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Chapter 8 - Magnetic Resonance Spectroscopy Investigations of Bioenergy and Mitochondrial Function in Mood Disorders

from Section 3 - Functional and Neurochemical Brain Studies

Published online by Cambridge University Press:  12 January 2021

By
Brent M. Kious  and
Perry F. Renshaw
Edited by
Sudhakar Selvaraj ,
Paolo Brambilla  and
Jair C. Soares
Sudhakar Selvaraj
Affiliation:
UTHealth School of Medicine, USA
Paolo Brambilla
Affiliation:
Università degli Studi di Milano
Jair C. Soares
Affiliation:
UT Harris County Psychiatric Center, USA
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Summary

Major depressive disorder (MDD) and bipolar disorder (BD) are likely to be etiologically diverse, resulting from the contributions of multiple pathophysiologic processes present in affected individuals to varying degrees. In MDD, there is abundant evidence that alterations in serotonin and other monoamines (1) and glutamatergic signaling (2) are implicated in its pathogenesis, and most available treatments target these pathways.

Type
Chapter
Information
Mood Disorders
Brain Imaging and Therapeutic Implications
 , pp. 83 - 104
Publisher: Cambridge University Press
Print publication year: 2021

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References

Fakhoury, M. Revisiting the serotonin hypothesis: Implications for major depressive disorders. Mol Neurobiol. 2016; 53(5): 2778–2786.CrossRefGoogle ScholarPubMed
Lener, MS, Niciu, MJ, Ballard, ED, et al. Glutamate and gamma-aminobutyric acid systems in the pathophysiology of major depression and antidepressant response to ketamine. Biological Psychiatry. 2017; 81(10): 886–897.CrossRefGoogle Scholar
Young, JJ, Bruno, D, Pomara, N. A review of the relationship between proinflammatory cytokines and major depressive disorder. Journal of Affective Disorders. 2014; 169: 15–20.CrossRefGoogle ScholarPubMed
Slavich, GM, Irwin, MR. From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. Psychological Bulletin. 2014; 140(3): 774.CrossRefGoogle ScholarPubMed
Maes, M, Galecki, P, Chang, YS, Berk, M. A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that illness. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2011; 35(3): 676–692.CrossRefGoogle Scholar
Cecil, KM. Proton magnetic resonance spectroscopy: Technique for the neuroradiologist. Neuroimaging Clinics of North America. 2013; 23(3): 381–392.CrossRefGoogle ScholarPubMed
Miller, BL, Changl, L, Booth, R, et al. In vivo 1 H MRS choline: Correlation with in vitro chemistry/histology. Life Sciences. 1996; 58(22): 1929–1935.CrossRefGoogle Scholar
Scremin, OU, Jenden, DJ. Acetylcholine turnover and release: the influence of energy metabolism and systemic choline availability. Progress in Brain Research. 98: Elsevier; 1993. p. 191–5.Google Scholar
Djuricic, B, Olson, SR, Assaf, HM, et al. Formation of free choline in brain tissue during in vitro energy deprivation. Journal of Cerebral Blood Flow & Metabolism. 1991; 11(2): 308–313.CrossRefGoogle ScholarPubMed
Wallimann, T, Wyss, M, Brdiczka, D, Nicolay, K, Eppenberger, H. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The’phosphocreatine circuit’for cellular energy homeostasis. Biochemical Journal. 1992; 281(Pt 1): 21.CrossRefGoogle ScholarPubMed
Li, BSY, Wang, H, Gonen, O. Metabolite ratios to assumed stable creatine level may confound the quantification of proton brain MR spectroscopy. Magnetic Resonance Imaging. 2003 October; 21 (8): 923–928.CrossRefGoogle ScholarPubMed
Choi, C, Ghose, S, Uh, J, et al. Measurement of N‐acetylaspartylglutamate in the human frontal brain by 1 H‐MRS at 7 T. Magnetic Resonance in Medicine. 2010; 64(5): 1247–1251.CrossRefGoogle Scholar
Ariyannur, PS, Madhavarao, CN, Namboodiri, AMA. N-acetylaspartate synthesis in the brain: Mitochondria vs. microsomes. Brain Research. 2008; 1227: 34–41.CrossRefGoogle ScholarPubMed
Wiame, E, Tyteca, D, Pierrot, N, et al. Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia. Biochemical Journal. 2010; 425(1): 127–139.CrossRefGoogle Scholar
