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16 - Diseases of the Gallbladder in Infancy, Childhood, and Adolescence

from SECTION II - CHOLESTATIC LIVER DISEASES

Published online by Cambridge University Press:  18 December 2009

By
James E. Heubi M.D.
Edited by
Frederick J. Suchy ,
Ronald J. Sokol  and
William F. Balistreri
James E. Heubi M.D.
Affiliation:
Professor and Associate Chair for Clinical Investigation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Program Director, General Clinical Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Frederick J. Suchy
Affiliation:
Mount Sinai School of Medicine, New York
Ronald J. Sokol
Affiliation:
University of Colorado, Denver
William F. Balistreri
Affiliation:
University of Cincinnati
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Summary

EMBRYOLOGIC DEVELOPMENT OF THE GALLBLADDER

The hepatic rudiment appears at approximately day 18 of gestation in the human embryo. By day 25, it can be recognized as an endodermal diverticulum, which projects into the mesenchymal septum transversum. By day 30, the hepatic diverticulum enlarges and divides into the pars hepatica cranially and the pars cystica caudally. The pars hepatica forms parenchymal liver components; the pars cystica differentiates into the gallbladder and cystic ducts (Figure 16.1). The gallbladder primordium is a solid structure that later in development becomes cystic, as found in the adult [1–3].

CONGENITAL ANOMALIES OF THE GALLBLADDER

A variety of structural anomalies of the gallbladder has been described (Table 16.1). Congenital absence of the gallbladder long has been recognized in humans; it was known to Aristotle. Overall, the incidence of agenesis of the gallbladder has been estimated at between 1 in 7500 and 1 in 10,000 among the general population [4, 5]. There are a number of mammalian species, including the horse, camel, deer, rat, and dolphin, lacking a gallbladder. Absence of the gallbladder may occur as an isolated anomaly or in association with other malformations. In the isolated form, absence of the gallbladder is of little clinical significance. It is believed to result from failed development of the pars cystica [6]. Rarely, symptoms develop related to calculi formation in the biliary ductal system.

A number of anomalies have been described in association with congenital absence of the gallbladder.

Type
Chapter
Information
Liver Disease in Children , pp. 346 - 366
Publisher: Cambridge University Press
Print publication year: 2007

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References

Langman, J. The digestive system. In: Langman's medical embryology, 3rd ed. Baltimore: Williams & Wilkins, 1981:217–20.Google Scholar
Hamilton, W J. The alimentary and respiratory systems. In: Patton, B. Human embryology, 3rd ed. New York: McMillan Press, 1981:341.Google Scholar
Langman, J. In: Langman's medical embryology, 6th ed. Baltimore: Williams & Wilkins, 1990:243.Google Scholar
Warkany, J. The liver in congenital malformations. Chicago: Yearbook Medical Publishers, 1971:722–3.Google Scholar
Vanderpool, D, Klinpensmith, W, Oles, P. Congenital absence of the gallbladder. Am Surgeon 1964;30:324–30.Google ScholarPubMed
Gross, R E. Congenital abnormalities of the gallbladder: a review of one hundred and forty eight cases, with report of a double gallbladder. Arch Surg 1936;32:131–62.CrossRefGoogle Scholar
Stolkind, E. Congenital abnormalities of the gallbladder and extrahepatic ducts: review of two hundred forty five reported cases with report of thirty one unpublished cases. Br J Child Dis 1939;36:115,182,295.Google Scholar
Isenberg, J N, L'Heureux, P R, Warwick, W J. Clinical observations on the biliary system in cystic fibrosis. Am J Gastroenterol 1976;65:134–41.Google ScholarPubMed
DeSchryver-Kecskemetri, K. Gallbladder and biliary ducts. In: Anderson's pathology. 9th ed. St. Louis: Mosby, 1990:1321–45.Google Scholar
Williamson, R. Acalculous disease of the gallbladder. Gut 1988;29:860–72.CrossRefGoogle Scholar
Curtis, L E, Sheahan, D G. Heterotopic tissues in the gallbladder. Arch Pathol 1969;88:677–83.Google ScholarPubMed
Busuttil, A. Ectopic adrenal within the gallbladder wall. J Pathol 1974;113:231–3.CrossRefGoogle Scholar
Thorsness, E T. An aberrant pancreatic nodule arising on the neck of a human gallbladder from multiple outgrowths of the mucosa. Anat Rec 1940;77:319–33.CrossRefGoogle Scholar
