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Chapter 29 - Practical Concerns for Patient Semen Banking

from Section 4 - Laboratory Evaluation and Treatment of Male Infertility

Published online by Cambridge University Press:  06 December 2023

By
Grace M. Centola
Edited by
Douglas T. Carrell ,
Alexander W. Pastuszak  and
James M. Hotaling
Douglas T. Carrell
Affiliation:
Utah Center for Reproductive Medicine
Alexander W. Pastuszak
Affiliation:
University of Utah
James M. Hotaling
Affiliation:
Utah Center for Reproductive Medicine
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Summary

Sperm banking, or male fertility preservation, is widely used prior to medical, surgical, and nonmedical procedures that might affect a male’s fertility. Both federal and state regulations have been instituted to regulate the sperm banking industry, requiring rigorous screening and testing of sperm donors and detailed records of the donors and clients that choose to store their own sperm. Cryopreservation consents are detailed and cover long-term storage, use of the specimens, and disposition of the specimens in case of incapacitation or death of the sperm banker or lack of need for the frozen specimens. Sperm cryopreservation is relatively simple in the laboratory, but does require trained staff working with cryopreservatives and liquid nitrogen. With the increased use of ART, cryopreservation of even the poorest specimens with only a few sperm has become routine. Sperm can be retrieved with testicular biopsy or epididymal aspiration even in the case of purported azoospermia. Use of fresh or frozen specimens have been shown to yield comparable results. The future of sperm cryopreservation is promising as we look to storage of testicular tissue for future autotransplantation as well as prepubertal spermatogonial stem cell storage for future in vitro maturation, or transplantation and growth of testicular tissue and sperm production.

Keywords

sperm cryopreservationsperm bankingassisted reproductiontesticular tissue cryopreservationspermatogonial stem cell cryopreservation
Type
Chapter
Information
Men's Reproductive and Sexual Health Throughout the Lifespan
An Integrated Approach to Fertility, Sexual Function, and Vitality
 , pp. 224 - 228
Publisher: Cambridge University Press
Print publication year: 2023

