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12 - Cushing’s syndrome in females

from Section 3 - Learning from the extremes

Published online by Cambridge University Press:  05 July 2015

Leo Plouffe, Jr
Affiliation:
Bayer Healthcare, Wayne, New Jersey
Botros R. M. B. Rizk
Affiliation:
University of South Alabama
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Publisher: Cambridge University Press
Print publication year: 2015

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References

1.Newell-Price, J, Bertagna, X, Grossman, AB, Nieman, LK. Cushing’s syndrome. Lancet 2006;367(9522):16051617.Google Scholar
2.Goodwin, S, Silverstein, J. Cushing’s syndrome. In: Henderson, KE, ed. The Washington Manual Endocrinology Subspecialty Consult. 3rd ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2009.Google Scholar
3.Hopkins, RL, Leinung, MC. Exogenous Cushing’s syndrome and glucocorticoid withdrawal. Endocrinol Metab Clin North Am 2005;34(2):371384, ix.CrossRefGoogle ScholarPubMed
4.Villanueva, RB, Brett, E, Gabrilove, JL. A cluster of cases of factitious Cushing’s syndrome. Endocr Pract 2000;6(2):143147.Google Scholar
5.Cushing, H. The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). 1932. Obes Res 1994;2(5):486508.CrossRefGoogle ScholarPubMed
6.Alexandraki, KI, Grossman, AB. The ectopic ACTH syndrome. Rev Endocr Metab Disord 2010;11(2):117126.Google Scholar
7.Kirschner, LS, Carney, JA, Pack, SD, et al. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the carney complex. Nat Genet 2000;26(1):8992.Google Scholar
8.Groussin, L, Jullian, E, Perlemoine, K, et al. Mutations of the PRKAR1A gene in Cushing’s syndrome due to sporadic primary pigmented nodular adrenocortical disease. J Clin Endocrinol Metab 2002;87(9):43244329.CrossRefGoogle ScholarPubMed
9.Weinstein, LS, Shenker, A, Gejman, PV, Merino, MJ, Friedman, E, Spiegel, AM. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med 1991;325(24):16881695.Google Scholar
10.Lindholm, J, Juul, S, Jorgensen, JO, et al. Incidence and late prognosis of Cushing’s syndrome: a population-based study. J Clin Endocrinol Metab 2001;86(1):117123.Google Scholar
11.Etxabe, J, Vazquez, JA. Morbidity and mortality in Cushing’s disease: an epidemiological approach. Clin Endocrinol (Oxf) 1994;40(4):479484.Google Scholar
12.Bolland, MJ, Holdaway, IM, Berkeley, JE, et al. Mortality and morbidity in Cushing’s syndrome in New Zealand. Clin Endocrinol (Oxf) 2011;75(4):436442.CrossRefGoogle ScholarPubMed
13.Terzolo, M, Pia, A, Reimondo, G. Subclinical Cushing’s syndrome: definition and management. Clin Endocrinol (Oxf) 2012;76(1):1218.CrossRefGoogle ScholarPubMed
14.Catargi, B, Rigalleau, V, Poussin, A, et al. Occult Cushing’s syndrome in type-2 diabetes. J Clin Endocrinol Metab 2003;88(12):58085813.CrossRefGoogle ScholarPubMed
15.Chiodini, I, Torlontano, M, Scillitani, A, et al. Association of subclinical hypercortisolism with type 2 diabetes mellitus: a case-control study in hospitalized patients. Eur J Endocrinol 2005;153(6):837844.Google Scholar
16.Leibowitz, G, Tsur, A, Chayen, SD, et al. Pre-clinical Cushing’s syndrome: an unexpected frequent cause of poor glycaemic control in obese diabetic patients. Clin Endocrinol (Oxf) 1996;44(6):717722.CrossRefGoogle ScholarPubMed
17.Chiodini, I, Mascia, ML, Muscarella, S, et al. Subclinical hypercortisolism among outpatients referred for osteoporosis. Ann Intern Med 2007;147(8):541548.CrossRefGoogle ScholarPubMed
18.Chiodini, I, Morelli, V, Masserini, B, et al. Bone mineral density, prevalence of vertebral fractures, and bone quality in patients with adrenal incidentalomas with and without subclinical hypercortisolism: an Italian multicenter study. J Clin Endocrinol Metab 2009;94(9):32073214.Google Scholar
19.Newell-Price, J, Trainer, P, Besser, M, Grossman, A. The diagnosis and differential diagnosis of Cushing’s syndrome and pseudo-Cushing’s states. Endocr Rev 1998;19(5):647672.Google Scholar
20.Zilio, M, Barbot, M, Ceccato, F, et al. Diagnosis and complications of Cushing’s disease: gender-related differences. Clin Endocrinol (Oxf) 2014;80(3):403410.Google Scholar