Ishibashi, T, Nagai, H, Yasuda, T. Pancreatic bladder or double gallbladder draining into the pancreatic duct?J Hepatobiliary Pancreat Surg 1999;6:199–203.CrossRefGoogle ScholarPubMed
Skielboe, B. Anomalies of the gallbladder-vesica fellea triplex: report of a case. Am J Clin Pathol 1958;30:252.CrossRefGoogle ScholarPubMed
Greenwood, R K. Torsion of the gallbladder. Gut 1963;4:27–9.CrossRefGoogle Scholar
Shaikh, A A, Charles, A, Domingo, S, Schaub, G. Gallbladder vol vulus: report of two original cases and review of the literature. Am Surg 2005;71:87–9.Google Scholar
Logan, G B, Thistle, J L. The gallbladder and bile ducts. In: Practice of pediatrics. Vol 5. Philadelphia: Harper and Row, 1986:1–18.Google Scholar
Holcomb, G W, O'Neill, J A, Holcomb, G W. Cholecystitis cholelithiasis and common duct stones in children and adolescents. Ann Surg 1980;191:626–35.CrossRefGoogle ScholarPubMed
Silverman, A, Roy, C C. Acute and chronic biliary tract disease. In: Pediatric clinical gastroenterology. 3rd ed. St. Louis: Mosby, 1983.Google Scholar
Rumley, T O, Rodgers, B M. Hydrops of the gallbladder in children. J Pediatr Surg 1983;18:138–40.CrossRefGoogle ScholarPubMed
Suddleson, E A, Reid, B, Woolley, M M. Hydrops of the gallbladder associated with Kawasaki syndrome. J Pediatr Surg 1987;22:956–9.CrossRefGoogle ScholarPubMed
Grisoni, E, Fisher, R, Izant, R. Kawasaki syndrome: report of four cases with acute gallbladder hydrops. J Pediatr Surg 1984;19:9–11.CrossRefGoogle ScholarPubMed
Melish, M E, Hicks, R V, Reddy, V. Kawasaki syndrome: an update. Hosp Pract (Off Ed) 1982;17:99–106.CrossRefGoogle ScholarPubMed
Friesen, C A, Gamis, A S, Riddell, L D. Bilirubinemia: an early indicator of gallbladder hydrops associated with Kawasaki disease. J Pediatr Gastroenterol Nutr 1989;8:384–6.CrossRefGoogle Scholar
Slovis, T L, Hight, D W, Pilippart, A I. Sonography in the diagnosis and management of hydrops of the gallbladder in children with mucocutaneous lymph node syndrome. Pediatrics 1980;65:789–94.Google ScholarPubMed
Mercer, S, Carpenter, B. Surgical complications of Kawasaki disease. J Pediatr Surg 1981;16:444–8.CrossRefGoogle ScholarPubMed
Sty, J R, Starshak, R J, Gorenstein, L. Gallbladder perforation in a case of Kawasaki disease: image correlation. J Clin Ultrasound 1983;11:381–4.CrossRefGoogle Scholar
Magilavy, D B, Speert, D P, Silver, T M. Mucocutaneous lymph node syndrome: report of two cases complicated by gallbladder hydrops and diagnosed by ultrasound. Pediatrics 1978;61:699–702.Google ScholarPubMed
Strauss, R G. Scarlet fever with hydrops of the gallbladder. Pediatrics 1969;44:741–5.Google ScholarPubMed
Dickinson, S J, Corley, G, Santulli, T. Acute cholecystitis as a sequel of scarlet fever. Am J Dis Child 1971;121:331–3.Google ScholarPubMed
Chamberlain, J W, Hight, D W. Acute hydrops of the gallbladder in childhood. Surgery 1970;68:899–905.Google ScholarPubMed
Bloom, R A, Swain, V A J. Non-calculous distension of the gallbladder in childhood. Arch Dis Child 1966;41:503–8.CrossRefGoogle ScholarPubMed
Tanaka, K, Shimada, M, Hattori, M. Sjogren's syndrome with abnormal manifestations of the gallbladder and central nervous system. J Pediatr Gastroenterol Nutr 1985;4:148–51.CrossRefGoogle ScholarPubMed
McGahan, J J, Whittinghill, J A. Acute idiopathic hydrops of the gallbladder not due to calculi possibly to infectious hepatitis. Pediatrics 1958;21:91–3.Google ScholarPubMed
McCrindle, B W, Wood, R A, Nussbaum, A R. Henoch-Schonlein Syndrome, unusual manifestations with hydrops of the gallbladder. Clin Pediatr 1988;27:254–6.CrossRefGoogle ScholarPubMed
Goren, A, Drachman, R, Hadas-Halperin, I. Transient gallbladder dilatation associated with hypokalemia in a patient with Bartter syndrome. Eur J Pediatr 1989;149:88–9.CrossRefGoogle Scholar
Gomezese, S, Garcia, F, Echeverry, J. New aspects of gallbladder pathology in children. Cir Pediatr 1989;2:114–16.Google ScholarPubMed
El-Shafie, M, Mah, C L. Transient gallbladder distension in sick premature infants: the value of ultrasonography and radionuclide scintigraphy. Pediatr Radiol 1986;16:468–71.CrossRefGoogle ScholarPubMed
Bowen, A. Acute gallbladder dilatation in a neonate: emphasis on ultrasonography. J Pediatr Gastroenterol Nutr 1984;3:304–8.CrossRefGoogle Scholar
Peevy, K J, Wiseman, H J. Gallbladder distension in septic neonates. Arch Dis Child 1982;57:75–6.Google ScholarPubMed
