Book contents
- Neonatal Hematology
- Neonatal Hematology
- Copyright page
- Contents
- Foreword
- Preface
- Contributors
- Section I Developmental Hematology
- Section II Bone Marrow Failure and Immune Disorders
- Section III Erythrocyte Disorders
- Section IV Platelet Disorders
- Section V Leucocyte Disorders
- Section VI Hemostatic Disorders
- Section VII Neonatal Transfusion Medicine
- Chapter 20 Transfusion Practices
- Section VIII Neonatal Oncology
- Section IX Miscellaneous
- Index
- Plate Section (PDF Only)
- References
Chapter 20 - Transfusion Practices
from Section VII - Neonatal Transfusion Medicine
Published online by Cambridge University Press: 30 January 2021
Book contents
- Neonatal Hematology
- Neonatal Hematology
- Copyright page
- Contents
- Foreword
- Preface
- Contributors
- Section I Developmental Hematology
- Section II Bone Marrow Failure and Immune Disorders
- Section III Erythrocyte Disorders
- Section IV Platelet Disorders
- Section V Leucocyte Disorders
- Section VI Hemostatic Disorders
- Section VII Neonatal Transfusion Medicine
- Chapter 20 Transfusion Practices
- Section VIII Neonatal Oncology
- Section IX Miscellaneous
- Index
- Plate Section (PDF Only)
- References
Summary
Neonatal transfusion therapy requires an understanding of the dynamic interactions of the fetomaternal unit, the physiologic changes that accompany the transition from fetus to neonate to infant, and the underlying pathophysiology of different hematologic disorders. Guidelines for neonatal transfusions remain controversial, since most have been extrapolated from evidence in adults or based on small studies in neonates with marginal statistical validity. Compared to older children and adults, neonates have small total blood volumes but high blood volume per body weight. Because of the limited capacity to expand their blood volume to compensate for their rapid growth, many sick and/or premature infants require significant blood component support, especially within the first weeks of life. Immaturity of many organ systems predisposes them to metabolic derangements from blood products and their additive solutions, and to the infectious and immunomodulatory hazards of transfusion, such as transfusion-acquired CMV (TA-CMV) infection and transfusion-associated graft versus host disease (TA-GVHD). Therefore, component modifications are often required to compensate for the infant’s small blood volume, immunologic immaturity, and/or compromised organ function, and constitute the uniqueness of neonatal transfusion therapy.
- Type
- Chapter
- Information
- Neonatal HematologyPathogenesis, Diagnosis, and Management of Hematologic Problems, pp. 329 - 366Publisher: Cambridge University PressPrint publication year: 2021
References
Ooley, PW, ed. Standards for Blood Banks and Transfusion Services, 31st ed. (Bethesda, MD: AABB Press, 2018), p. 122.Google Scholar
Wong, EC, Punzalan, RC. Neonatal and pediatric transfusion practice. In Fung, MK, ed. Technical Manual of the American Association of Blood Banks 19th ed. (Bethesda, MD: AABB Press, 2017) pp. 613–40.Google Scholar
Stockman, JA, 3rd. Anemia of prematurity. Current concepts in the issue of when to transfuse. Pediatr Clin North Am 1986;33(1):111–28.Google Scholar
Wong, EC, Roseff, SD, King, KE. Pediatric Transfusion: A Physician’s Handbook, 4th ed. (Bethesda, MD: AABB Press, 2015).Google Scholar
Jakacka, N, Snarski, E, Mekuria, S. Prevention of iatrogenic anemia in critical and neonatal care. Adv Clin Exp Med, 2016;25(1):191–7.Google Scholar
Widness, JA. Treatment and prevention of neonatal anemia. NeoReviews 2008;9(11):e526–33.Google Scholar
Del Vecchio, A, Franco, C, Petrillo, F, D‘Amato, G. Neonatal transfusion practice: When do neonates need red blood cells or platelets? Am J Perinatol 2016;33(11):1079–84.Google Scholar
Bednarek, FJ, Weisberger, S, Richardson, DK, et al. Variations in blood transfusions among newborn intensive care units. SNAP II Study Group. J Pediatr 1998;133(5):601–7.Google Scholar
Alverson, DC. The physiologic impact of anemia in the neonate. Clin Perinatol 1995; 22(3):609–25.Google Scholar
Ramasethu, J, Luban, NLC. Red cell transfusions in the newborn. Semin Neonatol 1999;4:5–16.Google Scholar
Pichler, G, Wolf, M, Roll, C, et al. Recommendations to increase the validity and comparability of peripheral measurements by near infrared spectroscopy in neonates. ‘Round table’, section of haematology, oxygen transport and microcirculation, 48th annual meeting of ESPR, Prague 2007. Neonatology 2008;94(4):320–2.Google ScholarPubMed
Greisen, G. Is near-infrared spectroscopy living up to its promises? Semin Fetal Neonatal Med 2006;11(6):498–502.Google Scholar
Strauss, RG. How I transfuse red blood cells and platelets to infants with the anemia and thrombocytopenia of prematurity. Transfusion 2008;48(2):209–17.CrossRefGoogle Scholar
Kirpalani, H, Whyte, RK, Andersen, C, et al. The Premature Infants in Need of Transfusion (PINT) study: A randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006;149(3):301–7.Google Scholar
Bell, EF, Strauss, RG, Widness, JA, et al. Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics 2005;115(6):1685–91.Google Scholar
Nopoulos, PC, Conrad, AL, Bell, EF, et al. Long-term outcome of brain structure in premature infants: Effects of liberal vs restricted red blood cell transfusions. Arch Pediatr Adolesc Med 2011;165(5):443–50.Google Scholar
Whyte, RK, Kirpalani, H, Asztalos, EV, et al. Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion. Pediatrics 2009;123(1):207–13.Google Scholar
Keir, A, Pal, S, Trivella, M, et al. Adverse effects of red blood cell transfusions in neonates: A systematic review and meta-analysis. Transfusion 2016;56(11):2773–80.Google Scholar
Jain, R, Jarosz, C. Safety and efficacy of AS-1 red blood cell use in neonates. Transfus Apher Sci 2001;24(2):111–15.CrossRefGoogle ScholarPubMed
Strauss, RG, Burmeister, LF, Johnson, K, et al. Feasibility and safety of AS-3 red blood cells for neonatal transfusions. J Pediatr 2000;136(2):215–19.Google Scholar
Luban, NL, Strauss, RG, Hume, HA. Commentary on the safety of red cells preserved in extended-storage media for neonatal transfusions. Transfusion 1991;31(3):229–35.Google Scholar
King, KE, Shirey, RS, Thomas, SK, et al. Universal leukoreduction decreases the incidence of febrile nonhemolytic transfusion reactions to RBCs. Transfusion 2004;44(1):25–9.Google Scholar
