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Published online by Cambridge University Press: 21 November 2024
Dermatomyositis is an immune-mediated myopathy characterized by proximal weakness, muscle tenderness and pain, and cutaneous manifestations. Although it most often occurs on its own, it can also present as part of a more systemic condition such as mixed connective tissue disease, malignancy, or systemic sclerosis. The pathophysiology of dermatomyositis is thought to be a B-cell-mediated autoimmune attack of the endomysial layer of muscles, specifically the endothelium of the blood vessels in this layer.
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