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Chapter 12 - Zona Binding: Hemizona Assay

Published online by Cambridge University Press:  05 April 2021

By
Shubhadeep Roychoudhury  and
Daniel Franken
Edited by
Ashok Agarwal ,
Ralf Henkel  and
Ahmad Majzoub
Ashok Agarwal
Affiliation:
The Cleveland Clinic Foundation, Cleveland, OH
Ralf Henkel
Affiliation:
University of the Western Cape, South Africa
Ahmad Majzoub
Affiliation:
Hamad Medical Corporation, Doha
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Summary

The incidence of infertility is up to 20–25 percent in men with poor semen quality with a contribution of the male factor in 30–50 percent of couples undergoing assisted reproduction, including in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). In 17 studies sampling 6410 women, the proportion of couples seeking such medical care was, on average, 56.1 percent (range 42–76.3 percent) in more developed countries and 51.2 percent (range 27–74.1 percent) in less developed countries [1]. Investigation of male infertility or sub-fertility basically comprises of semen analysis [2]. However, a standard semen analysis cannot always assess the multifunctional events and biological properties that spermatozoa express following capacitation. In many cases, it is only when couples fail to achieve conception, the male factor is suspected and advanced laboratory tests are recommended to establish this reliably.

Type
Chapter
Information
Manual of Sperm Function Testing in Human Assisted Reproduction , pp. 100 - 105
Publisher: Cambridge University Press
Print publication year: 2021

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References

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