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34 - Developmental origins of health and disease: public-health perspectives

Published online by Cambridge University Press:  08 August 2009

By
Catherine Law  and
Janis Baird
Edited by
Peter Gluckman  and
Mark Hanson
Catherine Law
Affiliation:
University College, London
Janis Baird
Affiliation:
University of Southampton
Peter Gluckman
Affiliation:
University of Auckland
Mark Hanson
Affiliation:
University of Southampton
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Summary

Introduction

The World Health Organization (WHO) describes public health as a social and political concept. It is based in ‘a comprehensive understanding of the ways in which lifestyles and living conditions determine health status, and a recognition of the need to mobilise resources and make sound investments in policies, programmes and services which create, maintain and protect health by supporting healthy lifestyles and creating supportive environments for health’ (World Health Organization 1998). From this, it follows that a public-health perspective on developmental origins of health and disease is focused on effecting change rather than dissection of the aetiology. Nonetheless, understanding of the mechanisms that underlie relationships between early life and adult disease would be helpful, though arguably not essential, in developing policies or programmes to improve public health.

The preceding chapters have illustrated the complexity of the human as a biological organism. In the biomedical science base the determinants of adult health include concepts such as gene expression, modulation of physiological systems and evolutionary pressures such as predictive adaptive responses (Hanson et al. 2004). Figure 34.1 shows a public-health view of the determinants of health. In this, the biological characteristics of individuals are central, but they are influenced by and interact with layers of influence deriving from their lifestyles, their social and community networks and the services (public and private) that they need or can access. All of these may be influenced by general economic, cultural and environmental conditions.

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Developmental Origins of Health and Disease , pp. 446 - 455
Publisher: Cambridge University Press
Print publication year: 2006