Moreno, A, Ross, BD, Blüml, S. Direct determination of the N‐acetyl‐l‐aspartate synthesis rate in the human brain by 13 C MRS and [1‐13 C]glucose infusion. Journal of Neurochemistry. 2001; 77(1): 347–350.Google ScholarPubMed
Choi, I-Y, Gruetter, R, editors. In vivo 13 C NMR measurement of total brain glycogen concentrations in the conscious rat. Proc Intl Soc Mag Reson Med; 2001.Google Scholar
Patel, TB, Clark, JB. Synthesis of N-acetyl-l-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport. Biochemical Journal. 1979; 184(3): 539–46.CrossRefGoogle ScholarPubMed
Yudkoff, M, Nelson, D, Daikhin, Y, Erecińska, M. Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle. Journal of Biological Chemistry. 1994; 269(44): 27414–27420.Google Scholar
Moffett, JR, Ross, B, Arun, P, Madhavarao, CN, Namboodiri, AMA. N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology. Progress in Neurobiology. 2007; 81(2): 89–131.CrossRefGoogle ScholarPubMed
Baslow, MH. N-Acetylaspartate in the Vertebrate Brain: Metabolism and Function. Neurochemical Research. 2003; 28(6): 941–53.CrossRefGoogle ScholarPubMed
Arun, P, Madhavarao, CN, Moffett, JR, Namboodiri, M. Regulation of N‐acetylaspartate and N‐acetylaspartylglutamate biosynthesis by protein kinase activators. Journal of Neurochemistry. 2006; 98(6): 2034–2042.CrossRefGoogle ScholarPubMed
Neale, JH, Bzdega, T, Wroblewska, B. N-Acetylaspartylglutamate: The most abundant peptide neurotransmitter in the mammalian central nervous system. J Neurochem. 2000; 75(2): 443–452.CrossRefGoogle ScholarPubMed
Brand, A, Richter-Landsberg, C, Leibfritz, D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Developmental Neuroscience. 1993; 15(3–5): 289–298.CrossRefGoogle ScholarPubMed
Moretto, E, Murru, L, Martano, G, Sassone, J, Passafaro, M. Glutamatergic synapses in neurodevelopmental disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2018; 84: 328–342.CrossRefGoogle ScholarPubMed
Kew, JN, Kemp, JA. Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology. 2005; 179(1): 4–29.CrossRefGoogle ScholarPubMed
Anderson, CM, Swanson, RA. Astrocyte glutamate transport: Review of properties, regulation, and physiological functions. Glia. 2000; 32(1): 1–14.3.0.CO;2-W>CrossRefGoogle ScholarPubMed
Hertz, L, Zielke, HR. Astrocytic control of glutamatergic activity: Astrocytes as stars of the show. Trends in Neurosciences. 2004; 27(12): 735–743.CrossRefGoogle Scholar
Sibson, NR, Dhankhar, A, Mason, GF, et al. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings of the National Academy of Sciences. 1998; 95(1): 316–321.CrossRefGoogle ScholarPubMed
Abdallah, Chadi G., Lihong, Jiang, De Feyter, Henk M., et al. Glutamate metabolism in major depressive disorder. American Journal of Psychiatry. 2014; 171(12): 1320–1327.CrossRefGoogle ScholarPubMed
Sappey-Marinier, D, Calabrese, G, Fein, G, et al. Effect of photic stimulation on human visual cortex lactate and phosphates using 1 H and 31P magnetic resonance spectroscopy. Journal of Cerebral Blood Flow & Metabolism. 1992; 12(4): 584–592.CrossRefGoogle Scholar
Fox, PT, Raichle, ME, Mintun, MA, Dence, C. Nonoxidative glucose consumption during focal physiologic neural activity. Science (New York, NY). 1988; 241(4864): 462–464.CrossRefGoogle ScholarPubMed
Cichocka, M, Kozub, J, Urbanik, A. PH Measurements of the brain using phosphorus magnetic resonance spectroscopy ((31)PMRS) in healthy men – comparison of two analysis methods. Polish Journal of Radiology. 2015; 80: 509–514.CrossRefGoogle Scholar
Petroff, OA, Prichard, JW, Behar, KL, et al. Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy. Neurology. 1985; 35(6): 781–788.CrossRefGoogle ScholarPubMed
Szulc, A, Wiedlocha, M, Waszkiewicz, N, et al. Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic Review. Psychiatry Research Neuroimaging. 2018; 273: 1–8.CrossRefGoogle ScholarPubMed
Auer, DP, Pütz, B, Kraft, E, et al. Reduced glutamate in the anterior cingulate cortex in depression: An in vivo proton magnetic resonance spectroscopy study. Biological Psychiatry. 2000; 47(4): 305–313.CrossRefGoogle Scholar
