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16 - Depression and physical activity

from Part 3 - Biological and behavioural processes

Published online by Cambridge University Press:  17 September 2009

Andrew Steptoe
Affiliation:
Department of Epidemiology and Public Health, University College London, London, UK
Andrew Steptoe
Affiliation:
University College London
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Summary

Introduction

There is an extensive scientific literature dating back several decades linking lack of physical exercise with depressed mood, limited coping skills and low levels of psychological well-being [1, 2]. Physical inactivity is also associated with increased risk for many of the medical problems discussed in this book. In some illnesses, such as coronary heart disease (CHD), physical inactivity is thought to have a causal role in disease risk, mediated through metabolic and other pathways [3]. In other conditions, such as chronic pain, inactivity does not cause the problem but nevertheless it contributes to disability. Physical exercise is also important in the regulation and management of chronic conditions, such as diabetes. The question therefore arises of whether the associations between depression and medical problems are mediated through low levels of physical activity and increased sedentary behaviour. Such possibilities have important implications for prevention and patient care.

This chapter discusses the evidence linking physical activity, depression and medical problems and addresses two general questions: First, is reduced physical activity responsible in part for associations between depression and the medical conditions and disabilities discussed in this book? Second, can increases in physical exercise improve the mood of patients and, therefore, be used in the management of these medical problems? The chapter begins with a discussion of the associations between physical activity, depression and depressed mood in clinical and population studies.

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Publisher: Cambridge University Press
Print publication year: 2006