Paglino, JC, Pomper, GJ, Fisch, GS, et al. Reduction of febrile but not allergic reactions to RBCs and platelets after conversion to universal prestorage leukoreduction. Transfusion 2004;44(1):16–24.Google Scholar
Leukocyte reduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions. The Trial to Reduce Alloimmunization to Platelets Study Group. N Engl J Med 1997;337(26):1861–9.Google Scholar
Paul, DA, Leef, KH, Locke, RG, et al. Transfusion volume in infants with very low birth weight: A randomized trial of 10 versus 20 ml/kg. J Pediatr Hematol Oncol 2002;24(1):43–6.Google Scholar
Luban, NL, Mikesell, G, Sacher, RA. Techniques for warming red blood cells packaged in different containers for neonatal use. Clin Pediatr (Phila) 1985;24(11):642–4.Google Scholar
Bandarenko, N, King, K, eds. Blood components. In Blood Transfusion Therapy: A Physician’s Handbook (Bethesda, MD: AABB, 2017).Google Scholar
Manno, CS, Hedberg, KW, Kim, HC, et al. Comparison of the hemostatic effects of fresh whole blood, stored whole blood, and components after open heart surgery in children. Blood 1991;77(5):930–6.CrossRefGoogle ScholarPubMed
Friesen, RH, Perryman, KM, Weigers, KR, et al. A trial of fresh autologous whole blood to treat dilutional coagulopathy following cardiopulmonary bypass in infants. Paediatr Anaesth 2006;16(4):429–35.Google Scholar
Mou, SS, Giroir, BP, Moliter-Kirsch, EA, et al. Fresh whole blood versus reconstituted blood for pump priming in heart surgery in infants. N Engl J Med 2004;351(16):1635–44.Google Scholar
Gruenwald, CE, McCrindle, BW, Crawford-Lean, L, et al. Reconstituted fresh whole blood improves clinical outcomes compared with stored component blood therapy for neonates undergoing cardiopulmonary bypass for cardiac surgery: A randomized controlled trial. J Thorac Cardiovasc Surg 2008;136(6):1442–9.Google Scholar
Widness, JA, Seward, VJ, Kromer, IJ, et al. Changing patterns of red blood cell transfusion in very low birth weight infants. J Pediatr 1996;129(5):680–7.Google Scholar
Lee, DA, Slagle, TA, Jackson, TM, et al. Reducing blood donor exposures in low birth weight infants by the use of older, unwashed packed red blood cells. J Pediatr 1995;126(2):280–6.Google Scholar
Strauss, RG, Burmeister, LF, Johnson, K, et al. AS-1 red cells for neonatal transfusions: A randomized trial assessing donor exposure and safety. Transfusion 1996;36(10):873–8.Google Scholar
Goodstein, MH, Locke, RG, Wlodarcyzk, D, et al. Comparison of two preservation solutions for erythrocyte transfusions in newborn infants. J Pediatr 1993;123(5):783–8.Google Scholar
Strauss, RG, Villhauer, PJ, Cordle, DG. A method to collect, store and issue multiple aliquots of packed red blood cells for neonatal transfusions. Vox Sang 1995;68(2):77–81.Google Scholar
Chambers, LA. Evaluation of a filter-syringe set for preparation of packed cell aliquots for neonatal transfusion. Am J Clin Pathol 1995;104(3):253–7.Google Scholar
Mangel, J, Goldman, M, Garcia, C, et al. Reduction of donor exposures in premature infants by the use of designated adenine-saline preserved split red blood cell packs. J Perinatol 2001;21(6):363–7.Google Scholar
Liu, EA, Mannino, FL, Lane, TA. Prospective, randomized trial of the safety and efficacy of a limited donor exposure transfusion program for premature neonates. J Pediatr 1994;125(1):92–6.Google Scholar
Baud, O, Lacaze, M, Masmonteil-Lion, A, et al. Single blood donor exposure programme for preterm infants: A large open study and an analysis of the risk factors to multiple donor exposure. Eur J Pediatr 1998;157(7):579–82.Google Scholar
Wang-Rodriguez, J, Mannino, FL, Liu, E, et al. A novel strategy to limit blood donor exposure and blood waste in multiply transfused premature infants. Transfusion 1996;36(1):64–70.Google Scholar
Fergusson, DA, Hébert, P, Hogan, DL, et al. Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: The ARIPI randomized trial. JAMA 2012;308(14):1443–51.Google Scholar
Nickel, RS, Josephson, CD. Neonatal transfusion medicine: Five major unanswered research questions for the twenty-first century. Clin Perinatol 2015;42(3):499–513.Google Scholar
Lacroix, J, Hébert, P, Fergusson, DA, et al. Age of transfused blood in critically ill adults. N Engl J Med 2015;372(15):1410–18.Google Scholar
Steiner, ME, Ness, PM, Assmann, SF, et al. Effects of red-cell storage duration on patients undergoing cardiac surgery. N Engl J Med 2015;372(15):1419–29.Google Scholar
Dhabangi, A, Ainomugisha, B, Cserti-Gazdewich, C, et al. Effect of transfusion of red blood cells with longer vs shorter storage duration on elevated blood lactate levels in children with Severe anemia: The TOTAL randomized clinical trial. JAMA 2015;314(23):2514–23.Google Scholar
Heddle, NM, Cook, RJ, Arnold, DM, et al. Effect of short-term vs. long-term blood storage on mortality after transfusion. N Engl J Med 2016;375(20):1937–45.Google Scholar
Carson, JL, Guyatt, G, Heddle, NM, et al. Clinical practice guidelines from the AABB: Red blood cell transfusion thresholds and storage. JAMA 2016;316(19):2025–35.Google Scholar
Tobian, AA, Heddle, NM, Wiegmann, TL, Carson, JL. Red blood cell transfusion: 2016 clinical practice guidelines from AABB. Transfusion 2016;56(10):2627–30.CrossRefGoogle ScholarPubMed
Strauss, RG, et al. Randomized trial assessing the feasibility and safety of biologic parents as RBC donors for their preterm infants. Transfusion, 2000;40(4):450–6.Google Scholar
Strauss, RG, Barnes, A Jr., Blanchette, VS, et al. Directed and limited-exposure blood donations for infants and children. Transfusion 1990;30(1):68–72.Google Scholar
Jacquot, C, Seo, A, Miller, PM, et al. Parental versus non-parental-directed donation: An 11-year experience of infectious disease testing at a pediatric tertiary care blood donor center. Transfusion 2017;57(11):2799–803.CrossRefGoogle Scholar
Elbert, C, Strauss, RG, Barrett, F, et al. Biological mothers may be dangerous blood donors for their neonates. Acta Haematol 1991;85(4):189–91.CrossRefGoogle ScholarPubMed
Fasano, R, Luban, NL. Blood component therapy. Pediatr Clin North Am 2008;55(2):421–45, ix.Google Scholar
Mainie, P. Is there a role for erythropoietin in neonatal medicine? Early Hum Dev 2008;84(8):525–32.Google Scholar
Shannon, KM, Keith, JF 3rd, Mentzer, WC, et al. Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants. Pediatrics 1995;95(1):1–8.Google Scholar
