Book contents
- Non-Neoplastic Pathology of the Gastrointestinal Tract
- Non-Neoplastic Pathology of the Gastrointestinal Tract
- Copyright page
- Dedication
- Contents
- Preface
- Acknowledgements
- Contributors
- Chapter 1 The Value of Gastrointestinal Biopsy
- Chapter 2 Gastrointestinal Involvement by Systemic Disease
- Chapter 3 Radiation and the Gastrointestinal Tract
- Chapter 4 Transplantation, Immunodeficiency, and Immunosuppression
- Chapter 5 Drug-Induced Gastrointestinal Disease
- Chapter 6 Gastrointestinal Ischemia and Vascular Disorders
- Chapter 7 Paediatric Conditions
- Chapter 8 Gastrointestinal Dysplasia
- Chapter 9 Normal Oesophageal, Gastric and Duodenal Mucosa
- Chapter 10 Histology of Gastroesophageal Reflux Disease and Barrett’s Oesophagus
- Chapter 11 Infections of the Oesophagus and Rare Forms of Oesophagitis
- Chapter 12 Assessment of Gastric Biopsies
- Chapter 13 Types of Gastritis
- Chapter 14 Duodenitis
- Chapter 15 Coeliac Disease
- Chapter 16 Inflammatory Bowel Disease and the Upper Gastrointestinal Tract
- Chapter 17 Normal Lower Gastrointestinal Mucosa
- Chapter 18 Infectious Disorders of the Lower Gastrointestinal Tract
- Chapter 19 Jejunitis and Ileitis
- Chapter 20 Microscopic Colitis
- Chapter 21 Inflammatory Bowel Disease Diagnosis
- Chapter 22 Mimics of Inflammatory Bowel Disease
- Chapter 23 Complications of Inflammatory Bowel Disease
- Chapter 24 Approach to Reporting Inflammatory Bowel Disease Biopsies
- Chapter 25 Ileal Pouch Anal Anastomosis
- Chapter 26 Diverticular Disease, Mucosal Prolapse, and Related Conditions
- Chapter 27 Non-Neoplastic Diseases of the Anal Canal
- Index
- References
Chapter 26 - Diverticular Disease, Mucosal Prolapse, and Related Conditions
Published online by Cambridge University Press: 06 June 2020
- Non-Neoplastic Pathology of the Gastrointestinal Tract
- Non-Neoplastic Pathology of the Gastrointestinal Tract
- Copyright page
- Dedication
- Contents
- Preface
- Acknowledgements
- Contributors
- Chapter 1 The Value of Gastrointestinal Biopsy
- Chapter 2 Gastrointestinal Involvement by Systemic Disease
- Chapter 3 Radiation and the Gastrointestinal Tract
- Chapter 4 Transplantation, Immunodeficiency, and Immunosuppression
- Chapter 5 Drug-Induced Gastrointestinal Disease
- Chapter 6 Gastrointestinal Ischemia and Vascular Disorders
- Chapter 7 Paediatric Conditions
- Chapter 8 Gastrointestinal Dysplasia
- Chapter 9 Normal Oesophageal, Gastric and Duodenal Mucosa
- Chapter 10 Histology of Gastroesophageal Reflux Disease and Barrett’s Oesophagus
- Chapter 11 Infections of the Oesophagus and Rare Forms of Oesophagitis
- Chapter 12 Assessment of Gastric Biopsies
- Chapter 13 Types of Gastritis
- Chapter 14 Duodenitis
- Chapter 15 Coeliac Disease
- Chapter 16 Inflammatory Bowel Disease and the Upper Gastrointestinal Tract
- Chapter 17 Normal Lower Gastrointestinal Mucosa
- Chapter 18 Infectious Disorders of the Lower Gastrointestinal Tract
- Chapter 19 Jejunitis and Ileitis
- Chapter 20 Microscopic Colitis
- Chapter 21 Inflammatory Bowel Disease Diagnosis
- Chapter 22 Mimics of Inflammatory Bowel Disease
- Chapter 23 Complications of Inflammatory Bowel Disease
- Chapter 24 Approach to Reporting Inflammatory Bowel Disease Biopsies
- Chapter 25 Ileal Pouch Anal Anastomosis
- Chapter 26 Diverticular Disease, Mucosal Prolapse, and Related Conditions
- Chapter 27 Non-Neoplastic Diseases of the Anal Canal
- Index
- References
Summary
Diverticular disease of the sigmoid colon is one of the most common diseases at sigmoidoscopy/colonoscopy and yet biopsies are not often taken from the colon afflicted by this disease. Indeed, biopsies are often contraindicated in acute diverticulitis because of the risks of perforation. Nevertheless, there is increasing understanding that the disease is associated with luminal mucosal pathology, namely diverticular colitis, which is a close histological mimic of chronic inflammatory bowel disease (IBD). Indeed, there is a close relationship between the diseases and there are occasional cases where diverticular colitis is followed, in due course, by the onset of true chronic IBD, specifically ulcerative colitis. The disease is also associated with characteristic mucosal polypoid change. Often mucosal biopsies show similar inflammatory changes to those seen in classical diverticular colitis but the pathology of mucosal prolapse may also be seen. The latter features may occur in many different situations, although all show the same characteristic morphological appearances. Such situations include stomas, both ileal and colonic, in association with ‘cap polyposis’, in solitary ulcer (mucosal prolapse) syndrome in the rectum, and at the anorectal junction in so-called inflammatory cloacogenic polyp. Several other conditions can produce mimicry of chronic IBD in mucosal biopsies, having in common the ability to produce underlying mass lesions that result in ‘secondary colitis’ in the mucosa. These conditions include endometriosis, pneumatosis coli, primary and secondary tumours, and inevitably, intramural and extramural suppuration associated with diverticular disease itself.
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- Non-Neoplastic Pathology of the Gastrointestinal TractA Practical Guide to Biopsy Diagnosis, pp. 417 - 433Publisher: Cambridge University PressPrint publication year: 2020
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