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Published online by Cambridge University Press: 18 January 2010
This volume represents the proceedings of a Symposium of the Cell Biology section of the Society for Experimental Biology held at Warwick University in March 1990. I am most grateful to Dr Malcolm Jackson for his encouragement and advice during the organisation of a most interesting and successful meeting and to SmithKline Beecham for financial support.
There is currently great interest in the underlying events of rapid cellular damage in a range of different organs, as shown by the chapters in this volume. Calcium ions and oxygen radicals have been implicated in many suggestions concerning the genesis of cellular damage, and the papers in this symposium explored the possibility that these two mechanisms were interrelated. Does intracellular calcium trigger the production of oxygen radicals; or is the main effect of oxygen radicals to damage calcium storage sites and thereby alter calcium homeostasis? Are there common pathways in cellular damage?
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