Maier, RF, Obladen, M, Seigalla, P, et al. The effect of epoetin beta (recombinant human erythropoietin) on the need for transfusion in very-low-birth-weight infants. European Multicentre Erythropoietin Study Group. N Engl J Med 1994;330(17):1173–8.Google Scholar
Meyer, MP, et al. Recombinant human erythropoietin in the treatment of the anemia of prematurity: Results of a double-blind, placebo-controlled study. Pediatrics 1994;93(6 Pt 1):918–23.CrossRefGoogle ScholarPubMed
Meyer, MP, Sharma E, and Carsons M. Recombinant erythropoietin and blood transfusion in selected preterm infants. Arch Dis Child Fetal Neonatal Ed 2003;88(1):F41–5.Google Scholar
Ohls, RK, Ehrenkranz, RA, Wright, LL, et al. Effects of early erythropoietin therapy on the transfusion requirements of preterm infants below 1250 grams birth weight: A multicenter, randomized, controlled trial. Pediatrics 2001;108(4):934–42.Google Scholar
Von Kohorn, I, Ehrenkranz, RA. Anemia in the preterm infant: Erythropoietin versus erythrocyte transfusion–it’s not that simple. Clin Perinatol 2009;36(1):111–23.Google Scholar
Aher, S, Ohlsson, A. Late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2006;3:CD004868.Google Scholar
Aher, S, Ohlsson, A. Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2006;3:CD004865.Google Scholar
Ohlsson, A, Aher, SM. Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2006;3:CD004863.Google Scholar
Fischer, HS, Reibel, NJ, Bührer, C, Dame, C. Prophylactic early erythropoietin for neuroprotection in preterm infants: A meta-analysis. Pediatrics 2017;139(5):e20164317.Google Scholar
Eichler, H, Schaible, T, Richter, E, et al. Cord blood as a source of autologous RBCs for transfusion to preterm infants. Transfusion 2000;40(9):1111–17.Google Scholar
Imura, K, Kawahara, H, Kitayama, Y, et al. Usefulness of cord-blood harvesting for autologous transfusion in surgical newborns with antenatal diagnosis of congenital anomalies. J Pediatr Surg 2001;36(6):851–4.Google Scholar
Brune, T, Garritsen, H, Hentschel, R, et al. Efficacy, recovery, and safety of RBCs from autologous placental blood: Clinical experience in 52 newborns. Transfusion 2003;43(9):1210–16.Google Scholar
Garritsen, HS, Brune, T, Louwen, F, et al. Autologous red cells derived from cord blood: Collection, preparation, storage and quality controls with optimal additive storage medium (Sag-mannitol). Transfus Med 2003;13(5):303–10.Google Scholar
Bifano, EM, Dracker, RA, Lorah, K, et al. Collection and 28-day storage of human placental blood. Pediatr Res 1994;36(1 Pt 1):90–4.Google Scholar
Aladangady, N, McHugh, S, Aitchison, TC, et al. Infants’ blood volume in a controlled trial of placental transfusion at preterm delivery. Pediatrics 2006;117(1):93–8.Google Scholar
Rabe, H, Reynolds, G, Diaz-Rossello, J. Early versus delayed umbilical cord clamping in preterm infants. Cochrane Database Syst Rev 2004;4:CD003248.Google Scholar
Rabe, H, Reynolds, G, Diaz-Rossello, J. A systematic review and meta-analysis of a brief delay in clamping the umbilical cord of preterm infants. Neonatology 2008;93(2):138–44.Google Scholar
Hosono, S, Mugishima, H, Fujita, H, et al. Umbilical cord milking reduces the need for red cell transfusions and improves neonatal adaptation in infants born at less than 29 weeks’ gestation: A randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 2008;93(1):F14–19.Google Scholar
Rabe, H, Jewison, A, Alvarez, RF, et al. Milking compared with delayed cord clamping to increase placental transfusion in preterm neonates: A randomized controlled trial. Obstet Gynecol 2011;117(2 Pt 1):205–11.Google Scholar
Rabe, H, Gyte, GM, Díaz-Rossello, JL, Duley, L. Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes. Cochrane Database Syst Rev 2012;8: CD003248.Google Scholar
Christensen, RD, Carroll, PD, Josephson, CD. Evidence-based advances in transfusion practice in neonatal intensive care units. Neonatology 2014;106(3):245–53.Google Scholar
Kc, A, Rana, N, Målqvist, M, et al. Effects of delayed umbilical cord clamping vs early clamping on anemia in infants at 8 and 12 months: A randomized clinical trial. JAMA Pediatr 2017;171(3):264–70.Google Scholar
ACOG Committee on Obstetric Practice. Committee Opinion No. 684: Delayed umbilical cord clamping after birth. Obstet Gynecol 2017;129(1):e5–e10.Google Scholar
Osborn, HH, Henry, G, Wax, P, et al. Theophylline toxicity in a premature neonate: Elimination kinetics of exchange transfusion. J Toxicol Clin Toxicol 1993;31(4):639–44.Google Scholar
Sancak, R, Kucukoduk, S, Tasdemir, HA, et al. Exchange transfusion treatment in a newborn with phenobarbital intoxication. Pediatr Emerg Care 1999;15(4):268–70.Google Scholar
Lawe, JE. Successful exchange transfusion of an infant for AIHA developing late in mother’s pregnancy. Transfusion 1982;22(1):66–8.Google Scholar
Motta, M, Cavazza, A, Migliori, C, Chirico, G. Autoimmune haemolytic anaemia in a newborn infant. Arch Dis Child Fetal Neonatal Ed 2003;88(4):F341–2.Google Scholar
Lorch, V, Jones, FS, Hoersten, IR. Treatment of hyperkalemia with exchange transfusion. Transfusion 1985;25(4):390–1.Google Scholar
Vemgal, P, Ohlsson, A. Interventions for non-oliguric hyperkalaemia in preterm neonates. Cochrane Database Syst Rev 2007;1:CD005257.Google Scholar
Mathur, NB, Subramanian, BK, Sharma, VK, et al. Exchange transfusion in neutropenic septicemic neonates: Effect on granulocyte functions. Acta Paediatr 1993;82(11):939–43.Google Scholar
Alpay, F, Sarici, SU, Okutan, V, et al. High-dose intravenous immunoglobulin therapy in neonatal immune haemolytic jaundice. Acta Paediatr 1999;88(2):216–19.Google Scholar
Mukhopadhyay, K, Murki, S, Narang, A, et al. Intravenous immunoglobulins in rhesus hemolytic disease. Indian J Pediatr 2003;70(9):697–9.Google Scholar
Walsh, SA, Yoa, N, Khuffash, A, et al. Efficacy of intravenous immunoglobulin in the management of haemolytic disease of the newborn. Ir Med J 2008;101(2):46–8.Google Scholar
Zwiers, C, Scheffer-Rath, ME, Lopriore, E, de Haas, M, Liley, HG. Immunoglobulin for alloimmune hemolytic disease in neonates. Cochrane Database Syst Rev 2018;3 CD003313.Google ScholarPubMed
Ip, S, Chung, M, Kulig, J, et al. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics 2004;114(1):e130–53.Google Scholar
Dash, N, Kumar, P, Sundaram, V, Attri, SV. Pre exchange albumin administration in neonates with hyperbilirubinemia: A randomized controlled trial. Indian Pediatr 2015. 52(9):763–7.Google Scholar
