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10.5 - Reserve, Resilience and Resistance to Neurodegeneration

from 10 - Neurodegeneration

Published online by Cambridge University Press:  08 November 2023

By
James B. Rowe  and
Alexander G. Murley
Edited by
Mary-Ellen Lynall ,
Peter B. Jones  and
Stephen M. Stahl
Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

We have seen that there is a long period of neurodegeneration in the absence of symptoms. This asymptomatic period highlights the issues of functional reserve, resilience and tolerance – that function (cognition, activities and roles etc.) can be maintained despite pathology (molecular pathology, neuroinflammation, synaptic loss, atrophy).

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Cambridge Textbook of Neuroscience for Psychiatrists , pp. 569 - 570
Publisher: Cambridge University Press
Print publication year: 2023

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