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References

Aihie, Sayer A., Poole, J., Cox, V.et al. (2003). Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis. Arthritis Rheum, 48, 1030–3.Google Scholar
Baird, J., Lucas, P., Fisher, D., Kleijnen, J., Roberts, H. and Law, C. M. (2005). Defining optimal infant growth for lifetime health: a systematic review of lay and scientific literature. MRC Epidemiology Resource Centre, University of Southampton. www.mrc.soton.ac.uk.
Barker, D. J. P. (2002). Commentary: components in the interpretation of the high mortality in the county of Finland. Int. J. Epidemiol., 31, 309–10.CrossRefGoogle Scholar
Barker, D. J. P., Winter, P. D., Osmond, C., Margetts, B. and Simmonds, S. J. (1989). Weight in infancy and death from ischaemic heart disease. Lancet, 2, 577–80.CrossRefGoogle ScholarPubMed
Barker, D. J. P., Osmond, C., Rodin, I., Fall, C. H. D. and Winter, P. D. (1995). Low weight gain in infancy and suicide in adult life. BMJ, 311, 1203.CrossRefGoogle ScholarPubMed
Barker, D. J. P., Eriksson, J. G., Forsen, T. and Osmond, C. (2002). Fetal origins of adult disease: strength of effects and biological basis. Int. J. Epidemiol., 31, 1235–9.CrossRefGoogle ScholarPubMed
Barker, D. J. P., Osmond, C., Forsen, T. J., Kajantie, E. and Eriksson, J. G. (2005). Trajectories of growth among children who have coronary events as adults. N. Engl. J. Med., 353, 1802–9.CrossRefGoogle ScholarPubMed
Bhargava, S. K., Sachdev, H. S., Fall, C. H.et al. (2004). Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N. Engl. J. Med., 350, 865–75.CrossRefGoogle ScholarPubMed
Black, N. (2001). Evidence based policy: proceed with care. BMJ, 323, 275–9.CrossRefGoogle ScholarPubMed
Campbell, M., Fitzpatrick, R., Haines, A.et al. (2000). Framework for design and evaluation of complex interventions to improve health. BMJ, 321, 694–6.CrossRefGoogle ScholarPubMed
Croce, P. (1999). Vivisection or Science? An Investigation into Testing Drugs and Safeguarding Health. London: Zed Books.Google Scholar
Curhan, G. C., Willett, W. C., Rimm, E. B., Spiegelman, D., Ascherio, A. L. and Stampfer, M. J. (1996). Birth weight and adult hypertension, diabetes mellitus and obesity in US men. Circulation, 94, 3246–50.CrossRefGoogle ScholarPubMed
Dahlgren, G. and Whitehead, M. (1991). Policies and Strategies to Promote Social Equity in Health. Stockholm: Institute of Futures Studies.Google Scholar
Delisle, H. (2002). Programming of Chronic Disease by Impaired Fetal Nutrition; Evidence and Implications for Policy and Intervention Strategies. Geneva: World Health Organization.Google Scholar
Department of Health (2003). Tackling Health Inequalities. London: Department of Health.
Stavola, B. L., Hardy, R., Kuh, D., Santos Silva, dos I., Wadsworth, M. and Swerdlow, A. J. (2000). Birthweight, childhood growth and risk of breast cancer in a British cohort. Br. J. Cancer, 83, 964–8.CrossRefGoogle Scholar
Stavola, B. L., Santos Silva, dos I., McCormack, V., Hardy, R. J., Kuh, D. J. and Wadsworth, M. E. (2004). Childhood growth and breast cancer. Am. J. Epidemiol., 159, 671–82.CrossRefGoogle ScholarPubMed
Eriksson, J. G., Forsen, T., Tuomilehto, J., Winter, P. D., Osmond, C. and Barker, D. J. P. (1999). Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ, 318, 427–31.CrossRefGoogle ScholarPubMed
Eriksson, J. G., Forsen, T., Tuomilehto, J., Osmond, C. and Barker, D. J. P. (2001). Early growth and coronary heart disease in later life: longitudinal study. BMJ, 322, 949–53.CrossRefGoogle ScholarPubMed
Eriksson, J. G., Forsen, T., Tuomilehto, J., Jaddoe, V. W. V., Osmond, C. and Barker, D. J. P. (2002). Effects of size at birth and childhood growth on the insulin resistance syndrome in elderly individuals. Diabetologia, 45, 342–8.CrossRefGoogle ScholarPubMed
Eriksson, J. G., Forsen, T., Tuomilehto, J., Osmond, C. and Barker, D. P. J. (2003). Early adiposity rebound in childhood and risk of type 2 diabetes in adult life. Diabetologia, 46, 190–4.CrossRefGoogle ScholarPubMed
Fall, C. H. D., Barker, D. J. P., Osmond, C., Winter, P. D., Clark, P. M. S. and Hales, C. N. (1992). Relation of infant feeding to adult serum cholesterol concentration and death from ischaemic heart disease. BMJ, 304, 801–5.CrossRefGoogle ScholarPubMed
Fall, C. H. D., Osmond, C., Barker, D. J. P.et al. (1995). Fetal and infant growth and cardiovascular risk factors in women. BMJ, 310, 428–32.CrossRefGoogle ScholarPubMed