Ramasethu, J. Exchange transfusions. In MacDonald, MG, Ramasethu, R, eds. Atlas of Procedures in Neonatology (Philadelphia, PA: JB Lippincott, 2002).Google Scholar
van de Bor, M, Benders, MJ, Dorrepaal, A, et al. Cerebral blood volume changes during exchange transfusions in infants born at or near term. J Pediatr 1994;125(4):617–21.Google Scholar
Patra, K, Storfer-Isser, A, Siner, B, et al. Adverse events associated with neonatal exchange transfusion in the 1990s. J Pediatr 2004;144(5):626–31.Google Scholar
Chima, RS, Johnson, LH, Bhutani, BK. Evaluation of adverse events due to exchange transfusions in term and near-term newborns (abstract). Pediatric Research 2001;49:324.Google Scholar
Steiner, LA, Bizzarro, MJ, Ehrenkranz, RA, Gallagher, PG. A decline in the frequency of neonatal exchange transfusions and its effect on exchange-related morbidity and mortality. Pediatrics 2007;120(1):27–32.Google Scholar
Chitty, HE, Ziegler, N, Savoia, H, Doyle, LW, Fox, LM. Neonatal exchange transfusions in the 21st century: A single hospital study. J Paediatr Child Health 2013;49(10):825–32.Google Scholar
Werner, EJ. Neonatal polycythemia and hyperviscosity. Clin Perinatol 1995;22(3):693–710.Google Scholar
Black, VD, Lubchenco, LO, Koops, BL, et al. Neonatal hyperviscosity: Randomized study of effect of partial plasma exchange transfusion on long-term outcome. Pediatrics 1985;75(6):1048–53.Google Scholar
Delaney-Black, V, Camp, BW, Lubchenco, LO, et al. Neonatal hyperviscosity association with lower achievement and IQ scores at school age. Pediatrics 1989;83(5):662–7.Google Scholar
Wong, W, Fok, TF, Lee, CH, et al. Randomised controlled trial: Comparison of colloid or crystalloid for partial exchange transfusion for treatment of neonatal polycythaemia. Arch Dis Child Fetal Neonatal Ed 1997;77(2):F115–18.Google Scholar
Schimmel, MS, Bromiker, R, Soll, RF. Neonatal polycythemia: Is partial exchange transfusion justified? Clin Perinatol 2004;31(3):545–53, ix-x.Google Scholar
Patil, S, Saini, SS, Kumar, P, Shah, R. Comparison of intra-procedural pain between a novel continuous arteriovenous exchange and conventional pull-push techniques of partial exchange transfusion in neonates: A randomized controlled trial. J Perinatol 2014;34(9):693–7.Google Scholar
Moise, KJ Jr. Management of rhesus alloimmunization in pregnancy. Obstet Gynecol 2008;112(1):164–76.Google Scholar
Moise, KJ Jr., Argoti, PS. Management and prevention of red cell alloimmunization in pregnancy: A systematic review. Obstet Gynecol 2012;120(5):1132–9.CrossRefGoogle ScholarPubMed
Zwiers, C, van der Bom, JG, van Kamp, IL, et al. Postponing early intrauterine transfusion with intravenous immunoglobulin treatment: The PETIT study on severe hemolytic disease of the fetus and newborn. Am J Obstet Gynecol 2018;219(3):291.e1–291.e9.Google Scholar
Zwiers, C, van Kamp, I, Oepkes, D, Lopriore, E. Intrauterine transfusion and non-invasive treatment options for hemolytic disease of the fetus and newborn: A review on current management and outcome. Expert Rev Hematol 2017;10(4):337–44.Google Scholar
Moise, KJ. Red blood cell alloimmunization in pregnancy. Semin Hematol 2005;42(3):169–78.Google Scholar
Van Kamp, IL, Klumper, FJ, Oepkes, D, et al. Complications of intrauterine intravascular transfusion for fetal anemia due to maternal red-cell alloimmunization. Am J Obstet Gynecol 2005;192(1):171–7.Google Scholar
Hallak, M, Moise, KJ Jr., Hesketh, DE, et al. Intravascular transfusion of fetuses with rhesus incompatibility: Prediction of fetal outcome by changes in umbilical venous pressure. Obstet Gynecol 1992;80(2):286–90.Google Scholar
Lindenburg, IT, van Kamp, IL, Oepkes, D. Intrauterine blood transfusion: Current indications and associated risks. Fetal Diagn Ther 2014;36(4):263–71.Google Scholar
Janssens, HM, de Haan, MJ, van Kamp, IL, et al. Outcome for children treated with fetal intravascular transfusions because of severe blood group antagonism. J Pediatr 1997;131(3):373–80.Google Scholar
De Boer, IP, Zeestraten, EC, Lopriore, E, et al. Pediatric outcome in Rhesus hemolytic disease treated with and without intrauterine transfusion. Am J Obstet Gynecol 2008;198(1):54 e1–4.Google Scholar
Oepkes, D, Adama van Scheltema, P. Intrauterine fetal transfusions in the management of fetal anemia and fetal thrombocytopenia. Semin Fetal Neonatal Med 2007;12(6):432–8.Google Scholar
Pacheco, LD, Berkowitz, RL, Moise, KJ Jr., et al. Fetal and neonatal alloimmune thrombocytopenia: A management algorithm based on risk stratification. Obstet Gynecol 2011;118(5):1157–63.Google Scholar
Sola-Visner, M, Sallmon, H, Brown, R. New insights into the mechanisms of nonimmune thrombocytopenia in neonates. Semin Perinatol 2009;33(1):43–51.Google Scholar
Andrew, M, Vegh, P, Caco, C, et al. A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants. J Pediatr 1993;123(2):285–91.Google Scholar
Stanworth, SJ, Clarke, P, Watts, T, et al. Prospective, observational study of outcomes in neonates with severe thrombocytopenia. Pediatrics 2009;124(5):e826–34.Google Scholar
Muthukumar, P, Venkatesh, V, Curley, A, et al. Severe thrombocytopenia and patterns of bleeding in neonates: Results from a prospective observational study and implications for use of platelet transfusions. Transfus Med 2012;22(5):338–43.Google Scholar
von Lindern, JS, Khodabux, CM, Hack, KE, et al. Long-term outcome in relationship to neonatal transfusion volume in extremely premature infants: A comparative cohort study. BMC Pediatr 2011;11:48.Google Scholar
Borges, JP, dos Santos, AM, da Cunha, DH, et al. Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants. Vox Sang 2013;104(3):207–13.Google Scholar
von Lindern, JS, Hulzebos, CV, Bos, AF, et al. Thrombocytopaenia and intraventricular haemorrhage in very premature infants: A tale of two cities. Arch Dis Child Fetal Neonatal Ed 2012;97(5):F348–52.Google Scholar
Curley, A, Stanworth, SJ, Willoughby, K, et al. Randomized trial of platelet-transfusion thresholds in neonates. N Engl J Med 2019;380(3):242–51.Google Scholar
Sparger, KA, Assmann, SF, Granger, S, et al. Platelet transfusion practices among very-low-birth-weight infants. JAMA Pediatr 2016;170(7):687–94.Google Scholar
Kelton, JG. Idiopathic thrombocytopenic purpura complicating pregnancy. Blood Rev 2002;16(1):43–6.Google Scholar
