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6 - Olfactory Processing and Brain Maturation

from Section I - Neurology, Neurophysiology and Neuropsychology: Olfactory Clues to Brain Development and Disorder

Published online by Cambridge University Press:  17 August 2009

By
Warrick J. Brewer ,
Christos Pantelis ,
Cinzia De Luca  and
Stephen J. Wood
Edited by
Warrick J. Brewer ,
David Castle  and
Christos Pantelis
Foreword by
Peter Doherty
Warrick J. Brewer
Affiliation:
Mental Health Research Institute of Victoria, Melbourne
David Castle
Affiliation:
University of Melbourne
Christos Pantelis
Affiliation:
University of Melbourne
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Summary

Introduction

Olfactory deficits are found in neurodegenerative disorders, predominantly in later life, as well as in disorders with an onset in childhood or adolescence. The former will be considered in detail in Chapters 14–16. It is clear that the neuropathological changes accompanying neurodegenerative disorders are implicated in causing such deficits in olfactory abilities. In contrast, the processes underlying olfactory abnormalities in disorders of early development are less clear and are best understood in the context of dynamic brain maturational changes that are occurring at this time. Thus, neurobiology relevant to the deficits observed in disorders having a neurodevelopmental basis, such as the autistic spectrum disorders, attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD) and schizophrenia, may relate more to abnormalities in the processes of brain maturation rather than to specific neuropathological processes, or to an interaction between brain maturation and other processes relevant to these conditions.

We suggest that in order to understand the nature of the deficits observed in various aspects of olfactory function in early developmental disorders, it is important to consider the nature of the normal brain structural and functional changes that are occurring at the time of their onset. It is likely that interruption of these normal processes by the emergence of such disorders at critical times of maturation adversely affect the development of olfactory functions. Interruption of normal neurodevelopment, reflected by olfactory deficits, may manifest as developmental arrest, developmental lag or possibly functional deterioration following onset of these conditions.

Keywords

adolescencebrain maturationchildhood-onset disorderslimbic-prefrontal networksolfactory deficitsolfactory processingneuropsychiatric disordersolfactory abilities
Type
Chapter
Information
Olfaction and the Brain , pp. 103 - 118
Publisher: Cambridge University Press
Print publication year: 2006

