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Chapter 17 - Myelodysplastic/Myeloproliferative Neoplasms

from Section IV - Precursor Hematopoietic Neoplasms and Related Neoplasms

Published online by Cambridge University Press:  25 November 2023

By
Kristian T. Schafernak ,
Rachel A. Mariani ,
Nicole Arva ,
Jeffrey Jacobsen  and
Katherine R. Calvo
Edited by
Silvia Tse Bunting ,
Xiayuan Liang ,
Michele E. Paessler  and
Satheesh Chonat
Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
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Summary

Myelodysplastic/myeloproliferative neoplasm (MDS/MPNs) constitute a group of clonal hematopoietic disorders with hybrid features; those of a myeloproliferative neoplasm (MPN) include bone marrow hypercellularity due to proliferation of one or more of the myeloid (as opposed to lymphoid) lineages with effective hematopoiesis, leading to a peripheral “cytosis” or “cytoses.” At the same time, these disorders show variable morphologic or functional dysplasia with ineffective hematopoiesis, resulting in cytopenia(s), findings more characteristic of myelodysplastic syndrome (MDS). The blast percentage is always less than 20, though sometimes transformation to acute myeloid leukemia (AML) occurs.

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Chapter
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Atlas of Pediatric Hematopathology , pp. 186 - 197
Publisher: Cambridge University Press
Print publication year: 2023

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References

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