Ende, G, Braus, DF, Walter, S, Weber-Fahr, W, Henn, FA. The hippocampus in patients treated with electroconvulsive therapy: A proton magnetic resonance spectroscopic imaging study. Archives of General Psychiatry. 2000; 57(10): 937–943.CrossRefGoogle ScholarPubMed
Farchione, TR, Moore, GJ, Rosenberg, DR. Proton magnetic resonance spectroscopic imaging in pediatric major depression. Biological Psychiatry. 2002; 52(2): 86–92.Google Scholar
Kumar, A, Thomas, A, Lavretsky, H, et al. Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy. American Journal of Psychiatry. 2002; 159(4): 630–636.CrossRefGoogle ScholarPubMed
Pfleiderer, B, Michael, N, Erfurth, A, et al. Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients. Psychiatry Research: Neuroimaging. 122(3): 185–192.CrossRefGoogle Scholar
Hasler, G, van der Veen, J, Tumonis, T, et al.Reduced prefrontal glutamate/glutamine and γ-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Archives of General Psychiatry. 2007; 64(2): 193–200.CrossRefGoogle ScholarPubMed
Gabbay, V, Hess, DA, Liu, S, et al. Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: A proton MR spectroscopy study. American Journal of Psychiatry. 2007; 164(12): 1881–1889.Google Scholar
Glodzik-Sobanska, L, Slowik, A, McHugh, P, et al. Single voxel proton magnetic resonance spectroscopy in post-stroke depression. Psychiatry Research: Neuroimaging. 2006; 148(2): 111–120.CrossRefGoogle ScholarPubMed
Block, W, Traber, F, von Widdern, O, et al. Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: Correlates and predictors of treatment response. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum. 2009; 12(3): 415–422.CrossRefGoogle ScholarPubMed
McEwen, AM, Burgess, DT, Hanstock, CC, et al. Increased glutamate levels in the medial prefrontal cortex in patients with postpartum depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 2012; 37(11): 2428–2435.Google Scholar
Wang, X, Li, Y-H, Li, M-H, et al. Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression. European Archives of Psychiatry and Clinical Neuroscience. 2012; 262(1): 33–38.CrossRefGoogle ScholarPubMed
Wang, Y, Jia, Y, Chen, X, et al. Hippocampal N-acetylaspartate and morning cortisol levels in drug-naive, first-episode patients with major depressive disorder: Effects of treatment. Journal of Psychopharmacology. 2012 November; 26(11): 1463–1470.CrossRefGoogle ScholarPubMed
Rosa, CE, Soares, JC, Figueiredo, FP, et al. Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy. Psychiatry Research: Neuroimaging. 2017; 265: 18–25.Google Scholar
Li, H, Xu, H, Zhang, Y, et al. Differential neurometabolite alterations in brains of medication‐free individuals with bipolar disorder and those with unipolar depression: A two‐dimensional proton magnetic resonance spectroscopy study. Bipolar Disorders. 2016; 18(7): 583–590.CrossRefGoogle ScholarPubMed
Yoon, S, Kim, JE, Hwang, J, et al. Effects of creatine monohydrate augmentation on brain metabolic and network outcome measures in women with major depressive disorder. Biological Psychiatry. 2016; 80(6): 439–447.CrossRefGoogle ScholarPubMed
Lefebvre, D, Langevin, LM, Jaworska, N, et al. A pilot study of hippocampal N-acetyl-aspartate in youth with treatment resistant major depression. Journal of Affective Disorders. 2017; 207: 110–113.CrossRefGoogle ScholarPubMed
Njau, S, Joshi, SH, Espinoza, R, et al. Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression. J Psychiatry Neurosci. 2017; 42(1): 6–16.CrossRefGoogle ScholarPubMed
Vythilingam, M, Charles, HC, Tupler, LA, et al. Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: An automated multivoxel proton magnetic resonance spectroscopy study. Biological Psychiatry. 2003 October; 54(7): 744–750.CrossRefGoogle ScholarPubMed
Gruber, S, Frey, R, Mlynárik, V, et al. Quantification of metabolic differences in the frontal brain of depressive patients and controls obtained by 1 H-MRS at 3 Tesla. Investigative Radiology. 2003; 38(7): 403–408.CrossRefGoogle Scholar
Chen, CS, Chiang, IC, Li, CW, et al. Proton magnetic resonance spectroscopy of late-life major depressive disorder. Psychiatry Research. 2009; 172(3): 210–214.CrossRefGoogle ScholarPubMed