Payne, SD, Resnik, R, Moore, TR, Hedriana, HL, Kelly, TF. Maternal characteristics and risk of severe neonatal thrombocytopenia and intracranial hemorrhage in pregnancies complicated by autoimmune thrombocytopenia. Am J Obstet Gynecol 1997;177(1):149–55.Google Scholar
van der Lugt, NM, van Kampen, A, Walther, FJ, Brand, A, Lopriore, E. Outcome and management in neonatal thrombocytopenia due to maternal idiopathic thrombocytopenic purpura. Vox Sang 2013;105(3):236–43.Google Scholar
Roberts, I, Stanworth, S, Murray, NA. Thrombocytopenia in the neonate. Blood Rev 2008;22(4):173–86.Google Scholar
Lieberman, L, Greinacher, A, Murphy, MF, et al. Fetal and neonatal alloimmune thrombocytopenia: Recommendations for evidence-based practice, an international approach. Br J Haematol 2019;185(3):549–62.Google Scholar
Ghevaert, C, Campbell, K, Walton, J, et al. Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia. Transfusion 2007;47(5):901–10.Google Scholar
Roseff, SD, Luban, NL, Manno, CS. Guidelines for assessing appropriateness of pediatric transfusion. Transfusion 2002;42(11):1398–413.Google Scholar
Angiolillo, A, Luban, NL. Hemolysis following an out-of-group platelet transfusion in an 8-month-old with Langerhans cell histiocytosis. J Pediatr Hematol Oncol 2004;26(4):267–9.Google Scholar
Cid, J, Lozano, M. Risk of Rh(D) alloimmunization after transfusion of platelets from D+ donors to D- recipients. Transfusion 2005;45(3):453; author reply 453–4.Google Scholar
Cid, J, Lozano, M, Ziman, A, et al. Low frequency of anti-D alloimmunization following D+ platelet transfusion: The Anti-D Alloimmunization after D-incompatible Platelet Transfusions (ADAPT) study. Br J Haematol 2015;168(4):598–603.Google Scholar
Delaney, M, Svensson, AM, Lieberman, L. Perinatal issues in transfusion practice. In Fung, MK, ed. Technical Manual of the American Association of Blood Banks, 19th ed. (Bethesda, MD: AABB Press, 2017), pp. 599–612.Google Scholar
Kiefel, V, Bassler, D, Kroll, H, et al. Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT). Blood 2006;107(9):3761–3.Google Scholar
Baker, JM, Shehata, N, Bussel, J, et al. Postnatal intervention for the treatment of FNAIT: A systematic review. J Perinatol 2019;39(10):1329–39.Google Scholar
Sidhu, RS, Le, T, Brimhall, B, Thompson, H. Study of coagulation factor activities in apheresed thawed fresh frozen plasma at 1–6 degrees C for five days. J Clin Apher, 2006;21(4):224–6.Google Scholar
Robitaille, N, Hume, HA. Blood components and fractionated plasma products: Preparations, indications, and administration. In Arceci, RJ, Hann, IM, Smith, OP, eds. Pediatric Hematology (Malden, MA: Blackwell, 2006), pp. 693–706.Google Scholar
Hellstern, P. Solvent/detergent-treated plasma: Composition, efficacy, and safety. Curr Opin Hematol 2004;11(5):346–50.Google Scholar
Riedler, GF, Haycox, AR, Duggan, AK, Dakin, HA. Cost-effectiveness of solvent/detergent-treated fresh-frozen plasma. Vox Sang 2003;85(2):88–95.Google Scholar
Keir, AK, Stanworth, SJ. Neonatal plasma transfusion: An evidence-based review. Transfus Med Rev 2016;30(4):174–82.Google Scholar
Acunas, BA, Peakman, M, Liossis, G, et al. Effect of fresh frozen plasma and gammaglobulin on humoral immunity in neonatal sepsis. Arch Dis Child Fetal Neonatal Ed 1994;70(3):F182–7.Google Scholar
Desborough, M, Sandu, R, Brunskill, SJ, et al. Fresh frozen plasma for cardiovascular surgery. Cochrane Database Syst Rev 2015;7:CD007614.Google Scholar
Fasano, R, Luban, NL. Blood component therapy. Pediatr Clin North Am 2008; 421–45, ix.Google Scholar
Carr, R. Neutrophil production and function in newborn infants. Br J Haematol 2000;110(1):18–28.Google Scholar
Sandberg, K, Fasth, A, Berger, A, et al. Preterm infants with low immunoglobulin G levels have increased risk of neonatal sepsis but do not benefit from prophylactic immunoglobulin G. J Pediatr 2000;137(5):623–8.Google Scholar
Price, TH, Boeckh, M, Harrison, RW, et al. Efficacy of transfusion with granulocytes from G-CSF/dexamethasone-treated donors in neutropenic patients with infection. Blood 2015;126(18):2153–61.Google Scholar
Marfin, AA, Price, TH. Granulocyte transfusion therapy. J Intensive Care Med 2015;30(2):79–88.Google Scholar
Pammi, M, Brocklehurst, P. Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropenia. Cochrane Database Syst Rev 2011;10:CD003956.Google Scholar
Carr, R, Modi, N, Dore, C. G-CSF and GM-CSF for treating or preventing neonatal infections. Cochrane Database Syst Rev 2003;3:CD003066.Google Scholar
Ohlsson, A, Lacy, JB. Intravenous immunoglobulin for suspected or proven infection in neonates. Cochrane Database Syst Rev 2015;3:CD001239.Google Scholar
Cairo, MS, Worcester, CC, Rucker, RW, et al. Randomized trial of granulocyte transfusions versus intravenous immune globulin therapy for neonatal neutropenia and sepsis. J Pediatr 1992;120(2 Pt 1):281–5.Google Scholar
Mohan, P, Brocklehurst, P. Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropaenia. Cochrane Database Syst Rev 2003;4:CD003956.Google Scholar
O’Connor, JC, Strauss, RG, Goeken, NE, Knox, LB. A near-fatal reaction during granulocyte transfusion of a neonate. Transfusion 1988;28(2):173–6.Google Scholar
Zylberberg, R, Schott, RJ, Fort, J, Roberts, J, Friedman, R. Sudden death following white cell transfusion in a premature infant. J Perinatol, 1987;7(2):90–2.Google Scholar
Dutcher, JP, Kendall, J, Norris, D, et al. Granulocyte transfusion therapy and amphotericin B: Adverse reactions? Am J Hematol 1989;31(2):102–8.Google Scholar
Freidman, DF, Montenegro, LM. Extracorporeal membrane oxygenation and cardiopulmonary bypass. In Hillyer, CD, Strauss, RG, Luban, NL, eds. Handbook of Pediatric Transfusion Medicine (London: Elsevier Academic Press, 2004), pp. 181–9.Google Scholar
Dalton, HJ, Reeder, R, Garcia-Filion, P, et al. Factors associated with bleeding and thrombosis in children receiving extracorporeal membrane oxygenation. Am J Respir Crit Care Med 2017;196(6):762–71.Google Scholar
Thomas, J, Kostousov, V, Teruya, J. Bleeding and thrombotic complications in the use of extracorporeal membrane oxygenation. Semin Thromb Hemost 2018;44(1):20–9.Google Scholar
Mok, YH, Lee, JH, Cheifetz, IM. Neonatal extracorporeal membrane oxygenation: Update on management strategies and long-term outcomes. Adv Neonatal Care 2016;16(1):26–36.Google Scholar
Sawyer, AA, Wise, L, Ghosh, S, Bhatia, J, Stansfield, BK. Comparison of transfusion thresholds during neonatal extracorporeal membrane oxygenation. Transfusion 2017;57(9):2115–20.Google Scholar
