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Chapter 16 - The Prospects of Infertility Treatment Using “Artificial” Eggs

Published online by Cambridge University Press:  02 December 2021

By
Katsuhiko Hayashi
Edited by
Gianpiero D. Palermo  and
Zsolt Peter Nagy
Gianpiero D. Palermo
Affiliation:
Cornell Institute of Reproductive Medicine, New York
Zsolt Peter Nagy
Affiliation:
Reproductive Biology Associates, Atlanta, GA
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Summary

The female germline undergoes a unique sequence of differentiation processes that finally endows the eggs with totipotency. The reconstitution in vitro of oogenesis using pluripotent stem cells, which eventually produces “artificial eggs,” has long been sought in reproductive biology and medicine, as this would contribute not only to a better understanding of the basic mechanisms underlying totipotency, but also to an alternative source of gametes for reproduction. This chapter introduces a scientific background, the current status and the prospects of artificial eggs in mice and humans.

Keywords

OocytesPluripotent stem cellsPrimordial germ cells
Type
Chapter
Information
Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction
With Other Advanced Micromanipulation Techniques to Edit the Genetic and Cytoplasmic Content of the Oocyte
 , pp. 154 - 160
Publisher: Cambridge University Press
Print publication year: 2021

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