Zhong, S, Wang, Y, Zhao, G, et al. Similarities of biochemical abnormalities between major depressive disorder and bipolar depression: A proton magnetic resonance spectroscopy study. Journal of Affective Disorders. 2014; 168: 380–386.CrossRefGoogle ScholarPubMed
Jia, Y, Zhong, S, Wang, Y, et al. The correlation between biochemical abnormalities in frontal white matter, hippocampus and serum thyroid hormone levels in first-episode patients with major depressive disorder. Journal of Affective Disorders. 2015; 180: 162–169.CrossRefGoogle ScholarPubMed
Huang, Y, Chen, W, Li, Y, et al. Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: A study using (1)H magnetic resonance spectroscopy. Psychiatry Research. 2010; 182(1): 48–52.CrossRefGoogle ScholarPubMed
Wang, Y, Jia, Y, Xu, G, et al. Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: A proton magnetic resonance spectroscopy study. Journal of Affective Disorders. 2012; 136(3): 620–626.CrossRefGoogle ScholarPubMed
Li, Y, Jakary, A, Gillung, E, et al. Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla. Magma (New York, Ny). 2016; 29: 523–533.Google Scholar
Nery, FG, Stanley, JA, Chen, HH, et al. Normal metabolite levels in the left dorsolateral prefrontal cortex of unmedicated major depressive disorder patients: A single voxel (1)H spectroscopy study. Psychiatry Research. 2009; 174(3): 177–183.CrossRefGoogle ScholarPubMed
Portella, MJ, de Diego-Adelino, J, Gomez-Anson, B, et al. Ventromedial prefrontal spectroscopic abnormalities over the course of depression: A comparison among first episode, remitted recurrent and chronic patients. Journal of Psychiatric Research. 2011; 45(4): 427–434.CrossRefGoogle ScholarPubMed
de Diego-Adelino, J, Portella, MJ, Gomez-Anson, B, et al. Hippocampal abnormalities of glutamate/glutamine, N-acetylaspartate and choline in patients with depression are related to past illness burden. J Psychiatry Neurosci. 2013; 38(2): 107–116.Google Scholar
Tae, WS, Kim, SS, Lee, KU, Nam, EC, Koh, SH. Progressive decrease of N-acetylaspartate to total creatine ratio in the pregenual anterior cingulate cortex in patients with major depressive disorder: Longitudinal 1 H-MR spectroscopy study. Acta Radiologica. 2014; 55(5): 594–603.CrossRefGoogle Scholar
Henigsberg, N, Šarac, H, Radoš, M, et al. Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: A proton magnetic resonance spectroscopy retrospective cohort study. Frontiers in Psychiatry. 2017; 8: 277.Google Scholar
Grachev, ID, Ramachandran, TS, Thomas, PS, Szeverenyi, NM, Fredrickson, BE. Association between dorsolateral prefrontal N-acetyl aspartate and depression in chronic back pain: An in vivo proton magnetic resonance spectroscopy study. Journal of Neural Transmission. 2003; 110(3): 287–312.Google Scholar
Woo Suk, T, Sam Soo, K, Kang, Uk L, Eui-Cheol, N, Sung Hye, K. Progressive decrease of N-acetylaspartate to total creatine ratio in the pregenual anterior cingulate cortex in patients with major depressive disorder: Longitudinal 1H-MR spectroscopy study. Acta Radiologica. 2014; 55(5): 594–603.Google Scholar
Wang, Y, Jia, Y, Chen, X, et al. Hippocampal N-acetylaspartate and morning cortisol levels in drug-naive, first-episode patients with major depressive disorder: Effects of treatment. Journal of Psychopharmacology (Oxford, England). 2012; 26(11): 1463–1470.CrossRefGoogle ScholarPubMed
Charles, HC, Lazeyras, F, Krishnan, KRR, Brain choline in depression: In vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1994; 18(7): 1121–1127.CrossRefGoogle ScholarPubMed
Huang, Y, Chen, W, Li, Y, et al. Effects of antidepressant treatment on & <em>N</em>-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: A study using 1H magnetic resonance spectroscopy. Psychiatry Research: Neuroimaging. 2010; 182(1): 48–52.CrossRefGoogle Scholar
Kaymak, SU, Demir, B, Oğuz, KK, Şentürk, S, Uluğ, B. Antidepressant effect detected on proton magnetic resonance spectroscopy in drug‐naïve female patients with first‐episode major depression. Psychiatry and Clinical Neurosciences. 2009; 63(3): 350–356.CrossRefGoogle ScholarPubMed
Lisanby, SH. Electroconvulsive therapy for depression. New England Journal of Medicine. 2007; 357(19): 1939–1945.CrossRefGoogle ScholarPubMed