Longino, L A, Martin, L W. Abdominal masses in the newborn infant. Pediatrics 1958;21:596–604.Google ScholarPubMed
Gremse, D A, Peevy, K J, Simon, N. Neonatal gallbladder enlargement and α1-antitrypsin deficiency. J Pediatr Gastroenterol Nutr 1987;6:977–9.CrossRefGoogle Scholar
Traynelis, V C, Hrabovsky, E E. Acalculous cholecystitis in the neonate. Am J Dis Child 1985;139:893–5.Google ScholarPubMed
Ternberg, J L, Keating, J P. Acute acalculous cholecystitis. Arch Surg 1975;110:543–7.CrossRefGoogle ScholarPubMed
Wald, M. Gangrenous cholecystitis with bile peritonitis as a complication of burns in a 14 year old boy. Med J Aust 1961;11:553–5.Google Scholar
Rice, J, Williams, H, Lewis, M F. Postraumatic acalculous cholecystitis. South Med J 1980;73:14–17.CrossRefGoogle Scholar
Imamoglu, M, Sarihan, H, Sari, A, Ahmetoglu, A. Acute acalculous cholecystitis in children: diagnosis and treatment. J Pediatr Surg 2002;37:36–9.CrossRefGoogle ScholarPubMed
Hyams, J S, Baker, E, Schwartz, A N. Acalculous cholecystitis in Crohn's disease. J Adolesc Health Care 1989;10:151–4.CrossRefGoogle ScholarPubMed
Wong, M L, Kaplan, S, Dunkle, L M. Leptospirosis: a childhood disease. J Pediatr 1977;90:532–7.CrossRefGoogle ScholarPubMed
Walker, D H, Leseske, H R, Varma, V A. Rocky Mountain spotted fever mimicking acute cholecystitis. Arch Intern Med 1985;145:2194–6.CrossRefGoogle ScholarPubMed
Reid, M R, Montgomery, J C. Acute cholecystitis in children as a complication of typhoid fever. Johns Hopkins Hosp Bull 1920;347:7–11.Google Scholar
Schmidt, M H, Sung, L, Shuckett, B M. Hemophaogcytic lymphohistiocytosis in children: abdominal US findings within 1 week of presentation. Radiology 2004;230:685–9.CrossRefGoogle ScholarPubMed
Chateil, J, Brun, M, Perel, Y. Abdominal ultrasound findings in children with hemophagocytic lymphohistiocytosis. Eur Radiol 1999;9:474–7.CrossRefGoogle ScholarPubMed
Weedon, D. Disease of the gallbladder. In: Pathology of the liver. 2nd ed. New York: Churchill Livingstone, 1987:454–77.Google Scholar
Schreiber, M, Black, L, Noah, Z. Gallbladder candidiasis in a leukemic child. Am J Dis Child 1982;136:462–3.Google Scholar
Reubner, B. The gallbladder. In: Diagnostic pathology of the liver and biliary tract. New York: Hemisphere, 1991:454–67.Google Scholar
Pitlik, S D, Fainstein, V, Garza, D. Human cryptosporidiosis: spectrum of disease. Arch Intern Med 1983;143:2269–75.CrossRefGoogle Scholar
Sanders, R. The significance of sonographic gallbladder wall thickening. J Clin Ultrasound 1980;8:143–6.CrossRefGoogle ScholarPubMed
Patriquin, H B, DiPietro, M, Barber, F E. Sonography of thickened gallbladder wall: causes in children. AJR 1983;141:57–60.CrossRefGoogle ScholarPubMed
Jeffrey, R B, Sommer, F G. Follow-up sonography in suspected acalculous cholecystitis: preliminary clinical experience. J Ultrasound Med 1993;12:183–7.CrossRefGoogle ScholarPubMed
Swayne, L C. Acute acalculous cholecystitis: sensitivity in detection using technetium-99m imiodiacetic acid cholescintigraphy. Radiology 1986;160:33–8.CrossRefGoogle ScholarPubMed
Mirvis, S E, Vainright, J R, Nelson, A W. The diagnosis of acute acalculous cholecystitis: a comparison of sonography, scintigraphy and CT. AJR 1986;147:1171–5.CrossRefGoogle Scholar
Shuman, W P, Gibbs, P, Rudd, T G. PIPIDA scintigraphy for cholecystitis: false positives in alcoholism and total parenteral nutrition. AJR 1982;138:1–5.CrossRefGoogle ScholarPubMed
Lugo-Vincente, H L. Gallbladder dyskinesia in children. J Soc Laparoendosc Surg 1997;1:61–4.Google Scholar
Gollin, G, Raschbaum, G R, Moorthy, C. Cholecystectomy for suspected biliary dyskinesia in children with chronic abdominal pain. J Pediatr Surg 1999;34:854–7.CrossRefGoogle ScholarPubMed
Dumont, R C, Caniano, D A. Hypokinetic gallbladder disease: a cause of chronic abdominal pain in children and adolescents. J Pediatr Surg 1999;34:858–61.CrossRefGoogle ScholarPubMed
Vegunta, R K, Raso, M, Pollock, J. Biliary dyskinesia: the most common indication for cholecystectomy in children. Surgery 2005;138:726–31.CrossRefGoogle ScholarPubMed
Tasdemir, H A, Cetinkaya, M C, Polat, C. Gallbladder motility in children with Down syndrome. J Pediatr Gastroent Nutr 2004;39:187–91.CrossRefGoogle ScholarPubMed
Arlanoglu, I, Unal, F, Sagin, F. Real-time sonography for screening gallbladder dysfunction in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2001;14:61–9.Google Scholar
McClure, J, Benerjee, S S, Schofield, P S. Crohn's disease of the gallbladder. J Clin Pathol 1984;37:516–18.CrossRefGoogle Scholar
