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4 - Sexual dysfunction, including hypoactive sexual desire disorder: Diagnosis and treatment recommendations

from Section 1 - Managing the basics

Published online by Cambridge University Press:  05 July 2015

By
Ricki Pollycove  and
James A. Simon
Edited by
Leo Plouffe, Jr  and
Botros R. M. B. Rizk
Leo Plouffe, Jr
Affiliation:
Bayer Healthcare, Wayne, New Jersey
Botros R. M. B. Rizk
Affiliation:
University of South Alabama
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Androgens in Gynecological Practice , pp. 38 - 54
Publisher: Cambridge University Press
Print publication year: 2015

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References

1.Kingsberg, S, Althof, SE. Evaluation and treatment of female sexual dysfunction. Int Urogynecol J Pelvic Floor Dysfunct 2009; 20 (Suppl 1): S33–43.Google Scholar
2.Laumann, EO, Paik, A, Rosen, RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999; 281(6): 537–44.CrossRefGoogle ScholarPubMed
3.Laumann, EO, Nicolosi, A, Glasser, DB, et al. Sexual problems among women and men aged 40–80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res 2005; 17(1): 39–57.Google Scholar
4.Shifren, JL, Monz, BU, Russo, PA, et al. Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol 2008; 112(5): 970–8.Google Scholar
5.Pontiroli, AE, Cortelazzi, D, Morabito, A. Female sexual dysfunction and diabetes: a systematic review and meta-analysis. J Sex Med 2013; 10(4): 1044–51.Google Scholar
6.Davis, SR, Davison, SL, Donath, S, Bell, RJ. Circulating androgen levels and self-reported sexual function in women. JAMA 2005; 294(1): 91–6.Google Scholar
7.Shufelt, CL, Braunstein, GD. Safety of testosterone use in women. Maturitas 2009; 63(1): 63–6.Google Scholar
8.Grazziottin, A, Leiblum, SR. Biological and psychosocial pathophysiology of female sexual dysfunction during the menopausal transition. J Sex Med 2005; 2 (Suppl 3): 133–45.Google Scholar
9.Palacios, S. Hypoactive sexual desire disorder and current pharmacotherapeutic options in women. Women’s Health 2011; 7(1): 95–107.Google Scholar
10.Basson, R, Berman, J, Burnett, A, et al. Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol 2000; 163(3) 888–93.Google Scholar
11.Geiss, IM, Umek, WH, Dungl, A, et al. Prevalence of female sexual dysfunction in gynecologic and urogynecologic patients according to the international consensus classification. Urology 2003; 62(3): 514–18.Google Scholar
12.Miller, KK, Lawson, EA, MacArthur, V, et al. Androgens in women with anorexia nervosa and normal weight women with hypothalamic amenorrhea. J Clin Endocrinol Metab 2007; 92(4): 1334–9.CrossRefGoogle ScholarPubMed
13.Kalantaridou, SN, Calis, KA, Venderhoof, VH, et al. Testosterone deficiency in young women with 46XX spontaneous ovarian failure. Fertil Steril 2006; 86(5): 1475–82.CrossRefGoogle Scholar
14.Meston, CM, Hull, E, Levin, RJ, Sipski, M. Disorders of orgasm in women. J Sex Med 2004; 1(1): 66–8.Google Scholar
15.Raghunandan, C, Agrawal, S, Dubey, P, et al. A comparative study of the effects of local estrogen with or without local testosterone on vulvovaginal and sexual dysfunction in postmenopausal women. J Sex Med 2010; 7(3): 1284–90.Google Scholar
16.Goodman, MP. Female genital cosmetic and plastic surgery: a review. J Sex Med 2011; 8(6): 1813–25.Google Scholar
17.Levine, KB, Williams, RE, Hartman, KE. Vulvovaginal atrophy is strongly associated with female sexual dysfunction among sexually active postmenopausal women. Menopause 2008; 15(4-Pt 1): 661–6.Google Scholar
18.Bachman, GA, Leiblum, SR. The impact of hormones on menopausal sexuality: a literature review. Menopause 2004; 11(1): 120–30.Google Scholar
19.Alexander, JL, Kotz, K, Dennerstein, L, et al. The effects of postmenopausal hormone therapies on female sexual functioning: a review of double-blind, randomized controlled trials. Menopause 2004; 11(6 Pt 2): 749–65.Google Scholar
