Bone forming and DISH

Tony Waldron

doi:10.1017/CBO9780511812569.006

5 - Bone forming and DISH

Published online by Cambridge University Press: 05 June 2012

Tony Waldron

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Tony Waldron: Affiliation:
University College London

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BONE FORMING AND BONE FORMERS

Within any skeletal assemblage there seems to be a proportion who apparently had a tendency to ossify soft tissues, especially the entheses, that is, the point at which tendons insert into bone, probably in response to minimal repetitive trauma. The result is the production of bony spurs at these points, which are referred to as enthesophytes. We alluded to these individuals as bone formers but our original definition was later modified by Rogers and her colleagues. Rogers and colleagues examined the sites of a series of entheses in the skeleton (fourteen in total) to see which showed the presence of an enthesophyte. The total number of enthesophytes was then divided by the number of sites examined and if the score was equal to, or greater than 0.3, that was considered evidence of bone forming. Bone formers are probably more likely than others to produce heterotopic ossification and to calcify or ossify costal cartilages, the thyroid cartilage and other soft tissues. It is not certain what proportion of the population are bone formers but it may be up to a fifth. There are several skeletal diseases in which bone forming is a feature – some joint diseases, some infections and Paget's disease, for example – and it is likely that the production of bone in these conditions will be particularly exuberant if the individual is also a bone former.

Type: Chapter
Information: Palaeopathology , pp. 72 - 82

DOI: https://doi.org/10.1017/CBO9780511812569.006 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2008

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References

Waldron, T and Rogers, J, An epidemiologic study of sacroiliac fusion in some human skeletal remains, American Journal of Physical Anthropology, 1990, 83, 123–127CrossRef Google Scholar PubMed

Rogers, J, Shepstone, L and Dieppe, P, Bone formers: osteophyte and enthesophyte formation are positively associated, Annals of the Rheumatic Diseases, 1997, 56, 85–90CrossRef Google Scholar PubMed

Felson, DT and Neogi, T, Osteoarthritis: is it a disease of cartilage or bone?Arthritis and Rheumatism, 2004, 50, 341–344CrossRef Google Scholar PubMed

Benjamin, M and McGonagle, D, The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites, Journal of Anatomy, 2001, 199, 503–526CrossRef Google Scholar PubMed

Forestier, J and Rotés-Quérol, J, Senile ankylosing hyperostosis of the spine, Annals of the Rheumatic Diseases, 1950, 9, 321–330CrossRef Google Scholar PubMed

Resnick, D, Shaul, SR and Robbins, JM, Diffuse idiopathic skeletal hyperostosis (DISH): Forestier's disease with extraspinal manifestations, Diagnostic Radiology, 1975, 115, 513–524Google Scholar PubMed

Ciocci, A, Diffuse idiopathic skeletal hyperostosis (DISH) and situs viscerum inversus. Report of a single case, Clinical and Experimental Rheumatology, 1987, 5, 159–160Google Scholar PubMed

Mata, S, Fortin, PR, Fitzcharles, MA, Starr, MR, Joseph, L, Watts, CS, Gore, B, Rosenberg, E, Chen, RK and Esdaile, JM, A controlled study of diffuse idiopathic skeletal hyperostosis. Clinical features and functional status, Medicine (Baltimore), 1997, 76, 104–117CrossRef Google Scholar PubMed

Julkunen, H, Heinonen, OP and Pyörälä, K, Hyperostosis of the spine in an adult population, Annals of the Rheumatic Diseases, 1971, 30, 605–612CrossRef Google Scholar

Abiteboul, M and Arlet, J, Retinonol-related hyperostosis, American Journal of Roentgenology, 1985, 144, 435–436CrossRef Google Scholar PubMed

Kiss, C, Szilágyi, M, Paksy, A and Poór, G, Risk factors for diffuse idiopathic skeletal hyperostosis: a case-control study, Rheumatology, 2002, 41, 27–30CrossRef Google Scholar PubMed

Denko, CW, Boja, B and Malemud, CJ, Growth hormone and insulin-like growth factor-I in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH), Frontiers in Bioscience, 2002, 7, a37–a43CrossRef Google Scholar

CW, Denko, Boja, B and Moskowitz, RW, Growth promoting peptides in osteoarthritis and diffuse idiopathic skeletal hyperostosis – insulin, insulin-like growth factor-I, growth hormone, Journal of Rheumatology, 1994, 21, 1725–1730Google Scholar

Hutton, C, DISH … a state not a disease?British Journal of Rheumatology, 1989, 28, 277–278CrossRef Google Scholar

Utsinger, P, Resnick, D and Shapiro, R, Diffuse skeletal abnormalities in Forestier disease, Archives of Internal Medicine, 1976, 136, 763–768CrossRef Google Scholar PubMed