Fisher, D. J., Baird, J., Lucas, P., Roberts, H., Kleijnan, J. and Law, C. M. (2004). Is infant growth related to health and well-being in adulthood? A systematic review of the evidence. Poster presented at the Society for Social Medicine 48th Annual Scientific Meeting. University of Birmingham, 15–17 September 2004.
Forsen T, , Eriksson, J. G., Tuomilehto, J., Teramo, K., Osmond, C. and Barker, D. J. P. (1997). Mother's weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study. BMJ, 315, 837–40.CrossRefGoogle Scholar
Forsen T, , Eriksson, J. G., Tuomilehto, J., Osmond, C. and Barker, D. J. P. (1999). Growth in utero and during childhood among women who develop coronary heart disease: longitudinal study. BMJ, 319, 1403–7.CrossRefGoogle ScholarPubMed
Forsen, T., Osmond, C., Eriksson, J. G. and Barker, D. J. P. (2004). Growth of girls who later develop coronary heart disease. Heart, 90, 20–4.CrossRefGoogle ScholarPubMed
Frankel, S., Elwood, J. H., Sweetnam, P., Yarnell, J. and Davey, Smith G. (1996). Birthweight, adult risk factors and incident coronary heart disease: the Caerphilly study. Public Health, 110, 139–43.CrossRefGoogle ScholarPubMed
Gunnell, D. J., Davey Smith, G., Frankel, S.et al. (1998). Childhood leg length and adult mortality: follow up of the Carnegie (Boyd Orr) Survey of Diet and Health in Pre-war Britain. J. Epid. Comm. Health, 52, 142–52.CrossRefGoogle ScholarPubMed
Hales, C. N., Barker, D. J. P., Clark, P. M. S.et al. (1991). Fetal and infant growth and impaired glucose tolerance at age 64. BMJ, 303, 1019–22.CrossRefGoogle ScholarPubMed
Hanson, M., Gluckman, P., Bier, D.et al. (2004). Report of the 2nd World Congress on Fetal Origins of Adult Disease, Brighton, UK., June 7–10, 2003. Pediatr. Res., 55, 894–7.CrossRefGoogle ScholarPubMed
Harding, J. E. (2001). The nutritional basis of the fetal origins of adult disease. Int. J. Epidemiol., 30, 15–23.CrossRefGoogle ScholarPubMed
Hill, A. B. (1965). The environment and disease: association or causation? Proc. R. Soc. Med., 58, 295–300.Google ScholarPubMed
Huxley, R., Neil, A. and Collins, R. (2002). Unravelling the fetal origins hypothesis: is there really an inverse assocation between birthweight and subsequent blood pressure? Lancet, 360, 659–65.CrossRefGoogle Scholar
Huxley, R. R., Shiell, A. W. and Law, C. M. (2000). The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature. J. Hypertens., 18, 815–31.CrossRefGoogle ScholarPubMed
Independent Inquiry into Inequalities in Health. (1998). Report of the Independent Inquiry into Inequalities in Health. London: Stationery Office.
Jones, W. H. S. (1923). Hipprocrates. Loeb Classical Libary, 147: Ancient Medicine. Cambridge, MA; Harvard University Press.Google Scholar
Kmietowicz, Z. (2002). Government launches intensive media campaign on MMR. BMJ, 324, 383.CrossRefGoogle ScholarPubMed
Kramer, M. S. (2000). Invited commentary: association between restricted fetal growth and adult chronic disease. Is it causal? Is it important? Am. J. Epidemiol, 152, 605–8.CrossRefGoogle ScholarPubMed
Langley-Evans, S. C., Langley-Evans, A. J. and Marchand, M. C. (2003). Nutritional programming of blood pressure and renal morphology. Arch. Physiol. Biochem., 111, 8–16.CrossRefGoogle ScholarPubMed
Law, C. M. (2002). Commentary: using research evidence to promote cardiovascular health in children. Int. J. Epidemiol., 31, 1127–9.CrossRefGoogle ScholarPubMed
Lawlor, D. A., Ebrahim, S. and Davey, Smith G. (2002). Is there a sex difference in the association between birth weight and systolic blood pressure in later life? Findings from a meta-regression analysis. Am. J. Epidemiol., 156, 1100–4.CrossRefGoogle Scholar
Leon, D. A., Koupilova, I., Lithell, H. O.et al. (1996). Failure to realise growth potential in utero and adult obesity in relation to blood pressure in 50 year old Swedish men. BMJ, 312, 401–6.CrossRefGoogle ScholarPubMed
Leon, D. A., Lithell, H. O., Vagero, D.et al. (1998). Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15,000 Swedish men and women born 1915–29. BMJ, 317, 241–5.CrossRefGoogle ScholarPubMed
Lucas, A., Fewtrell, M. S. and Cole, T. J. (1999). Fetal origins of adult disease: the hypothesis revisited. BMJ, 319, 245–9.CrossRefGoogle ScholarPubMed
Lucas, P. J., Roberts, H., Baird, J., Fisher, D. J. and Law, C. M. (2004). Who cares about growth? The views of parents and others on the importance of growth in babies. Poster presented at the Society for Social Medicine 48th Annual Scientific Meeting. University of Birmingham, 15–17 September 2004.
Marmot, M. (2001). Aetiology of coronary heart disease. BMJ, 323, 1261–2.CrossRefGoogle ScholarPubMed
