Book contents
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- 1 Human Caspases – Apoptosis and Inflammation Signaling Proteases
- 2 Inhibitor of Apoptosis Proteins
- 3 Death Domain–Containing Receptors – Decisions between Suicide and Fire
- 4 Mitochondria and Cell Death
- 5 The Control of Mitochondrial Apoptosis by the BCL-2 Family
- 6 Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival
- 7 Autophagy – The Liaison between the Lysosomal System and Cell Death
- 8 Cell Death in Response to Genotoxic Stress and DNA Damage
- 9 Ceramide and Lipid Mediators in Apoptosis
- 10 Cytotoxic Granules House Potent Proapoptotic Toxins Critical for Antiviral Responses and Immune Homeostasis
- Part II Cell Death in Tissues and Organs
- Part III Cell Death in Nonmammalian Organisms
- Plate section
- References
3 - Death Domain–Containing Receptors – Decisions between Suicide and Fire
from Part I - General Principles of Cell Death
Published online by Cambridge University Press: 07 September 2011
Book contents
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- 1 Human Caspases – Apoptosis and Inflammation Signaling Proteases
- 2 Inhibitor of Apoptosis Proteins
- 3 Death Domain–Containing Receptors – Decisions between Suicide and Fire
- 4 Mitochondria and Cell Death
- 5 The Control of Mitochondrial Apoptosis by the BCL-2 Family
- 6 Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival
- 7 Autophagy – The Liaison between the Lysosomal System and Cell Death
- 8 Cell Death in Response to Genotoxic Stress and DNA Damage
- 9 Ceramide and Lipid Mediators in Apoptosis
- 10 Cytotoxic Granules House Potent Proapoptotic Toxins Critical for Antiviral Responses and Immune Homeostasis
- Part II Cell Death in Tissues and Organs
- Part III Cell Death in Nonmammalian Organisms
- Plate section
- References
Summary
Introduction
The tumor necrosis factor (TNF) was among the first cytokines to be characterized both functionally and molecularly. This is due to its pivotal role in physiology and also in pathological conditions. A major driving force behind the initial studies into TNF and its functions was the hope its name already spells out: could TNF serve as a new drug to treat cancer? However, in the end TNF inhibition turned out to be an extremely successful novel therapeutic concept that has revolutionized the treatment of inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis, a truly remarkable turnaround.
- Type
- Chapter
- Information
- ApoptosisPhysiology and Pathology, pp. 23 - 36Publisher: Cambridge University PressPrint publication year: 2011
References
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