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References

Anderson, V., Lajoie, G. & Bell, R. (1995) Neuropsychological assessment of the school-aged child. In Department of Psychology. University of Melbourne, Australia.
Anderson, V. (1998) Assessing executive functioning in children: Biological, physiological and developmental considerations. Neuropsychological Rehab, 8, 319–49.Google Scholar
American Psychiatric Association (APA) (1994) Diagonostic and Statistical Mannual of Mental Disorders, Fourth Edition, Text Revision. Washington, DC, American Psychiatric Association.
Ardila, A & Rosselli, M. (1994) Development of language, memory and visuo-spatial abilities in 5- to 12-year-old children using a neuropsychological battery. Dev Neuropsychology, 10, 97–120.Google Scholar
Balogh, R. D. & Porter, R. H. (1986) Olfactory preferences resulting from mere exposure in human neonates. Infant Beh Dev, 9, 395–401.Google Scholar
Bachevalier, J. & Merjanian, P. M. (1994) The contribution of medical temporal lobe structures in infantile autism: a neurobehavioral study in primates. In The Neurobiology of Autism (eds Bauman, M. L. & Kemper, T. L.), pp. 146–69, Baltimore: The Johns Hopkins University Press.
Barnett, R., Maruff, P., Purcell, R., et al. (1999) Impairment of olfactory identification in obsessive-compulsive disorder. Psychol Med, 29, 1227–33.Google Scholar
Bartoshuk, L. M. & Beauchamp, G. K. (1994) Chemical senses. Ann Rev Psychol, 45, 419–49.Google Scholar
Beauchamp, G. K. & Pearson, P. (1991) Human development and umami taste. Physiol Behav, 49, 1009–12.Google Scholar
Benes, F. M., Turtle, M., Khan, Y., et al. (1994) Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence and adulthood. Arch Gen Psychiatry, 51, 477–84.Google Scholar
Brewer, W. J., Edwards, J., Anderson, V., et al. (1996) Neuropsychological, olfactory and hygiene deficits in men with negative symptom schizophrenia. Biol Psychiatry, 40, 1021–31.Google Scholar
Brewer, W. J., Pantelis, C., Anderson, V., et al. (2001) Stability of olfactory identification deficits in neuroleptic-naive patients with first episode psychosis. Am J Psychiatry, 158(1), 107–15.Google Scholar
Brewer, W. J., Wood, S. J., McGorry, P. D., et al. (2003) Olfactory identification ability is impaired in individuals at high risk for psychosis who later develop schizophrenia. Am J Psychiatry, 160, 1790–4.Google Scholar
Brewer, W. J., Costa, S., Brereton, A., et al. (In submission) Olfactory identification in children with Autism: a pilot investigation using a visual analogue of the UPSIT.
Cain, W. S., Stevens, J. C., Nickou, C., et al. (1995) Life-span development of odor identification, learning and olfactory sensitivity. Perception, 24, 1457–72.Google Scholar
Case, R. (1992) The role of the frontal lobes in the regulation of cognitive development. Brain & Cognition, 20, 51–73.Google Scholar
Chelune, G. J. & Baer, R. (1986) Developmental norms of the Wisconsin Card Sorting Test. J Clin Exp Neuropsychol, 8, 219–28.Google Scholar
Davis, R. G. (1975) Acquisition of verbal associations to olfactory stimuli of varying familiarity and to abstract verbal stimuli. J Exp Psychol: Hum Learning & Mem, 104, 134–42.Google Scholar
Dawson, G., Meltzoff, A. N., Osterling, J., et al. (1998) Neuropsychological correlates of early symptoms of Autism. Child Development, 69(5), 1276–85.Google Scholar
Luca, C. R., Wood, S. J., Anderson, V., et al. (2003) Normative data from the CANTAB. I: Development of executive function over the lifespan. J Clin Exp Neuropsychology, 25, 242–54.Google Scholar
Wijk, R. A. & Cain, W. S. (1994) Odor identification by name and by edibility: Life-span development and safety. Human Factors, 36, 182–7.Google Scholar
Dorries, K. M., Schmidt, H. J., Beauchamp, G. K., et al. (1989) Changes in sensitivity to the odor of androstenone during adolescence. Dev Psychobiology, 22, 423–5.Google Scholar
Doty, R. L., Shaman, P. & Dann, M. (1984) Development of the University of Pennsylvania Smell Identification Test: A standardised microencapsulated test of olfactory function. Physiol Behav, 32, 489–502.Google Scholar
Engen, T. (1982) The Perception of Odors. pp. 79–90, New York: Academic Press.
Espy, K. (1997) The shape school: Assessing executive function in preschool children. Dev Neuropsychol, 13, 495–9.Google Scholar
