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Chapter 5 - Benign Non-neoplastic Noninfective Lymphadenopathy

from Section II - Normal and Non-neoplastic Hematolymphoid Diseases

Published online by Cambridge University Press:  25 November 2023

By
Dehua Wang  and
Shunyou Gong
Edited by
Silvia Tse Bunting ,
Xiayuan Liang ,
Michele E. Paessler  and
Satheesh Chonat
Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
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Summary

Lymphadenopathy (LAD) is a common presentation in the pediatric population. Cervical LAD with neck mass is the most common manifestation [1]. The etiology of LAD is diverse, including various benign nonspecific reactive conditions, infections, neoplasms, and immune disorders, among others. In spite of the initial concern of lymphoma or infectious conditions, most cases of LAD turn out to be benign and nonspecific reactive. The morphologic features of nonspecific reactive LAD can overlap with those of specific infective LAD or lymphoma. Although some features are more associated with certain etiologies, they are not pathognomonic. Clinical correlation would be essential on this ground. The goal of this chapter is to use case-based illustration to thoroughly demonstrate the morphological features of reactive lymph node and specific entities of non-neoplastic/noninfective LAD.

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Chapter
Information
Atlas of Pediatric Hematopathology , pp. 31 - 41
Publisher: Cambridge University Press
Print publication year: 2023

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References

Deosthali, A, Donches, K, DelVecchio, M, Aronoff, S. Etiologies of pediatric cervical lymphadenopathy: A systematic review of 2687 subjects. Global Pediatric Health. 2019 Jul; 6: 2333794X19865440.CrossRefGoogle ScholarPubMed
Chang, CC, Osipov, V, Wheaton, S, Tripp, S, Perkins, SL. Follicular hyperplasia, follicular lysis, and progressive transformation of germinal centers: A sequential spectrum of morphologic evolution in lymphoid hyperplasia. Am J Clin Pathol. 2003 Sep 1; 120(3): 322–6.CrossRefGoogle ScholarPubMed
Ioachim, HL, Medeiros, LJ. The normal lymph node. In Medeiros, LJ, ed. Ioachim’s lymph node pathology. 4th ed. Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins; 2009:1–14.Google Scholar
Shrestha, D, Dhakal, AK, KC SR, Shakya, A, Shah, SC, Shakya, H. Systemic lupus erythematosus and granulomatous lymphadenopathy. BMC Pediatrics. 2013 Dec; 13(1): 1–6.CrossRefGoogle ScholarPubMed
Attygalle, AD, Liu, H, Shirali, S et al. Atypical marginal zone hyperplasia of mucosa-associated lymphoid tissue: A reactive condition of childhood showing immunoglobulin lambda light-chain restriction. Blood. 2004; 104(10): 3343–8.CrossRefGoogle ScholarPubMed

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