Ranchod, M, Kahn, L B. Malacoplakia of the GI tract. Arch Pathol 1972;94:90–7.Google Scholar
Livolsi, V A, Perzin, K H, Porter, M. Polyarteritis nodosa of the gallbladder presenting as acute cholecystitis. Gastroenterology 1973;65:115–23.Google ScholarPubMed
Mogilner, J G, Dharan, M, Siplovich, M. Adenoma of the gallbladder in childhood. J Pediatr Surg 1991;26:223–4.CrossRefGoogle ScholarPubMed
Stringel, G, Beneck, D, Bostwick, H E. Polypoid lesions of the gallbladder in children. J Soc Laparoendosc Surg 1997;1:247–9.Google ScholarPubMed
Foster, D R, Foster, D B E. Gallbladder polyps in Peutz-Jeghers syndrome. Postgrad Med J 1980;56:373–6.CrossRefGoogle ScholarPubMed
Cetinkursum, S, Surer, I, Devceci, S. Adenomyomatosis of the gallbladder in a child. Dig Dis Sci 2003;48:733–6.CrossRefGoogle Scholar
Alberti, D, Callea, F, Camoni, G. Adenomyomatosis of the gallbladder in childhood. J Pediatr Surg 1998;33:1411–12.CrossRefGoogle ScholarPubMed
Zani, A, Pacilli, M, Conforti, A. Adenomyomatosis of the gallbladder in childhood: report of a case and review of the literature. Pediatr Dev Path 2005;8:577–80.CrossRefGoogle ScholarPubMed
Ruymann, F B, Raney, R B, Crist, W M. Rhabdomyosarcoma of the biliary tree in childhood: a report from the Intergroup Rhabdomyosarcoma Study. Cancer 1985;56:575–81.Google ScholarPubMed
Casteel, H B, Williamson, S L, Golladay, E S. Porcelain gallbladder in a child: a case report. J Pediatr Surg 1990;25:1302–3.CrossRefGoogle Scholar
Snajdauf, J, Petru, O, Pycha, K. Porcelain gallbladder with extrahepatic duct obstruction in a child. Pediatr Surg Int 2006;22:293–6.CrossRefGoogle Scholar
Beauregard, W G, Ferguson, W T. Milk of calcium cholecystitis. J Pediatr 1980;96:876–7.CrossRefGoogle ScholarPubMed
Takiff, H, Funkalsrud, E W. Gallbladder disease in childhood. Am J Dis Child 1984;138:565–8.Google ScholarPubMed
Strom, B L, West, S L. The epidemiology of gallstone disease. In: Cohen, S, Soloway, R D. Gallstones. New York: Churchill Livingstone, 1985.Google Scholar
Friedman, G D, Kannel, W B, Dawber, T R. The epidemiology of gallbladder disease: observations in Framingham study. J Chron Dis 1966;19:273–92.CrossRefGoogle ScholarPubMed
Kingensmith, W C, Cioffi-Ragan, D T. Fetal gallstones. Radiology 1988;167:143–4.CrossRefGoogle Scholar
Suma, V, Marini, A, Bucci, N. Fetal gallstones: sonographic and clinical observations. Ultrasound Obstet Gynecol 1998;12:439–41.CrossRefGoogle ScholarPubMed
Ghose, I, Stringer, M D. Successful nonoperative management of neonatal acute calculous cholecystitis. J Pediatr Surg 1999;34:1029–30.CrossRefGoogle ScholarPubMed
Palasciano, G, Portincasa, P, Vinciguerra, V. Gallstone prevalence and gallbladder volume in children and adolescents: an epidemiological ultrasonographic survey and relationship to body mass index. Am J Gastroenterol 1989;84:1378–82.Google ScholarPubMed
Barbara, L, Sama, C, Labate, A M M. A population study on the prevalence of gallstone disease: the Sirmione Study. Hepatology 1987;7:913–17.CrossRefGoogle ScholarPubMed
Nilsson, S. Gallbladder disease and sex hormones. Acta Chir Scand 1966;132:275–9.Google ScholarPubMed
Jorgensen, T. Prevalence of gallstones in a Danish population. Am J Epidemiol 1987;126:912–21.CrossRefGoogle Scholar
Shaffer, E A, Small, D M. Gallstone disease: pathogenesis and management. Curr Probl Surg 1976;13:3–72.CrossRefGoogle ScholarPubMed
Friesen, C A, Roberts, C C. Cholelithiasis: clinical characteristics in children. Clin Pediatr 1989;7:294–8.CrossRefGoogle Scholar
Stringer, M D, Taylor, D R, Soloway, R D. Gallstone composition: are children different?J Pediatr 2003;142:435–40.CrossRefGoogle ScholarPubMed
Soderlund, S, Zetterstrom, B. Cholecystitis and cholelithiasis in children. Arch Dis Child 1962;37:174–80.CrossRefGoogle ScholarPubMed
Sears, H F, Golden, G T, Horsley, J S. Cholecystitis in adolescents. Arch Surg 1973;106:651–3.CrossRefGoogle Scholar
Newman, H F, Northrup, J D. The autopsy incidence of gallstones. Int Abst Surg 1959;109:1–13.Google ScholarPubMed
Trotman, B W, Soloway, R D. Pigment vs. cholesterol cholelithiasis: clinical and epidemiological aspects. Am J Dig Dis 1975;20:735–40.CrossRefGoogle ScholarPubMed
Holcomb, G W, Holcomb, G W. Cholelithiasis in infants, children and adolescents. Pediatr Rev 1991;11:268–74.CrossRefGoogle Scholar