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References

Shehata, F, Chian, RC. Cryopreservation of sperm: an overview. In: Chian, RC, Quinn, P, eds. Fertility Cryopreservation. Cambridge University Press; 2010:39–45.Google Scholar
Sherman, JK. Synopsis of the use of frozen human semen since 1964: state of the art of human semen banking. Fertil Steril. 1973;24:397–412.Google Scholar
Bunge, RG, Sherman, JK. Fertilizing capacity of frozen human spermatozoa. Nature. 1953;172:767–768.Google Scholar
Li, K, Rodriguez, D, Gabrielsen, JS, Centola, GM, Tanrikut, C. Transgender sperm cryopreservation: trends and findings in the past decade. Andrology. 2018;6(6):860–864.CrossRefGoogle ScholarPubMed
Alouf, CA, Celia, G, Centola, GM. Sperm cryopreservation – a practical guide. In: Allahbadia, GN, Ata, B, Lindheim, SR, Woodward, BJ, Bhagavath, B, eds. Textbook of Assisted Reproduction. Springer; 2019:497–504.Google Scholar
Centola, GM, Sperm banking, donation, and transport in the age of assisted reproduction: federal and state regulation. In: Carrell, DT, Peterson, CM, eds. Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice. Springer; 2010:509–516.Google Scholar
Di Santo, M, Tarozzi, N, Nadalini, M, Borini, A. Human sperm cryopreservation: update on techniques, effect on DNA integrity, and implications for ART. Adv Urol. 2012;2012:854837.Google Scholar
Kong, A, Frigge, ML, Masson, G, et al. Rate of de novo mutations and the importance of father’s age to disease risk. Nature. 2012;488(7412):471–475.Google Scholar
Centola, GM, Blanchard, A, Demick, J, Li, S, Eisenberg, M. Decline in sperm count and motility in young adult men from 2003–2013: observations from a U.S. sperm bank. Andrology. 2016;4(3):270–276.Google Scholar
Sharma, R, Agarwal, A, Rohra, VK, Assidi, M, Abu-Elmagd, M, Turki, RF. Effects of increased paternal age on sperm quality, reproductive outcome and associated genetic risks to offspring. Reprod Biol Endoc. 2015;13:35.Google Scholar
D’Onofrio, BM, Rickert, ME, Frans, E, et al. Paternal age at childbearing and offspring psychiatric and academic morbidity. JAMA Psychiatry. 2014;71(4):432–438.Google Scholar
Pacey, AA. Referring patients for sperm banking. In: Pacey, AA, Tomlinson, MJ, eds. Sperm Banking: Theory and Practice. Cambridge University Press; 2009:30–40.CrossRefGoogle Scholar
New York State, Part 52, Tissue Banks and Non Transplant Anatomic Banks, Public Health Section 4365; Subpart 52–58; www.wadsworth.org/regulatory/btrp/laws. Accessed November 9, 2022.Google Scholar
US Food and Drug Administration, 21 CFR 1271; www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=1271. Accessed November 9, 2022.Google Scholar
California Department of Public Health (CDPH) Tissue Bank Regulation, Article 2. 1639–1641.1. https://leginfo.legislature.ca.gov/faces/codes_displayText.xhtml?lawCode=HSC&division=2.&title=&part=&chapter=4.1.&article=2. Accessed November 9, 2022.Google Scholar
Practice Committee of American Society for Reproductive Medicine and the Practice Committee of Society for Assisted Reproductive Technology. Recommendations for gamete and embryo donation: a committee opinion. Fertil Steril. 2013;99(1):47–62.CrossRefGoogle Scholar
American Association of Tissue Bank. Standards for Tissue Banking, 14th ed., January 31, 2020. https://static1.squarespace.com/static/5f2dc76b6a743f2147b29a37/t/5f3334d90f2540201689051c/1597191396553/AATB+Standards+for+Tissue+Banking+-14th+Edition-+-+-Posted+8-3-16-.pdf. Accessed November 9, 2022.Google Scholar
Shuster, TG, Hickner-Cruz, K, Ohl, DA, Goldman, E, Smith, G. Legal considerations for cryopreservation of sperm and embryos. Fertil Steril. 2003;80:61–66.Google Scholar
Joint Commission. Informed consent: more than getting a signature. www.jointcommission.org/-/media/tjc/documents/newsletters/quick_safety_issue_twenty-one_february_2016pdf.pdfGoogle Scholar
Centola, GM. Sperm or no sperm, that is the question! Finding the elusive spermatozoa. Fertil Steril. 2012;98:822.Google Scholar
Centola, GM, Raubertas, RF, Mattox, JH. Cryopreservation of human semen: comparison of cryopreservatives, sources of variability and prediction of post-thaw survival. J Androl. 1992;13(3):283–288.Google Scholar
Cohen, J, Garrisi, GJ, Congedo-Ferrara, TA, Kieck, KA, Sehimmel, TW, Scott, RT. Cryopreservation of single human spermatozoa. Hum Reprod. 1997;12:994–1001.Google Scholar
Gvakharia, M, Adamson, G. A method of successful cryopreservation of small numbers of human spermatozoa. Fertil Steril. 2001;76:S101.Google Scholar
Desai, NN, Culler, C, Goldfarb, J. Cryopreservation of single sperm from epidermal and testicular samples on cryoloops: preliminary case report. Fertil Steril. 2004;82:S264.CrossRefGoogle Scholar
Isachemko, V, Isachenko, E, Montag, M, et al. Clean technique for cryoprotectant-free vitrification of human spermatozoa. RBMO. 2005;10:350–354.Google Scholar