21.Storr, HL, Isidori, AM, Monson, JP, Besser, GM, Grossman, AB, Savage, MO. Prepubertal Cushing’s disease is more common in males, but there is no increase in severity at diagnosis. J Clin Endocrinol Metab 2004;89(8):38183820.Google Scholar
22.Pecori Giraldi, F, Moro, M, Cavagnini, F, Study Group on the Hypothalamo-Pituitary-Adrenal Axis of the Italian Society of Endocrinology. Gender-related differences in the presentation and course of Cushing’s disease. J Clin Endocrinol Metab 2003;88(4):15541558.Google Scholar
23.Chaidarun, SS, Swearingen, B, Alexander, JM. Differential expression of estrogen receptor-beta (ER beta) in human pituitary tumors: functional interactions with ER alpha and a tumor-specific splice variant. J Clin Endocrinol Metab 1998;83(9):33083315.Google Scholar
24.Cushing’s disease and syndrome. In: Jones, H, Scott, W, eds. Hermaphroditism, Genital Anomalies and Related Endocrine Disorders. 2nd edition. Chapter 24. Baltimore: The Williams & Wilkins Company, 1971; 491–506Google Scholar
25.Nieman, LK, Biller, BM, Findling, JW, et al. The diagnosis of Cushing’s syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2008;93(5):15261540.CrossRefGoogle ScholarPubMed
26.Nugent, CA, Warner, HR, Dunn, JT, TYLER FH. Probability theory in the diagnosis of Cushing’s syndrome. J Clin Endocrinol Metab 1964;24:621627.CrossRefGoogle ScholarPubMed
27.Pecori Giraldi, F, Pivonello, R, Ambrogio, AG, et al. The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing’s syndrome from pseudo-Cushing’s states. Clin Endocrinol (Oxf) 2007;66(2):251–257.CrossRefGoogle ScholarPubMed
28.Ross, EJ, Linch, DC. Cushing’s syndrome–killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet 1982;2(8299):646649.CrossRefGoogle ScholarPubMed
29.Arnaldi, G, Angeli, A, Atkinson, AB, et al. Diagnosis and complications of Cushing’s syndrome: a consensus statement. J Clin Endocrinol Metab 2003;88(12):55935602.Google Scholar
30.Dekkers, OM, Horvath-Puho, E, Jorgensen, JO, et al. Multisystem morbidity and mortality in Cushing’s syndrome: a cohort study. J Clin Endocrinol Metab 2013;98(6):22772284.Google Scholar
31.Graversen, D, Vestergaard, P, Stochholm, K, Gravholt, CH, Jorgensen, JO. Mortality in Cushing’s syndrome: a systematic review and meta-analysis. Eur J Intern Med 2012;23(3):278282.Google Scholar
32.Hassan-Smith, ZK, Sherlock, M, Reulen, RC, et al. Outcome of Cushing’s disease following transsphenoidal surgery in a single center over 20 years. J Clin Endocrinol Metab 2012;97(4):11941201.Google Scholar
33.Clayton, RN, Raskauskiene, D, Reulen, RC, Jones, PW. Mortality and morbidity in Cushing’s disease over 50 years in Stoke-on-Trent, UK: audit and meta-analysis of literature. J Clin Endocrinol Metab 2011;96(3):632642.CrossRefGoogle ScholarPubMed
34.Barahona, MJ, Sucunza, N, Resmini, E, et al. Persistent body fat mass and inflammatory marker increases after long-term cure of Cushing’s syndrome. J Clin Endocrinol Metab 2009;94(9):33653371.Google Scholar
35.Geer, EB, Shen, W, Strohmayer, E, Post, KD, Freda, PU. Body composition and cardiovascular risk markers after remission of Cushing’s disease: a prospective study using whole-body MRI. J Clin Endocrinol Metab 2012;97(5):17021711.Google Scholar
36.Pecori Giraldi, F, Ambrogio, AG, De Martin, M, Fatti, LM, Scacchi, M, Cavagnini, F. Specificity of first-line tests for the diagnosis of Cushing’s syndrome: assessment in a large series. J Clin Endocrinol Metab 2007;92(11):41234129.Google Scholar
37.Carroll, T, Raff, H, Findling, JW. Late-night salivary cortisol for the diagnosis of Cushing syndrome: a meta-analysis. Endocr Pract 2009;15(4):335342.Google Scholar
38.Nieman, L. Editorial: The dexamethasone-suppressed corticotropin-releasing hormone test for the diagnosis of Cushing’s syndrome: what have we learned in 14 years? J Clin Endocrinol Metab 2007;92(8):28762878.Google Scholar
39.Elamin, MB, Murad, MH, Mullan, R, et al. Accuracy of diagnostic tests for Cushing’s syndrome: a systematic review and metaanalyses. J Clin Endocrinol Metab 2008;93(5):15531562.Google Scholar