20.Lieblum, S, Bachman, GA, Kemmann, E, et al. The importance of sexual activity and hormones. JAMA 1983; 249: 2195.CrossRefGoogle Scholar
21.Witherby, S, Johnson, J, Demers, L, et al. Topical testosterone for breast cancer patients with vaginal atrophy related to aromatase inhibitors: a phase I/II study. Oncologist 2011; 16(4): 424–31.Google Scholar
22.Davis, SR, Papalia, MA, Norman, RJ, et al. Safety and efficacy of a testosterone metered dose transdermal spray for treatment of decreased sexual satisfaction in premenopausal women: a placebo-controlled randomized, dose ranging study. Ann Inter Med 2008; 148: 569–77.Google Scholar
23.Goldstat, R, Briganti, E, Tran, J, et al. Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women. Menopause 2003; 10(5): 390–8.Google Scholar
24.Davison, SL, Bell, R, Donath, S, et al. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 2005; 90(7): 3847.Google Scholar
25.Mushayandebvu, T, Castracane, VD, Gimpel, T, et al. Evidence for diminished midcycle ovarian androgen production in older reproductive aged women. Fertil Steril 1996; 65(4): 721–3.Google Scholar
26.Zumoff, B, Strain, GW, Miller, LK, Rosner, W. Twenty-four hour mean plasma Testosterone concentrations declines with age in normal premenopausal women. J Clin Endocrinol Metab 1995; 80(4): 1429–30.Google Scholar
27.Longcope, C. Adrenal and gonadal secretion in normal females. J Clin Endocrinol Metab 1986; 15: 213–28.Google ScholarPubMed
28.Bachman, G, Bancroft, J, Braunstein, G, et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification and assessment. Fertil Steril 2002; 77(4): 660–5.Google Scholar
29.Shifren, J, Braunstein, G, Simon, J, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000; 343(10): 682–8.Google Scholar
30.Erekson, EA, Martin, DK, Zhu, K. Sexual function in older women after oophorectomy. ObGyn 2012; 120(4): 833–42.Google Scholar
31.Panay, N, Al-Azzawi, F, Bouchard, C, et al. Testosterone treatment of HSDD in naturally menopausal women: the ADORE study. Climacteric 2010; 13(2): 121–31.Google Scholar
32.Nachtigall, L, Casson, P, Lucas, J, et al. Safety and tolerability of testosterone patch therapy for up to 4 years in surgically menopausal women receiving oral or transdermal oestrogen. Gynecol Endocrinol 2011; 27(1): 39–48.Google Scholar
33.Simon, J, Braunstein, G, Nachtigall, L, et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2000; 90(9): 5226–33.Google Scholar
34.Swerdloff, RS, Wang, C, Cunningham, G, et al. Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. J Clin Endocrinol Metab 2000; 85(12): 4500–10.Google Scholar
35.Singh, AB, Lee, ML, Sinha-Hikim, I, et al. Pharmacokinetics of a testosterone gel in healthy postmenopausal women. J Clin Endocrinol Metab 2006; 91(1): 136–44.CrossRefGoogle ScholarPubMed
36.Pharmacy Compounding Accreditation Board. www.pcab.org/prescribers, accessed May 28, 2013.Google Scholar
37.LaCroix, AZ, Chlebowski, RT, Manson, JE, et al. Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial. JAMA 2011; 305(13): 1305–14.CrossRefGoogle ScholarPubMed
38.Tamimi, RM, Hankinson, SE, Chen, WY, et al. Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women. Arch Intern Med 2006; 166(14): 1483–9.Google Scholar
39.Danforth, KN, Eliassen, AH, Tworoger, SS, et al. The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women. Int J Cancer 2010; 126(1): 199–207.Google Scholar
40.Davis, SR, Hirschberg, AL, Wagner, LK, et al. The effect of transdermal testosterone on mammographic density in postmenopausal women not receiving systemic estrogen therapy. J Clin Endocrinol Metab 2009; 94(12): 4907–13.Google Scholar
