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44 - Postnatal nutritional influences on subsequent health

Published online by Cambridge University Press:  10 December 2009

Patti J. Thureen
By
Josef Neu ,
Amy Mackey  and
Ying Huang
Edited by
William W. Hay
Patti J. Thureen
Affiliation:
University of Colorado at Denver and Health Sciences Center
Josef Neu
Affiliation:
Department of Pediatrics, University of Florida, Gainesville, FL
Amy Mackey
Affiliation:
Department of Pediatrics, University of Florida, Gainesville, FL
Ying Huang
Affiliation:
Children’s Hospital of Fudan University, Shanghai, China
William W. Hay
Affiliation:
University of Colorado at Denver and Health Sciences Center
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Summary

Introduction

It is clear that intrauterine undernutrition and subsequent low birth weight result in significant health problems during adult life. These include obesity, cardiovascular disease, hypertension, and Type 2 diabetes. Evidence for a relationship between early postnatal nutrition and the subsequent development of allergies, immune dysfunction, and autoimmune disorders such as Type 1 diabetes, is beginning to accumulate. Numerous questions about the effects of early postnatal nutrition on subsequent short as well as long-term health have been raised: What happens to infants born prematurely who are subjected to postnatal undernutrition for a “critical period” of rapid growth and development? Are these infants, if born appropriate for gestational age and subjected to nutritional stresses “programmed” for a greater susceptibility to chronic diseases such as obesity, Type 2 diabetes and hypertension, as are undernourished fetuses? Does it matter what infants are fed in terms of development of chronic diseases related to autoimmunity, such as Type 1 diabetes and asthma? Can under or overexposure to certain nutrients such as carbohydrates, lipids or proteins in early life have an effect on the development of chronic disease and can these effects be passed on to subsequent generations? In this chapter, we note that there are several remarkable similarities and differences between the chronic effects of pre- versus postnatal undernutrition. Some of the health consequences of early postnatal malnutrition and hypothetical mechanisms by which early nutrition “programs” the individual for long-term outcomes will be addressed.

Type
Chapter
Information
Neonatal Nutrition and Metabolism , pp. 631 - 639
Publisher: Cambridge University Press
Print publication year: 2006

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  • Postnatal nutritional influences on subsequent health
    • By Josef Neu, Department of Pediatrics, University of Florida, Gainesville, FL, Amy Mackey, Department of Pediatrics, University of Florida, Gainesville, FL, Ying Huang, Children’s Hospital of Fudan University, Shanghai, China
  • Patti J. Thureen, University of Colorado at Denver and Health Sciences Center
  • Edited by William W. Hay, University of Colorado at Denver and Health Sciences Center
  • Book: Neonatal Nutrition and Metabolism
  • Online publication: 10 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544712.045
Available formats
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Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Postnatal nutritional influences on subsequent health
    • By Josef Neu, Department of Pediatrics, University of Florida, Gainesville, FL, Amy Mackey, Department of Pediatrics, University of Florida, Gainesville, FL, Ying Huang, Children’s Hospital of Fudan University, Shanghai, China
  • Patti J. Thureen, University of Colorado at Denver and Health Sciences Center
  • Edited by William W. Hay, University of Colorado at Denver and Health Sciences Center
  • Book: Neonatal Nutrition and Metabolism
  • Online publication: 10 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544712.045
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Postnatal nutritional influences on subsequent health
    • By Josef Neu, Department of Pediatrics, University of Florida, Gainesville, FL, Amy Mackey, Department of Pediatrics, University of Florida, Gainesville, FL, Ying Huang, Children’s Hospital of Fudan University, Shanghai, China
  • Patti J. Thureen, University of Colorado at Denver and Health Sciences Center
  • Edited by William W. Hay, University of Colorado at Denver and Health Sciences Center
  • Book: Neonatal Nutrition and Metabolism
  • Online publication: 10 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544712.045
Available formats
×