Geddes, J., Huws, R. & Pratt, P. (1991) Olfactory acuity in the positive and negative syndromes of schizophrenia. Biol Psychiatry, 29, 774–8.Google Scholar
Gansler, M., et al. (1998) Are there cognitive subtypes in adult attention deficit/hyperactivity disorder?J Nerv Ment Disease, 186(12), 776–81.Google Scholar
Giedd, J. N., Blumenthal, J., Jeffries, N. O., et al. (1999) Brain development during childhood and adolescence: A longitudinal MRI study. Nat Neurosci, 2, 861–3.Google Scholar
Giedd, J. N. (2004) Structural magnetic resonance imaging of the adolescent brain. Ann N Y Acad Sci, 1021, 77–85.Google Scholar
Gogtay, N.Giedd, J. N., Lusk, L., et al. (2004) Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci USA, 101(21), 8174–9.Google Scholar
Huttenlocher, P. (1984) Synapse elimination and plasticity in developing human cerebral cortex. Am J Ment Defic, 88, 488–96.Google Scholar
Hvastja, L. & Zanuttini, L. (1989) Odour memory and odour hedonics in children. Perception, 18, 391–6.Google Scholar
Isseroff, R. G., Stoler, M., Ophir, D., et al. (1987) Olfactory sensitivity to androstenone in schizophrenic patients. Biol Psychiatry, 22, 922–5.Google Scholar
Jablensky, A. & Cole, S. W. (1997) Is the earlier age at onset of schizophrenia in males a confounding finding? Results from a cross-cultural investigation. Br J Psychiatry, 170, 234–40.Google Scholar
Karsz, F., Brewer, W. J., Anderson, V., et al. Olfactory identification deficits in ADHD. Am J Psychiatry, (Manuscript in Submission)
Klingberg, T., Vaidya, C. J., Gabrieli, J. D., et al. (1999) Myelination and organisation of frontal white matter in children: A diffusion tensor MRI study. Neuroreport, 10, 2817–21.Google Scholar
Koelega, H. S. (1994) Prepubescent children may have specific deficits in olfactory sensitivity. Perceptual Motor Skills, 78, 191–9.Google Scholar
Koelega, H. S. & Koster, E. P. (1974) Some experiments on sex differences in odor perception. Ann NY Acad Sci, 237, 234–46.Google Scholar
Kopala, L., Clark, C. & Hurwitz, T. A. (1989) Sex differences in olfactory function in schizophrenia. Am J Psychiatry, 146, 1320–22.Google Scholar
Kopala, L., Clark, C. & Hurwitz, T. A. (1992) Olfactory deficits in neuroleptic naïve patients with schizophrenia. Schizophr Res, 8, 245–50.Google Scholar
Kopala, L. C., Good, K. P. & Honer, W. G. (1994) Olfactory hallucinations and olfactory identification ability in patients with schizophrenia and other psychiatric disorders. Schizophr Res, 12, 205–22.Google Scholar
Kopala, L. C., Clark, C. & Hurwitz, T. (1993) Olfactory deficits in neuroleptic naive patients with schizophrenia. Schizophr Res, 8(3), 245–50.Google Scholar
Larsson, M. & Backman, L. (1997) Age-related differences in episodic odour recognition: The role of access to specific odour names. Memory, 5(3), 361–78.Google Scholar
Levin, H. S., Culhane, K. A., Hartmann, J., et al. (1991) Developmental changes in performance on tests of purported frontal lobe functioning. Dev Neuropsychology, 7, 377–95.CrossRefGoogle Scholar
Luciana, M. & Nelson, C. A. (1998) The functional emergence of prefrontally-guided working memory systems in four- to eight-year-old children. Neuropsychologia, 36, 273–93.Google Scholar
Moberg, P. J., Agrin, R., Gur, R. E., et al. (1999) Olfactory dysfunction in schizophrenia: A qualitative and quantitative review. Neuropsychopharmacology, 21(3), 325–40.Google Scholar
Murphy, J. M., Barkley, R. A. & Bush, T. (2001) Executive functioning and olfactory identification in young adults with attention deficit-hyperactivity disorder. Neuropsychology, 15(2), 211–20.Google Scholar
Pantelis, C. & Brewer, W. J. (1996) Neuropsychological and olfactory dysfunction in schizophrenia: Relationship of frontal syndromes to syndromes of schizophrenia. Schiz Res, 17, 35–45.Google Scholar
Pantelis, C., Stuart, G. W., Nelson, H. E., et al. (2001) Spatial working memory deficits in schizophrenia: Relationship with tardive dyskinesia and negative symptoms. Am J Psychiatry, 158(8), 1276–85.Google Scholar
Pantelis, C. & Maruff, P. (2002) The cognitive neuropsychiatric approach to investigating the neurobiology of schizophrenia and other disorders. J Psychosom Res, 53(2), 655–64.CrossRefGoogle Scholar
Pantelis, C., Velakoulis, D., McGorry, P., et al. (2002) Neuroanatomical abnormalities before and after the onset of psychosis: A cross sectional and longitudinal MRI comparison. Lancet, 361, 281–8.CrossRefGoogle Scholar
