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6 - Understanding Hematologic Monitoring and Benign Ethnic Neutropenia

Published online by Cambridge University Press:  19 October 2021

Jonathan M. Meyer  and
Stephen M. Stahl
Jonathan M. Meyer
Affiliation:
University of California, San Diego
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Many nonchemotherapy medications are associated with neutropenia risk, but it was the cluster of 16 severe clozapine-related neutropenia cases reported from Finland in mid-summer 1975 with a 50% fatality rate that prompted clozapine’s withdrawal. Clozapine was subsequently reintroduced to the world market in the late 1980s based on demonstrable efficacy in treatment-resistant schizophrenia, albeit with mandatory hematologic monitoring and patient tracking.

Type
Chapter
Information
The Clozapine Handbook
Stahl's Handbooks
 , pp. 114 - 139
Publisher: Cambridge University Press
Print publication year: 2019

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