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References

Hammett, V. B., Psychological changes with physical fitness training. Can. Med. Assoc. J. 96 (1967), 764–9.Google Scholar
Folkins, C. H., Sime, W. E., Physical fitness training and mental health. Am. Psychol. 36 (1981), 373–89.Google Scholar
Thompson, P. D., Buchner, D., Pina, I. L., et al., Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation 107 (2003), 3109–16.Google Scholar
Jolliffe, J. A., Rees, K., Taylor, R. S., et al., Exercise-based rehabilitation for coronary heart disease. Cochrane Database Syst. Rev. (1) (2001), CD001800.Google Scholar
Penninx, B. W., Rejeski, W. J., Pandya, J., et al., Exercise and depressive symptoms: a comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology. J. Gerontol. B Psychol. Sci. Soc. Sci. 57 (2002), P124–32.Google Scholar
Mittleman, M. A., Maclure, M., Tofler, G. H., et al., Triggering of acute myocardial infarction by heavy physical exertion: protection against triggering by regular exertion – Determinants of Myocardial Infarction Onset Study Investigators. N. Engl. J. Med. 329 (1993), 1677–83.Google Scholar
Johnsgard, K. W., The Exercise Prescription for Depression and Anxiety (New York: Plenum Press, 1989).
Morgan, W. P., Goldston, S. E. (eds), Exercise and Mental Health (Washington, DC: Hemisphere, 1987).
Stephens, T., Physical activity and mental health in the United States and Canada evidence from four population surveys. Prev. Med. 17 (1988), 35–47.Google Scholar
Goodwin, A. D., Association between physical activity and mental disorders among adults in the United States. Prev. Med. 36 (2003), 698–703.Google Scholar
Brown, D. W., Brown, D. R., Heath, G. W., et al., Associations between physical activity dose and health-related quality of life. Med. Sci. Sports Exerc. 36 (2004), 890–96.Google Scholar
Mendlowicz, M. V., Jean-Louis, G., Gizycki, H., Zizi, F., Nunes, J., Actigraphic predictors of depressed mood in a cohort of non-psychiatric adults. Aust. N. Z. J. Psychiatry 33 (1999), 553–8.Google Scholar
Teicher, M. H., Actigraphy and motion analysis: new tools for psychiatry. Harv. Rev. Psychiatry 3 (1995), 18–35.Google Scholar
Steptoe, A., Butler, N., Sports participation and emotional wellbeing in adolescents. Lancet 347 (1996), 1789–92.Google Scholar
Brodersen, N. H., Steptoe, A., Williamson, S., Wardle, J., Sociodemographic, developmental, environmental, and psychological correlates of physical activity and sedentary behavior at age 11 to 12. Ann. Behav. Med. 29 (2005), 2–11.Google Scholar
Goodman, R., Psychometric properties of the strengths and difficulties questionnaire. J. Am. Acad. Child Adolesc. Psychiatry 40 (2001), 1337–45.Google Scholar
Camacho, T. C., Roberts, R. E., Lazarus, N. B., Kaplan, G. A., Cohen, R. D., Physical activity and depression evidence from the Alameda County Study. Am. J. Epidemiol. 134 (1991), 220–31.Google Scholar
Strawbridge, W. J., Deleger, S., Roberts, R. E., Kaplan, G. A., Physical activity reduces the risk of subsequent depression for older adults. Am. J. Epidemiol. 156 (2002), 328–34.Google Scholar
Farmer, M. E., Locke, B. Z., Moscicki, E. K., et al., Physical activity and depressive symptoms: the NHANES I Epidemiologic Follow-up Study. Am. J. Epidemiol. 128 (1988), 1340–51.Google Scholar
Lampinen, P., Heikkinen, R. L., Ruoppila, I., Changes in intensity of physical exercise as predictors of depressive symptoms among older adults: an eight-year follow-up. Prev. Med. 30 (2000), 371–80.Google Scholar
Mobily, K. E., Rubenstein, L. M., Lemke, J. H., O'Hara, M. W., Wallance, R. B., Walking and depression in a cohort of older adults: The Iowa 65+ Rural Health Study. J. Aging Phys. Act. 4 (1996), 119–35.Google Scholar
Morgan, K., Bath, P. A., Customary physical activity and psychological wellbeing: a longitudinal study. Age Ageing 27: Suppl 3 (1998), 35–40.Google Scholar
Kritz-Silverstein, D., Barrett-Connor, E., Corbeau, C., Cross-sectional and prospective study of exercise and depressed mood in the elderly: the Rancho Bernardo study. Am. J. Epidemiol. 153 (2001), 596–603.Google Scholar
Weyerer, S., Physical inactivity and depression in the community: evidence from the Upper Bavarian Field Study. Int. J. Sports Med. 13 (1992), 492–6.Google Scholar
Stewart, A. L., Hays, R. D., Wells, K. B., et al., Long-term functioning and well-being outcomes associated with physical activity and exercise in patients with chronic conditions in the Medical Outcomes Study. J. Clin. Epidemiol. 47 (1994), 719–30.Google Scholar
Cooper-Patrick, L., Ford, D. E., Mead, L. A., Chang, P. P., Klag, M. J., Exercise and depression in midlife: a prospective study. Am. J. Public Health 87 (1997), 670–73.Google Scholar
Foreyt, J. P., Brunner, R. L., Goodrick, G. K., Jeor, S. T. St, Miller, G. D., Psychological correlates of reported physical activity in normal-weight and obese adults: the Reno diet-heart study. Int. J. Obes. Relat. Metab. Disord. 19: Suppl 4 (1995), 69–72.Google Scholar
Motl, R. W., Birnbaum, A. S., Kubik, M. Y., Dishman, R. K., Naturally occurring changes in physical activity are inversely related to depressive symptoms during early adolescence. Psychosom. Med. 66 (2004), 336–42.Google Scholar
Sobin, C., Sackeim, H. A., Psychomotor symptoms of depression. Am. J. Psychiatry 154 (1997), 4–17.Google Scholar
Raoux, N., Benoit, O., Dantchev, N., et al., Circadian pattern of motor activity in major depressed patients undergoing antidepressant therapy: relationship between actigraphic measures and clinical course. Psychiatry Res. 52 (1994), 85–98.Google Scholar