Schlapbach, P, Beyeler, C, Gerber, NJ, Linder, S, Burgi, U, Fuchs, WA and Ehrengruber, H, Diffuse idiopathic skeletal hyperostosis (DISH) of the spine: a cause of pain? A controlled study, British Journal of Rheumatology, 1989, 28, 299–303CrossRef Google Scholar

Girolamo, C di, Pappone, N, Rengo, C, Miniero, E, Crisci, C and Olivieri, I, Intervertebral disc lesions in diffuse idiopathic skeletal hyperostosis (DISH), Clinical and Experimental Rheumatology, 2001, 19, 310–312Google Scholar

Hendrix, RW, Melany, M, Miller, F and Rogers, LF, Fracture of the spine in patients with ankylosis due to diffuse idiopathic skeletal hyperostosis: clinical and imaging findings, American Journal of Roentgenology, 1994, 162, 899–904CrossRef Google Scholar PubMed

Sreedharan, S and Li, YH, Diffuse idiopathic skeletal hyperostosis with cervical spine cord injury – a report of 3 cases and a literature review, Annals of the Academy of Medicine of Singapore, 2005, 34, 257–261Google Scholar

Miyazawa, N and Akiyama, I, Diffuse idiopathic skeletal hyperostosis associated with risk factors for stroke – a case-control study, Spine, 2006, 31, 225–229CrossRef Google Scholar PubMed

Waldron, T, DISH at Merton Priory; evidence for a ‘new’ occupational disease?British Medical Journal, 1985, 291, 1762–1763CrossRef Google Scholar PubMed

Rogers, J and Waldron, T, DISH and the monastic way of life, International Journal of Osteoarchaeology, 2001, 11, 357–365CrossRef Google Scholar

Janssen, HAM and Maat, GJR, Canons buried in the ‘Stiftskapel’ of the Saint Servaas Basilica at Maastricht AD 1070–1521. A palaeopathological study, Barge's Anthropologica No 5, Leiden, Barge's Anthropologica

Harvey, B, Living and dying in England 1100–1540. The monastic experience, Oxford, Clarendon Press, 1993Google Scholar

Gasquet, F, Monastic life in the middle ages, London, G Bell, 1922Google Scholar

Bishop, M, The Pelican book of the middle ages, London, Penguin, 1983Google Scholar

Bruntjes, TJD, Diffuse idiopathic skeletal hyperostosis (DISH). A 10th century AD case from the St Servaas church at Maastricht, Bone, 1987, 1, 23–28Google Scholar

Schmidt, MH, Quinones-Hinojosa, A and Rosenberg, WS, Cervical myelopathy associated with degenerative spine disease and ossification of the posterior longitudinal ligament, Seminars in Neurology, 2002, 22, 143–148CrossRef Google Scholar PubMed

Inamasu, J, Guilot, BH and Sachs, DC, Ossification of the posterior longitudinal ligaments: an update on its biology, epidemiology, and natural history, Neurosurgery, 2006, 58, 1027–1039CrossRef Google Scholar

Epstein, NE, The surgical management of ossification of the posterior longitudinal ligament in 43 North Americans, Spine, 1994, 19, 664–672CrossRef Google Scholar PubMed

Hasegawa, T, Ito, H, Yamamoto, S, Haba, K and Murata, H, Unilateral hyperostosis frontalis interna. A case report, Journal of Neurosurgery, 1983, 59, 710–713CrossRef Google Scholar

Perou, ML, Cranial hyperostosis, Springfield, CC Thomas, 1964Google Scholar

Dihlmann, W, Computerized tomography in typical hyperostosis cranii (THC), European Journal of Radiology, 1981, 1, 2–8Google Scholar

Morgagni, GB, Adversaria anatomica, Padua, 1719Google Scholar

Moore, S, The Troell-Junet syndrome, Acta Radiologica, 1953, 39, 485–493CrossRef Google Scholar PubMed

Dann, S, Metabolic craniopathy: a review of the literature with report of a case with diabetes, Annals of Internal Medicine, 1951, 34, 163–202Google Scholar PubMed

Devriendt, W, Piercecchi-Marti, MD, Adalian, P, Sanvoisin, A, Dutour, O and Leonettit, G, Hyperostosis frontalis interna: forensic issues, Journal of Forensic Science, 2005, 50, 143–146CrossRef Google Scholar PubMed

Ruhli, FJ, Bone, T and Hennenberg, M, Hyperostosis frontalis interna: archaeological evidence of possible microevolution of human sex steroids?Homo, 2004, 55, 91–99CrossRef Google Scholar PubMed

Maffei, P, Munno, V, Marshall, JD, Scandellai, C and Sicolo, N, The Alstrom syndrome: is it a rare or unknown disease?Annali Italiani di Medicina Interna, 2002, 17, 221–228Google Scholar PubMed