Berlim, MT, van den Eynde, F, Tovar-Perdomo, S, Daskalakis, ZJ. Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials. Psychological Medicine. 2014; 44(2): 225–239.CrossRefGoogle ScholarPubMed
Cano, M, Martínez-Zalacaín, I, Bernabéu-Sanz, Á, et al. Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: A longitudinal neuroimaging study. Translational Psychiatry. 2017; 7: e1023.Google Scholar
Michael, N, Erfurth, A, Ohrmann, P, et al. Neurotrophic effects of electroconvulsive therapy: A proton magnetic resonance study of the left amygdalar region in patients with treatment-resistant depression. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology. 2003; 28: 720.CrossRefGoogle ScholarPubMed
Zheng, H, Jia, F, Guo, G, et al. Abnormal anterior cingulate N-acetylaspartate and executive functioning in treatment-resistant depression after rTMS therapy. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum. 2015; 18(11): pyv059.CrossRefGoogle ScholarPubMed
Mirza, Y, O’Neill, J, Smith, EA, et al. Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls. Journal of Child Neurology. 2006; 21(2): 106–111.CrossRefGoogle ScholarPubMed
Nery, FG, Stanley, JA, Chen, H-H, et al. Normal metabolite levels in the left dorsolateral prefrontal cortex of unmedicated major depressive disorder patients: A single voxel 1 H spectroscopy study. Psychiatry Research: Neuroimaging. 2009; 174(3): 177–183.CrossRefGoogle ScholarPubMed
Iosifescu, DV, Renshaw, PF. 31P-Magnetic resonance spectroscopy and thyroid hormones in major depressive disorder: Toward a bioenergetic mechanism in depression? Harvard Review of Psychiatry. 2003; 11(2): 51–63.Google Scholar
Kato, T, Takahashi, S, Shioiri, T, Inubushi, T. Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. Journal of Affective Disorders. 1992; 26(4): 223–230.CrossRefGoogle ScholarPubMed
Moore, CM, Christensen, JD, Lafer, B, Fava, M, Renshaw, PF. Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: A phosphorous-31 magnetic resonance spectroscopy study. American Journal of Psychiatry. 1997; 154(1): 116–118.Google ScholarPubMed
Volz, HP, Rzanny, R, Riehemann, S, et al. 31P magnetic resonance spectroscopy in the frontal lobe of major depressed patients. European Archives of Psychiatry and Clinical Neuroscience. 1998; 248(6): 289–295.CrossRefGoogle ScholarPubMed
Renshaw, PF, Parow, AM, Hirashima, F, et al. Multinuclear magnetic resonance spectroscopy studies of brain purines in major depression. American Journal of Psychiatry. 2001; 158(12): 2048–2055.CrossRefGoogle ScholarPubMed
Kondo, DG, Sung, Y-H, Hellem, TL, et al. Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: A 31-phosphorus magnetic resonance spectroscopy study. Journal of Affective Disorders. 2011; 135(1): 354–361.CrossRefGoogle ScholarPubMed
Iosifescu, DV, Bolo, NR, Nierenberg, AA, et al. Brain bioenergetics and response to triiodothyronine augmentation in major depressive disorder. Biological Psychiatry. 2008; 63(12): 1127–1134.CrossRefGoogle ScholarPubMed
Pettegrew, JW, Levine, J, Gershon, S, et al. 31P-MRS study of acetyl-L-carnitine treatment in geriatric depression: Preliminary results. Bipolar Disorders. 2002; 4(1): 61–66.CrossRefGoogle ScholarPubMed
Forester, BP, Harper, DG, Jensen, JE, et al. 31Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression. International Journal of Geriatric Psychiatry. 2009; 24(8): 788–797.CrossRefGoogle ScholarPubMed
Harper, DG, Joe, EB, Jensen, JE, Ravichandran, C, Forester, BP. Brain levels of high‐energy phosphate metabolites and executive function in geriatric depression. International Journal of Geriatric Psychiatry. 2016; 31(11): 1241–1249.CrossRefGoogle ScholarPubMed
Harper, DG, Jensen, JE, Ravichandran, C, et al. Tissue type-specific bioenergetic abnormalities in adults with major depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 2017; 42(4): 876–885.Google Scholar
Sassi RB, Stanley JA, Axelson D, et al. Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients. American Journal of Psychiatry. 2005; 162(11): 2109–2115.CrossRefGoogle Scholar
