementation. Journal of Child Neurology, 19, 362–78.CrossRefGoogle ScholarPubMed
Gross-Tsur, V., Manor, O., Meere, J., Joseph, A. & Shalev, R. S. (1997). Epilepsy and attention deficit hyperactivity disorder: Is methylphenidate safe and effective?Journal of Pediatrics, 130, 670–4.CrossRefGoogle ScholarPubMed
Guerrini, R. & Aicardi, J. (2003). Epileptic encephalopathies with myoclonic seizures in infants and children (severe myoclonic epilepsy and myoclonic-astatic epilepsy). Journal of Clinical Neurophysiology, 20, 449–61.CrossRefGoogle Scholar
Helmers, S. L., Wheless, J. W., Frost, M.et al. (2001). Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy: A retrospective study. Journal of Child Neurology, 16, 843–8.CrossRefGoogle ScholarPubMed
Hermann, B., Seidenberg, M., Bell, B.et al. (2002). The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function. Epilepsia, 43, 1062–71.CrossRefGoogle ScholarPubMed
Hertz-Pannier, L., Chiron, C., Vera, P.et al. (2001). Functional imaging in the work-up of childhood epilepsy. Child's Nervous System, 17, 223–8.CrossRefGoogle ScholarPubMed
Hesdorffer, D. C., Ludvigsson, P., Olafsson, E.et al. (2004). ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Archives of General Psychiatry, 61, 731–6.CrossRefGoogle ScholarPubMed
Humphries, T., Neufeld, N., Johnson, C., Engels, K. & McKay, R. (2005). A pilot study of the effect of Direct Instruction programming on the academic performance of students with intractable epilepsy. Epilepsy and Behavior, 6, 405–12.CrossRefGoogle ScholarPubMed
Hoare, P. & Kerley, S. (1992). Helping parents and children with epilepsy cope successfully: the outcome of a group programme for parents. Journal of Psychosomatic Research, 36, 759–67.CrossRefGoogle ScholarPubMed
Kadis, D. S., Stollstorff, M., Elliott, I., Lach, L. & Smith, M. L. (2004). Cognitive and psychological predictors of everyday memory in children with intractable epilepsy. Epilepsy and Behavior, 5, 37–43.CrossRefGoogle ScholarPubMed
Knake, S., Grant, P. E., Stufflebeam, S. M.et al. (2004). Aids to telemetry in the presurgical evaluation of epilepsy patients: MRI, MEG and other non-invasive imaging techniques. Clinical Neurophysiology, 57 (Suppl.), 494–502.Google ScholarPubMed
Kossoff, E. H., Krauss, G. L., McGrogan, J. R. & Freeman, J. M. (2003). Efficacy of the Atkins diet as therapy for intractable epilepsy. Neurology, 62, 1789–91.CrossRefGoogle Scholar
LaJoie, J. & Miles, D. K. (2002). Treatment of attention-deficit disorder, cerebral palsy, and mental retardation in epilepsy. Epilepsy and Behavior, 3, 42–8.CrossRefGoogle ScholarPubMed
Lee, G. P., Park, Y. D., Hempel, A., Westerveld, M. & Loring, D. W. (2002). Prediction of seizure-onset laterality by using Wada memory asymmetries in pediatric epilepsy surgery candidates. Epilepsia, 43, 1049–55.CrossRefGoogle ScholarPubMed
Lee, G. P., Westerveld, M., Blackburn, L. B., Park, Y. D. & Loring, D. W. (2003). Wada memory performance predicts seizure outcome after epilepsy surgery in children. Epilepsia, 44, 936–47.CrossRefGoogle ScholarPubMed
Lee, G. P., Westerveld, M., Blackburn, L. B., Park, Y. D. & Loring, D. W. (2005). Prediction of verbal memory decline after epilepsy surgery in children: Effectiveness of Wada memory asymmetries. Epilepsia, 46, 97–103.CrossRefGoogle ScholarPubMed
Lewis, M. A., Salas, I., Sota, A., Chiofalo, N. & Leake, B. (1990). Randomized trial of a program to enhance the competencies of children with epilepsy. Epilepsia, 31, 101–9.CrossRefGoogle ScholarPubMed
Loring, D. W. & Meador, K. J. (2004). Cognitive side effects of antiepileptic drugs in children. Neurology, 62, 872–7.CrossRefGoogle ScholarPubMed
Mangano, S., Fontana, A. & Cusumano, L. (2005). Benign myoclonic epilepsy in infancy: neuropsychological and behavioural outcome. Brain and Development, 27, 218–23.CrossRefGoogle ScholarPubMed
Meador, K. J. & Loring, D. W. (1999). The Wada test: controversies, concerns, and insights. Neurology, 52, 1535–6.CrossRefGoogle ScholarPubMed
Mizrahi, E. M. & Clancy, R. R. (2000). Neonatal seizures: early-onset seizure syndromes and their consequences for development. Mental Retardation Developmental Disabilities Research Review, 6, 229–41.3.0.CO;2-Y>CrossRefGoogle Scholar
Murphy, J. V., Torkelson, R., Dowler, I., Simon, S. & Hudson, S. (2003). Vagal nerve stimulation in refractory epilepsy: the first 100 patients receiving vagal nerve stimulation at a pediatric epilepsy center. Archives of Pediatric and Adolescent Medicine, 157, 560–4.CrossRefGoogle Scholar
Nolan, M. A., Redoblado, M. A., Lah, S.et al. (2003). Intelligence in childhood epilepsy syndromes. Epilepsy Research, 53, 139–50.CrossRefGoogle ScholarPubMed