Pokorny, W J, Saleem, M, O'Gorman, R B. Cholelithiasis and cholecystitis in childhood. Am J Surg 1984;148:742–4.CrossRefGoogle ScholarPubMed
MacMillan, R W, Schullinger, J N, Santulli, T V. Cholelithiasis in childhood. Am J Surg 1974;127:689–92.CrossRefGoogle ScholarPubMed
Harned, R K, Babbit, D P. Cholelithiasis in childhood. Radiology 1975;117:391–3.CrossRefGoogle Scholar
Andrassy, R J, Treadwell, T A, Ratner, I A. Gallbladder disease in childhood and adolescents. Am J Surg 1976;132:19–21.CrossRefGoogle Scholar
Odom, F C, Oliver, B B, Kline, M. Gallbladder disease in patients 20 years of age and younger. South Med J 1976;69:1299–300.CrossRefGoogle Scholar
Grace, N, Rogers, B. Cholecystitis in childhood. Clin Pediatr 1977;16:179–81.CrossRefGoogle ScholarPubMed
Reif, S, Sloven, D G, Lebenthal, E. Gallstones in children. Am J Dis Child 1991;145:105–8.CrossRefGoogle ScholarPubMed
Goodman, D B. Cholelithiasis in persons under 25 years old. JAMA 1976;236:1731–2.CrossRefGoogle ScholarPubMed
Bailey, P V, Connors, R H, Tracy, T F. Changing spectrum of cholelithiasis and cholecystitis in infants and children. Am J Surg 1989;158:585–8.CrossRefGoogle ScholarPubMed
Strauss, R T. Cholelithiasis in childhood. Am J Dis Child 1969;117:689–92.Google ScholarPubMed
Trotman, B W, Soloway, R D. Pigment gallstone disease: summary of the National Institutes of Health – International Workshop. Hepatology 1982;2:879–84.CrossRefGoogle ScholarPubMed
Dolgin, S M, Schwartz, S, Knessel, H S. Identification of patients with cholesterol on pigment stones by discriminant analysis of radiographic features. N Engl J Med 1981;304:808–11.CrossRefGoogle ScholarPubMed
Trotman, B W, Petrella, E J, Soloway, R D. Evaluation of radiographic lucency or opaqueness of gallstones as a means of identifying cholesterol or pigment stones. Gastroenterology 1975;68:1563–6.Google ScholarPubMed
Soloway, R D, Trotman, B W, Ostrow, J D. Pigment gallstones. Gastroenterology 1977;72:167–82.Google ScholarPubMed
Ostrow, J D, Celic, L. Bilirubin chemistry, ionization and solubilization by bile salts. Hepatology 1984;4:385–455.CrossRefGoogle ScholarPubMed
Cahalane, M J, Neubrand, M W, Carey, M C. Physical-chemical pathogenesis of pigment gallstones. Semin Liver Dis 1988;8: 317–28.CrossRefGoogle ScholarPubMed
LaMont, J T, Ventola, A S, Trotman, B W. Mucin glycoprotein content of human pigment gallstones. Hepatology 1983;3:377–82.CrossRefGoogle ScholarPubMed
Bond, L R, Hatty, S R, Horn, M E C. Gallstones in sickle cell disease in the United Kingdom. Br J Med 1987;295:234–6.CrossRefGoogle Scholar
Schubert, T T. Hepatobiliary system in sickle cell disease. Gastroenterology 1986;90:2013–21.CrossRefGoogle ScholarPubMed
Sarnaik, S, Slovis, T L, Corbett, D P. Incidence of cholelithiasis in sickle-cell anemia using the ultrasonic gray-scale technique. J Pediatrics 1980;96:1005–8.CrossRefGoogle ScholarPubMed
Walker, W M, Hambleton, I R, Serjeant, G R. Gallstones in sickle cell disease: observations from the Jamaican cohort study. J Pediatr 2000;136:80–5.CrossRefGoogle ScholarPubMed
Suell, M N, Horton, T M, Dishop, M K. Outcomes for children with gallbladder abnormalities and sickle cell disease. J Pediatr 2004;145:617–21.CrossRefGoogle ScholarPubMed
Alonso, M H. Gallbladder abnormalities in children with sickle cell disease: management with laparoscopic cholecystectomy. J Pediatr 2004;145:580–1.CrossRefGoogle Scholar
Matos, C, Avni, E F, Gansbeke, D. Total parenteral nutrition (TPN) and gallbladder diseases in neonates. J Ultrasound Med 1987;6:243–8.CrossRefGoogle ScholarPubMed
King, D R, Ginn-Pease, M E, Lloyd, T V. Parenteral nutrition with associated cholelithiasis: another iatrogenic disease of infants and children. J Pediatr Surg 1987;22:593–6.CrossRefGoogle ScholarPubMed
Roslyn, J J, Berquist, W E, Pitt, H A. Increased risk of gallstones in children receiving total parenteral nutrition. Pediatrics 1983;71:784–9.Google ScholarPubMed
Jacir, N N, Anderson, K D, Eichelberger, M. Cholelithiasis in infancy: resolution of gallstones in three of four infants. J Pediatr Surg 1986;21:567–9.CrossRefGoogle ScholarPubMed
Keller, M S, Markle, B M, Laffey, P A. Spontaneous resolution of cholelithiasis in infants. Radiology 1985;155:345–8.CrossRefGoogle Scholar
Schirmer, W J, Grisoni, E R, Gauderer, W L. The spectrum of cholelithiasis in the first year of life. J Pediatr Surg 1989;24:1064–7.CrossRefGoogle ScholarPubMed