Caetano, SC, Olvera, RL, Hatch, JP, et al. Lower <em>N</em>-Acetyl-Aspartate levels in prefrontal cortices in pediatric bipolar disorder: A 1H magnetic resonance spectroscopy study. Journal of the American Academy of Child & Adolescent Psychiatry. 2011; 50(1): 85–94.Google Scholar
Olvera, RL, Caetano, SC, Fonseca, M, et al. Low levels of N-Acetyl aspartate in the left dorsolateral prefrontal cortex of pediatric bipolar patients. Journal of Child and Adolescent Psychopharmacology. 2007; 17(4): 461–473.CrossRefGoogle ScholarPubMed
Winsberg, ME, Sachs, N, Tate, DL, et al. Decreased dorsolateral prefrontal <em>N</em>-acetyl aspartate in bipolar disorder. Biological Psychiatry. 2000; 47(6): 475–481.CrossRefGoogle Scholar
Cecil, KM, DelBello, MP, Morey, R, Strakowski, SM. Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disorders. 2002; 4(6): 357–365.CrossRefGoogle ScholarPubMed
Özdel, O, Kalayci, D, Sözeri-Varma, G, et al. Neurochemical metabolites in the medial prefrontal cortex in bipolar disorder: A proton magnetic resonance spectroscopy study. Neural Regeneration Research. 2012; 7(36): 2929–2936.Google ScholarPubMed
Bertolino, A, Frye, M, Callicott, JH, et al. Neuronal pathology in the hippocampal area of patients with bipolar disorder: A study with proton magnetic resonance spectroscopic imaging. Biological Psychiatry. 2003; 53(10): 906–913.CrossRefGoogle ScholarPubMed
Deicken, RF, Pegues, MP, Anzalone, S, Feiwell, R, Soher, B. Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder. The American Journal of Psychiatry. 2003; 160(5): 873–882.CrossRefGoogle ScholarPubMed
Port, JD, Unal, SS, Mrazek, DA, Marcus, SM. Metabolic alterations in medication-free patients with bipolar disorder: A 3 T CSF-corrected magnetic resonance spectroscopic imaging study. Psychiatry Research: Neuroimaging. 2008; 162(2): 113–121.CrossRefGoogle Scholar
Zhong, S, Wang, Y, Zhao, G, et al. Similarities of biochemical abnormalities between major depressive disorder and bipolar depression: A proton magnetic resonance spectroscopy study. Journal of Affective Disorders. 2014; 168: 380–386.CrossRefGoogle ScholarPubMed
Croarkin, PE, Thomas, MA, Port, JD, et al. N-acetylaspartate normalization in bipolar depression after lamotrigine treatment. Bipolar Disorders. 2015; 17(4): 450–457.CrossRefGoogle ScholarPubMed
Sharma, R, Venkatasubramanian, PN, Bárány, M, Davis, JM. Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients. Schizophrenia Research. 1992; 8(1): 43–49.CrossRefGoogle ScholarPubMed
Deicken, RF, Eliaz, Y, Feiwell, R, Schuff, N. Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder. Psychiatry Research: Neuroimaging. 2001; 106(1): 35–45.CrossRefGoogle ScholarPubMed
Ohara, K, Isoda, H, Suzuki, Y, et al. Proton magnetic resonance spectroscopy of the lenticular nuclei in bipolar I affective disorder. Psychiatry Research: Neuroimaging. 1998; 84(2): 55–60.CrossRefGoogle ScholarPubMed
Castillo, M, Kwock, L, Courvoisie, H, Hooper, SR. Proton MR spectroscopy in children with bipolar affective disorder: Preliminary observations. American Journal of Neuroradiology. 2000; 21(5): 832.Google ScholarPubMed
Davanzo, P, Thomas, MA, Yue, K, et al. Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 2001; 24(4): 359–369.CrossRefGoogle ScholarPubMed
Moore, CM, Frazier, JA, Glod, CA, et al. Glutamine and glutamate levels in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2007 April; 46(4): 524–534.CrossRefGoogle ScholarPubMed
Davanzo, Pablo, Kenneth Yue, M. Thomas, Albert, et al. Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. American Journal of Psychiatry. 2003; 160(8): 1442–1452.CrossRefGoogle ScholarPubMed
Brambilla, P, Stanley, JA, Nicoletti, MA, et al. 1 H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients. Journal of Affective Disorders. 2005; 86(1): 61–67.CrossRefGoogle ScholarPubMed
DelBello, MP, Cecil, KM, Adler, CM, Daniels, JP, Strakowski, SM. Neurochemical effects of olanzapine in first-hospitalization manic adolescents: A proton magnetic resonance spectroscopy study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 2005; 31: 1264.CrossRefGoogle Scholar
Michael, N, Erfurth, A, Ohrmann, P, et al. Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex. Psychopharmacology. 2003; 168(3): 344–346.CrossRefGoogle ScholarPubMed