Nolan, M. A., Redoblado, M. A., Lah, S.et al. (2004). Memory function in childhood epilepsy syndromes. Journal of Paediatrics and Child Health, 40, 20–7.CrossRefGoogle ScholarPubMed
Ojemann, S. G., Berger, M. S., Lettich, E. & Ojemann, G. A. (2003). Localization of language function in children: Results of electrical stimulation mapping. Journal of Neurosurgery, 98, 465–70.CrossRefGoogle ScholarPubMed
Ojemann, G. A. & Dodrill, C. (1985). Verbal memory deficits after left temporal lobectomy for epilepsy: Mechanism and intraoperative prediction. Journal of Neurosurgery, 62, 101–7.CrossRefGoogle ScholarPubMed
Ott, D., Siddarth, P., Gurbani, S.et al. (2003). Behavioral disorders in pediatric epilepsy: Unmet psychiatric need. Epilepsia, 44, 591–7.CrossRefGoogle ScholarPubMed
Pavone, P., Bianchini, R., Trifiletti, R. R.et al. (2001). Neuropsychological assessment in children with absence epilepsy. Neurology, 56, 1047–51.CrossRefGoogle ScholarPubMed
Robinson, R. O., Baird, G., Robinson, G. & Simonoff, E. (2001). Landau-Kleffner syndrome: Course and correlates with outcome. Developmental Medicine and Child Neurology, 43, 243–7.CrossRefGoogle ScholarPubMed
Rodenburg, R., Meijer, A. M., Dekovic, M. & Aldenkamp, A. P. (2005). Family factors and psychopathology in children with epilepsy: A literature review. Epilepsy and Behavior, 6, 488–503.CrossRefGoogle ScholarPubMed
Rodenburg, R., Stams, G. J., Meijer, A. M., Aldenkamp, A. P. & Dekovic, M. (2005a). Psychopathology in children with epilepsy: A meta-analysis. Journal of Pediatric Psychology, 30, 453–68.CrossRefGoogle Scholar
Scholtes, F. B., Hendriks, M. P. & Renier, W. O. (2005b). Cognitive deterioration and electrical status epilepticus during slow sleep. Epilepsy and Behavior, 6, 167–73.CrossRefGoogle Scholar
Shahar, E., Barak, S., Andraus, J. & Kramer, U. (2004). Primary generalized epilepsy during infancy and early childhood. Journal of Child Neurology, 19, 170–4.Google Scholar
Sherman, E., Slick, D. J., Connolly, M. B., Steinbok, P., Martin, R. & Strauss, E.et al. (2003). Reexamining the effects of epilepsy surgery on IQ in children: Use of repression-based change scores. Journal of the International Neuropsychological Society, 9, 879–86.CrossRefGoogle Scholar
Shinnar, S. (2005). Mood disorders in children with epilepsy. Retrieved on November 4, 2005 in Teleconsults in Epilepsy by American Epilepsy Society at www.aesnet.org/Visitors/ProfessionalDevelopment/Teleconsults.
Sonmez, F., Atakli, D., Sari, H., Atay, T. & Arpaci, B. (2004). Cognitive function in juvenile myoclonic epilepsy. Epilepsy and Behavior, 5, 329–36.CrossRefGoogle ScholarPubMed
Szabo, C. A., Wyllie, E., Stanford, L. D.et al. (1998). Neuropsychological effect of temporal lobe resection in preadolescent children with epilepsy. Epilepsia, 39, 814–19.CrossRefGoogle ScholarPubMed
Tieffenberg, J. A., Wood, E. I., Alonso, A, Tossutti, M. S. & Vincete, M. F. (2000). A randomized field trial of ACINDES: A child-centered training model for children with chronic illnesses (asthma and epilepsy). Journal of Urban Health, 77, 280–97.CrossRefGoogle Scholar
The National Association of Epilepsy Centers. (2001). Guidelines for essential services, personnel, and facilities in specialized epilepsy centers in the United States. Epilepsia, 42, 804–14.CrossRef
Vermeulen, J., Kortstee, S. W., Alpherts, W. C. & Aldenkamp, A. P. (1994). Cognitive performance in learning disabled children with and without epilepsy. Seizure, 3, 13–21.CrossRefGoogle ScholarPubMed
Wagner, J. L. & Smith, G. (2006). Psychosocial intervention in pediatric epilepsy: A critique of the literature. Epilepsy and Behavior, 8, 39–49.CrossRefGoogle ScholarPubMed
Wheless, J. W. & Kim, H. L. (2002). Adolescent seizures and epilepsy syndromes. Epilepsia, 43 (Suppl. 3), 33–52.CrossRefGoogle ScholarPubMed
Williams, J., Phillips, T., Griebel, M. L.et al. (2001). Patterns of memory performance in children with controlled epilepsy on the CVLT-C. Child Neuropsychology, 7, 15–20.CrossRefGoogle ScholarPubMed
Williams, J., Steel, C., Sharp, G. B.et al. (2003). Parental anxiety and quality of life in children with epilepsy. Epilepsy and Behavior, 4, 483–6.CrossRefGoogle ScholarPubMed
Winawer, M. R. & Shinnar, S. (2005). Genetic epidemiology of epilepsy or what do we tell families?Epilepsia, 46 (Suppl. 10), 24–30.CrossRefGoogle ScholarPubMed
Wolff, M., Weiskopf, N., Serra, E.et al. (2005). Benign partial epilepsy in childhood: selective cognitive deficits are related to the location of focal spikes determined by combined EEG/MEG. Epilepsia, 46, 1661–7.CrossRefGoogle ScholarPubMed
Ziegler, R. G., Erba, G., Holden, L. & Dennison, H. (2000). The coordinated psychosocial and neurologic care of children with seizures and their families. Epilepsia, 41, 732–43.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×