Bjerke, HS, Kelly, RE Jr., Foglia, RP, Barcliff, L, Petz, L. Decreasing transfusion exposure risk during extracorporeal membrane oxygenation (ECMO). Transfus Med 1992;2(1):43–9.Google Scholar
Wong, TE, Delaney, M, Gernsheimer, T, et al. Antithrombin concentrates use in children on extracorporeal membrane oxygenation: A retrospective cohort study. Pediatr Crit Care Med 2015;16(3):264–9.Google Scholar
Todd Tzanetos, DR, Myers, J, Wells, T, et al. The use of recombinant antithrombin III in pediatric and neonatal ECMO patients. ASAIO J 2017;63(1):93–8.Google Scholar
Punzalan, RC, Gottschall, JL. Use and future investigations of recombinant and plasma-derived coagulation and anticoagulant products in the neonate. Transfus Med Rev 2016;30(4):189–96.Google Scholar
DeYoung Sullivan, K, Vu, T, Richardson, G, Castillo, E, Martinez, F. Evaluating the frequency of vital sign monitoring during blood transfusion: An evidence-based practice initiative. Clin J Oncol Nurs 2015;19(5):516–20.Google Scholar
Kennedy, LD, Case, LD, Hurd, DD, Cruz, JM, Pomper, GJ. A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. Transfusion 2008;48(11):2285–91.Google Scholar
Sanders, RP, Maddirala, SD, Geiger, TL, et al. Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children. Br J Haematol 2005;130(5):781–7.Google Scholar
Vamvakas, EC. Allergic and anaphylactic reactions. In Popovsky, MA, ed. Transfusion Reactions 3rd ed. (Bethesda, MD: AABB Press, 2007), pp. 105–56.Google Scholar
Shimada, E, Tadokoro, K, Watanabe, Y, et al. Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies. Transfusion 2002;42(6):766–73.Google Scholar
Cohn, CS, Stubbs, J, Schwartz, J, et al. A comparison of adverse reaction rates for PAS C versus plasma platelet units. Transfusion 2014;54(8):1927–34.Google Scholar
Kojima, S, Yanagisawa, R, Tanaka, M, Nakazawa, Y, Shimodaira, S. Comparison of administration of platelet concentrates suspended in M-sol or BRS-A for pediatric patients. Transfusion 2018;58(12):2952–8.Google Scholar
Wong, EC, Luban, NL, Hazards of transfusion. In Hann, IM, Arceci, RJ, Smith, OP, eds. Pediatric Hematology (Malden, MA: Blackwell Publishing, 2006), pp. 724–44.Google Scholar
Strauss, RG, Cordle, DG, Quijana, J, Goeken, NE. Comparing alloimmunization in preterm infants after transfusion of fresh unmodified versus stored leukocyte-reduced red blood cells. J Pediatr Hematol Oncol 1999;21(3):224–30.Google Scholar
Turkmen, T, Qiu, D, Cooper, N, et al. Red blood cell alloimmunization in neonates and children up to 3 years of age. Transfusion 2017;57(11):2720–6.Google Scholar
Fasano, RM, Paul, WM, Pisciotto, PT. Complications of neonatal transfusion. In Popovsky, MA, ed. Transfusion Reactions 4th ed. (Bethesda, MD: AABB Press, 2012) pp. 471–518.Google Scholar
Roseff, SD. Cryptantigens: Time to uncover the real significance of T-activation. Transfusion 2017;57(11):2553–7.Google Scholar
Holman, P, Blajchman, MA, Heddle, N. Noninfectious adverse effects of blood transfusion in the neonate. Transfus Med Rev 1995;9(3):277–87.Google Scholar
Miller, MA, Schlueter, AJ. Transfusions via hand-held syringes and small-gauge needles as risk factors for hyperkalemia. Transfusion 2004;44(3):373–81.Google Scholar
Jackman, RP, Deng, X, Bolgiano, D, et al. Leukoreduction and ultraviolet treatment reduce both the magnitude and the duration of the HLA antibody response. Transfusion 2014;54(3):672–80.Google Scholar
Fergusson, D, Hébert, PC, Lee, SK, et al. Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infants. JAMA 2003;289(15):1950–6.Google Scholar
Crawford, TM, Andersen, CC, Hodyl, NA, Robertson, SA, Stark, MJ. The contribution of red blood cell transfusion to neonatal morbidity and mortality. J Paediatr Child Health 2019;55(4):387–92.Google Scholar
Muszynski, JA, Spinella, PC, Cholette, JM, et al. Transfusion-related immunomodulation: Review of the literature and implications for pediatric critical illness. Transfusion 2017;57(1):195–206.Google Scholar
Sanchez, R, Toy, P. Transfusion related acute lung injury: A pediatric perspective. Pediatr Blood Cancer 2005;45(3):248–55.Google Scholar
Kopko, PM and Popovsky MA., Transfusion related acute lung injury. In Popovsky, MA, ed. Transfusion Reactions, (Bethesda, MD: AABB Press, 2007), pp. 207–28.Google Scholar
Yang, X, Ahmed, S, Chandrasekaran, V. Transfusion-related acute lung injury resulting from designated blood transfusion between mother and child: A report of two cases. Am J Clin Pathol 2004;121(4):590–2.Google Scholar
De Cloedt, L, Savy, N, Gauvin, F, et al. Transfusion-associated circulatory overload in ICUs: A scoping review of incidence, risk factors, and outcomes. Crit Care Med 2019;47(6):849–56.Google Scholar
Pendergrast, J, Armali, C, Cserti-Gazdewich, C, et al. Can furosemide prevent transfusion-associated circulatory overload? Results of a pilot, double-blind, randomized controlled trial. Transfusion 2019;59(6):1997–2006.Google Scholar
Flidel, O, Barak, Y, Lifschitz-Mercer, B, Frumkin, A, Mogilner, BM. Graft versus host disease in extremely low birth weight neonate. Pediatrics 1992;89(4 Pt 1):689–90.Google Scholar
Funkhouser, AW, Vogelsang, G, Zehnbauer, B, et al. Graft versus host disease after blood transfusions in a premature infant. Pediatrics, 1991;87(2):247–50.Google Scholar
Sanders, MR, Graeber, JE. Posttransfusion graft-versus-host disease in infancy. J Pediatr 1990;117(1 Pt 1):159–63.Google Scholar
Strauss, RG. Data-driven blood banking practices for neonatal RBC transfusions. Transfusion 2000;40(12):1528–40.Google Scholar
Delaney, M. How I reduce the risk of missed irradiation transfusion events in children. Transfusion 2018;58(11):2517–21.Google Scholar
Davey, RJ, McCoy, NC, Yu, M, et al. The effect of prestorage irradiation on posttransfusion red cell survival. Transfusion 1992;32(6):525–8.Google Scholar
Josephson, CD, Wesolowski, A, Bao, G, et al. Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants? J Pediatr 2010;157(6): 972–8, e1–3.Google Scholar
Blau, J, Calo, JM, Dozor, D, et al. Transfusion-related acute gut injury: Necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion. J Pediatr 2011;158(3):403–9.Google Scholar
Paul, DA, Mackley, A, Novitsky, A, et al. Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants. Pediatrics 2011;127(4):635–41.Google Scholar