40.Read, GF, Walker, RF, Wilson, DW, Griffiths, K. Steroid analysis in saliva for the assessment of endocrine function. Ann NY Acad Sci 1990;595:260274.Google Scholar
41.Doi, SA, Clark, J, Russell, AW. Concordance of the late night salivary cortisol in patients with Cushing’s syndrome and elevated urine-free cortisol. Endocrine 2013;43(2):327333.CrossRefGoogle ScholarPubMed
42.Baid, SK, Sinaii, N, Wade, M, Rubino, D, Nieman, LK. Radioimmunoassay and tandem mass spectrometry measurement of bedtime salivary cortisol levels: a comparison of assays to establish hypercortisolism. J Clin Endocrinol Metab 2007;92(8):31023107.Google Scholar
43.Qureshi, AC, Bahri, A, Breen, LA, et al. The influence of the route of oestrogen administration on serum levels of cortisol-binding globulin and total cortisol. Clin Endocrinol (Oxf) 2007;66(5):632635.Google Scholar
44.Invitti, C, Pecori, Giraldi F, de Martin, M, Cavagnini, F. Diagnosis and management of Cushing’s syndrome: results of an Italian multicentre study. study group of the Italian Society of Endocrinology on the pathophysiology of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab 1999;84(2):440448.Google Scholar
45.Aron, DC, Raff, H, Findling, JW. Effectiveness versus efficacy: the limited value in clinical practice of high dose dexamethasone suppression testing in the differential diagnosis of adrenocorticotropin-dependent Cushing’s syndrome. J Clin Endocrinol Metab 1997;82(6):17801785.Google Scholar
46.Nieman, LK, Oldfield, EH, Wesley, R, Chrousos, GP, Loriaux, DL, Cutler, GB, Jr. A simplified morning ovine corticotropin-releasing hormone stimulation test for the differential diagnosis of adrenocorticotropin-dependent Cushing’s syndrome. J Clin Endocrinol Metab 1993;77(5):13081312.Google Scholar
47.de Keyzer, Y, Lenne, F, Auzan, C, et al. The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome. J Clin Invest 1996;97(5):13111318.Google Scholar
48.Biller, BM, Grossman, AB, Stewart, PM, et al. Treatment of adrenocorticotropin-dependent Cushing’s syndrome: a consensus statement. J Clin Endocrinol Metab 2008;93(7):24542462.Google Scholar
49.Dinsen, S, Baslund, B, Klose, M, et al. Why glucocorticoid withdrawal may sometimes be as dangerous as the treatment itself. Eur J Intern Med 2013;24(8):714720.CrossRefGoogle Scholar
50.Young, WF, Jr, Thompson, GB. Laparoscopic adrenalectomy for patients who have Cushing’s syndrome. Endocrinol Metab Clin North Am 2005;34(2):489499, xi.Google Scholar
51.Assalia, A, Gagner, M. Laparoscopic adrenalectomy. Br J Surg. 2004;91(10):12591274.Google Scholar
52.Dekkers, OM, Biermasz, NR, Pereira, AM, et al. Mortality in patients treated for Cushing’s disease is increased, compared with patients treated for nonfunctioning pituitary macroadenoma. J Clin Endocrinol Metab 2007;92(3):976981.Google Scholar
53.Rees, DA, Hanna, FW, Davies, JS, Mills, RG, Vafidis, J, Scanlon, MF. Long-term follow-up results of transsphenoidal surgery for Cushing’s disease in a single centre using strict criteria for remission. Clin Endocrinol (Oxf) 2002;56(4):541551.CrossRefGoogle Scholar
54.Assie, G, Bahurel, H, Coste, J, et al. Corticotroph tumor progression after adrenalectomy in Cushing’s disease: a reappraisal of nelson’s syndrome. J Clin Endocrinol Metab 2007;92(1):172179.CrossRefGoogle ScholarPubMed
55.Jenkins, PJ, Trainer, PJ, Plowman, PN, et al. The long-term outcome after adrenalectomy and prophylactic pituitary radiotherapy in adrenocorticotropin-dependent Cushing’s syndrome. J Clin Endocrinol Metab 1995;80(1):165171.Google Scholar
56.Ding, D, Starke, RM, Sheehan, JP. Treatment paradigms for pituitary adenomas: defining the roles of radiosurgery and radiation therapy. J Neurooncol 2013; 117(3):445457.Google Scholar
57.Jagannathan, J, Sheehan, JP, Pouratian, N, Laws, ER, Steiner, L, Vance, ML. Gamma knife surgery for Cushing’s disease. J Neurosurg 2007;106(6):980987.CrossRefGoogle ScholarPubMed

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