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Chapter 14 - Sleep–Wake Disorders in Parkinson’s Disease

from Section 2: - Hypokinetic Movement Disorders

Published online by Cambridge University Press:  07 January 2025

By
Alex Iranzo  and
Christian R. Baumann
Edited by
Erik Ch. Wolters  and
Christian R. Baumann
Erik Ch. Wolters
Affiliation:
Universität Zürich
Christian R. Baumann
Affiliation:
Universität Zürich
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Summary

Sleep–wake disturbances belong to the most frequent non-motor symptoms in patients with Parkinson’s disease. They encompass insomnia, excessive daytime sleepiness, different forms of parasomnias, sleep-related breathing disorders, restless legs syndrome, and circadian sleep–wake disorders. All of these sleep–wake disorders have the potential to severely impact the quality of life of patients and their bedpartners, and some of them not only get more frequent with longer disease duration, but may even precede motor manifestations of Parkinson’s disease. Isolated REM sleep behavior disorder in particular is a specific biomarker heralding synuclein-related neurodegenerative disease. Although very common, both diagnostic and therapeutic approaches for Parkinson-related sleep–wake disorders are still under evaluation. This chapter discusses the current knowledge on the pathophysiology and clinical manifestations of Parkinson-related sleep–wake disorders, and contributes a clinical guide on how to diagnose and treat them.

Keywords

insomniaexcessive daytime sleepinesscircadian disordersleep apnearestless legs syndromehypersomnia
Type
Chapter
Information
International Compendium of Movement Disorders , pp. 166 - 180
Publisher: Cambridge University Press
Print publication year: 2025

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