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Chapter 2 - Pharmacology and Physiology in the Term Neonate

Published online by Cambridge University Press:  30 November 2019

By
Adam C. Adler  and
Ronald S. Litman
Edited by
Adam C. Adler ,
Arvind Chandrakantan  and
Ronald S. Litman
Adam C. Adler
Affiliation:
Texas Children's Hospital
Arvind Chandrakantan
Affiliation:
Texas Children's Hospital
Ronald S. Litman
Affiliation:
The Children's Hospital of Philadelphia
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Summary

This chapter, provides an overview of the basics of pharmacology and physiology in the neonate. The authors focus on the physiological differences between children and adults using a background case of omphalocele. Key concepts for pediatric anesthesia are considered including, hyperbilirubinemia, oxygenation, hepatic function and metabolism and thyroid function.

Keywords

gastroschisisomphaloceleneonatal hypoglycemiaBeckwith–Wiedemann syndromebilirubinjaundicecongenital hypothyroidismneonatal apneaneonatal liverneonatal coagulationneonatal opioid metabolismneonatal spinal.
Type
Chapter
Information
Case Studies in Pediatric Anesthesia , pp. 6 - 15
Publisher: Cambridge University Press
Print publication year: 2019

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References

Suggested Reading

Beardsall, K. Measurement of glucose levels in the newborn. Early Hum Dev. 2010;86(5):263–7. PMID: 20542649.CrossRefGoogle ScholarPubMed
Blazer, S, Zimmer, EZ, Gover, A, Bronshtein, M. Fetal omphalocele detected early in pregnancy: associated anomalies and outcomes. Radiology. 2004;232:191–5. PMID: 15220502.CrossRefGoogle ScholarPubMed
Brantberg, A, Blaas, HG, Haugen, SE, Eik-Nes, SH. Characteristics and outcome of 90 cases of fetal omphalocele. Ultrasound Obstet Gynecol. 2005;26:527–37. PMID: 16184512.CrossRefGoogle ScholarPubMed
Büyükgebiz, A. Newborn screening for congenital hypothyroidism. J Clin Res Pediatr Endocrinol. 2013;5S1:8–12. PMID: 23154158.Google Scholar
Christison-Lagay, ER, Kelleher, CM, Langer, JC. Neonatal abdominal wall defects. Semin Fetal Neonatal Med. 2011;16:164–72. PMID: 21474399.CrossRefGoogle ScholarPubMed
Coté, CJ, Zaslavsky, A, Downes, JJ, et al. Postoperative apnea in former preterm infants after inguinal herniorrhaphy. A combined analysis. Anesthesiology. 1995;82:809–22. PMID: 7717551.CrossRefGoogle ScholarPubMed
Davis, RP, Mychaliska, GB. Neonatal pulmonary physiology. Semin Pediatr Surg. 2013;22:179–84. PMID: 24331091.CrossRefGoogle ScholarPubMed
Diaz-Miron, J, Miller, J, Vogel, AM. Neonatal hematology. Semin Pediatr Surg. 2013;22:199–204. PMID: 24331095.CrossRefGoogle ScholarPubMed
Grijalva, J, Vakili, K. Neonatal liver physiology. Semin Pediatr Surg. 2013;22:185–9. PMID: 24331092.CrossRefGoogle ScholarPubMed
Harris, DL, Weston, PJ, Harding, JE. Incidence of neonatal hypoglycemia in babies identified as at risk. J Pediatr. 2012;161:787–91. PMID: 22727868.CrossRefGoogle ScholarPubMed
Hiraki, S, Green, NS. Newborn screening for treatable genetic conditions: past, present and future. Obstet Gynecol Clin North Am. 2010;37:11–21. PMID: 22727868.CrossRefGoogle ScholarPubMed
Kaplan, M, Bromiker, R, Hammerman, C. Hyperbilirubinemia, hemolysis, and increased bilirubin neurotoxicity. Semin Perinatol. 2014;38:429–37. PMID: 25284470.CrossRefGoogle ScholarPubMed
Lerman, J, Robinson, S, Willis, MM, Gregory, GA. Anesthetic requirements for halothane in young children 0–1 month and 1–6 months of age. Anesthesiology. 1983;59:421–4. PMID: 6638549.CrossRefGoogle ScholarPubMed
López, T, Sánchez, FJ, Garzón, JC, Muriel, C. Spinal anesthesia in pediatric patients. Minerva Anestesiol. 2012;78:78–87. PMID: 22211775.Google ScholarPubMed
Maitra, S, Baidya, DK, Khanna, P, et al. Acute perioperative pain in neonates: An evidence-based review of neurophysiology and management. Acta Anaesthesiol Taiwan. 2014;52:30–7. PMID: 24999216.CrossRefGoogle ScholarPubMed
Nandi-Munshi, D, Taplin, CE. Thyroid-related neurological disorders and complications in children. Pediatr Neurol. 2015;52(4):373–82. PMID: 25661286.CrossRefGoogle ScholarPubMed
Nargozian, C, Ririe, DG, Bennun, RD, et al. Hemifacial microsomia: anatomical prediction of difficult intubation. Paediatr Anaesth. 1999;9:393–8. PMID: 10447900.CrossRefGoogle ScholarPubMed
Sale, SM. Neonatal apnoea. Best Pract Res Clin Anaesthesiol. 2010;24:323–36. PMID: 21033010.CrossRefGoogle ScholarPubMed
Sulemanji, M, Vakili, K. Neonatal renal physiology. Semin Pediatr Surg. 2013;22:195–8. PMID: 24331094.CrossRefGoogle ScholarPubMed
Weksberg, R, Shuman, C, Beckwith, JB. Beckwith–Wiedemann syndrome. Eur J Hum Genet. 2010;18:8–14. PMID: 19550435.CrossRefGoogle ScholarPubMed
Yaster, M, Scherer, TL, Stone, MM, et al. Prediction of successful primary closure of congenital abdominal wall defects using intraoperative measurements. J Pediatr Surg. 1989;24:1217–20. PMID: 2531789.CrossRefGoogle ScholarPubMed

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