41.McCormack, VA, Dowsett, M, Folkerd, E, et al. Sex steroids, growth factors and mammographic density: a cross-sectional study of UK postmenopausal Caucasian and Afro-Caribbean women. Breast Cancer Res 2009; 11(3): R38.Google Scholar
42.Tworoger, SS, Lee, IM, Buring, JE, Hankinson, SE. Plasma androgen concentrations and risk of incident ovarian cancer. Am J Epidemiol 2008; 167(2): 211–18.Google ScholarPubMed
43.Li, AJ, Karlan, BY. Androgens and epithelial ovarian cancer: what’s the connection? Cancer Biol Ther 2008; 7(11):1712–16.Google Scholar
44.Jansen, I, Powell, LH, Crawford, S, et al. Menopause and the metabolic syndrome. The Study of Women’s Health Across the Nation. Arch Intern Med 2008; 168: 1568–75.Google Scholar
45.Montalcini, T, Gorgone, G, Gazzaruso, C, et al. Role of endogenous androgens on carotid atherosclerosis in non-obese postmenopausal women. Nutr Metab Cardiovasc Dis 2007; 17(10): 705–11.Google Scholar
46.Karim, R, Hodis, HN, Stanczyk, FZ, et al. Relationship between serum levels of sex hormones and progression of subclinical atherosclerosis in postmenopausal women. J Clin Endocrinol Metab 2008; 93(1): 131–8.Google Scholar
47.Shaw, LJ, Bairey Merz, CN, Azziz, R, et al. Post-menopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health – National Heart, Lung and Blood Institute sponsored women’s ischemia syndrome evaluation. J Clin Endocrinol Metab 2008; 93: 1276–84.CrossRefGoogle Scholar
48.Iellamo, F, Volterrani, M, Caminiti, G, et al. Testosterone therapy in women with chronic heart failure: a pilot double-blind, randomized, placebo-controlled study. J Am Coll Cardiol 2010; 56(16): 1310–16.Google Scholar
49.Mudali, S, Dobs, AS, Ding, J, et al. Endogenous postmenopausal hormones and serum lipids: the atherosclerosis risk in communities study. J Clin Endocrinol Metab 2005; 90(2): 1202–9.Google Scholar
50.Lambrinoudaki, I, Christodoulakos, G, Rizos, D, et al. Endogenous sex hormones and risk factors for atherosclerosis in healthy Greek postmenopausal women. Eur J Endocrinol 2006; 154(6): 907–16.CrossRefGoogle ScholarPubMed
51.Manolakou, P, Angelopoulou, R, Bakoyiannis, C, Bastounis, E. The effects of endogenous and exogenous androgens on cardiovascular disease risk factors and progression. Reprod Biol Endocrinol 2009; 7: 44.Google Scholar
52.Basson, R, Wierman, ME, van Lankveld, J, Brotto, L. Summary of the recommendations on sexual dysfunctions in women. J Sex Med 2010; 7(1 Pt 2): 314–26.Google Scholar
53.Lebbe, M, Hughes, D, Reisch, N, Arlt, W. Androgen replacement therapy in women. Expert Rev Endocrinol Metab 2012; 7(5): 515–29.Google Scholar
54.Barrett-Connor, E, Young, R, Notelovitz, M, et al. A two-year, double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women. Effects on bone mineral density, symptoms and lipid profiles. J Reprod Med 1999; 44(12): 1012–20.Google Scholar
55.Braunstein, GD, Sundwall, DA, Katz, M, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med 2005; 165(14): 1582–9.Google Scholar
56.Basaria, S, Nguyen, T, Rosenson, RS, Dobs, AS. Effect of methyl testosterone administration on plasma viscosity in postmenopausal women. Clin Endocrinol (Oxf) 2002; 57(2): 209–14.Google Scholar
57.Buster, JE, Kingsberg, SA, Aguirre, O, et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 2005; 105(5 Pt 1): 944–52.Google Scholar
58.Chiuve, SE, Martin, LA, Campos, H, Sacks, FM. Effect of the combination of methyltestosterone and esterified estrogens compared with esterified estrogens alone on apolipoprotein CIII and other apolipoproteins in very low density, low density, and high density lipoproteins in surgically postmenopausal women. J Clin Endocrinol Metab 2004; 89(5): 2207–13.Google Scholar
59.Davis, SR, McCloud, P, Strauss, BJ, Burger, H. Testosterone enhances estradiol’s effects on postmenopausal bone density and sexuality. Maturitas 1995; 21(3): 227–36.Google Scholar
