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Chapter 13 - Magnetic resonance imaging of multiple system atrophy

Published online by Cambridge University Press:  05 October 2013

By
Klaus Seppi ,
Christoph Mueller ,
Gregor K. Wenning  and
Michael Schocke
Edited by
Paul Tuite  and
Alain Dagher
Paul Tuite
Affiliation:
University of Minnesota
Alain Dagher
Affiliation:
Montreal Neurological Institute
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Summary

Neuroimaging has become more important for multiple system atrophy (MSA) clinically as well as in research studies. This chapter focuses on structural MR techniques such as conventional magnetic resonance imaging (cMRI) including standard T1- and T2-weighted as well as fluid-attenuated inversion recovery (FLAIR) sequences. It also focuses on different advanced MR techniques including methods to assess regional cerebral atrophy quantitatively, such as magnetic resonance volumetry (MRV), diffusion-weighted imaging and diffusion tensor imaging (DWI/DTI), as well as magnetization transfer imaging (MTI). As an indirect method of measuring regional brain atrophy, groups have applied simple quantitative measures of diameters, areas, and volumes including region of interest (ROI)-based assessment of various structures on MRI for differential diagnostic purposes. A summary of these methods and their diagnostic accuracy for MSA is provided in the chapter; the methods include: MR-planimetry, -volumetry, and voxel-based morphometry (VBM).

Keywords

non-cortico-striatal mechanismsfunctional imaging methodsfunctional neuroanatomyimpulse control disordersParkinson's diseasedopamine systemcognitive impairmentcortico-striatal network function
Type
Chapter
Information
Magnetic Resonance Imaging in Movement Disorders
A Guide for Clinicians and Scientists
 , pp. 167 - 203
Publisher: Cambridge University Press
Print publication year: 2013

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