Volkers, A. C., Tulen, J. H., Broek, W. W., et al., 24-hour motor activity after treatment with imipramine or fluvoxamine in major depressive disorder. Eur. Neuropsychopharmacol. 12 (2002), 273–8.Google Scholar
Biddle, S. J. H., Mutrie, N., Psychology of Physical Activity (London: Routledge, 2001).
Lawlor, D. A., Hopker, S. W., The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials. Br. Med. J. 322 (2001), 763–7.Google Scholar
A. Steptoe, Physical activity and psychological well-being. In Physical Activity and Mental Health, ed. Norgan, N. G. (Cambridge: Cambridge University Press, 1992), pp. 207–29.
Sonstroem, R. J., Morgan, W. P., Exercise and self-esteem: rationale and model. Med. Sci. Sports Exerc. 21 (1989), 329–37.Google Scholar
Hollis, S., Campbell, F., What is meant by intention to treat analysis? Survey of published randomised controlled trials. Br. Med. J. 319 (1999), 670–74.Google Scholar
Blumenthal, J. A., Babyak, M. A., Moore, K. A., et al., Effects of exercise training on older patients with major depression. Arch. Intern. Med. 159 (1999), 2349–56.Google Scholar
Mather, A. S., Rodriguez, C., Guthrie, M. F., et al., Effects of exercise on depressive symptoms in older adults with poorly responsive depressive disorder: randomised controlled trial. Br. J. Psychiatry 180 (2002), 411–15.Google Scholar
Singh, N. A., Clements, K. M., Fiatarone, M. A., A randomized controlled trial of progressive resistance training in depressed elders. J. Gerontol. A Biol. Sci. Med. Sci. 52 (1997), M27–35.Google Scholar
Dunn, A. L., Trivedi, M. H., Kampert, J. B., Clark, C. G., Chambliss, H. O., Exercise treatment for depression: efficacy and dose response. Am. J. Prev. Med. 28 (2005), 1–8.Google Scholar
Dunn, A. L., Trivedi, M. H., Kampert, J. B., Clark, C. G., Chambliss, H. O., The DOSE study: a clinical trial to examine efficacy and dose response of exercise as treatment for depression. Control. Clin. Trials 23 (2002), 584–603.Google Scholar
Dunn, A. L., Trivedi, M. H., O'Neal, H. A., Physical activity dose-response effects on outcomes of depression and anxiety. Med. Sci. Sports Exerc. 33 (2001), S587–97, 609–10.Google Scholar
Singh, N. A., Clements, K. M., Singh, M. A., The efficacy of exercise as a long-term antidepressant in elderly subjects: a randomized, controlled trial. J. Gerontol. A Biol. Sci. Med. Sci. 56 (2001), M497–504.Google Scholar
Babyak, M., Blumenthal, J. A., Herman, S., et al., Exercise treatment for major depression maintenance of therapeutic benefit at 10 months. Psychosom. Med. 62 (2000), 633–8.Google Scholar
Carney, R. M., Templeton, B., Hong, B. A., et al., Exercise training reduces depression and increases the performance of pleasant activities in hemodialysis patients. Nephron 47 (1987), 194–8.Google Scholar
Finkelstein, F. O., Finkelstein, S. H., Depression in chronic dialysis patients assessment and treatment. Nephrol. Dial. Transplant 15 (2000), 1911–13.Google Scholar
Einwohner, R., Bernardini, J., Fried, L., Piraino, B., The effect of depressive symptoms on survival in peritoneal dialysis patients. Perit. Dial. Int. 24 (2004), 256–63.Google Scholar
Kouidi, E., Iacovides, A., Iordanidis, P., et al., Exercise renal rehabilitation program: psychosocial effects. Nephron 77 (1997), 152–8.Google Scholar
Emery, C. F., Schein, R. L., Hauck, E. R., MacIntyre, N. R., Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary disease. Health Psychol. 17 (1998), 232–40.Google Scholar
Emery, C. F., Shermer, R. L., Hauck, E. R., Hsiao, E. T., MacIntyre, N. R., Cognitive and psychological outcomes of exercise in a 1-year follow-up study of patients with chronic obstructive pulmonary disease. Health Psychol. 22 (2003), 598–604.Google Scholar
Nixon, S., O'Brien, K., Glazier, R. H., Tynan, A. M., Aerobic exercise interventions for adults living with HIV/AIDS. Cochrane Database Syst. Rev. (2) (2005), CD001796.Google Scholar
Stringer, W. W., Berezovskaya, M., O'Brien, W. A., Beck, C. K., Casaburi, R., The effect of exercise training on aerobic fitness, immune indices, and quality of life in HIV+ patients. Med. Sci. Sports Exerc. 30 (1998), 11–16.Google Scholar
Redondo, J. R., Justo, C. M., Moraleda, F. V., et al., Long-term efficacy of therapy in patients with fibromyalgia a physical exercise-based program and a cognitive-behavioral approach. Arthritis Rheum. 51 (2004), 184–92.Google Scholar
Ylinen, J., Takala, E. P., Nykanen, M., et al., Active neck muscle training in the treatment of chronic neck pain in women: a randomized controlled trial. J. Am. Med. Assoc. 289 (2003), 2509–16.Google Scholar
Courneya, K. S., Exercise in cancer survivors: an overview of research. Med. Sci. Sports Exerc. 35 (2003), 1846–52.Google Scholar
Oldervoll, L. M., Kaasa, S., Hjermstad, M. J., Lund, J. A., Loge, J. H., Physical exercise results in the improved subjective well-being of a few or is effective rehabilitation for all cancer patients?Eur. J. Cancer 40 (2004), 951–62.Google Scholar
Courneya, K. S., Friedenreich, C. M., Sela, R. A., et al., The group psychotherapy and home-based physical exercise (group-hope) trial in cancer survivors physical fitness and quality of life outcomes. Psychooncology 12 (2003), 357–74.Google Scholar
Daley, A. J., Mutrie, N., Crank, H., Coleman, R., Saxton, J., Exercise therapy in women who have had breast cancer: design of the Sheffield women's exercise and well-being project. Health Educ. Res. 19 (2004), 686–97.Google Scholar