60.Davis, SR, Walker, KZ, Strauss, BJ. Effects of estradiol with and without testosterone on body composition and relationships with lipids in postmenopausal women. Menopause 2000; 7(6): 395–401.CrossRefGoogle ScholarPubMed
61.Davis, SR, van der Mooren, MJ, van Lunsen, RH, et al. Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Menopause 2006; 13(3): 387–96.Google Scholar
62.Davis, SR, Moreau, M, Kroll, R, et al. APHRODITE Study Team. Testosterone for low libido in postmenopausal women not taking estrogen. N Engl J Med 2008; 359(19): 2005–17.Google Scholar
63.de Paula, FJ, Soares, JM Jr, Haidar, MA, et al. The benefits of androgens combined with hormone replacement therapy regarding to patients with postmenopausal sexual symptoms. Maturitas 2007; 56(1): 69–77.Google Scholar
64.Dobs, AS, Nguyen, T, Pace, C, Roberts, CP. Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women. J Clin Endocrinol Metab 2002; 87(4): 1509–16.CrossRefGoogle ScholarPubMed
65.El-Hage, G, Eden, JA, Manga, RZ. A double-blind, randomized, placebo-controlled trial of the effect of testosterone cream on the sexual motivation of menopausal hysterectomized women with hypoactive sexual desire disorder. Climacteric 2007; 10(4): 335–43.Google Scholar
66.Flöter, A, Nathorst-Böös, J, Carlström, K, et al. Effects of combined estrogen/testosterone therapy on bone and body composition in oophorectomized women. Gynecol Endocrinol 2005; 20(3): 155–60.Google Scholar
67.Nathorst-Böös, J, Jarkander-Rolff, M, Carlström, K, et al. Percutaneous administration of testosterone gel in postmenopausal women – a pharmacological study. Gynecol Endocrinol 2005; 20(5): 243–48.Google Scholar
68.Hofling, M, Lundström, E, Azavedo, E, et al. Testosterone addition during menopausal hormone therapy: effects on mammographic breast density. Climacteric 2007; 10(2): 155–63.Google Scholar
69.Hofling, M, Hirschberg, AL, Skoog, L, et al. Testosterone inhibits estrogen/progestogen-induced breast cell proliferation in postmenopausal women. Menopause 2007; 14(2): 183–90.Google Scholar
70.Penotti, M, Sironi, L, Cannata, L, et al. Effects of androgen supplementation of hormone replacement therapy on the vascular reactivity of cerebral arteries. Fertil. Steril 2001; 76(2): 235–40.CrossRefGoogle ScholarPubMed
71.Penteado, SR, Fonseca, AM, Bagnoli, VR, et al. Effects of the addition of methyltestosterone to combined hormone therapy with estrogens and progestogens on sexual energy and on orgasm in postmenopausal women. Climacteric 2008; 11(1): 17–25.Google Scholar
72.Raisz, LG, Wiita, B, Artis, A, et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol Metab 1996; 81(1): 37–43.Google Scholar
73.Sherwin, BB, Gelfand, MM, Brender, W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985; 47(4): 339–51.Google Scholar
74.Sherwin, BB, Gelfand, MM. Sex steroids and affect in the surgical menopause: a double-blind, cross-over study. Psychoneuroendocrinology 1985; 10(3): 325–35.Google Scholar
75.Shifren, JL, Davis, SR, Moreau, M et al. Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study. Menopause 2006; 13(5): 770–9.Google ScholarPubMed
76.Warnock, JK, Swanson, SG, Borel, RW, Zipfel, LM, Brennan, JJ; ESTRATEST Clinical Study Group. Combined esterified estrogens and methyltestosterone versus esterified estrogens alone in the treatment of loss of sexual interest in surgically menopausal women. Menopause 2005; 12(4): 374–84.Google ScholarPubMed
77.Watts, NB, Notelovitz, M, Timmons, MC, et al. Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause. Obstet Gynecol 1995; 85(4): 529–37.Google Scholar
78.Zang, H, Carlström, K, Arner, P, Hirschberg, AL. Effects of treatment with testosterone alone or in combination with estrogen on insulin sensitivity in postmenopausal women. Fertil Steril 2006; 86(1): 136–44.Google Scholar

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