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Chapter 27 - Hyperhidrosis

Published online by Cambridge University Press:  02 November 2023

By
Berthold Rzany  and
Markus K. Naumann
Edited by
Daniel Truong ,
Dirk Dressler ,
Mark Hallett ,
Christopher Zachary  and
Mayank Pathak
Daniel Truong
Affiliation:
University of California, Riverside
Dirk Dressler
Affiliation:
Hannover Medical School
Mark Hallett
Affiliation:
National Institutes of Health (NIH)
Christopher Zachary
Affiliation:
University of California, Irvine
Mayank Pathak
Affiliation:
Truong Neuroscience Institute
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Summary

Hyperhidrosis is excessive sweating, beyond physiological needs. It may be divided into generalized and localized/focal types, and into primary/idiopathic and secondary forms. Primary axillary hyperhidrosis appears to be the most frequent type, followed by palmar hyperhidrosis and other patterns. Hyperhidrosis may negatively affect many fields of daily life to a significant extent, including emotional status, personal hygiene, work and productivity, leisure activities and self-esteem.

When injected intra- or subdermally, botulinum neurotoxin (BoNT) blocks the release of acetylcholine from the sympathetic nerve fibers that stimulate the eccrine sweat glands and causes a localized, long-lasting but reversible abolishment of sweating. This chapter describes in detail the techniques for BoNT injection to treat primary axillary and palmar hyperhidrosis, as well as showing treatment of scalp and segmental hyperhidrosis. Techniques for assessing the degree and distribution of hyperhidrosis, the area to be treated and the degree of benefit are described.

Keywords

Botulinum neurotoxinBoNThyperhydrosispalmar hyperhydrosisaxillary hyperhydrosisonabotulinumtoxinAincobotulinumtoxinAabobotulinumtoxinARoss syndrome
Type
Chapter
Information
Manual of Botulinum Toxin Therapy , pp. 223 - 229
Publisher: Cambridge University Press
Print publication year: 2023

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References

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