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Chapter 16 - The Influence of Physical Exercise on Cognitive Aging

Published online by Cambridge University Press:  30 November 2019

By
Jamie C. Peven ,
Chelsea M. Stillman  and
Kirk I. Erickson
Edited by
Kenneth M. Heilman  and
Stephen E. Nadeau
Kenneth M. Heilman
Affiliation:
University of Florida
Stephen E. Nadeau
Affiliation:
University of Florida
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Summary

Declines in cognitive functioning are a normal and widespread consequence of normal aging. Lacking promising drug interventions for reducing cognitive deficits, the field of cognitive aging has turned to nonpharmacologic treatments that could prevent or delay cognitive decline, or even improve performance in those at risk for decline. Physical activity is one of the most promising behavioral approaches for influencing cognitive and brain health. In this chapter, we first describe the ways of studying the relationship between physical activity, cardiorespiratory fitness, and cognitive functioning. We then summarize the existing evidence for how physical activity and cardiorespiratory fitness influence both cognition and the brain in the context of aging. By the end of the chapter, readers should be able to describe (1) typical patterns of associations between physical activity, cardiorespiratory fitness, and cognitive and brain health in older adults; (2) the evidence that increasing physical activity improves cognitive functioning in older adults; and (3) whether physical activity influences cognitive functions and brain health in older adults with mild to more severe cognitive deficits, such as found in people with mild cognitive impairment or dementia.

Keywords

exercisephysical activitycardiorespiratory fitnesscognitionbrainaginghealth
Type
Chapter
Information
Cognitive Changes and the Aging Brain , pp. 245 - 263
Publisher: Cambridge University Press
Print publication year: 2019

