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Chapter 12 - Malignant Hyperthermia

Published online by Cambridge University Press:  30 November 2019

By
Giselle Torres
Edited by
Adam C. Adler ,
Arvind Chandrakantan  and
Ronald S. Litman
Adam C. Adler
Affiliation:
Texas Children's Hospital
Arvind Chandrakantan
Affiliation:
Texas Children's Hospital
Ronald S. Litman
Affiliation:
The Children's Hospital of Philadelphia
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Summary

This chapter provides a review of malignant hyperthermia. The author discusses the considerations related to intraoperative hyperthermia. The differential diagnosis of severe perioperative hyperthermia is considered including thyroid storm and neuroleptic malignant syndrome. The incidence, genetics, diagnostic testing and treatment of malignant hyperthermia is presented.

Keywords

Malignant Hyperthermiamuscle rigiditymasseter muscle spasmmetabolic acidosisneuroleptic malignant syndromethyroid storm.
Type
Chapter
Information
Case Studies in Pediatric Anesthesia , pp. 57 - 59
Publisher: Cambridge University Press
Print publication year: 2019

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References

Suggested Reading

Birgenheier, N, Stoker, R, Westenskow, D, et al. Activated charcoal effectively removes inhaled anesthetics from modern anesthesia machines. Anesth Analg. 2011;112(6):1363–70. PMID: 21543783.CrossRefGoogle ScholarPubMed
Kim, TW, Nemergut, ME. Preparation of modern anesthesia workstations for malignant hyperthermia-susceptible patients: a review of past and present practice. Anesthesiology. 2011;114(1):205–12. PMID: 21169802.CrossRefGoogle ScholarPubMed
Larach, MG, Gronert, GA, Allen, GC, et al. Clinical presentation, treatment, and complications of malignant hyperthermia in North America from 1987 to 2006. Anesth Analg. 2010 Feb 1;110(2):498–507. PMID: 20081135.CrossRefGoogle ScholarPubMed
Nelson, P, Litman, RS. Malignant hyperthermia in children: an analysis of the North American malignant hyperthermia registry. Anesth Analg. 2014;118(2):369–74. PMID: 24299931.CrossRefGoogle ScholarPubMed
Rosero, EB, Adesanya, AO, Timaran, CH, et al. Trends and outcomes of malignant hyperthermia in the United States, 2000 to 2005. Anesthesiology. 2009;110(1):89–94. PMID: 19104175.CrossRefGoogle ScholarPubMed
Salazar, JH, Yang, J, Shen, L, et al. Pediatric malignant hyperthermia: risk factors, morbidity, and mortality identified from the Nationwide Inpatient Sample and Kids’ Inpatient Database. Paediatr Anaesth. 2014;24(12):1212–6. PMID: 24974921.CrossRefGoogle ScholarPubMed
Wappler, F. Anesthesia for patients with a history of malignant hyperthermia. Curr Opin Anaesthesiol. 2010;23(3):417–22. PMID: 20173632.CrossRefGoogle ScholarPubMed

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