Messing, B, Bories, C, Kunstlinger, F. Does total parenteral nutrition induce gallbladder sludge formation and lithiasis?Gastroenterology 1983;84:1012–19.Google ScholarPubMed
Sitzmann, J V, Pitt, H A, Steinborn, P A. Cholecystokinin prevents parenteral nutrition induced biliary sludge in humans. Surg Gynecol Obstet 1990;170:25–31.Google ScholarPubMed
Tsai, S, Strouse, P J, Drongowski, R A. Failure of cholecystokinin-octapeptide to prevent TPN-associated gallstone disease. J Pediatr Surg 2005;40:263–7.CrossRefGoogle ScholarPubMed
Mashako, N N L, Cezard, J-P, Borge, N. The effect of artificial feeding on cholestasis, gallbladder sludge and lithiasis in infants: correlation with plasma cholecystokinin levels. Clin Nutr 1991;10:320–7.CrossRefGoogle ScholarPubMed
Nicholas, P, Rinaudo, P A, Conn, C O. Increased incidence of cholelithiasis in Laennec's cirrhosis. Gastroenterology 1972;62:112–14.Google Scholar
Bonchier, I A D. Postmortem study of the frequency of gallstones in patients with cirrhosis of the liver. Gut 1969;10:705–10.CrossRefGoogle Scholar
Angelin, B, Einarsson, K, Ewerth, S. Biliary lipid composition in patients with portal cirrhosis of the liver. Scand J Gastroenterol 1980;15:849–52.CrossRefGoogle ScholarPubMed
Odievre, M, Gautier, M, Hadchouel, M. Severe familial intrahepatic cholestasis. Arch Dis Child 1973;48:806–12.CrossRefGoogle ScholarPubMed
Fiqueroa-Colon, R, Tolaymat, N, Kao, S C S. Gallbladder sludge and lithiasis in an infant born to a morphine user mother. J Pediatr Gastroenterol Nutr 1990;10:234–8.CrossRefGoogle Scholar
Schaad, U B, Suter, S, Gianella-Borradovi, A. A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children. N Engl J Med 1990;522:141–7.CrossRefGoogle Scholar
Xia, Y, Lembert, K, Gu, J J. The mechanism of biliary sludge formation during ceftriaxone therapy. Gastroenterology 1989;95:A674.Google Scholar
Mahmond, H, Schell, M, Pui, C-H. Cholelithiasis after treatment for childhood cancer. Cancer 1991;67:1439–42.3.0.CO;2-R>CrossRefGoogle Scholar
Sakopoulos, A G, Gundry, S, Razzouk, A J. Cholelithiasis in infant and pediatric heart transplant patients. Pediatr Transplant 2002;6:231–4.CrossRefGoogle ScholarPubMed
Percy, A K, Lane, J B. Rett syndrome: model of neurodevelopmental disorders. J Clin Neurol 2005;20:718–21.Google ScholarPubMed
Shaffer, E A. Gallbladder disease. In: Walker, W A, Durie, P R, Hamilton, J R., eds. Pediatric gastrointestinal disease. Vol 2. Philadelphia: Mosby, 1991:1152–70.Google Scholar
Treem, W R, Malet, P F, Gourley, G R. Bile and stone analysis in two infants with brown pigment gallstones and infected bile. Gastroenterology 1989;96:519–23.CrossRefGoogle ScholarPubMed
Holzbach, R T, Marsh, M, Olszewski, M. Cholesterol solubility in bile: evidence that supersaturated bile is frequent in healthy man. J Clin Invest 1973;52:1467–79.CrossRefGoogle ScholarPubMed
Admirand, W H, Small, D M. The physico-chemical basis of cholesterol gallstone formation in man. J Clin Invest 1968;47:1043–52.CrossRefGoogle Scholar
Carey, M C, Small, D M. The physical chemistry of cholesterol solubility in bile: relationship to gallstone formation and dissolution in man. J Clin Invest 1978;61:998–1026.CrossRefGoogle ScholarPubMed
Groen, A K, Noordam, C, Drapers, J A G. Isolation of a potent cholesterol nucleation-promoting activity from human gallbladder bile: role in the pathogenesis of gallstone disease. Hepatology 1990;11:525–33.CrossRefGoogle ScholarPubMed
Kibe, A, Holzbach, R T, LaRusso, N F. Inhibition of cholesterol crystal formation by apolipoproteins in supersaturated model bile. Science 1984;25:514–16.CrossRefGoogle Scholar
Bouchier, I A D, Cooperband, S R, Aikodsi, B M. Mucous substances and viscosity of normal and pathological human bile. Gastroenterology 1965;49:343–53.Google ScholarPubMed
Lee, S P, LaMont, J T, Carey, M C. Role of gallstone mucous hypersecretion in the evolution of cholesterol gallstone: studies in a prairie dog. J Clin Invest 1981;67:1712–23.CrossRefGoogle Scholar
Fridhandler, T M, Davison, J S, Shaffer, E A. Defective gallbladder contractility in the ground squirrel and prairie dog during the early stages of cholesterol gallstone formation. Gastroenterology 1983;85:830–6.Google ScholarPubMed
Kern, F, Everson, G T, DeMark, B. Biliary lipids, bile acids, and gallbladder function in the human female: effects of pregnancy and the ovulatory cycle. J Clin Invest 1981;68:1229–42.CrossRefGoogle ScholarPubMed
