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16 - The development of “mis-wired” limbic lobe circuitry in schizophrenia and bipolar disorder

Published online by Cambridge University Press:  04 August 2010

By
Francine M. Benes
Edited by
Matcheri S. Keshavan ,
James L. Kennedy  and
Robin M. Murray
Francine M. Benes
Affiliation:
McLean Hospital, Belmont and Harvard Medical School, Boston, USA
Matcheri S. Keshavan
Affiliation:
University of Pittsburgh
James L. Kennedy
Affiliation:
Clarke Institute of Psychiatry, Toronto
Robin M. Murray
Affiliation:
Institute of Psychiatry, London
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Summary

In patients with schizophrenia, a variety of anomalies have been detected in the limbic lobe, a phylogenetically old portion of the cerebral cortex that includes the anterior cingulate region and hippocampal formation. In addition, the basolateral subdivision of the amygdala, another component of the limbic lobe, has been implicated in the pathophysiology of psychotic disorders, in part because it sends important inputs to the cingulate cortex and hippocampus. The three major components of the limbic lobe play a central role in generating disturbances in motivation, attention, emotion, and social interactions in schizophrenia and bipolar disorder. This chapter describes studies in both human and rodent brains that have contributed to our understanding of how this complex circuitry may be altered during development, leading to the appearance of psychotic disorders during late adolescence and early adulthood. It discusses two particular neurotransmitters: gamma-aminobutyric acid (GABA) and dopamine.

Keywords

amygdalabipolar disorderdopamineschizophrenialimbic lobe circuitrygamma-aminobutyric acid
Type
Chapter
Information
Neurodevelopment and Schizophrenia , pp. 295 - 309
Publisher: Cambridge University Press
Print publication year: 2004

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