Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-28T04:13:20.720Z Has data issue: false hasContentIssue false

Chapter 20 - Cerebral microbleeds and thrombolysis

from Section 3 - Microbleeds in relation to specific populations, diseases and neurological symptoms

Published online by Cambridge University Press:  05 July 2011

By
Chelsea S. Kidwell
Edited by
David J. Werring
David J. Werring
Affiliation:
Institute of Neurology, London
Get access

Summary

Thrombolytic therapy is the only treatment for acute ischemic stroke proven to improve clinical outcome. Identifying patients at higher risk for hemorrhagic transformation following thrombolysis is an important goal, and this information could increase the overall safety profile of thrombolytic therapy. The most comprehensive and informative data on the risk of thrombolysis-induced hemorrhage in the setting of cerebral microbleeds (CMBs) and acute stroke comes from the Bleeding Risk Analysis in Stroke Imaging before thrombolysis (BRASIL) study. In cerebral amyloid angiopathy (CAA), CMBs are located predominantly in lobar regions and the total number of lesions is often significant (10-75 or more). A lobar location is also a more common site for thrombolysis-related hemorrhages. In contrast, CMBs linked to hypertensive small vessel disease are typically located in predominantly deep regions and may be far fewer in number.

Keywords

cerebral amyloid angiopathycerebral microbleedshypertensive vasculopathyneuropathological examinationintracerebral hemorrhageneuroimaging findings
Type
Chapter
Information
Cerebral Microbleeds
Pathophysiology to Clinical Practice
 , pp. 173 - 177
Publisher: Cambridge University Press
Print publication year: 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×