Heubi, J E, Soloway, R D, Balistreri, W F. Biliary lipid composition in healthy and diseased infants, children and young adults. Gastroenterology 1982;82:1295–9.Google ScholarPubMed
Bergmann, J, Bergmann, K, Hadorn, B. Biliary lipid composition in early childhood. Clin Chim Acta 1975;64:241–6.CrossRefGoogle Scholar
Heubi, J E, Balistreri, W F, Suchy, F J. Bile salt metabolism in first year of life. J Lab Clin Med 1982;100:127–36.Google ScholarPubMed
Bennion, L J, Knowler, W C, Mott, D M. Development of lithogenic bile during puberty in Pima Indians. N. Engl J Med 1979;300:873–6.CrossRefGoogle Scholar
Sampliner, R E, Bennett, P H, Comess, L J. Gallbladder disease in Pima Indians: demonstration of high prevalence and early onset by cholecystography. N Engl J Med 1970;283:1358–64.CrossRefGoogle ScholarPubMed
Bergmann, K, Becker, M, Leiss, O. Biliary cholesterol saturation in non-obese women and non-obese men before and after puberty. Eur J Clin Invest 1986;16:531–5.CrossRefGoogle Scholar
Bennion, L J, Grundy, S M. Effects of obesity and caloric intake on biliary lipid metabolism in man. J Clin Invest 1975;56:996–1011.CrossRefGoogle ScholarPubMed
Shaffer, E A, Small, D M. Biliary lipid secretion in cholesterol gallstone disease: the effect of cholecystectomy and obesity. J Clin Invest 1977;59:828–40.CrossRefGoogle ScholarPubMed
Honore, L H. Cholesterol cholelithiasis in adolescent females. Arch Surg 1980;114:62–4.CrossRefGoogle Scholar
Kaechele, V, Wabitsch, M, Thiere, D. Prevalence of gallbladder stone disease in obese children and adolescents: influence of the degree of obesity, sex and pubertal development. J Pediatr Gastroent Nutr 2006;42:66–70.CrossRefGoogle ScholarPubMed
Dowling, R H, Bell, G D, White, J. Lithogenic bile in patients with ileal dysfunction. Gut 1972;13:415–20.CrossRefGoogle ScholarPubMed
Brink, M A, Sors, J P M, Keulemans, C A. Enterohepatic cycling of bilirubin: a putative mechanism for pigment gallstone formation in Crohn's disase. Gastroenterology 1999;116:1420–7.CrossRefGoogle Scholar
Heaton, K W, Read, A E. Gallstones in patients with disorders of the terminal ileum and disturbed bile salt metabolism. Br Med J 1969;3:494–6.CrossRefGoogle Scholar
Baker, A L, Kaplan, M M, Norton, R A. Gallstones in inflammatory bowel disease. Am J Dig Dis 1974;19:109–12.CrossRefGoogle ScholarPubMed
Cohen, S, Kaplan, M, Gottlieb, L. Liver disease and gallstones in regional enteritis. Gastroenterology 1971;60:237–45.Google ScholarPubMed
Farkkila, M A. Biliary cholesterol and lithogenicity of bile in patients after ileal resection. Surgery 1988;104:18–25.Google Scholar
Pellerin, D, Bertin, P, Nikhoul-Fekete, C. Cholelithiasis and ileal pathology in childhood. J Pediatr Surg 1975;10:35–41.CrossRefGoogle ScholarPubMed
Kirks, D R. Lithiasis due to interruption of the enterohepatic circulation of bile salts. Am J Radiol 1979;133:383–8.Google ScholarPubMed
Heubi, J E, O'Connell, N C, Setchell, K D R. Ileal resection/dysfunction in childhood predisposes to lithogenic bile after puberty. Gastroenterology 1992;103:636–40.CrossRefGoogle ScholarPubMed
Esterly, J, Oppenheimer, E. Observations in cystic fibrosis of the pancreas: 1. the gallbladder. Johns Hopkins Hosp Bull 1962;110:247–54.Google Scholar
Williams, S M, Goodman, R, Thomson, A. Ultrasound evaluation of liver disease in cystic fibrosis as part of an annual assessment clinic: a 9-year review. Clin Radiol 2002;57:365–70.CrossRefGoogle ScholarPubMed
Weber, A, Roy, C, Morin, C. Malabsorption of bile acids in children with cystic fibrosis. N Engl J Med 1973;289:1001–5.CrossRefGoogle ScholarPubMed
Watkins, J, Tercyal, A, Szcepanik, P. Bile salt kinetics in cystic fibrosis: influence of pancreatic enzyme replacement. Gastroenterology 1977;73:1023–8.Google ScholarPubMed
Roy, C, Weber, A, Morin, C. Abnormal biliary lipid composition in cystic fibrosis. N Engl J Med 1977;297:1301–5.CrossRefGoogle ScholarPubMed
Strandvik, B, Angelin, B, Einarsson, K. Bile acid kinetics and bile lipid composition in cystic fibrosis [abstract]. Scand J Gastroenterol 1988;23(suppl 143):166.Google Scholar
Becker, M, Staab, D, Leiss, O. Biliary lipid composition in patients with cystic fibrosis. J Pediatr Gastroenterol Nutr 1989;8:308–12.CrossRefGoogle ScholarPubMed
Angelico, M, Gandin, C, Canuzzi, P. Gallstones in cystic fibrosis: a critical reappraisal. Hepatology 1991;14:768–75.CrossRefGoogle ScholarPubMed
Santamaria, F, Vajro, P, Oggero, V. Volume and emptying of the gallbladder in patients with cystic fibrosis. J Pediatr Gastroenterol Nutr 1990;10:303–6.CrossRefGoogle ScholarPubMed
