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25 - Bone regeneration

from Part V - Animal models and clinical applications

Published online by Cambridge University Press:  05 February 2015

By
Eric W. Hsu ,
Pedro Alvarez ,
Lyndsey Shutte ,
Amy Donovan ,
Shiguang Liu ,
Arun R. Shivats  and
Jeffrey O. Hollinger
Edited by
Peter X. Ma
Eric W. Hsu
Affiliation:
Carnegie Mellon University
Pedro Alvarez
Affiliation:
Carnegie Mellon University
Lyndsey Shutte
Affiliation:
Carnegie Mellon University
Amy Donovan
Affiliation:
Carnegie Mellon University
Shiguang Liu
Affiliation:
Carnegie Mellon University
Arun R. Shivats
Affiliation:
Carnegie Mellon University
Jeffrey O. Hollinger
Affiliation:
Carnegie Mellon University
Peter X. Ma
Affiliation:
University of Michigan, Ann Arbor
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Summary

Bone biology

Bone is a complex tissue-organ system integrating multiple components in hierarchical layers of molecular cues, cellular communities, and networking highways. Bone moves through space and time in a dynamic manner modulated by homeostatic mechanisms nuanced through a coordinated intercalation of biological and biomechanical rhythms. The price we vertebrate species pay for maintaining this magnificently orchestrated tissue-organ is daunting.

Bone is the most metabolically expensive tissue in the human body. For every ounce of bone, a pound of soft tissue is required for maintenance [1]. Moreover, the human skeletal system must be rugged in order to handle years of cyclic loading at high forces on the order of kilonewtons, and highly sensitive to the calibrated kinetics of calcium and phosphate release in order to maintain meticulously modulated ion levels [2]. Consequently, the intrinsic design of bone and the dynamics that sustain it are an instructional core for regenerative bone therapeutics.

In this chapter we will introduce the profoundly compelling biodynamic structural marvel that gives shape to the amorphous mass in which it is wrapped and provides the fulcrums and pulleys that propel our anatomy along the avenues and boulevards of our towns. We will probe the blueprint of bone as a defining mold that guides and mentors attempts in the laboratory to design and develop compositions to repair and regenerate this structural tour de force.

Type
Chapter
Information
Biomaterials and Regenerative Medicine , pp. 449 - 477
Publisher: Cambridge University Press
Print publication year: 2014

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