Belardinelli, R., Georgiou, D., Cianci, G., Purcaro, A., Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome. Circulation 99 (1999), 1173–82.Google Scholar
Berg-Emons, R., Balk, A., Bussmann, H., Stam, H., Does aerobic training lead to a more active lifestyle and improved quality of life in patients with chronic heart failure?Eur. J. Heart Fail. 6 (2004), 95–100.Google Scholar
Blumenthal, J. A., Babyak, M. A., Carney, R. M., et al., Exercise, depression, and mortality after myocardial infarction in the ENRICHD trial. Med. Sci. Sports Exerc. 36 (2004), 746–55.Google Scholar
Shephard, R. J., Cytokine responses to physical activity, with particular reference to IL-6: sources, actions, and clinical implications. Crit. Rev. Immunol. 22 (2002), 165–82.Google Scholar
Shephard, R. J., Adhesion molecules, catecholamines and leucocyte redistribution during and following exercise. Sports Med. 33 (2003), 261–84.Google Scholar
Ford, E. S., Does exercise reduce inflammation? Physical activity and C-reactive protein among US adults. Epidemiology 13 (2002), 561–8.Google Scholar
Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., Kavouras, S., Stefanadis, C., The associations between leisure-time physical activity and inflammatory and coagulation markers related to cardiovascular disease: the ATTICA Study. Prev. Med. 40 (2005), 432–7.Google Scholar
Smith, J. K., Dykes, R., Douglas, J. E., Krishnaswamy, G., Berk, S., Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. J. Am. Med. Assoc. 281 (1999), 1722–7.Google Scholar
LeMaitre, J. P., Harris, S., Fox, K. A., Denvir, M., Change in circulating cytokines after 2 forms of exercise training in chronic stable heart failure. Am. Heart J. 147 (2004), 100–105.Google Scholar
Broadley, A. J., Korszun, A., Jones, C. J., Frenneaux, M. P., Arterial endothelial function is impaired in treated depression. Heart 88 (2002), 521–3.Google Scholar
Laufs, U., Wassmann, S., Czech, T., et al., Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 25 (2005), 809–14.Google Scholar
Hambrecht, R., Wolf, A., Gielen, S., et al., Effect of exercise on coronary endothelial function in patients with coronary artery disease. N. Engl. J. Med. 342 (2000), 454–60.Google Scholar
Edwards, D. G., Schofield, R. S., Lennon, S. L., et al., Effect of exercise training on endothelial function in men with coronary artery disease. Am. J. Cardiol. 93 (2004), 617–20.Google Scholar
Duclos, M., Gouarne, C., Bonnemaison, D., Acute and chronic effects of exercise on tissue sensitivity to glucocorticoids. J. Appl. Physiol. 94 (2003), 869–75.Google Scholar
Aizawa, K., Akimoto, T., Inoue, H., et al., Resting serum dehydroepiandrosterone sulfate level increases after 8-week resistance training among young females. Eur. J. Appl. Physiol. 90 (2003), 575–80.Google Scholar
Tremblay, M. S., Copeland, J. L., Helder, W., Effect of training status and exercise mode on endogenous steroid hormones in men. J. Appl. Physiol. 96 (2004), 531–9.Google Scholar
Light, K. C., Kothandapani, R. V., Allen, M. T., Enhanced cardiovascular and catecholamine responses in women with depressive symptoms. Int. J. Psychophysiol. 28 (1998), 157–66.Google Scholar
Jennings, J. R., Kamarck, T. W., Everson-Rose, S. A., et al., Exaggerated blood pressure responses during mental stress are prospectively related to enhanced carotid atherosclerosis in middle-aged Finnish men. Circulation 110 (2004), 2198–203.Google Scholar
Treiber, F. A., Kamarck, T., Schneiderman, N., et al., Cardiovascular reactivity and development of preclinical and clinical disease states. Psychosom. Med. 65 (2003), 46–62.Google Scholar
Steptoe, A., Marmot, M., Impaired cardiovascular recovery following stress predicts 3-year increases in blood pressure. J. Hypertens. 23 (2005), 529–36.Google Scholar
Spalding, T. W., Lyon, L. A., Steel, D. H., Hatfield, B. D., Aerobic exercise training and cardiovascular reactivity to psychological stress in sedentary young normotensive men and women. Psychophysiology 41 (2004), 552–62.Google Scholar
Steptoe, A., Kearsley, N., Walters, N., Cardiovascular activity during mental stress following vigorous exercise in sportsmen and inactive men. Psychophysiology 30 (1993), 245–52.Google Scholar

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  • Depression and physical activity
    • By Andrew Steptoe, Department of Epidemiology and Public Health, University College London, London, UK
  • Edited by Andrew Steptoe, University College London
  • Book: Depression and Physical Illness
  • Online publication: 17 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544293.017
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  • Depression and physical activity
    • By Andrew Steptoe, Department of Epidemiology and Public Health, University College London, London, UK
  • Edited by Andrew Steptoe, University College London
  • Book: Depression and Physical Illness
  • Online publication: 17 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544293.017
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Depression and physical activity
    • By Andrew Steptoe, Department of Epidemiology and Public Health, University College London, London, UK
  • Edited by Andrew Steptoe, University College London
  • Book: Depression and Physical Illness
  • Online publication: 17 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544293.017
Available formats
×