Baxi, AC, Josephson, CD, Iannucci, GJ, Mahle, WT. Necrotizing enterocolitis in infants with congenital heart disease: The role of red blood cell transfusions. Pediatr Cardiol 2014;35(6):1024–9.Google Scholar
Singh, R, Visintainer, PF, Frantz, ID 3rd, et al.Association of necrotizing enterocolitis with anemia and packed red blood cell transfusions in preterm infants. J Perinatol 2011;31(3):176–82.Google Scholar
Kirpalani, H, Zupancic, JA. Do transfusions cause necrotizing enterocolitis? The complementary role of randomized trials and observational studies. Semin Perinatol 2012;36(4):269–76.Google Scholar
Garg, P, Pinotti, R, Lal, CV, Salas, AA. Transfusion-associated necrotizing enterocolitis in preterm infants: An updated meta-analysis of observational data. J Perinat Med 2018;46(6):677–85.Google Scholar
Patel, RM, Knezevic, A, Shenvi, N, et al. Association of red blood cell transfusion, anemia, and necrotizing enterocolitis in very low-birth-weight infants. JAMA 2016;315(9):889–97.Google Scholar
Marin, T, Patel, RM, Roback, JD, et al. Does red blood cell irradiation and/or anemia trigger intestinal injury in premature infants with birth weight</= 1250 g? An observational birth cohort study. BMC Pediatr 2018;18(1):270.Google Scholar
Pisciotto, PT, Luban, NLC. Complications of neonatal transfusion. In Popovsky, MA, ed. Transfusion Reactions, (Bethesda, MD: AABB Press, 2007), pp. 459–500.Google Scholar
Yigit, S, Gursoy, T, Kanra, T, et al. Whole blood versus red cells and plasma for exchange transfusion in ABO haemolytic disease. Transfus Med 2005;15(4):313–18.Google Scholar
Jackson, JC. Adverse events associated with exchange transfusion in healthy and ill newborns. Pediatrics 1997;99(5):E7.Google Scholar
Lee, AC, Reduque, LL, Luban, NL, et al. Transfusion-associated hyperkalemic cardiac arrest in pediatric patients receiving massive transfusion. Transfusion 2014;54(1):244–54.Google Scholar
Shaz, BH, Grima, K, Hillyer, CD 2-(Diethylhexyl)phthalate in blood bags: Is this a public health issue? Transfusion 2011;51(11):2510–17.Google Scholar
Mallow, EB, Fox, MA. Phthalates and critically ill neonates: Device-related exposures and non-endocrine toxic risks. J Perinatol 2014;34(12):892–7.Google Scholar
Sampson, J, de Korte, D. DEHP-plasticised PVC: Relevance to blood services. Transfus Med, 2011;21(2):73–83.Google Scholar
Jaimes, R 3rd, Swiercz A, Sherman M, Muselimyan N, Marvar PJ, Posnack NG. Plastics and cardiovascular health: phthalates may disrupt heart rate variability and cardiovascular reactivity. Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H1044-H1053.Google Scholar
Snyder, EL, Hedberg, SL, Napychank, PA, et al. Stability of red cell antigens and plasma coagulation factors stored in a non-diethylhexyl phthalate-plasticized container. Transfusion 1993;33(6):515–19.Google Scholar
van der Meer, PF, Devine, DV, Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Alternatives in blood operations when choosing non-DEHP bags. Vox Sang 2017;112(2):183–4.Google Scholar
Katz, L, Dodd, R. Transfusion-transmitted diseases. In Shaz, BH, Hillyer, CD, Roshal, M, Abrams, CS, eds. Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects, 2nd ed. (London: Elsevier, 2013).Google Scholar
Jacquot, C, Delaney, M. Efforts toward elimination of infectious agents in blood products. J Intensive Care Med 2018;33(10):543–50.Google Scholar
Stramer, SL, Galel, SA. Infectious disease screening. In Fung, MK ed. Technical Manual of the American Association of Blood Banks 18th ed. (Bethesda, MD: AABB Press, 2017), pp. 161–205.Google Scholar
Williamson, PC, Linnen, JM, Kessler, DA, et al. First cases of Zika virus-infected US blood donors outside states with areas of active transmission. Transfusion 2017;57(3pt2):770–8.Google Scholar
Lieb, LE, Mundy, TM, Goldfinger, D, et al. Unrecognized human immunodeficiency virus type 1 infection in a cohort of transfused neonates: A retrospective investigation. Pediatrics, 1995;95(5):717–21.Google Scholar
Zou, S, Dorsey, KA, Notari, EP, et al. Prevalence, incidence, and residual risk of human immunodeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testing. Transfusion 2010;50(7):1495–504.Google Scholar
Schillie, S, Walker, T, Veselsky, S, et al. Outcomes of infants born to women infected with hepatitis B. Pediatrics 2015;135(5):e1141–7.Google Scholar
Seeff, LB, Hollinger, FB, Alter, HJ, et al. Long-term mortality and morbidity of transfusion-associated non-A, non-B, and type C hepatitis: A National Heart, Lung, and Blood Institute collaborative study. Hepatology 2001;33(2):455–63.Google Scholar
Casiraghi, MA, De Paschale, M, Romanò, L, et al. Long-term outcome (35 years) of hepatitis C after acquisition of infection through mini transfusions of blood given at birth. Hepatology 2004;39(1):90–6.Google Scholar
Luban, NL, Colvin, CA, Mohan, P, Alter, HJ. The epidemiology of transfusion-associated hepatitis C in a children’s hospital. Transfusion 2007;47(4):615–20.Google Scholar
Goodman, ZD, Makhlouf, HR, Liu, L, et al. Pathology of chronic hepatitis C in children: Liver biopsy findings in the Peds-C Trial. Hepatology 2008;47(3):836–43.Google Scholar
Karnsakul, W, Schwarz, KB. Management of hepatitis C infection in children in the era of direct-acting antiviral agents. J Viral Hepat 2019;26(9):1034–9.Google Scholar
Bowden, RA, Slichter, SJ, Sayers, M, et al. A comparison of filtered leukocyte-reduced and cytomegalovirus (CMV) seronegative blood products for the prevention of transfusion-associated CMV infection after marrow transplant. Blood 1995;86(9):3598–603.Google Scholar
Josephson, CD, Caliendo, AM, Easley, KA, et al. Blood transfusion and breast milk transmission of cytomegalovirus in very low-birth-weight infants: A prospective cohort study. JAMA Pediatr 2014;168(11):1054–62.Google Scholar
Strauss, RG. Optimal prevention of transfusion-transmitted cytomegalovirus (TTCMV) infection by modern leukocyte reduction alone: CMV sero/antibody-negative donors needed only for leukocyte products. Transfusion 2016;56(8):1921–4.Google Scholar
Goldfinger, D, Burner, JD. You can’t get CMV from a blood transfusion: 2017 Emily Cooley award lecture. Transfusion 2018;58(12):3038–43.Google Scholar
AABB, Clinical Transfusion Medicine Committee, Heddle, NM, Boeckh, M, et al. AABB Committee Report: Reducing transfusion-transmitted cytomegalovirus infections. Transfusion 2016;56(6 Pt 2):1581–7.Google Scholar