Pantelis, C., Yucel, M., Wood, S. J., et al. (2003) Early and late neurodevelopmental disturbances in schizophrenia and their functional consequences. Aust NZ J Psychiatry, 37(4), 399–406.Google Scholar
Pantelis, C., Yucel, M., Wood, S. J., et al. (2005) Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia. Schizophr Bull, 31(3), 672–96.Google Scholar
Paus, T., Zijdenbos, A., Worsley, K., et al. (1999) Structural maturation of neural pathways in children and adolescents: in vivo study. Science, 283, 1908–11.CrossRefGoogle Scholar
Paus, T. (2005) Mapping brain maturation and cognitive development during adolescence. Trends Cogn Sci, 9(2), 60–8.Google Scholar
Reiss, A. L., Abrams, M. T., Singer, H. S., et al. (1996) Brain development, gender and IQ in children: A volumetric imaging study. Brain, 119, 1763–74.CrossRefGoogle Scholar
Richman, R. A., Sheehe, P. R., McCanty, T., et al. (1988) Olfactory deficits in boys with cleft palate. Pediatr, 82, 840–4.Google Scholar
Richman, R. A., Post, E. M., Sheehe, P. R., et al. (1992) Olfactory performance during childhood. I. Development of an odourant identification test for children. J Pediatr, 121, 908–11.Google Scholar
Richman, R. A., Sheehe, P. R., Wallance, K., et al. (1995) Olfactory performance during childhood. II. Developing a discrimination task for children. J Pediatr, 127, 421–6.CrossRefGoogle Scholar
Rupp, C. I., Fleischhacker, W. W., Kemmler, G., et al. (2005) Olfactory functions and volumetric measures of orbitofrontal and limbic regions in schizophrenia. Schiz Res, 74, 149–61.Google Scholar
Schall, B. (1988) Olfaction in infants and children: Developmental and functional perspectives. Chem Senses, 13, 145–90.CrossRefGoogle Scholar
Schall, B., Marlier, L. & Soussignan, R. (1998) Olfactory function in the human fetus: Evidence from selective neonatal responsiveness to the odor of amniotic fluid. Behav Neurosci, 112(6), 1438–49.Google Scholar
Schleidt, M. & Genzell, C. (1990) The significance of mother's perfume for infants in the first week of their life. Ethol Sociobiol, 11, 145–54.Google Scholar
Schmidt, H. J. & Beauchamp, G. K. (1988) Adult-like odor preferences and aversions in three-year-old children. Child Dev, 59, 1136–43.Google Scholar
Serby, M., Larson, P. & Kalkstein, D. (1990) Olfactory sense in psychoses. Biol Psych, 28, 829–30.Google Scholar
Sowell, E. R., Delis, D., Stiles, J., et al. (2001) Improved memory functioning and frontal lobe maturation between childhood and adolescence: A structural MRI study. J Int Neuropsychol Soc, 7, 312–22.Google Scholar
Sowell, E. R., Peterson, B. S., Welcome, S. E., et al. (2003) Mapping cortical change across the human life span. Nat Neurosci, 6(3), 309–15.Google Scholar
Spear, L. (2000) The adolescent brain and age-related behavioral manifestation. Neurosci Biobehav Rev, 24, 417–63.Google Scholar
Steinberg, L. (2005) Cognitive and affective development in adolescence. Trends Cog Sci, 9, 69–74.Google Scholar
Strauss, E. L. (1970) A study on olfactory acuity. Ann Otol Rhinol Laryngol, 79(1), 95–104.Google Scholar
Stuss, D. T. (1992) Biological and psychological development of executive functions. Brain Cogn, 20, 8–23.Google Scholar
Suzuki, Y., Critchley, H. D., Rowe, A., et al. (2003) Impaired olfactory identification in Asperger's syndrome. J Neuropsychiatry Clin Neurosci, 15, 105–7.Google Scholar
Travis, F. (1998) Cortical and cognitive development in 4th, 8th and 12th grade students: The contribution of speed of processing and executive function to cognitive development. Biol Psychol, 48, 37–56.CrossRefGoogle Scholar
Weinberger, D. R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatr, 44, 660–9.Google Scholar
Welsh, M. C. & Pennington, B. F. (1988) Assessing frontal lobe functioning in children: Views from developmental psychology. Dev Psychology, 4, 199–230.Google Scholar
Wood, S. J., De Luca, C. R., Anderson, V., et al. (2004) Cognitive development in adolescence: Cerebral underpinnings, neural trajectories and the impact of aberrations. In Neurodevelopment and Schizophrenia, eds Keshavan, M., Kennedy, J. & Murray, R., pp. 69–88, CUP: Cambridge–UK.
Yakovlev, P. & Lecours, A. (1967) The myelinogetic cycles of regional brain maturation of the brain. In Regional Development of the Brain in Early Life, (ed Minowski, A.), pp. 3–70, Oxford: Blackwell.

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