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References

Caspersen, CJ, Powell, KE, Christenson, GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 1985;100(2):126–31.Google ScholarPubMed
Adams, SA, Matthews, CE, Ebbeling, CB, Moore, CG, Cunningham, JE, Fulton, J, et al. The effect of social desirability and social approval on self-reports of physical activity. Am J Epidemiol. 2005;161(4):389–98.Google Scholar
Prince, SA, Adamo, KB, Hamel, ME, Hardt, J, Connor Gorber, S, Tremblay, M. A comparison of direct versus self-report measures for assessing physical activity in adults: a systematic review. Int J Behav Nutr Phys Act. 2008;5(56):56.Google Scholar
Committee PAGA. 2018 Physical Activity Guidelines Advisory Committee Scientific Report. Washington, DC: US Department of Health and Human Services; 2018.Google Scholar
Pate, RR, Pratt, M, Blair, SN, Haskell, WL, Macera, CA, Bouchard, C, et al. Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA. 1995;273(5):402–7.Google Scholar
Spirduso, W. Physical fitness, aging, and psychomotor speed: a review. J Gerontol. 1980;35(6):850–65.Google Scholar
Spirduso, W. Exercise and the aging brain. Res Q Exerc Sport. 1982;54(2):208–18.Google Scholar
Folstein, M, Folstein, S, McHugh, P. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98.Google Scholar
Middleton, LE, Barnes, DE, Lui, LY, Yaffe, K. Physical activity over the life course and its association with cognitive performance and impairment in old age. J Am Geriatr Soc. 2010;58(7):1322–6.Google Scholar
Oberlin, L, Verstynen, T, Burzynska, A, Voss, M, Prakash, R, Chaddock-Heyman, L, et al. White matter microstructure mediates the relationship between cardiorespiratory fitness and spatial working memory in older adults. NeuroImage. 2016;131:91–101.Google Scholar
Freudenberger, P, Petrovic, K, Sen, A, Toglhofer, A, Fixa, A, Hofer, E, et al. Fitness and cognition in the elderly: the Australian Stroke Prevention Study. Neurology. 2016;86(5):418–24.Google Scholar
Dupuy, O, Gauthier, CJ, Fraser, SA, Desjardins-Crepeau, L, Desjardins, M, Mekary, S, et al. Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women. Front Hum Neurosci. 2015;9:66.CrossRefGoogle ScholarPubMed
Hayes, SM, Hayes, JP, Cadden, M, Verfaellie, M. A review of cardiorespiratory fitness-related neuroplasticity in the aging brain. Front Aging Neurosci. 2013;5:31.CrossRefGoogle ScholarPubMed
Weuve, J, Kang, JH, Manson, JE, Breteler, MM, Ware, JH, Grodstein, F. Physical activity, including walking, and cognitive function in older women. JAMA. 2004;292(12):1454–61.Google Scholar
Hillman, CH, Motl, RW, Pontifex, MB, Posthuma, D, Stubbe, JH, Boomsma, DI, et al. Physical activity and cognitive function in a cross-section of younger and older community-dwelling individuals. Health Psychol. 2006;25(6):678–87.Google Scholar
Ainsworth, BE, Haskell, WL, Leon, AS, Jacobs, DR Jr., Montoye, HJ, Sallis, JF, et al. Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc. 1993;25(1):71–80.Google Scholar
Shephard, R, Vuillemin, A. Limits to the measurements of habitual physical activity by questionnaires. Br J Sports Med. 2003;37(3):197–206.Google Scholar
Innerd, P, Catt, M, Collerton, J, Davies, K, Trenell, M, Kirkwood, T, et al. A comparison of subjective and objective measures of physical activity from the Newcastle 85+ study. Age and Ageing. 2015;44(4):691–4.CrossRefGoogle ScholarPubMed
DeFina, L, Willis, B, Radford, N, Gao, A, Leonard, D, Haskell, W, et al. The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study. Ann Intern Med. 2013;158(3):162–8.Google Scholar
Laurin, D, Verreault, R, Lindsay, J, MacPherson, K, Rockwood, K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 2001;58(3):498–504.Google Scholar
Etgen, T, Sander, D, Huntgeburth, U, Poppert, H, Forstl, H, Bickel, H. Physical activity and incident cognitive impairment in elderly persons: the INVADE study. Arch Intern Med. 2010;170(2):186–93.Google Scholar
Sofi, F, Valecchi, D, Bacci, D, Abbate, R, Gensini, GF, Casini, A, et al. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J Intern Med. 2011;269(1):107–17.Google Scholar
Hamer, M, Lavoie, KL, Bacon, SL. Taking up physical activity in later life and healthy ageing: the English longitudinal study of ageing. Br J Sports Med. 2014;48(3):239–43.Google Scholar
Blondell, S, Hammersley-Mather, R, Veerman, J. Does physical activity prevent cognitive decline and dementia? A systematic review and meta-analysis of longitudinal studies. BMC Public Health. 2014;14(1).CrossRefGoogle ScholarPubMed
Grande, G, Vanacore, N, Maggiore, L, Cucumo, V, Ghiretti, R, Galimberti, D, et al. Physical activity reduces the risk of dementia in mild cognitive impairment subjects: a cohort study. J Alzheimers Dis. 2014;39(4):833–9.Google Scholar
Bherer, L, Erickson, KI, Liu-Ambrose, T. A review of the effects of physical activity and exercise on cognitive and brain functions in older adults. J Aging Res. 2013;2013:657508.Google Scholar
