Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-07T22:57:49.275Z Has data issue: false hasContentIssue false

Meningitis

from Medical topics

Published online by Cambridge University Press:  18 December 2014

Julie A. Carter
Affiliation:
University College London and Kenya Medical Research Institute/Wellcome Trust Research Laboratories
Susan Ayers
Affiliation:
University of Sussex
Andrew Baum
Affiliation:
University of Pittsburgh
Chris McManus
Affiliation:
St Mary's Hospital Medical School
Stanton Newman
Affiliation:
University College and Middlesex School of Medicine
Kenneth Wallston
Affiliation:
Vanderbilt University School of Nursing
John Weinman
Affiliation:
United Medical and Dental Schools of Guy's and St Thomas's
Robert West
Affiliation:
St George's Hospital Medical School, University of London
Get access

Summary

Meningitis is an acute infectious disease, arising from infection of the membranes surrounding the brain and spinal cord by one of several microorganisms, such as bacteria, viruses, parasites and fungi. Recovery from meningitis has long been associated with severe neurological and/or cognitive deficits, including hearing impairment, epilepsy, motor impairments and learning disability. Those surviving without obvious or severe deficits have traditionally been considered to make a complete recovery. This view has recently been challenged by evidence that subtle cognitive, academic or behavioural problems may persist years after recovery from the disease.

Overview

Most research studies on impairments associated with meningitis have examined bacterial meningitis. Acute bacterial meningitis is one of the most common infections of the central nervous system (CNS). In more developed countries, Streptococcus pneumoniae and Neisseria meningitides are the most common pathogens responsible for community-acquired bacterial meningitis. Haemophilus influenzae meningitis has almost been eliminated due to the Hib vaccination. Bacterial meningitis is 10 times more common in children from less developed than more developed countries and the case fatality rate is higher, partly due to the prevalence of HIV infection, which makes children more prone to invasive bacterial infections (Molyneux et al., 2003). In sub-Saharan Africa, the ‘meningitis belt’, an area stretching from Senegal in the west to Ethiopia in the east with a population of 300 million people, is also subject to recurring epidemics of meningococcal disease, primarily due to the serogroups N. meningitidis A, C and W135.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baraff, L. J., Lee, S. I. & Schriger, D. L. (1993). Outcomes of bacterial meningitis in children: a meta-analysis. Pediatric Infectious Disease Journal, 12, 389–94.Google Scholar
Carter, J. A., Neville, B. G. R. & Newton, C. R. J. C. (2003). Neuro-cognitive sequelae of acquired central nervous system infections in children: a systematic review. Brain Research Reviews, 43, 57–69.Google Scholar
Day, J. N. & Lalloo, D. G. (2004). Neurological syndromes and the traveler: an approach to differential diagnosis. Journal of Neurology Neurosurgery and Psychiatry, 75 (suppl. 1), i2–9.Google Scholar
Donald, P. R. & Schoeman, J. F. (2004). Tuberculous meningitis. New England Journal of Medicine, 351, 1719–20.Google Scholar
Franco, S. M., Cornelius, V. E. & Andrews, B. F. (1992). Long-term outcome of neonatal meningitis. American Journal of Diseases of Children, 146, 567–71.Google Scholar
Grimwood, K., Anderson, V. A., Bond, L.et al. (1995). Adverse outcomes of bacterial meningitis in school-age survivors. Pediatrics, 95, 646–56.Google Scholar
Klinger, G., Chin, C. N., Beyene, J. & Perlman, M. (2000). Predicting the outcome of neonatal bacterial meningitis. Pediatrics, 106, 477–82.Google Scholar
Koomen, I., Grobbee, D. E., Jennekens-Schinkel, A., Roord, J. J. & Furth, A. M. (2003). Parental perception of educational, behavioural and general health problems in school-age survivors of bacterial meningitis. Acta Paediatrica, 92, 177–85.Google Scholar
Koomen, I., Grobbee, D. E., Roord, J. J.et al. (2004 b). Prediction of academic and behavioural limitations in school-age survivors of bacterial meningitis. Acta Paediatrica, 93, 1378–85.Google Scholar
Koomen, I., Furth, A. M., Kraak, M. A. C.et al. (2004 a). Neuropsychology of academic and behavioural limitations in school-age survivors of bacterial meningitis. Developmental Medicine and Child Neurology, 46, 724–32.Google Scholar
McIntyre, P. B., Berkey, C. S., King, S. M.et al. (1997). Dexamethasone as adjunctive therapy in bacterial meningitis. A meta-analysis of randomized clinical trials since 1988. Journal of the American Medical Association, 278, 925–31.Google Scholar
Molyneux, E. M., Tembo, M., Kayira, K.et al. (2003). The effect of HIV infection on paediatric bacterial meningitis in Blantyre, Malawi. Archives of Disease in Childhood, 88, 1112–18.Google Scholar
Pikis, A., Kavaliotis, J., Tsikoulas, J.et al. (1996). Long-term sequelae of pneumococcal meningitis in children. Clinical Pediatrics, 35, 72–8.Google Scholar
Pomeroy, S. L., Holmes, S. J., Dodge, P. R. & Feigin, R. D. (1990). Seizures and other neurologic sequelae of bacterial meningitis in children. New England Journal of Medicine, 323, 1651–7.Google Scholar
Richardson, M. P., Reid, A., Tarlow, M. J. & Rudd, P. T. (1997). Hearing loss during bacterial meningitis. Archives of Disease in Childhood, 76, 134–8.Google Scholar
Saez-Llorens, X. & McCracken, G. H. Jr. (2003). Bacterial meningitis in children. Lancet, 361, 2139–48.Google Scholar
Salih, M. A., Khaleefa, O. H., Bushara, M.et al. (1991). Long term sequelae of childhood acute bacterial meningitis in a developing country. A study from the Sudan. Scandinavian Journal of Infectious Diseases, 23, 175–82.Google Scholar
Thwaites, G. E., Nguyen, D. B., Nguyen, H. D.et al. (2004). Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. New England Journal of Medicine, 351, 1741–51.Google Scholar
Beek, D., Gans, J., McIntyre, P. & Prasad, K. (2004 b). Steroids in adults with bacterial meningitis: a systematic review. Lancet Infectious Diseases, 3, 139–43.Google Scholar
Beek, D., Gans, J., Spanjaard, L.et al. (2004 a). Clinical features and prognostic factors in adults with bacterial meningitis. New England Journal of Medicine, 351, 1849–59.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×