Book contents
- Frontmatter
- Contents
- List of Contributors
- Preface
- NEURODEVELOPMENTAL MECHANISMS IN PSYCHOPATHOLOGY
- Part One Basic Mechanisms in Prenatal, Perinatal, and Postnatal Neurodevelopmental Processes and Their Associations with High-Risk Conditions and Adult Mental Disorders
- Part Two Animal Models of Neurodevelopment and Psychopathology
- Part Three Models of the Nature of Genetic and Environmental Influences on the Developmental Course of Psychopathology
- 10 Genetic Structure of Neurodevelopmental Traits: Implications for the Development (and Definition of) Psychopathology
- 11 Prospects and Problems in the Search for Genetic Influences on Neurodevelopment and Psychopathology: Application to Childhood Disruptive Disorders
- 12 Developmental Psychoneuroimmunology: The Role of Cytokine Network Activation in the Epigenesis of Developmental Psychopathology
- 13 The Hypothalamic–Pituitary–Adrenal System (HPA) and the Development of Aggressive, Antisocial, and Substance Abuse Disorders
- 14 Neuroendocrine Functioning in Maltreated Children
- 15 Toward Unraveling the Premorbid Neurodevelopmental Risk for Schizophrenia
- 16 Interactions of the Dopamine, Serotonin, and GABA Systems During Childhood and Adolescence: Influence of Stress on the Vulnerability for Psychopathology
- Part Four The Neurodevelopmental Course of Illustrative High-Risk Conditions and Mental Disorders
- Index
- References
12 - Developmental Psychoneuroimmunology: The Role of Cytokine Network Activation in the Epigenesis of Developmental Psychopathology
Published online by Cambridge University Press: 10 August 2009
- Frontmatter
- Contents
- List of Contributors
- Preface
- NEURODEVELOPMENTAL MECHANISMS IN PSYCHOPATHOLOGY
- Part One Basic Mechanisms in Prenatal, Perinatal, and Postnatal Neurodevelopmental Processes and Their Associations with High-Risk Conditions and Adult Mental Disorders
- Part Two Animal Models of Neurodevelopment and Psychopathology
- Part Three Models of the Nature of Genetic and Environmental Influences on the Developmental Course of Psychopathology
- 10 Genetic Structure of Neurodevelopmental Traits: Implications for the Development (and Definition of) Psychopathology
- 11 Prospects and Problems in the Search for Genetic Influences on Neurodevelopment and Psychopathology: Application to Childhood Disruptive Disorders
- 12 Developmental Psychoneuroimmunology: The Role of Cytokine Network Activation in the Epigenesis of Developmental Psychopathology
- 13 The Hypothalamic–Pituitary–Adrenal System (HPA) and the Development of Aggressive, Antisocial, and Substance Abuse Disorders
- 14 Neuroendocrine Functioning in Maltreated Children
- 15 Toward Unraveling the Premorbid Neurodevelopmental Risk for Schizophrenia
- 16 Interactions of the Dopamine, Serotonin, and GABA Systems During Childhood and Adolescence: Influence of Stress on the Vulnerability for Psychopathology
- Part Four The Neurodevelopmental Course of Illustrative High-Risk Conditions and Mental Disorders
- Index
- References
Summary
The past three decades have witnessed exponential growth in our knowledge of the interactions among the central and peripheral nervous systems and the immune system (Ader, 1981, 2000; Ader, Felten, & Cohen, 1991). In particular, the signals and routes via which psychological and physical stressors lead to endocrine and immune responses have been studied extensively. A detailed picture of an intriguing puzzle has now begun to emerge. Theorists, applied researchers, and professionals are extrapolating these basic findings in order to consider how individual differences in psychological traits and states might be associated with immunity, illness susceptibility, and negative health outcomes (see Cohen & Herbert, 1996; Herbert & Cohen, 1993b; Kemeny & Gruenewald, 1999; Kemeny & Laudenslager, 1999; Kiecolt-Glaser & Glaser, 1995). Quite surprisingly, how such processes affect children's immunity has received scant empirical attention (e.g., Adamson-Macedo, 2000; Boyce et al., 1995; Coe, 1996, 1999). Although the field should be concerned with the ultimate impact of these phenomena for children's health, and additional research with that particular focus seems warranted, the focus of this chapter is on the implications of another leading edge of psychoneuroimmunologic research (e.g., Maier & Watkins, 1998a, b; Maier, Watkins, & Fleshner, 1994). Specifically, accumulated findings have sparked a scientific revolution regarding the direction of effects among the brain, behavior, and immunity (e.g., Blalock, 1994a; Dantzer, 2001).
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- Neurodevelopmental Mechanisms in Psychopathology , pp. 293 - 323Publisher: Cambridge University PressPrint publication year: 2003
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