Hamer, M, Chida, Y. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol Med. 2009;39(1):3–11.Google Scholar
Stephen, R, Hongisto, K, Solomon, A, Lonnroos, E. Physical activity and Alzheimer’s disease: a systematic review. J Gerontol A Biol Sci Med Sci. 2017;72(6):733–9.Google Scholar
Dustman, R, Ruhling, R, Russell, E, Shearer, D, Bonekat, H, Shigeoka, J, et al. Aerobic exercise training and improved neuropsychological function of older adults. Neurobiol Aging. 1984;5:35–42.Google Scholar
Colcombe, S, Kramer, AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003;14(2):125–30.Google Scholar
Heyn, P, Abreu, BC, Ottenbacher, KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil. 2004;85(10):1694–704.Google Scholar
Groot, C, Hooghiemstra, A, Raijmakers, P, van Berckel, B, Scheltens, P, Scherder, E, et al. The effect of physical activity on cognitive function in patients with dementia: a meta-analysis of randomized control trials. Ageing Res Rev. 2016;25:13–23.Google Scholar
Lautenschlager, N, Cox, K, Flicker, L, Foster, J, van Bockxmeer, F, Xiao, J, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA. 2008;300(9):1027–37.CrossRefGoogle ScholarPubMed
Stewart, AL, Mills, KM, King, AC, Haskell, WL, Gillis, D, Ritter, PL. CHAMPS physical activity questionnaire for older adults: outcomes for interventions. Med Sci Sports Exerc. 2001;33(7):1126–41.Google ScholarPubMed
Rosen, WG, Mohs, RC, Davis, KL. A new rating scale for Alzheimer’s disease. Am J Psychiatry. 1984;141(11):1356–64.Google Scholar
Morris, J, Vidoni, E, Johnson, D, Van Sciver, A, Mahnken, J, Honea, R, et al. Aerobic exercise for Alzheimer’s disease: a randomized controlled pilot trial. PLoS ONE. 2017;12(2).CrossRefGoogle ScholarPubMed
Angevaren, M, Aufdemkampe, G, Verhaar, HJ, Aleman, A, Vanhees, L. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. 2008;3(3).Google Scholar
Barnes, DE, Santos-Modesitt, W, Poelke, G, Kramer, AF, Castro, C, Middleton, LE, et al. The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults. JAMA Intern Med. 2013;173(9):797–804.Google Scholar
Sink, KM, Espeland, MA, Castro, CM, Church, T, Cohen, R, Dodson, JA, et al. Effect of a 24-month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: the LIFE randomized trial. JAMA. 2015;314(8):781–90.Google Scholar
Young, J, Angevaren, M, Rusted, J, Tabet, N. Aerobic exercise to improve cognitive function in older adults without known cognitive impairment. Cochrane Database Syst Rev. 2015 Apr 22;(4):CD005381.Google Scholar
Stillman, C, Cohen, J, Lehman, M, Erickson, K. Mediators of physical activity on neurocognitive function: a review at multiple levels of analysis. Frontiers in Human Neuroscience. 2016 Dec 8;10:626.Google Scholar
Hamilton, G, Rhodes, J. Exercise regulation of cognitive function and neuroplasticity in the healthy and diseased brain. Prog Mol Biol Transl Sci. 2015;135:381–406.Google Scholar
Cotman, C, Berchtold, N, Christie, L. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007;30(9):464–72.Google Scholar
Raz, N, Lindenberger, U, Rodrigue, K, Kennedy, K, Head, D, Williamson, A, et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex. 2005;15(11):1676–89.CrossRefGoogle ScholarPubMed
Erickson, KI, Leckie, R, Weinstein, A. Physical activity, fitness, and gray matter volume. Neurobiol Aging. 2014;35(Suppl 2):S20–S28.Google Scholar
Colcombe, S, Erickson, KI, Raz, N, Webb, AG, Cohen, NJ, McAuley, E, et al. Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol A Biol Sci Med Scie. 2003;58(2):M176–M180.Google Scholar
Erickson, KI, Prakash, R, Voss, M, Chaddock-Heyman, L, Hu, L, Morris, K, et al. Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus. 2009;19(10):1030–9.CrossRefGoogle ScholarPubMed
Sen, A, Gider, P, Cavalieri, M, Freudenberge, P, Farzi, A, Schallert, M, et al. Association of cardiorespiratory fitness and morphological brain changes in the elderly: results of the Australian Stroke Prevention Study. Neurodegener Dis. 2012;10:135–7.Google Scholar
Burzynska, A, Chaddock-Heyman, L, Voss, M, Wong, C, Gothe, N, Olson, E, et al. Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults. PLoS ONE. 2014;9(9).Google Scholar
Tian, Q, Simonsick, E, Erickson, KI, Aizenstein, H, Glynn, N, Boudreau, R, et al. Cardiorespiratory fitness and brain diffusion tensor imaging in adults over 80 years of age. Brain Research. 2014;1588:63–72.Google Scholar
Schwarb, H, Johnson, C, Daugherty, A, Hillman, CH, Kramer, AF, Cohen, NJ, et al. Aerobic fitness, hippocampal viscoelasticity, and relational memory performance. NeuroImage. 2017;153:179–88.Google Scholar
Fletcher, M, Low, K, Boyd, R, Zimmerman, B, Gordon, B, Tan, C, et al. Comparing aging and fitness effects on brain anatomy. Front Hum Neurosci. 2016;10.Google Scholar
Teixeira, C, Rezende, T, Weiler, M, Nogueira, M, Campos, B, Pegoraro, L, et al. Relation between aerobic fitness and brain structures in amnestic mild cognitive impairment elderly. Age (Dordr). 2016 Jun;38(3):51.CrossRefGoogle ScholarPubMed
