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Chapter 5 - Automation and Robotics with the Agilent Dako Omnis

Published online by Cambridge University Press:  16 June 2022

By
Andrew Dinan
Edited by
Trung Nguyen
Trung Nguyen
Affiliation:
Peter MacCallum Cancer Centre, Australia
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Summary

Immunohistochemistry robotics and automation as defined by Agilent comes in the form of the Dako Omnis. An appraisal is given by a medical scientist with intimate knowledge of the principles behind the technology, the various machine components and Dako’s proprietary reagents. Daily operations with the instrument allow for an honest review of stain protocols, workflow logistics and maintenance obligations. An explanation of the unique dynamic gap technology is provided along with in-built quality assurance measures. As the Omnis is a new instrument when compared to Leica’s Bond III and Ventana’s BenchMark ULTRA, discussions are based upon the good and bad points of both the hardware and the software aspects. The reader should get an idea of how the Omnis produces stained slides and the capabilities of the machine.

Keywords

dynamic gapinstrumentationautostainerFlexprotocoloptimizationvalidationvendormanufacturerpolymer
Type
Chapter
Information
Immunohistochemistry
A Technical Guide to Current Practices
 , pp. 120 - 159
Publisher: Cambridge University Press
Print publication year: 2022

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References

Agilent 2018. Dako Omnis: A comprehensive IHC and ISH solution designed for true patient case management. Agilent Technologies (online). Available at www.agilent.com/cs/library/datasheets/public/29067_dako-omnis-data-sheet.pdf (Accessed 1 March 2020).Google Scholar
Brenner, TL, Adams, VR 1999. First MAb approved for treatment of metastatic breast cancer. J Am Pharm Assoc (Wash) 39(2):236–8.Google Scholar
Diercks, GF, Pas, HH, Jonkman, MF 2017. Immunofluorescence of autoimmune bullous diseases. Surg Pathol Clin 10(2):505–12.CrossRefGoogle ScholarPubMed
Mogens, V, Nielsen, S 2016. Proficiency testing in immunohistochemistry: Experiences from Nordic Immunohistochemical Quality Control (NordiQC). Virchows Arch 468:19–29.Google Scholar
Rasmussen, OF, Binzer, T, Rudbeck, L 2014. Dynamic gap staining: A new IHC staining technology. Agilent Technologies (online). Available at www.agilent.com/cs/library/whitepaper/public/29079_dynamic_gap_staining.pdf (Accessed 1 March 2020).Google Scholar

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