Book contents
- Frontmatter
- Contents
- List of Contributors
- Preface
- 1 Are there common biochemical pathways in cell damage and cell death?
- 2 Free radicals in the pathogenesis of tissue damage
- 3 Calcium and signal transduction in oxidative cell damage
- 4 Regulation of neutrophil oxidant production
- 5 Reperfusion arrhythmias: role of oxidant stress
- 6 Biochemical pathways that lead to the release of cytosolic proteins in the perfused rat heart
- 7 Malignant hyperthermia: the roles of free radicals and calcium?
- 8 Free radicals, calcium and damage in dystrophic and normal skeletal muscle
- 9 Ultrastructural changes in mitochondria during rapid damage triggered by calcium
- 10 The importance of oxygen free radicals, iron and calcium in renal ischaemia
- 11 The Rubicon Hypothesis: a quantal framework for understanding the molecular pathway of cell activation and injury
- Index
Preface
Published online by Cambridge University Press: 18 January 2010
- Frontmatter
- Contents
- List of Contributors
- Preface
- 1 Are there common biochemical pathways in cell damage and cell death?
- 2 Free radicals in the pathogenesis of tissue damage
- 3 Calcium and signal transduction in oxidative cell damage
- 4 Regulation of neutrophil oxidant production
- 5 Reperfusion arrhythmias: role of oxidant stress
- 6 Biochemical pathways that lead to the release of cytosolic proteins in the perfused rat heart
- 7 Malignant hyperthermia: the roles of free radicals and calcium?
- 8 Free radicals, calcium and damage in dystrophic and normal skeletal muscle
- 9 Ultrastructural changes in mitochondria during rapid damage triggered by calcium
- 10 The importance of oxygen free radicals, iron and calcium in renal ischaemia
- 11 The Rubicon Hypothesis: a quantal framework for understanding the molecular pathway of cell activation and injury
- Index
Summary
This volume represents the proceedings of a Symposium of the Cell Biology section of the Society for Experimental Biology held at Warwick University in March 1990. I am most grateful to Dr Malcolm Jackson for his encouragement and advice during the organisation of a most interesting and successful meeting and to SmithKline Beecham for financial support.
There is currently great interest in the underlying events of rapid cellular damage in a range of different organs, as shown by the chapters in this volume. Calcium ions and oxygen radicals have been implicated in many suggestions concerning the genesis of cellular damage, and the papers in this symposium explored the possibility that these two mechanisms were interrelated. Does intracellular calcium trigger the production of oxygen radicals; or is the main effect of oxygen radicals to damage calcium storage sites and thereby alter calcium homeostasis? Are there common pathways in cellular damage?
- Type
- Chapter
- Information
- Calcium, Oxygen Radicals and Cellular Damage , pp. xi - xiiPublisher: Cambridge University PressPrint publication year: 1991