Experience-induced Changes Reveal Functional Dissociation within Olfactory Pathways

doi:10.1017/CBO9780511546389.029

21 - Experience-induced Changes Reveal Functional Dissociation within Olfactory Pathways

Published online by Cambridge University Press: 21 September 2009

Pascal Chabaud and

Edited by

Rémi Gervais and

Nadine Ravel: Affiliation:
Institut des Sciences Cognitives, CNRS/Université Claude Bernard, Lyon 1, 69675, Bron, France
Anne-Marie Mouly: Affiliation:
Institut des Sciences Cognitives, CNRS/Université Claude Bernard, Lyon 1, 69675, Bron, France
Pascal Chabaud: Affiliation:
Institut des Sciences Cognitives, CNRS/Université Claude Bernard, Lyon 1, 69675, Bron, France
Rémi Gervais: Affiliation:
Research Director CNRS, Institut des Sciences Cognitives, Lyon
Catherine Rouby: Affiliation:
Université Lyon I
Benoist Schaal: Affiliation:
Centre National de la Recherche Scientifique (CNRS), Paris
Danièle Dubois: Affiliation:
Centre National de la Recherche Scientifique (CNRS), Paris
Rémi Gervais: Affiliation:
Centre National de la Recherche Scientifique (CNRS), Paris
A. Holley: Affiliation:
Centre National de la Recherche Scientifique (CNRS), Paris

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Summary

Learning more about the neural basis of olfactory cognition should greatly improve our understanding of how different brain structures deal with information. Progress can be facilitated by simultaneous advances with animal models and human studies, for in the olfactory system, conservatism across mammalian species in the organization of olfactory pathways allows integration of data obtained in animals and humans. In each species, output neurons from the olfactory bulb (OB) monosynaptically reach the piriform cortex (PC), the peri-amygdaloid cortex, and the lateral entorhinal cortex (LEC). The LEC provides massive input to the hippocampus, and the PC sends information to the orbitofrontal neocortical area, both directly and after a relay in the dorsomedial thalamic nuclei (Haberly, 1998). As in other sensory systems, two strategies have been developed thus far in order to identify hierarchical organization: collecting information from one structure at a time, and looking at the system as a network of interconnected structures. The first strategy is typical for most animal studies and is implemented through single-cell recordings in anesthetized animals (Mori, Nagao, and Yoshiara, 1999) and active animals (Schoenbaum, Chiba, and Gallagher, 1999; Weibe and Staubli, 1999; Wood, Dudchenko, and Eichenbaum, 1999) or through surface EEG recordings in awake restrained animals (Freeman and Skarda, 1985). When using anesthetized animals, most studies have focused on the OB, and fewer on the PC. When using active rats, such studies have investigated hippocampal, amygdalar, and orbitofrontal electrophysiological characteristics.

Type: Chapter
Information: Olfaction, Taste, and Cognition , pp. 335 - 349

DOI: https://doi.org/10.1017/CBO9780511546389.029 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2002

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