Martyn, C. N., Barker, D. J. P. and Osmond, C. (1996). Mothers' pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK. Lancet, 348, 1264–8.CrossRefGoogle ScholarPubMed
Measham, A. and Gillespie, S. (1998). Implementation Completion Report: Second Tamil Nadu Integrated Nutrition Project. Washington, DC: World Bank.Google Scholar
Merialdi, M., Carroli, G., Villar, J.et al. (2003). Nutritional interventions during pregnancy for the prevention or treatment of impaired fetal growth: an overview of randomized controlled trials. J Nutr., 133, 1626–31S.CrossRefGoogle ScholarPubMed
Mi, J., Law, C. M., Zhang, K-L., Osmond, C., Stein, C. and Barker, D. (2000). Effects of infant birthweight and maternal body mass index in pregnancy on components of the insulin resistance syndrome in China. Ann. Int. Med., 132, 253–60.CrossRefGoogle Scholar
Murray, C. J. L. and Lopez, A. D. (1997). Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet, 349, 1498–504.CrossRefGoogle ScholarPubMed
Osmond, C., Barker, D. J. P., Winter, P. D., Fall, C. H. D. and Simmonds, S. J. (1993). Early growth and death from cardiovascular disease in women. BMJ, 307, 1519–24.CrossRefGoogle ScholarPubMed
Owen, C. G., Whincup, P. H., Odoki, K., Gilg, J. A. and Cook, D. G. (2003a). Birthweight and blood cholesterol level: a study of adolescents and systematic review. Pediatrics, 111, 1081–9.CrossRefGoogle Scholar
Owen, C. G., Whincup, P. H., Gilg, J. A. and Cook, D. G. (2003b). Effect of breast feeding in infancy on blood pressure in later life: systematic review and meta-analysis. BMJ, 327, 1189–95.CrossRefGoogle Scholar
Parsons, T. J., Power, C. and Manor, O. (2001). Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort. BMJ, 323, 1331–5.CrossRefGoogle ScholarPubMed
Podja, J. and Kelly, L. (2000). Low birthweight: a report based on the International Low Birthweight Symposium, Dhaka, Bangladesh, June 1999. United Nations Administrative Committee on Coordination/Sub-Committee on Nutrition. Geneva; World Health Organization.
Ravelli, A. C. J., Meulen, J. H. P., Michels, R. P. J.et al. (1998). Glucose tolerance in adults after prenatal exposure to famine. Lancet, 351, 173–7.CrossRefGoogle Scholar
Rich-Edwards, J., Stampfer, M., Manson, J.et al. (1995). Birthweight, breastfeeding and the risk of coronary heart disease in the Nurses Health Study. Am. J. Epidemiol, 141, S78.Google Scholar
Robinson, R. (2001). The fetal origins of adult disease. BMJ, 322, 375–6.CrossRefGoogle ScholarPubMed
Rose, G. (1985). Sick individuals and sick populations. Int. J. Epidemiol., 14, 32–8.CrossRefGoogle ScholarPubMed
Rose, G. (1992). The Strategy of Preventive Medicine. Oxford: Oxford University Press.Google Scholar
Rush, D. (2000). Nutrition and maternal mortality in the developing world. Am. J. Clin. Nutr., 72, 212–40S.CrossRefGoogle ScholarPubMed
Singhal, A. and Lucas, A. (2004). Early origins of cardiovascular disease: is there a unifying hypothesis? Lancet, 363, 1642–5.CrossRefGoogle Scholar
Singhal, A., Cole, T. J. and Lucas, A. (2001). Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet, 357, 413–19.CrossRefGoogle ScholarPubMed
Stein, C. E., Fall, C. H. D., Kumaran, K., Osmond, C., Cox, V. and Barker, D. J. P. (1996). Fetal growth and coronary heart disease in South India. Lancet, 348, 1269–73.CrossRefGoogle ScholarPubMed
Susser, M. and Levin, B. (1999). Ordeals for the fetal programming hypothesis: the hypothesis largely survives one ordeal but not another. BMJ, 318, 885–6.CrossRefGoogle ScholarPubMed
Syddall, H. E., Aihie Sayer, A., Simmonds, S. J.et al. (2005). Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study. Am. J. Epidemiol., 161, 1074–80.CrossRefGoogle ScholarPubMed
Thompson, C., Syddall, H., Rodin, I., Osmond, C. and Barker, D. J. P. (2001). Birth weight and the risk of depressive disorder in late life. Br. J. Psychiatry, 179, 450–5.CrossRefGoogle ScholarPubMed
Trostel, P. A. and Taylor, G. A. (2001). A theory of time preference. Economic Inquiry 39, 379–95.CrossRefGoogle Scholar
United Nations (1999). UN Convention on the Rights of the Child. Geneva: United Nations.
Whincup, P. H., Cook, D. G. and Shaper, A. G. (1989). Early influences on blood pressure: a study of children aged 5–7 years. BMJ, 299, 587–91.CrossRefGoogle ScholarPubMed
World Health Organization (1998). Health Promotion Glossary. Geneva: World Health Organization.
World Health Organization. (2001). Life Course Perspectives on Coronary Heart Disease, Stroke and Diabetes. Geneva: WHO.

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