Forester, BP, Finn, CT, Berlow, YA, et al. Brain lithium, N‐acetyl aspartate and myo‐inositol levels in older adults with bipolar disorder treated with lithium: A lithium‐7 and proton magnetic resonance spectroscopy study. Bipolar Disorders. 2008; 10(6): 691–700.CrossRefGoogle ScholarPubMed
Hamakawa, H, Kato, T, Shioiri, T, Inubushi, T, Kato, N. Quantitative proton magnetic resonance spectroscopy of the bilateral frontal lobes in patients with bipolar disorder. Psychological Medicine. 1999; 29(3): 639–644.CrossRefGoogle ScholarPubMed
Cecil, KM, DelBello, MP, Sellars, MC, Strakowski, SM. Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders. Journal of Child and Adolescent Psychopharmacology. 2003; 13(4): 545–555.Google Scholar
Öngür, D, Prescot, AP, Jensen, JE, Cohen, BM, Renshaw, PF. Creatine abnormalities in schizophrenia and bipolar disorder. Psychiatry Research: Neuroimaging. 2009; 172(1): 44–48.CrossRefGoogle ScholarPubMed
Dager, SR, Friedman, SD, Parow, A, et al. Brain metabolic alterations in medication-free patients with bipolardisorder. Archives of General Psychiatry. 2004; 61(5): 450–458.CrossRefGoogle Scholar
Frye, MA, Watzl, J, Banakar, S, et al. Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 2007; 32: 2490.CrossRefGoogle ScholarPubMed
Kato, T, Takahashi, S, Shioiri, T, et al. Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. Journal of Affective Disorders. 1994; 31(2): 125–133.CrossRefGoogle ScholarPubMed
Weber, WA, Dudley, J, Lee, J-H, et al. A pilot study of alterations in high energy phosphoryl compounds and intracellular pH in unmedicated adolescents with bipolar disorder. Journal of Affective Disorders. 2013; 150(3): 1109–1113.CrossRefGoogle ScholarPubMed
Dudley, J, DelBello, MP, Weber, WA, et al. Tissue-dependent cerebral energy metabolism in adolescents with bipolar disorder. Journal of Affective Disorders. 2016; 191: 248–255.CrossRefGoogle ScholarPubMed
Brennan, BP, Jensen, JE, Hudson, JI, et al. A placebo-controlled trial of acetyl-L-carnitine and alpha-lipoic acid in the treatment of bipolar depression. J Clin Psychopharmacol. 2013; 33(5): 627–635.CrossRefGoogle ScholarPubMed
Deicken, RF, Fein, G, Weiner, MW. Abnormal frontal lobe phosphorous metabolism in bipolar disorder. American Journal of Psychiatry. 1995; 152(6): 915–918.Google Scholar
Du, F, Yuksel, C, Chouinard, V-A, et al. Abnormalities in high-energy phosphate metabolism in first-episode bipolar disorder measured using 31P-magnetic resonance spectroscopy. Biological Psychiatry. 2018 December 1; 84(11): 797–802.CrossRefGoogle Scholar
Jensen, JE, Daniels, M, Haws, C, et al. Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients. Experimental and Clinical Psychopharmacology. 2008; 16(3): 199–206.CrossRefGoogle Scholar
Murashita, J, Kato, T, Shioiri, T, Inubushi, T, Kato, N. Altered brain energy metabolism in lithium-resistant bipolar disorder detected by photic stimulated 31P-MR spectroscopy. Psychological Medicine. 2000; 30(1): 107–115.CrossRefGoogle Scholar
Shi, XF, Carlson, PJ, Sung, YH, et al. Decreased brain PME/PDE ratio in bipolar disorder: A preliminary 31P magnetic resonance spectroscopy study. Bipolar Disorders. 2015; 17(7): 743–752.CrossRefGoogle ScholarPubMed
Yuksel, C, Du, F, Ravichandran, C, et al. Abnormal high-energy phosphate molecule metabolism during regional brain activation in patients with bipolar disorder. Molecular Psychiatry. 2015; 20(9): 1079–1084.CrossRefGoogle ScholarPubMed
Sikoglu, EM, Jensen, JE, Vitaliano, G, et al. Bioenergetic measurements in children with bipolar disorder: A pilot 31P magnetic resonance spectroscopy study. PloS One. 2013; 8(1): e54536.CrossRefGoogle ScholarPubMed
Kato, T, Takahashi, S, Shioiri, T, Inubushi, T. Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy. Journal of Affective Disorders. 1993; 27(1): 53–59.Google Scholar
Kato, T, Shioiri, T, Murashita, J, et al. Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder. Psychiatry Research. 1994; 55(1): 41–50.CrossRefGoogle ScholarPubMed
