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Chapter 10 - Non-Hodgkin's lymphoma during pregnancy

from Section 1 - Specific tumors during pregnancy

Published online by Cambridge University Press:  05 December 2011

By
David Pereg  and
Michael Lishner
Edited by
Gideon Koren  and
Michael Lishner
Gideon Koren
Affiliation:
University of Toronto
Michael Lishner
Affiliation:
Tel-Aviv University
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Summary

This chapter describes the diagnosis, treatment, and prognosis for non-Hodgkin's lymphoma (NHL) in pregnancy. Indolent NHL includes follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, which are extremely rare during pregnancy. Aggressive NHL, which includes large B-cell lymphomas, mantle cell lymphoma, and mature T-cell and NK-cell neoplasms, represents the majority of NHL cases diagnosed during gestation. Due to the aggressive course of these lymphomas, most patients should be treated promptly with intensive combination chemotherapy. Aggressive NHL group includes precursor (B or T) lymphoblastic leukemia/lymphoma and Burkitt's lymphoma. Most chemotherapy regimens for very aggressive lymphomas include high-dose methotrexate, which among the currently used anticancer drugs, poses the greatest risk to the developing fetus when administered during the first trimester. Placental involvement in pregnancy associated NHL is extremely rare, but a single case of dissemination to the fetus has been reported.

Keywords

breast cancerchemotherapyestrogen receptorradiation therapymastectomypregnancy
Type
Chapter
Information
Cancer in Pregnancy and Lactation
The Motherisk Guide
 , pp. 49 - 52
Publisher: Cambridge University Press
Print publication year: 2011

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