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Chapter 7 - Infectious Diseases

from Section II - Normal and Non-neoplastic Hematolymphoid Diseases

Published online by Cambridge University Press:  25 November 2023

Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
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Summary

Lymphadenopathy (LAD) refers to the enlargement and/or abnormal consistency of lymph nodes and may be localized or diffuse. It reflects the results of immune responses to different insulants such as infection, autoimmunity, or malignancy [1]. Children with LAD are much more likely to have benign etiologies than adults, and most commonly present with a cervical mass [2]. While most benign LADs in children have no identifiable cause and are defined as nonspecific reactive LAD, some cases are found to be of infectious origin, including bacteria, yeast, parasite, or virus, often referred to as lymphadenitis [3].

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Oguz, A, Karadeniz, C, Temel, EA, Citak, EC, Okur, FV. Evaluation of peripheral lymphadenopathy in children. Pediatr Hematol Oncol. 2006; 23(7): 549–61.CrossRefGoogle ScholarPubMed
Rajasekaran, K, Krakovitz, P. Enlarged neck lymph nodes in children. Pediatr Clin North Am. 2013; 60(4): 923–36.CrossRefGoogle ScholarPubMed
Deosthali, A, Donches, K, DelVecchio, M, Aronoff, S. Etiologies of pediatric cervical lymphadenopathy: A systematic review of 2687 subjects. Glob Pediatr Health. 2019; 6: 2333794X19865440.Google ScholarPubMed
Chen, Y, Fu, YB, Xu, XF, Pan, Y, Lu, CY, Zhu, XL, et al. Lymphadenitis associated with cat-scratch disease simulating a neoplasm: Imaging findings with histopathological associations. Oncol Lett. 2018; 15(1): 195204.Google ScholarPubMed
Yuan, Y, Zhang, X, Xu, N, Wang, L, Li, F, Zhang, P, et al. Clinical and pathologic diagnosis and different diagnosis of syphilis cervical lymphadenitis. Int J Clin Exp Pathol. 2015; 8(10): 13635–8.Google ScholarPubMed
Cruz, AT, Ong, LT, Starke, JR. Mycobacterial infections in Texas children: A 5-year case series. Pediatr Infect Dis J. 2010; 29(8): 772–4.CrossRefGoogle ScholarPubMed
Reuss, AM, Wiese-Posselt, M, Weissmann, B, Siedler, A, Zuschneid, I, An der Heiden, M, et al. Incidence rate of nontuberculous mycobacterial disease in immunocompetent children: A prospective nationwide surveillance study in Germany. Pediatr Infect Dis J. 2009; 28(7): 642–4.CrossRefGoogle ScholarPubMed
Lewis, LL, Butler, KM, Husson, RN, Mueller, BU, Fowler, CL, Steinberg, SM, et al. Defining the population of human immunodeficiency virus-infected children at risk for Mycobacterium avium-intracellulare infection. J Pediatr. 1992; 121 (5 Pt 1): 677–83.CrossRefGoogle ScholarPubMed
Mishra, DP, Ramamurthy, S, Behera, SK. Histoplasmosis presenting as isolated cervical lymphadenopathy: A rare presentation. J Cytol. 2015; 32(3): 188–90.Google ScholarPubMed
Li, B, Zou, J, Wang, WY, Liu, SX. Toxoplasmosis presented as a submental mass: A common disease, uncommon presentation. Int J Clin Exp Pathol. 2015; 8(3): 3308–11.Google Scholar
Saxena, S, Kumar, S, Kharbanda, J. Toxoplasmosis submandibular lymphadenitis: Report of an unusual case with a brief review. J Oral Maxillofac Pathol. 2018; 22(1): 116–20.CrossRefGoogle ScholarPubMed
Pittaluga, S. Viral-associated lymphoid proliferations. Semin Diagn Pathol. 2013; 30(2): 130–6.CrossRefGoogle ScholarPubMed
Childs, CC, Parham, DM, Berard, CW. Infectious mononucleosis: The spectrum of morphologic changes simulating lymphoma in lymph nodes and tonsils.Am J Surg Pathol. 1987; 11(2): 122–32.CrossRefGoogle ScholarPubMed
Lum, EL, Schaenman, JM, DeNicola, M, Reddy, UG, Shen, JI, Pullarkat, ST. A case report of CMV lymphadenitis in an adult kidney transplant recipient. Transplant Proc. 2015; 47(1): 141–5.CrossRefGoogle Scholar
Staras, SA, Dollard, SC, Radford, KW, Flanders, WD, Pass, RF, Cannon, MJ. Seroprevalence of cytomegalovirus infection in the United States, 1988–1994. Clin Infect Dis. 2006; 43(9): 1143–51.CrossRefGoogle ScholarPubMed
Yusuf, H, Fields, E, Arrington-Sanders, R, Griffith, D, Agwu, AL. HIV preexposure prophylaxis among adolescents in the US: A review. JAMA Pediatr. 2020; 174(11): 1102–8.CrossRefGoogle ScholarPubMed
Posner, MR, Cavacini, LA, Emes, CL, Power, J, Byrn, R. Neutralization of HIV-1 by F105, a human monoclonal antibody to the CD4 binding site of gp120. J Acquir Immune Defic Syndr (1988). 1993; 6(1): 714.Google Scholar
Henn, A, Flateau, C, Gallien, S. Primary HIV infection: Clinical presentation, testing, and treatment. Curr Infect Dis Rep. 2017; 19(10): 37.CrossRefGoogle ScholarPubMed

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