Hamakawa H, Murashita J, Yamada N, et al. Reduced intracellular pH in the basal ganglia and whole brain measured by 31P‐MRS in bipolar disorder. Psychiatry and Clinical Neurosciences. 2004; 58(1): 82–88.CrossRefGoogle Scholar
Jensen, JE, Daniels, M, Haws, C, et al. Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients. Experimental and Clinical Psychopharmacology. 2008; 16(3): 199–206.CrossRefGoogle Scholar
Kim, DJ, Lyoo, IK, Yoon, SJ, et al. Clinical response of quetiapine in rapid cycling manic bipolar patients and lactate level changes in proton magnetic resonance spectroscopy. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2007; 31(6): 1182–1188.CrossRefGoogle ScholarPubMed
Bradley, EH, Curry, L, Horwitz, LI, Sipsma, H, Thompson, JW, Elma, M. Contemporary evidence about hospital strategies for reducing 30-day readmissions: a national study. J Am Coll Cardiol. 2012; 60.CrossRefGoogle ScholarPubMed
Xu, J, Dydak, U, Harezlak, J, et al. Neurochemical abnormalities in unmedicated bipolar depression and mania: A 2D 1H MRS investigation. Psychiatry Research: Neuroimaging. 2013; 213(3): 235–241.CrossRefGoogle Scholar
Soeiro-de-Souza, MG, Pastorello, BF, Leite, CdC, et al. Dorsal anterior cingulate lactate and glutathione levels in euthymic bipolar I disorder: 1 H-MRS study. International Journal of Neuropsychopharmacology. 2016; 19(8): pyw032–pyw.Google Scholar
Machado-Vieira, R, Zanetti, MV, Otaduy, MC, et al. Increased brain lactate during depressive episodes and reversal effects by lithium monotherapy in drug-naive bipolar disorder: A 3-T 1 H-MRS study. Journal of Clinical Psychopharmacology. 2017; 37(1): 40–45.CrossRefGoogle Scholar
Yousha, M, Joseph, ON, Ethan, AS, et al. Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls. Journal of Child Neurology. 2006; 21(2): 106–111.Google Scholar
Chen, C-S, Chiang, IC, Li, C-W, Lin, W-C, Lu, C-Y, Hsieh, T-J, et al. Proton magnetic resonance spectroscopy of late-life major depressive disorder. Psychiatry Research: Neuroimaging. 2009; 172(3): 210–4.Google ScholarPubMed
Wang, Y, Jia, Y, Xu, G, et al. Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: A proton magnetic resonance spectroscopy study. Journal of Affective Disorders. 2012; 136(3): 620–626.Google Scholar
Jia, Y, Zhong, S, Wang, Y, et al. The correlation between biochemical abnormalities in frontal white matter, hippocampus and serum thyroid hormone levels in first-episode patients with major depressive disorder. Journal of Affective Disorders. 2015; 180: 162–169.CrossRefGoogle ScholarPubMed
Moore, CM, Christensen, JD, Lafer, B, Fava, M, Renshaw, PF. Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: A phosphorous-31 magnetic resonance spectroscopy study. American Journal of Psychiatry. 1997; 154(1): 116–118.Google ScholarPubMed
Harper, DG, Jensen, JE, Ravichandran, C, et al. Tissue type-specific bioenergetic abnormalities in adults with major depression. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology. 2016; 42: 876.CrossRefGoogle ScholarPubMed
Hamakawa, H, Kato, T, Shioiri, T, Inubushi, T, Kato, N. Quantitative proton magnetic resonance spectroscopy of the bilateral frontal lobes in patients with bipolar disorder. Psychological Medicine. 1999; 29(3): 639–644.Google Scholar
Moore, CM, Breeze, JL, Gruber, SA, et al. Choline, myo‐inositol and mood in bipolar disorder: A proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. Bipolar Disorders. 2000; 2(3p2): 207–216.CrossRefGoogle ScholarPubMed
Patel, NC, Cecil, KM, Strakowski, SM, Adler, CM, DelBello, MP. Neurochemical alterations in adolescent bipolar depression: A proton magnetic resonance spectroscopy pilot study of the prefrontal cortex. Journal of Child and Adolescent Psychopharmacology. 2008; 18(6): 623–627.CrossRefGoogle ScholarPubMed
Brady, Jr RO, Cooper, A, Jensen, JE, et al. A longitudinal pilot proton MRS investigation of the manic and euthymic states of bipolar disorder. Translational Psychiatry. 2012; 2: e160.Google Scholar
Deicken, RF, Weiner, MW, Fein, G. Decreased temporal lobe phosphomonoesters in bipolar disorder. Journal of Affective Disorders. 1995; 33(3): 195–199.CrossRefGoogle ScholarPubMed

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