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Chapter 30 - Contributions of Ovarian Stromal Cells to Follicle Culture

from Section 8 - In Vitro Follicle Culture

Published online by Cambridge University Press:  27 March 2021

By
Emma S Gargus  and
Teresa K Woodruff
Edited by
Jacques Donnez  and
S. Samuel Kim
Jacques Donnez
Affiliation:
Catholic University of Louvain, Brussels
S. Samuel Kim
Affiliation:
University of Kansas School of Medicine
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Summary

With the advent of culture models for studying the process of ovarian folliculogenesis some 40 years ago, opportunities arose for the more systematic evaluation of the factors that regulated ovarian function [1]. The initial focus of studies using cultured follicles emphasized two of the then widely recognized roles of the follicle in mammals: the production of ovarian steroid hormones and of viable oocytes during the process of ovulation. As our understanding of the molecular and cellular complexity of this tissue compartment has evolved and deepened, so too has the need to redefine the major functions of the follicle at both local ovarian and systemic levels in the context of reproduction in mammalian species, especially as it relates to the origins and treatments for human infertility [2]. Thus, a shift in the motivation to use cultured follicles in humans has taken place owing primarily to the rapidly evolving field of fertility preservation.

Type
Chapter
Information
Fertility Preservation
Principles and Practice
 , pp. 341 - 354
Publisher: Cambridge University Press
Print publication year: 2021

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