Centola, GM, Allen, J. The ability of sperm to survive cryopreservation is not related to initial sperm concentration. Paper presented at the American Society of Andrology Annual Meeting, April 1993.Google Scholar
Nagy, Z, Liu, J, Cecile, J, Silber, S, Devroey, P, Van Steirteghem, A. Using ejaculated, fresh, and frozen-thawed epididymal and testicular spermatozoa gives rise to comparable results after intracytoplasmic sperm injection. Fertil Steril. 1995;63(4):808–815.CrossRefGoogle ScholarPubMed
Yu, Z, Wei, Z, Yang, J, et al. Comparison of intracytoplasmic sperm injection outcome with fresh versus frozen-thawed testicular sperm in men with nonobstructive azoospermia: a systematic review and meta-analysis. J Assist Reprod Genet. 2018;35(7):1247–1257.Google Scholar
Kuczyński, W, Dhont, M, Grygoruk, C, Grochowski, D, Wołczyński, S, Szamatowicz, M. The outcome of intracytoplasmic injection of fresh and cryopreserved ejaculated spermatozoa: a prospective randomized study. Hum Reprod. 2001;16(10):2109–2113.Google Scholar
Ragni, G, Caccamo, AM, Dalla Serra, A, Guercilena, S. Computerized slow-staged freezing of semen from men with testicular tumors or Hodgkin’s disease preserves sperm better than standard vapor freezing. Fertil Steril. 1990;53(6):1072–1075.Google Scholar
Ragni, G, Somigliana, E, Restelli, L, Salvi, R, Arnoldi, M, Paffoni, A. Sperm banking and rate of assisted reproduction treatment: insights from a 15 year cryopreservation program for male cancer patients. Cancer. 2003;97(7):1624–1629.Google Scholar
Borges, E, Jr., Rossi, LM, Locambo de Freitas, CV, et al. Fertilization and pregnancy outcome after intracytoplasmic injection with fresh or cryopreserved ejaculated spermatozoa. Fertil Steril. 2007;87(2):316–320.CrossRefGoogle ScholarPubMed
Gerkowicz, SA, Crawford, S, Hipp, H, Boulet, S, Kissin, DM, Kawwass, JF. Assisted reproductive technology with donor sperm: national trends and perinatal outcomes. Fertil Steril. 2017;108(3):e72.Google Scholar
Fritz, R, Jindal, S, Yu, B, Vega, M, Buyuk, E. Does donor sperm affect birth weight, preterm birth, and miscarriage rates in fresh autologous in vitro fertilization cycles? Analysis of 46.061 cycles reported to SART. Fertil Steril. 2017;107(3):e30.CrossRefGoogle Scholar
Malchau, SS, Loft, A, Henningsen, A-K, Andersen, AN, Pinborg, A. Perinatal outcomes in 6338 singletons born after intrauterine insemination in Denmark, 2007 to 2012: the influence of ovarian stimulation. Fertil Steril. 2014;102:1110–1116.CrossRefGoogle Scholar
Shin, DH, Turek, PJ. Sperm retrieval techniques. Nature Rev Urology. 2013;10:723–730.Google Scholar
Devroey, P, Silber, S, Nagy, Z, et al. Ongoing pregnancies and births after intracytoplasmic sperm injection with frozen-thawed epididymal spermatozoa. Hum Reprod. 1995;10:903–906.Google Scholar
Fischer, R, Baukloh, V, Naether, OGJ, Schulze, W, Salzbrunn, A, Benson, DM. Pregnancy after intracytoplasmic sperm injection of spermatozoa extracted from frozen-thawed testicular biopsy. Hum Reprod. 1996;11:2197–2199.Google Scholar
Gil-Slamon, M, Romeo, J, Mingues, Y. Pregnancies after intracytoplasmic sperm injection with cryopreserved testicular sperm. Hum Reprod. 1996;11:1309–1313.Google Scholar
Patrizio, P, Natan, Y, Barak, Y, Levi Setti, P. A simple new method for the freeze-drying and storage of human sperm. Fertil Steril. 2016;106(3):e307.CrossRefGoogle Scholar
Frydman, R, Grynberg, M. Male fertility preservation: innovations and questions. Fertil Steril. 2015;105:247–248.Google Scholar
Moss, JL, Choi, A, Keeter, MKF, Brannigan, RE. Male adolescent fertility preservation. Fertil Steril. 2015;105(2):267–273.Google Scholar
Gies, I, Oates, R, De Schepper, J, Tournaye, H. Testicular biopsy and cryopreservation for fertility preservation of prepubertal boys with Klinefelter syndrome: a pro/con debate. Fertil Steril. 2016;105(2):249–255.Google Scholar
Gassei, K, Orwig, KE. Experimental methods to preserve male fertility and treat male factor infertility. Fertil Steril. 2016;105(2):256–266.Google Scholar
Sinha, N, Whelan, EC, Brinster, RL. Isolation, cryopreservation, and transplantation of spermatogonial stem cells. Methods Mol Biol. 2019;2005:205–220.Google Scholar
Valli, H, Phillips, BT, Shetty, G, et al. Germline stem cells: toward the regeneration of spermatogenesis. Fertil Steril. 2014;101(1):3–13.CrossRefGoogle ScholarPubMed
Goossens, E, Van Saen, D, Tournaye, H. Spermatogonial stem cell preservation and transplantation: from research to clinic. Hum Reprod. 2013;28:897–907.CrossRefGoogle ScholarPubMed
Fertility preservation program of Magee-Womens Hospital in Pittsburgh. https://mageewomens.org/for-researchers/research-centers/fertility-preservation-program-fpp#:~:text=The%20Fertility%20Preservation%20Program%20in%20Pittsburgh%20is%20committed%20to%3A,preserve%20fertility%20and%20treat%20infertility.Google Scholar

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