Zubicaray, GI, Chalk, JB, Rose, SE, Semple, J and Smith, GA, Deficits on self ordered tasks associated with hyperostosis frontalis interna, Journal of Neurology, Neurosurgery and Psychiatry, 1997, 63, 309–314CrossRef Google Scholar PubMed

Chaljub, G, Johnson, RF III, Johnson, RF Sr and Sitton, CW, Unusually exuberant hyperostosis frontalis interna: MRI, Neuroradiology, 1999, 41, 45–45CrossRef Google Scholar PubMed

She, R and Szakacs, J, Hyperostosis frontalis interna: case report and review of the literature, Annals of Clinical Laboratory Science, 2004, 34, 206–208Google Scholar

Šikanjić, PR, Analysis of human skeletal remains from Nadin iron age burial mound, Collegium Anthropologicum, 2006, 30, 795–759Google Scholar PubMed

Barber, G, Watt, I and Rogers, J, A comparison of radiological and palaeopathological diagnostic criteria for hyperostosis frontalis interna, International Journal of Osteoarchaeology, 1997, 7, 157–1643.0.CO;2-8>CrossRef Google Scholar

Dayton, L, The fat hairy women of Pompeii, New Scientist, 1994, September 24, p 10Google Scholar

Glab, H, Szostek, K and Kaczanowski, K, Hyperostosis frontalis interna, a genetic disease? Two medieval cases from Southern Poland, Homo, 2006, 57, 19–27CrossRef Google Scholar PubMed

McCarthy, EF and Sunderam, M, Heterotopic ossification: a review, Skeletal Radiology, 2005, 34, 609–619CrossRef Google Scholar PubMed

Potter, BK, Burns, TC, Lacap, AP, Granville, RR and Gajewski, DA, Heterotopic ossification following traumatic and combat-related amputations. Prevalence, risk factors, and preliminary results of excision, Journal of Bone and Joint Surgery, 2007, 89A, 476–486CrossRef Google Scholar

Tortolani, PJ, Cunningham, BW, Eng, M, McAfee, PC, Holsapple, GA and Adams, KA, Prevalence of heterotopic ossification following disc replacement. A prospective, randomized study of two hundred and seventy-six patients, Journal of Bone and Joint Surgery, 2007, 89A, 82–88CrossRef Google Scholar

Gurr, A, Sinclair, M, Caruso, E, Peretti, G and Zaleske, D, Heterotopic ossification around the elbow following burns in children: results after excision, Journal of Bone and Joint Surgery, 2003, 85A, 1538–1543CrossRef Google Scholar

Hudson, SJ and Brett, SJ, Heterotopic ossification – a long-term consequence of prolonged immobility, Critical Care, 2006, 10, 174CrossRef Google Scholar PubMed

Bossche, L Vanden and Vanderstraeten, G, Heterotopic ossification: a review, Journal of Rehabilitation Medicine, 2005, 37, 129–136CrossRef Google Scholar

Balboni, TA, Gobezie, R and Mamon, HJ, Heterotopic ossification: pathophysiology, clinical features, and the role of radiotherapy in prophylaxis, International Journal of Radiation Oncology, Biology, Physics, 2006, 66, 1597–1598Google Scholar

Couzin, J, Bone disease gene finally found, Science, 2006, 312, 514–515CrossRef Google Scholar

Kaplan, FS, Fiori, J, Pena, LS, Ahn, J, Billings, PC and Shore, EM, Dysregulation of the BMP-4 signaling pathway in fibrodysplasia ossificans progressive, Annals of the New York Academy of Sciences, 2006, 1068, 54–65CrossRef Google Scholar

Olszewski, AD, Yaszemski, MJ and White, AA, The anatomy of the human lumbar ligamentum flavum: new observations and their surgical importance, Spine, 1006, 21, 2307–2312CrossRef Google Scholar

Lirk, P, Moriggl, M, Colvin, J, Keller, C, Kirchmai, L, Rieder, J and Kolbitsch, C, The incidence of lumbar ligamentum flavum midline gaps, Anesthesia and Analgesia, 2004, 98, 1178–1180CrossRef Google Scholar PubMed

Inamasu, J and Guiot, BH, A review of the factors predictive of surgical outcome for ossification of the ligamentum flavum of the thoracic spine, Journal of Neurosurgery Spine, 2006, 5, 133–139CrossRef Google Scholar PubMed

Benoist, M, Natural history of the aging spine, European Spine Journal, 2003, 12 (Supplement 2), S86–S89CrossRef Google Scholar PubMed

Trivedi, P, Behari, S, Paul, L, Banerji, D, Jain, VK and Chhabra, DK, Thoracic myelopathy secondary to ossified ligamentum flavum, Acta Neurochirurgica (Wien, 2001, 143, 775–782CrossRef Google Scholar PubMed

Stirland, AJ and Waldron, T, Evidence for activity related markers in the vertebrae of the crew of the Mary Rose, Journal of Archaeological Science, 1997, 24, 329–335CrossRef Google Scholar

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