Perea, R, Vidoni, E, Morris, J, Graves, R, Burns, J, Honea, R. Cardiorespiratory fitness and white matter integrity in Alzheimer’s disease. Brain Imaging Behav. 2016;10(3):660–8.Google Scholar
Voss, M, Prakash, R, Erickson, K, Basak, C, Chaddock, L, Kim, J, et al. Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front Aging Neurosci. 2010; 2.Google Scholar
Voss, M, Weng, T, Burzynska, A, Wong, C, Cooke, G, Clark, R, et al. Fitness, but not physical activity, is related to functional integrity of brain networks associated with aging. NeuroImage. 2016;131:113–25.Google Scholar
Albinet, C, Mandrick, K, Bernard, P, Perrey, S, Blain, H. Improved cerebral oxygenation response and executive performance as a function of cardiorespiratory fitness in older women: a fNIRS study. Front Aging Neurosci. 2014;6.Google Scholar
Wong, C, Chaddock-Heyman, L, Voss, M, Burzynska, A, Basak, C, Erickson, KI, et al. Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults. Front Aging Neurosci. 2015 Aug 12;7:154.Google Scholar
Erickson, KI, Raji, C, Lopez, O, Becker, J, Rosano, C, Newman, A, et al. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology. 2010;75(16):1415–22.Google Scholar
Gow, A, Bastin, M, Maniega, S, Valdes Hernandez, M, Morris, Z, Murray, C, et al. Neuroprotective lifestyles and the aging brain: activity, atrophy, and white matter integrity. Neurology. 2012;79(17):1802–8.Google Scholar
Best, J, Rosano, C, Aizenstein, H, Tian, Q, Boudreau, R, Ayonayon, H, et al. Long-term changes in time spent walking and subsequent cognitive and structural brain changes in older adults. Neurobiol Aging. 2017;57:153–61.Google Scholar
Erickson, KI, Voss, MW, Prakash, RS, Basak, C, Szabo, A, Chaddock, L, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A. 2011;108(7):3017–22.Google Scholar
Niemann, C, Godde, B, Voelcker-Rehage, C. Not only cardiovascular, but also coordinative exercise increases hippocampal volume in older adults. Front Aging Neurosci. 2014;6.Google Scholar
Ten Brinke, L, Bolandzadeh, N, Nagamatsu, L, Hsu, C, Davis, J, Miran-Khan, K, et al. Aerobic exercise increases hippocampal volume in older women with probably mild cognitive impairment: a 6-month randomised controlled trial. Br J Sports Med. 2014;49(4):248–54.Google Scholar
Colcombe, S, Erickson, KI, Scalf, P, Kim, J, Prakash, R, McAuley, E, et al. Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci. 2006;61(11):1166–70.Google Scholar
Firth, J, Stubbs, B, Vancampfort, D, Schuch, F, Lagopoulos, J, Rosenbaum, S, et al. Effect of aerobic exercise on hippocampal volume in humans: a systematic review and meta-analysis. NeuroImage. 2018;166:230–8.Google Scholar
Smith, J, Nielson, K, Antuono, P, Lyons, J, Hanson, R, Butts, A, et al. Semantic memory functional MRI and cognitive function after exercise intervention in mild cognitive impairment. J Alzheimer’s Dis. 2013;37(1):197–215.Google Scholar
Suzuki, T, Shimada, H, Makizako, H, Doi, T, Yoshida, D, Ito, K, et al. A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS ONE. 2013;8(4):e61483.Google Scholar
Burdette, J, Laurienti, P, Espeland, M, Morgan, A, Telesford, Q, Vechlekar, C, et al. Using network science to evaluate exercise-associated brain changes in older adults. Front Aging Neurosci. 2010;2.Google Scholar
Biswal, B, Kylen, J, Hyde, J. Simultaneous assessment of flow and BOLD signals in resting-state functional connectivity maps. NMR in Biomedicine. 1997;10(4–5):165–70.Google Scholar
Reiter, K, Nielson, K, Smith, T, Weiss, L, Alfini, A, Smith, J. Improved cardiorespiratory fitness is associated with increased cortical thickness in mild cognitive impairment. J Int Neuropsychol Soc. 2015;21(10):757–67.Google Scholar
Devenney, K, Sanders, M, Lawlor, B, Olde Rikkert, M, Schneider, S, Group, NS. The effects of an extensive exercise programme on the progression of mild cognitive impairment (MCI): study protocol for a randomised controlled trial. BMC Geriatrics. 2017;17(1).Google Scholar
Leeuwis, A, Hooghiemstra, A, Amier, R, Ferro, D, Franken, L, Nijveldt, R, et al. Design of the ECersion-VCI study: the effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment. ALzheimer’s & Dementia. 2017;3(2):157–65.Google Scholar
Cotman, C, Berchtold, N. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25(6):295–301.Google Scholar
Erickson, KI, Miller, D, Roecklein, K. The aging hippocampus: interactions between exercise, depression, and BDNF. Neuroscientist. 2012;18(1):82–97.Google Scholar
Leckie, R, Weinstein, A, Hodzic, J, Erickson, KI. Potential moderators of physical activity on brain health. J Aging Res. 2012;2012:948981.CrossRefGoogle ScholarPubMed
Rosendorff, C, Beeri, M, Silverman, J. Cardiovascular risk factors for Alzheimer’s disease. Am J Geriatr Cardiol. 2007;16(3):143–9.Google Scholar
O’Donovan, C, Lithander, F, Raftery, T, Gormley, J, Mahmud, A, Hussey, J. Inverse relationship between physical activity and arterial stiffness in adults with hypertension. J Phys Act Health. 2014;11:272–7.Google Scholar

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