Bennion, L J, Drobny, E, Knowler, W C. Sex differences in the size of bile acid pools. Metabolism 1978;27:961–9.CrossRefGoogle ScholarPubMed
Kern, F, Everson, G T, DeMark, B. Biliary lipids, bile acids, and gallbladder function in the human female: effects of pregnancy and the ovulatory cycle. J Clin Invest 1981;68:1229–42.CrossRefGoogle ScholarPubMed
Braverman, D Z, Johnson, M L, Kern, F. Effects of pregnancy and contraceptive steroids on gallbladder function. N Engl J Med 1980;302:362–4.CrossRefGoogle ScholarPubMed
Buimsohn, A, Albu, E, Geist, P H. Cholelithiasis and teenage mothers. J Adolesc Health Care 1990;11:339–42.CrossRefGoogle Scholar
Lancellotti, S, Zaffanello, M, DiLeo, E. Pediatric gallstone disease in familial hypobetalipoproteinemia. J Hepatol 2005;43:188–91.CrossRefGoogle ScholarPubMed
Gracie, W A, Ransohoff, D F. The natural history of silent gallstones. The innocent gallstone is not a myth. N Engl J Med 1982;307:798–800.CrossRefGoogle Scholar
Way, L A, Sleisenger, M H. Cholelithiasis: chronic and acute cholecystitis in gastrointestinal disease. In: Sleisinger, M H, Fordtran, J S. Gastrointestinal disease. 4th ed. Philadelphia: WB Saunders, 1989:1691–714.Google Scholar
Comfort, M W, Gray, H K, Wilson, J M. The silent gallstone: a ten to twenty year follow-up of 112 cases. Ann Surg 1948;128:931–7.CrossRefGoogle Scholar
Sauerbruch, T, Paumgartner, G. Gallbladder stones: management. Lancet 1991;338:1121–4.CrossRefGoogle ScholarPubMed
Simi, M, Schietroma, M, Carlei, F. Is laparoscopic cholecystectomy a safe alternative to open cholecystectomy for pediatric patients with cholelithiasis. Endoscopy 1996;28:312–15.CrossRefGoogle ScholarPubMed
Davidoff, A M, Branum, G D, Murray, E A. The technique of laparoscopic cholecystectomy in children. Ann Surg 1992;215:186–91.CrossRefGoogle ScholarPubMed
Vinograd, I, Halevy, A, Klin, B. Laparoscopic cholecystectomy: treatment of choice for cholelithiasis in children. World J Surg 1993;17:263–6.CrossRefGoogle ScholarPubMed
Ware, R E, Kinney, T R, Casey, J R. Laparoscopic cholecystectomy in young patients with sickle hemoglobinopathies. J Pediatr 1992;120:58–61.CrossRefGoogle ScholarPubMed
Holcomb, G W, Naffis, D. Laparoscopic cholecystectomy in infants. J Pediatr Surg 1994;29:86–7.CrossRefGoogle ScholarPubMed
The Southern Surgeons Club. A prospective analysis of 1518 laparoscopic cholecystectomies. N Engl J Med 1991;324:1073–8.CrossRef
Newman, K D, Marmon, L M, Attorri, R. Laparoscopic cholecystectomy in pediatric patients. J Pediatr Surg 1991;26:1184–5.CrossRefGoogle ScholarPubMed
Esposito, C, Gonzales Sabin, M A, Corcione, F. Results and complications of laparoscopic cholecystectomy in childhood. Surg Endosc 2001;15:890–2.CrossRefGoogle ScholarPubMed
Fromm, H, Malavolti, M. Dissolving gallstones. Adv Intern Med 1988;33:409–30.Google ScholarPubMed
Podda, M, Zuin, M, Battezzati, P M. Efficacy and safety of a combination of chenodeoxycholic acid and ursodeoxycholic acid for gallstone dissolution: a comparison with ursodeoxycholic acid alone. Gastroenterology 1989;96:222–9.CrossRefGoogle ScholarPubMed
Lancini, A, Jazrawi, R P, Kupfer, R M. Gallstone recurrence after medical dissolution: an overestimated threat?J Hepatol 1986;3:241–6.CrossRefGoogle Scholar
O'Donnell, L D J, Heaton, K W. Recurrence and re-recurrence of gallstones after medical dissolution: a long-term follow up. Gut 1988;29:655–8.CrossRefGoogle Scholar
Villanova, N, Bazzoli, F, Taroni, F. Gallstone recurrence after successful oral bile acid treatment. Gastroenterology 1989;97:726–31.CrossRefGoogle ScholarPubMed
Sackman, M, Pauletzki, J, Sauerbruch, T. The Munich gallbladder lithotripsy study: results of the first five years with 711 patients. Ann Intern Med 1991;114:290–6.CrossRefGoogle Scholar
Schoenfield, L J, Berci, G, Carnoval, R L. The effect of ursodiol on the efficacy and safety of extracorporeal shock-wave lithotripsy of gallbladder stones: the Dornier National Biliary Lithotripsy Study. N Engl J Med 1990;323:1239–45.CrossRefGoogle ScholarPubMed
Sackmann, M, Ippisch, E, Sauerbruch, T. Early gallstone recurrence rate after successful shock-wave therapy. Gastroenterology 1990;98:392–6.CrossRefGoogle ScholarPubMed
Diehl, A K. Gallstone size and the risk of gallbladder cancer. JAMA 1983;250:2323–6.CrossRefGoogle ScholarPubMed

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