Stramer, SL, Fang, CT, Foster, GA, et al. West Nile virus among blood donors in the United States, 2003 and 2004. N Engl J Med 2005;353(5):451–9.Google Scholar
Busch, MP, Bloch, EM, Kleinman, S. Prevention of transfusion-transmitted infections. Blood 2019;133(17):1854–64.Google Scholar
O’Leary, DR, Kuhn, S, Kniss, KL, et al. Birth outcomes following West Nile virus infection of pregnant women in the United States: 2003–2004. Pediatrics 2006;117(3):e537–45.Google Scholar
Plourde, AR, Bloch, EM. A literature review of zika virus. Emerg Infect Dis 2016;22(7):1185–92.Google Scholar
Shirley, DT, Nataro, JP. Zika virus infection. Pediatr Clin North Am 2017;64(4):937–51.Google Scholar
Simonsen, KA, Harwell, JI, Lainwala, S. Clinical presentation and treatment of transfusion-associated babesiosis in premature infants. Pediatrics 2011;128(4):e1019–24.Google Scholar
Glanternik, JR, Baine, IL, Rychalsky, MR, et al. A cluster of cases of Babesia microti among neonates traced to a single unit of donor blood. Pediatr Infect Dis J 2018;37(3):269–71.Google Scholar
Moritz, ED, Winton, CS, Tonnetti, L, et al. Screening for Babesia microti in the US blood supply. N Engl J Med 2016;375(23):2236–45.Google Scholar
Goodell, AJ, Bloch, EM, Krause, PJ, Custer, B. Costs, consequences, and cost-effectiveness of strategies for Babesia microti donor screening of the US blood supply. Transfusion 2014;54(9):2245–57.Google Scholar
Ward, SJ, Stramer, SL, Szczepiorkowski, ZM. Assessing the risk of Babesia to the United States blood supply using a risk-based decision-making approach: Report of AABB’s Ad Hoc Babesia Policy Working Group (original report). Transfusion 2018;58(8):1916–23.Google Scholar
Prowse, CV. Component pathogen inactivation: A critical review. Vox Sang 2013;104(3):183–99.Google Scholar
Kleinman, S, Stassinopoulos, A. Risks associated with red blood cell transfusions: Potential benefits from application of pathogen inactivation. Transfusion 2015;55(12):2983–3000.Google Scholar
Cid, J. Prevention of transfusion-associated graft-versus-host disease with pathogen-reduced platelets with amotosalen and ultraviolet A light: A review. Vox Sang 2017;112(7):607–13.Google Scholar
Hess, JR, Pagano, MB, Barbeau, JD, Johannson, PI. Will pathogen reduction of blood components harm more people than it helps in developed countries? Transfusion 2016;56(5):1236–41.Google Scholar
Kaiser-Guignard, J, Canellini, G, Lion, N, et al. The clinical and biological impact of new pathogen inactivation technologies on platelet concentrates. Blood Rev 2014;28(6):235–41.Google Scholar
Ciaravino, V, McCullough, T, Cimino, G. The role of toxicology assessment in transfusion medicine. Transfusion 2003;43(10):1481–92.Google Scholar
Musso, D, Richard, V, Broult, J, Cao-Lormeau, VM. Inactivation of dengue virus in plasma with amotosalen and ultraviolet A illumination. Transfusion 2014;54(11):2924–30.Google Scholar
Irsch, J, Seghatchian, J. Update on pathogen inactivation treatment of plasma, with the INTERCEPT Blood System: Current position on methodological, clinical and regulatory aspects. Transfus Apher Sci 2015;52(2):240–4.Google Scholar
Hauser, L, Roque-Afonso, AM, Beylouné, A, et al. Hepatitis E transmission by transfusion of Intercept blood system-treated plasma. Blood 2014;123(5):796–7.Google Scholar
Schmidt, M, Hourfar, MK, Sireis, W, et al. Evaluation of the effectiveness of a pathogen inactivation technology against clinically relevant transfusion-transmitted bacterial strains. Transfusion 2015;55(9):2104–12.Google Scholar
Knutson, F, Osselaer, J, Pierelli, L, et al. A prospective, active haemovigilance study with combined cohort analysis of 19,175 transfusions of platelet components prepared with amotosalen-UVA photochemical treatment. Vox Sang 2015;109(4):343–52.Google Scholar
Cardo, LJ, Salata, J, Mendez, J, Reddy, H, Goodrich, R. Pathogen inactivation of Trypanosoma cruzi in plasma and platelet concentrates using riboflavin and ultraviolet light. Transfus Apher Sci 2007;37(2):131–7.Google Scholar
Goodrich, RP, Edrich, RA, Li, J, Seghatchian, J. The Mirasol PRT system for pathogen reduction of platelets and plasma: An overview of current status and future trends. Transfus Apher Sci 2006;35(1):5–17.Google Scholar
Perez-Pujol, S, Tonda, R, Lozano, M, et al. Effects of a new pathogen-reduction technology (Mirasol PRT) on functional aspects of platelet concentrates. Transfusion 2005;45(6):911–19.Google Scholar
Tonnetti, L, Proctor, MC, Reddy, HL, Goodrich, RP, Leiby, DA. Evaluation of the Mirasol pathogen [corrected] reduction technology system against Babesia microti in apheresis platelets and plasma. Transfusion 2010;50(5):1019–27.Google Scholar
Aubry, M, Richard, V, Green, J, Broult, J, Musso, D Inactivation of Zika virus in plasma with amotosalen and ultraviolet A illumination. Transfusion 2016;56(1):33–40.Google Scholar
Butler, C, Doree, C, Estcourt, LJ, et al. Pathogen-reduced platelets for the prevention of bleeding. Cochrane Database Syst Rev 2013;(3):CD009072.Google Scholar
Amato, M, Schennach, H, Astl, M, et al. Impact of platelet pathogen inactivation on blood component utilization and patient safety in a large Austrian Regional Medical Centre. Vox Sang 2017;112(1):47–55.Google Scholar
Hubbard, T, Backholer, L, Wiltshire, M, Cardigan, R, Ariëns, RA. Effects of riboflavin and amotosalen photoactivation systems for pathogen inactivation of fresh-frozen plasma on fibrin clot structure. Transfusion 2016;56(1):41–8.Google Scholar
Jacquot, C, Delaney, M. Pathogen-inactivated blood products for pediatric patients: Blood safety, patient safety, or both? Transfusion 2018;58(9):2095–101.Google Scholar
Cure, P, Bembea, M, Chou, S, et al. 2016 proceedings of the National Heart, Lung, and Blood Institute’s scientific priorities in pediatric transfusion medicine. Transfusion 2017;57(6):1568–81.Google Scholar
US FDA. Recommendations for reducing the risk of transfusion-transmitted babesiosis: guidance for industry. US Department of Health and Human Services Food and Drug Administration Center for Biologics Evaluation and Research. 2019. Available online at www.fda.gov/media/114847/download.Google Scholar
Hong, H, Xiao, W, Lazarus, HM, et al. Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance. Blood 2016;127(4):496–502.Google Scholar
Stramer, SL, Notari, EP, Krysztof, DE, Dodd, RY. Hepatitis B virus testing by minipool nucleic acid testing: Does it improve blood safety? Transfusion 2013;53(10 Pt 2):2449–58.Google Scholar