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Published online by Cambridge University Press: 21 November 2024
The pathogenesis of idiopathic normal pressure hydrocephalus (NPH) is poorly understood and even its existence has been contested. Normal pressure hydrocephalus is a chronic form of hydrocephalus (excessive fluid accumulation in the brain), which unlike acute hydrocephalus has a normal intracranial fluid pressure. Also, unlike acute hydrocephalus, in NPH there is no obstruction in the CSF flow pathway, earning NPH its other name, communicating hydrocephalus. Understanding the exact mechanism of NPH has been difficult given often co-occurring neurodegenerative diseases, particularly dementias.
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